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Items: 37


Role of MSC-derived galectin 3 in the AML microenvironment.

Ruvolo PP, Ruvolo VR, Burks JK, Qiu Y, Wang RY, Shpall EJ, Mirandola L, Hail N Jr, Zeng Z, McQueen T, Daver N, Post SM, Chiriva-Internati M, Kornblau SM, Andreeff M.

Biochim Biophys Acta Mol Cell Res. 2018 Jul;1865(7):959-969. doi: 10.1016/j.bbamcr.2018.04.005. Epub 2018 Apr 12.


Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival.

Kornblau SM, Ruvolo PP, Wang RY, Battula VL, Shpall EJ, Ruvolo VR, McQueen T, Qui Y, Zeng Z, Pierce S, Jacamo R, Yoo SY, Le PM, Sun J, Hail N Jr, Konopleva M, Andreeff M.

Haematologica. 2018 May;103(5):810-821. doi: 10.3324/haematol.2017.172429. Epub 2018 Mar 15.


IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells.

Battula VL, Nguyen K, Sun J, Pitner MK, Yuan B, Bartholomeusz C, Hail N, Andreeff M.

Oncotarget. 2017 Jun 6;8(23):36936-36949. doi: 10.18632/oncotarget.16294.


Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells.

Tabe Y, Yamamoto S, Saitoh K, Sekihara K, Monma N, Ikeo K, Mogushi K, Shikami M, Ruvolo V, Ishizawa J, Hail N Jr, Kazuno S, Igarashi M, Matsushita H, Yamanaka Y, Arai H, Nagaoka I, Miida T, Hayashizaki Y, Konopleva M, Andreeff M.

Cancer Res. 2017 Mar 15;77(6):1453-1464. doi: 10.1158/0008-5472.CAN-16-1645. Epub 2017 Jan 20.


Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia.

Piya S, Kornblau SM, Ruvolo VR, Mu H, Ruvolo PP, McQueen T, Davis RE, Hail N Jr, Kantarjian H, Andreeff M, Borthakur G.

Blood. 2016 Sep 1;128(9):1260-9. doi: 10.1182/blood-2016-01-692244. Epub 2016 Jun 7.


Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells.

Ruvolo PP, Ruvolo VR, Benton CB, AlRawi A, Burks JK, Schober W, Rolke J, Tidmarsh G, Hail N Jr, Davis RE, Andreeff M.

Biochim Biophys Acta. 2016 Apr;1863(4):562-71. doi: 10.1016/j.bbamcr.2015.12.008. Epub 2015 Dec 17.


Phosphorylation of GSK3α/β correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients.

Ruvolo PP, Qiu Y, Coombes KR, Zhang N, Neeley ES, Ruvolo VR, Hail N Jr, Borthakur G, Konopleva M, Andreeff M, Kornblau SM.

BBA Clin. 2015 Jul 23;4:59-68. doi: 10.1016/j.bbacli.2015.07.001. eCollection 2015 Dec.


Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein.

Ishizawa J, Kojima K, Hail N Jr, Tabe Y, Andreeff M.

Pharmacol Ther. 2015 Sep;153:25-35. doi: 10.1016/j.pharmthera.2015.06.001. Epub 2015 Jun 3. Review.


The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells.

Ruvolo PP, Ruvolo VR, Jacamo R, Burks JK, Zeng Z, Duvvuri SR, Zhou L, Qiu Y, Coombes KR, Zhang N, Yoo SY, Pan R, Hail N Jr, Konopleva M, Calin G, Kornblau SM, Andreeff M.

Biochim Biophys Acta. 2014 Sep;1843(9):1969-77. doi: 10.1016/j.bbamcr.2014.05.006. Epub 2014 May 21.


Mitochondrial uncoupling and the reprograming of intermediary metabolism in leukemia cells.

Vélez J, Hail N Jr, Konopleva M, Zeng Z, Kojima K, Samudio I, Andreeff M.

Front Oncol. 2013 Apr 2;3:67. doi: 10.3389/fonc.2013.00067. eCollection 2013.


The CXCR4 antagonist AMD3465 regulates oncogenic signaling and invasiveness in vitro and prevents breast cancer growth and metastasis in vivo.

Ling X, Spaeth E, Chen Y, Shi Y, Zhang W, Schober W, Hail N Jr, Konopleva M, Andreeff M.

PLoS One. 2013;8(3):e58426. doi: 10.1371/journal.pone.0058426. Epub 2013 Mar 6.


Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes.

Shearn CT, Smathers RL, Stewart BJ, Fritz KS, Galligan JJ, Hail N Jr, Petersen DR.

Mol Pharmacol. 2011 Jun;79(6):941-52. doi: 10.1124/mol.110.069534. Epub 2011 Mar 17.


The hydroxyl functional group of N-(4-hydroxyphenyl)retinamide mediates cellular uptake and cytotoxicity in premalignant and malignant human epithelial cells.

Hail N Jr, Chen P, Wempe MF.

Free Radic Biol Med. 2010 Dec 15;49(12):2001-9. doi: 10.1016/j.freeradbiomed.2010.09.032. Epub 2010 Oct 23.


Teriflunomide encourages cytostatic and apoptotic effects in premalignant and malignant cutaneous keratinocytes.

Hail N Jr, Chen P, Rower J, Bushman LR.

Apoptosis. 2010 Oct;15(10):1234-46. doi: 10.1007/s10495-010-0518-4.


Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis.

Hail N Jr, Chen P, Kepa JJ, Bushman LR, Shearn C.

Free Radic Biol Med. 2010 Jul 1;49(1):109-16. doi: 10.1016/j.freeradbiomed.2010.04.006. Epub 2010 Apr 24.


Lactoferrin protects against acetaminophen-induced liver injury in mice.

Yin H, Cheng L, Holt M, Hail N Jr, Maclaren R, Ju C.

Hepatology. 2010 Mar;51(3):1007-16. doi: 10.1002/hep.23476.


Cancer chemoprevention and mitochondria: targeting apoptosis in transformed cells via the disruption of mitochondrial bioenergetics/redox state.

Hail N Jr, Lotan R.

Mol Nutr Food Res. 2009 Jan;53(1):49-67. doi: 10.1002/mnfr.200700527. Review.


Cancer chemoprevention: a radical perspective.

Hail N Jr, Cortes M, Drake EN, Spallholz JE.

Free Radic Biol Med. 2008 Jul 15;45(2):97-110. doi: 10.1016/j.freeradbiomed.2008.04.004. Epub 2008 Apr 15. Review.


Mitochondrial reactive oxygen species affect sensitivity to curcumin-induced apoptosis.

Hail N Jr.

Free Radic Biol Med. 2008 Apr 1;44(7):1382-93. doi: 10.1016/j.freeradbiomed.2007.12.034. Epub 2008 Jan 4.


Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells.

Leroux ME, Auzenne E, Evans R, Hail N Jr, Spohn W, Ghosh SC, Farquhar D, McDonnell T, Klostergaard J.

Prostate. 2007 Nov 1;67(15):1699-717.


Mechanisms of fenretinide-induced apoptosis.

Hail N Jr, Kim HJ, Lotan R.

Apoptosis. 2006 Oct;11(10):1677-94. Review.


Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.

Zeng Z, Samudio IJ, Zhang W, Estrov Z, Pelicano H, Harris D, Frolova O, Hail N Jr, Chen W, Kornblau SM, Huang P, Lu Y, Mills GB, Andreeff M, Konopleva M.

Cancer Res. 2006 Apr 1;66(7):3737-46.


Apoptosis effector mechanisms: a requiem performed in different keys.

Hail N Jr, Carter BZ, Konopleva M, Andreeff M.

Apoptosis. 2006 Jun;11(6):889-904. Review.


Mitochondria: A novel target for the chemoprevention of cancer.

Hail N Jr.

Apoptosis. 2005 Aug;10(4):687-705. Review.


2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer.

Samudio I, Konopleva M, Hail N Jr, Shi YX, McQueen T, Hsu T, Evans R, Honda T, Gribble GW, Sporn M, Gilbert HF, Safe S, Andreeff M.

J Biol Chem. 2005 Oct 28;280(43):36273-82. Epub 2005 Aug 23.


Apoptosis as a novel target for cancer chemoprevention.

Sun SY, Hail N Jr, Lotan R.

J Natl Cancer Inst. 2004 May 5;96(9):662-72. Review.


Evidence supporting a role for calcium in apoptosis induction by the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO).

Hail N Jr, Konopleva M, Sporn M, Lotan R, Andreeff M.

J Biol Chem. 2004 Mar 19;279(12):11179-87. Epub 2004 Jan 7.


Mechanisms of vanilloid-induced apoptosis.

Hail N Jr.

Apoptosis. 2003 Jun;8(3):251-62. Review.


Examining the role of mitochondrial respiration in vanilloid-induced apoptosis.

Hail N Jr, Lotan R.

J Natl Cancer Inst. 2002 Sep 4;94(17):1281-92.


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