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Items: 1 to 50 of 84

1.

Pazopanib radio-sensitization of human sarcoma tumors.

Wang F, Li H, Markovsky E, Glass R, de Stanchina E, Powell SN, Schwartz GK, Haimovitz-Friedman A.

Oncotarget. 2018 Jan 20;9(10):9311-9324. doi: 10.18632/oncotarget.24281. eCollection 2018 Feb 6.

2.

Logarithmic expansion of LGR5+ cells in human colorectal cancer.

Martin ML, Zeng Z, Adileh M, Jacobo A, Li C, Vakiani E, Hua G, Zhang L, Haimovitz-Friedman A, Fuks Z, Kolesnick R, Paty PB.

Cell Signal. 2018 Jan;42:97-105. doi: 10.1016/j.cellsig.2017.09.018. Epub 2017 Sep 25.

PMID:
28958617
3.

A Combination of Radiation and the Hypoxia-Activated Prodrug Evofosfamide (TH-302) is Efficacious against a Human Orthotopic Pancreatic Tumor Model.

Hajj C, Russell J, Hart CP, Goodman KA, Lowery MA, Haimovitz-Friedman A, Deasy JO, Humm JL.

Transl Oncol. 2017 Oct;10(5):760-765. doi: 10.1016/j.tranon.2017.06.010. Epub 2017 Jul 31.

4.

In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2'-deoxy-2'-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models.

Russell J, Pillarsetty N, Kramer RM, Romesser PB, Desai P, Haimovitz-Friedman A, Lowery MA, Humm JL.

Mol Imaging Biol. 2017 Dec;19(6):885-892. doi: 10.1007/s11307-017-1078-6.

5.

Gemcitabine kills proliferating endothelial cells exclusively via acid sphingomyelinase activation.

van Hell AJ, Haimovitz-Friedman A, Fuks Z, Tap WD, Kolesnick R.

Cell Signal. 2017 Jun;34:86-91. doi: 10.1016/j.cellsig.2017.02.021. Epub 2017 Feb 24.

6.

Distinct Levels of Radioresistance in Lgr5+ Colonic Epithelial Stem Cells versus Lgr5+ Small Intestinal Stem Cells.

Hua G, Wang C, Pan Y, Zeng Z, Lee SG, Martin ML, Haimovitz-Friedman A, Fuks Z, Paty PB, Kolesnick R.

Cancer Res. 2017 Apr 15;77(8):2124-2133. doi: 10.1158/0008-5472.CAN-15-2870. Epub 2017 Feb 15.

7.

Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma.

Mizrachi A, Shamay Y, Shah J, Brook S, Soong J, Rajasekhar VK, Humm JL, Healey JH, Powell SN, Baselga J, Heller DA, Haimovitz-Friedman A, Scaltriti M.

Nat Commun. 2017 Feb 13;8:14292. doi: 10.1038/ncomms14292.

8.

Targeting acid sphingomyelinase with anti-angiogenic chemotherapy.

Jacobi J, García-Barros M, Rao S, Rotolo JA, Thompson C, Mizrachi A, Feldman R, Manova K, Bielawska A, Bielawska J, Fuks Z, Kolesnick R, Haimovitz-Friedman A.

Cell Signal. 2017 Jan;29:52-61. doi: 10.1016/j.cellsig.2016.09.010. Epub 2016 Oct 1.

9.

Radiation-Induced Microvascular Injury as a Mechanism of Salivary Gland Hypofunction and Potential Target for Radioprotectors.

Mizrachi A, Cotrim AP, Katabi N, Mitchell JB, Verheij M, Haimovitz-Friedman A.

Radiat Res. 2016 Aug;186(2):189-95. doi: 10.1667/RR14431.1. Epub 2016 Jul 26.

10.

P-selectin is a nanotherapeutic delivery target in the tumor microenvironment.

Shamay Y, Elkabets M, Li H, Shah J, Brook S, Wang F, Adler K, Baut E, Scaltriti M, Jena PV, Gardner EE, Poirier JT, Rudin CM, Baselga J, Haimovitz-Friedman A, Heller DA.

Sci Transl Med. 2016 Jun 29;8(345):345ra87. doi: 10.1126/scitranslmed.aaf7374.

11.

Correction: Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors.

Deng X, Michaelson D, Tchieu J, Cheng J, Rothenstein D, Feldman R, Lee SG, Fuller J, Haimovitz-Friedman A, Studer L, Powell S, Fuks Z, Albert Hubbard EJ, Kolesnick R.

PLoS One. 2016 Jan 22;11(1):e0141673. doi: 10.1371/journal.pone.0141673. eCollection 2016. No abstract available.

12.

Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation.

Lee H, Rotolo JA, Mesicek J, Penate-Medina T, Rimner A, Liao WC, Yin X, Ragupathi G, Ehleiter D, Gulbins E, Zhai D, Reed JC, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

PLoS One. 2015 Dec 30;10(12):e0146210. doi: 10.1371/journal.pone.0146210. eCollection 2015. No abstract available.

13.

Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors.

Deng X, Michaelson D, Tchieu J, Cheng J, Rothenstein D, Feldman R, Lee SG, Fuller J, Haimovitz-Friedman A, Studer L, Powell S, Fuks Z, Hubbard EJ, Kolesnick R.

PLoS One. 2015 Jun 29;10(6):e0127862. doi: 10.1371/journal.pone.0127862. eCollection 2015. Erratum in: PLoS One. 2016;11(1):e0141673.

14.

Novel mechanisms of action of classical chemotherapeutic agents on sphingolipid pathways.

Hajj C, Becker-Flegler KA, Haimovitz-Friedman A.

Biol Chem. 2015 Jun;396(6-7):669-79. doi: 10.1515/hsz-2014-0302. Review.

15.

Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization.

Boppana NB, Kodiha M, Stochaj U, Lin HS, Haimovitz-Friedman A, Bielawska A, Bielawski J, Divine GW, Boyd JA, Korbelik M, Separovic D.

Photochem Photobiol Sci. 2014 Nov;13(11):1621-7. doi: 10.1039/c4pp00292j.

16.

Axitinib sensitization of high Single Dose Radiotherapy.

Rao SS, Thompson C, Cheng J, Haimovitz-Friedman A, Powell SN, Fuks Z, Kolesnick RN.

Radiother Oncol. 2014 Apr;111(1):88-93. doi: 10.1016/j.radonc.2014.02.010. Epub 2014 Apr 29.

17.

Adenoviral transduction of human acid sphingomyelinase into neo-angiogenic endothelium radiosensitizes tumor cure.

Stancevic B, Varda-Bloom N, Cheng J, Fuller JD, Rotolo JA, García-Barros M, Feldman R, Rao S, Weichselbaum RR, Harats D, Haimovitz-Friedman A, Fuks Z, Sadelain M, Kolesnick R.

PLoS One. 2013 Aug 2;8(8):e69025. doi: 10.1371/journal.pone.0069025. Print 2013.

18.

Sphingolipids' role in radiotherapy for prostate cancer.

Hajj C, Haimovitz-Friedman A.

Handb Exp Pharmacol. 2013;(216):115-30. doi: 10.1007/978-3-7091-1511-4_6. Review.

PMID:
23563654
19.

Anticancer therapy and apoptosis imaging.

Yang TJ, Haimovitz-Friedman A, Verheij M.

Exp Oncol. 2012 Oct;34(3):269-76. Review.

PMID:
23070012
20.

Crypt base columnar stem cells in small intestines of mice are radioresistant.

Hua G, Thin TH, Feldman R, Haimovitz-Friedman A, Clevers H, Fuks Z, Kolesnick R.

Gastroenterology. 2012 Nov;143(5):1266-1276. doi: 10.1053/j.gastro.2012.07.106. Epub 2012 Jul 27.

21.

Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice.

Rotolo J, Stancevic B, Zhang J, Hua G, Fuller J, Yin X, Haimovitz-Friedman A, Kim K, Qian M, Cardó-Vila M, Fuks Z, Pasqualini R, Arap W, Kolesnick R.

J Clin Invest. 2012 May;122(5):1786-90. doi: 10.1172/JCI59920. Epub 2012 Apr 2.

22.

Imaging radiotherapy-induced apoptosis.

Haimovitz-Friedman A, Yang TJ, Thin TH, Verheij M.

Radiat Res. 2012 Apr;177(4):467-82. Epub 2012 Feb 21. Review.

PMID:
22348249
23.

Disruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice.

Xiong X, Chorzalska A, Dubielecka PM, White JR, Vedvyas Y, Hedvat CV, Haimovitz-Friedman A, Koutcher JA, Reimand J, Bader GD, Sawicki JA, Kotula L.

Oncogenesis. 2012 Sep 3;1:e26. doi: 10.1038/oncsis.2012.28.

24.

Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation.

Lee H, Rotolo JA, Mesicek J, Penate-Medina T, Rimner A, Liao WC, Yin X, Ragupathi G, Ehleiter D, Gulbins E, Zhai D, Reed JC, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

PLoS One. 2011;6(6):e19783. doi: 10.1371/journal.pone.0019783. Epub 2011 Jun 13. Erratum in: PLoS One. 2015;10(12):e0146210.

25.

Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery.

Truman JP, García-Barros M, Kaag M, Hambardzumyan D, Stancevic B, Chan M, Fuks Z, Kolesnick R, Haimovitz-Friedman A.

PLoS One. 2010 Sep 30;5(9). doi: 10.1371/annotation/6e222ad5-b175-4a00-9d04-4d120568a897.

26.

Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited.

García-Barros M, Thin TH, Maj J, Cordon-Cardo C, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Cancer Res. 2010 Oct 15;70(20):8179-86. doi: 10.1158/0008-5472.CAN-10-1871. Epub 2010 Oct 5.

27.

Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery.

Truman JP, García-Barros M, Kaag M, Hambardzumyan D, Stancevic B, Chan M, Fuks Z, Kolesnick R, Haimovitz-Friedman A.

PLoS One. 2010 Aug 19;5(8):e12310. doi: 10.1371/journal.pone.0012310. Corrected and republished in: PLoS One. 2010;5(9). doi: 10.1371/annotation/6e222ad5-b175-4a00-9d04-4d120568a897.

28.

Radiation therapy causes loss of dermal lymphatic vessels and interferes with lymphatic function by TGF-beta1-mediated tissue fibrosis.

Avraham T, Yan A, Zampell JC, Daluvoy SV, Haimovitz-Friedman A, Cordeiro AP, Mehrara BJ.

Am J Physiol Cell Physiol. 2010 Sep;299(3):C589-605. doi: 10.1152/ajpcell.00535.2009. Epub 2010 Jun 2.

29.

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.

Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Cell Signal. 2010 Sep;22(9):1300-7. doi: 10.1016/j.cellsig.2010.04.006. Epub 2010 Apr 18.

30.

Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.

Rotolo JA, Mesicek J, Maj J, Truman JP, Haimovitz-Friedman A, Kolesnick R, Fuks Z.

Cancer Res. 2010 Feb 1;70(3):957-67. doi: 10.1158/0008-5472.CAN-09-1562. Epub 2010 Jan 19.

31.

Kinase suppressor of Ras transphosphorylates c-Raf-1.

Zafrullah M, Yin X, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):434-40. doi: 10.1016/j.bbrc.2009.09.048. Epub 2009 Sep 17.

32.

A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation.

Yin X, Zafrullah M, Lee H, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Cell Physiol Biochem. 2009;24(3-4):219-30. doi: 10.1159/000233248. Epub 2009 Aug 3.

33.

Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway.

Coward J, Ambrosini G, Musi E, Truman JP, Haimovitz-Friedman A, Allegood JC, Wang E, Merrill AH Jr, Schwartz GK.

Autophagy. 2009 Feb;5(2):184-93. Epub 2009 Feb 6.

PMID:
19098447
34.

PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo.

Truman JP, Rotenberg SA, Kang JH, Lerman G, Fuks Z, Kolesnick R, Marquez VE, Haimovitz-Friedman A.

Cancer Biol Ther. 2009 Jan;8(1):54-63. Epub 2009 Jan 4.

35.

Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans.

Deng X, Yin X, Allan R, Lu DD, Maurer CW, Haimovitz-Friedman A, Fuks Z, Shaham S, Kolesnick R.

Science. 2008 Oct 3;322(5898):110-5. doi: 10.1126/science.1158111.

36.

Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.

Duan D, Sigano DM, Kelley JA, Lai CC, Lewin NE, Kedei N, Peach ML, Lee J, Abeyweera TP, Rotenberg SA, Kim H, Kim YH, El Kazzouli S, Chung JU, Young HA, Young MR, Baker A, Colburn NH, Haimovitz-Friedman A, Truman JP, Parrish DA, Deschamps JR, Perry NA, Surawski RJ, Blumberg PM, Marquez VE.

J Med Chem. 2008 Sep 11;51(17):5198-220. doi: 10.1021/jm8001907. Epub 2008 Aug 13.

37.

Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa.

Rotolo JA, Maj JG, Feldman R, Ren D, Haimovitz-Friedman A, Cordon-Cardo C, Cheng EH, Kolesnick R, Fuks Z.

Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):804-15. doi: 10.1016/j.ijrobp.2007.11.043. Epub 2008 Jan 11.

PMID:
18191336
38.

Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.

Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, Futerman AH.

FEBS Lett. 2007 Nov 13;581(27):5289-94. Epub 2007 Oct 23.

39.

ATM regulates target switching to escalating doses of radiation in the intestines.

Ch'ang HJ, Maj JG, Paris F, Xing HR, Zhang J, Truman JP, Cardon-Cardo C, Haimovitz-Friedman A, Kolesnick R, Fuks Z.

Nat Med. 2005 May;11(5):484-90. Epub 2005 May 1. Erratum in: Nat Med. 2006 Feb;12(2):253.

PMID:
15864314
40.

Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis.

Truman JP, Gueven N, Lavin M, Leibel S, Kolesnick R, Fuks Z, Haimovitz-Friedman A.

J Biol Chem. 2005 Jun 17;280(24):23262-72. Epub 2005 Apr 18.

41.

Host acid sphingomyelinase regulates microvascular function not tumor immunity.

Garcia-Barros M, Lacorazza D, Petrie H, Haimovitz-Friedman A, Cardon-Cardo C, Nimer S, Fuks Z, Kolesnick R.

Cancer Res. 2004 Nov 15;64(22):8285-91.

42.

The cyclin-dependent kinase inhibitor flavopiridol potentiates gamma-irradiation-induced apoptosis in colon and gastric cancer cells.

Jung C, Motwani M, Kortmansky J, Sirotnak FM, She Y, Gonen M, Haimovitz-Friedman A, Schwartz GK.

Clin Cancer Res. 2003 Dec 1;9(16 Pt 1):6052-61.

43.

Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation.

Li YQ, Chen P, Haimovitz-Friedman A, Reilly RM, Wong CS.

Cancer Res. 2003 Sep 15;63(18):5950-6.

44.

The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 selectively potentiates radiation response of human tumors in nude mice, with a marked improvement in therapeutic index.

She Y, Lee F, Chen J, Haimovitz-Friedman A, Miller VA, Rusch VR, Kris MG, Sirotnak FM.

Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3773-8.

45.

Microvascular function regulates intestinal crypt response to radiation.

Maj JG, Paris F, Haimovitz-Friedman A, Venkatraman E, Kolesnick R, Fuks Z.

Cancer Res. 2003 Aug 1;63(15):4338-41.

46.

Tumor response to radiotherapy regulated by endothelial cell apoptosis.

Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Science. 2003 May 16;300(5622):1155-9.

47.

Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring.

Paris F, Perez GI, Fuks Z, Haimovitz-Friedman A, Nguyen H, Bose M, Ilagan A, Hunt PA, Morgan WF, Tilly JL, Kolesnick R.

Nat Med. 2002 Sep;8(9):901-2. No abstract available. Erratum in: Nat Med 2002 Nov;8(11):1329.

PMID:
12205432
48.

Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.

Paris F, Fuks Z, Kang A, Capodieci P, Juan G, Ehleiter D, Haimovitz-Friedman A, Cordon-Cardo C, Kolesnick R.

Science. 2001 Jul 13;293(5528):293-7.

49.

Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes.

Paris F, Grassmé H, Cremesti A, Zager J, Fong Y, Haimovitz-Friedman A, Fuks Z, Gulbins E, Kolesnick R.

J Biol Chem. 2001 Mar 16;276(11):8297-305. Epub 2000 Nov 28.

50.

Cell autonomous apoptosis defects in acid sphingomyelinase knockout fibroblasts.

Lozano J, Menendez S, Morales A, Ehleiter D, Liao WC, Wagman R, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

J Biol Chem. 2001 Jan 5;276(1):442-8.

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