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Items: 1 to 50 of 69

1.

Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation.

Brubaker DK, Paulo JA, Sheth S, Poulin EJ, Popow O, Joughin BA, Strasser SD, Starchenko A, Gygi SP, Lauffenburger DA, Haigis KM.

Cell Syst. 2019 Aug 23. pii: S2405-4712(19)30238-8. doi: 10.1016/j.cels.2019.07.006. [Epub ahead of print]

PMID:
31521603
2.

Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D.

Johnson CW, Lin YJ, Reid D, Parker J, Pavlopoulos S, Dischinger P, Graveel C, Aguirre AJ, Steensma M, Haigis KM, Mattos C.

Cell Rep. 2019 Aug 6;28(6):1538-1550.e7. doi: 10.1016/j.celrep.2019.07.026.

3.

Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics.

Popow O, Paulo JA, Tatham MH, Volk MS, Rojas-Fernandez A, Loyer N, Newton IP, Januschke J, Haigis KM, Näthke I.

Mol Cancer Res. 2019 Sep;17(9):1828-1841. doi: 10.1158/1541-7786.MCR-18-1154. Epub 2019 Jun 3.

PMID:
31160382
4.

Tissue-Specific Oncogenic Activity of KRASA146T.

Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM.

Cancer Discov. 2019 Jun;9(6):738-755. doi: 10.1158/2159-8290.CD-18-1220. Epub 2019 Apr 5.

PMID:
30952657
5.

Tissue-specificity in cancer: The rule, not the exception.

Haigis KM, Cichowski K, Elledge SJ.

Science. 2019 Mar 15;363(6432):1150-1151. doi: 10.1126/science.aaw3472. No abstract available.

PMID:
30872507
6.

Computational translation of genomic responses from experimental model systems to humans.

Brubaker DK, Proctor EA, Haigis KM, Lauffenburger DA.

PLoS Comput Biol. 2019 Jan 10;15(1):e1006286. doi: 10.1371/journal.pcbi.1006286. eCollection 2019 Jan.

7.

MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.

Suarez-Lopez L, Sriram G, Kong YW, Morandell S, Merrick KA, Hernandez Y, Haigis KM, Yaffe MB.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4236-E4244. doi: 10.1073/pnas.1722020115. Epub 2018 Apr 16.

8.

The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile.

Lyons J, Ghazi PC, Starchenko A, Tovaglieri A, Baldwin KR, Poulin EJ, Gierut JJ, Genetti C, Yajnik V, Breault DT, Lauffenburger DA, Haigis KM.

PLoS Biol. 2018 Mar 29;16(3):e2002417. doi: 10.1371/journal.pbio.2002417. eCollection 2018 Mar.

9.

Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis.

Lyons J, Brubaker DK, Ghazi PC, Baldwin KR, Edwards A, Boukhali M, Strasser SD, Suarez-Lopez L, Lin YJ, Yajnik V, Kissil JL, Haas W, Lauffenburger DA, Haigis KM.

Sci Signal. 2018 Feb 27;11(519). pii: eaan3580. doi: 10.1126/scisignal.aan3580.

10.

Brother's Keeper: Wild-Type Mutant K-Ras Dimers Limit Oncogenesis.

Lin YJ, Haigis KM.

Cell. 2018 Feb 8;172(4):645-647. doi: 10.1016/j.cell.2018.01.019.

11.

KRAS Alleles: The Devil Is in the Detail.

Haigis KM.

Trends Cancer. 2017 Oct;3(10):686-697. doi: 10.1016/j.trecan.2017.08.006. Epub 2017 Sep 12. Review.

12.

A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.

Martin TD, Cook DR, Choi MY, Li MZ, Haigis KM, Elledge SJ.

Cell Rep. 2017 Jul 11;20(2):427-438. doi: 10.1016/j.celrep.2017.06.061.

13.

No back seat for a progression event-K-RAS as a therapeutic target in CRC.

Poulin EJ, Haigis KM.

Genes Dev. 2017 Feb 15;31(4):333-335. doi: 10.1101/gad.297630.117. Epub 2017 Mar 17. Review.

14.

Intra-pancreatic Distal Bile Duct Carcinoma is Morphologically, Genetically, and Clinically Distinct from Pancreatic Ductal Adenocarcinoma.

Deshpande V, Konstantinidis IT, Castillo CF, Hezel AF, Haigis KM, Ting DT, Bardeesy N, Goyal L, Zhu AX, Warshaw AL, Lillemoe KD, Ferrone CR.

J Gastrointest Surg. 2016 May;20(5):953-9. doi: 10.1007/s11605-016-3108-0. Epub 2016 Mar 8.

PMID:
26956004
15.

Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium.

Gierut JJ, Wood LB, Lau KS, Lin YJ, Genetti C, Samatar AA, Lauffenburger DA, Haigis KM.

Sci Signal. 2015 Dec 15;8(407):ra129. doi: 10.1126/scisignal.aac7235.

16.

Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening.

Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM.

Sci Rep. 2015 Nov 13;5:16622. doi: 10.1038/srep16622.

17.

Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells.

Gierut JJ, Lyons J, Shah MS, Genetti C, Breault DT, Haigis KM.

Stem Cell Res. 2015 Jul;15(1):165-71. doi: 10.1016/j.scr.2015.06.003. Epub 2015 Jun 10.

18.

RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.

Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP.

Nat Cell Biol. 2015 Jun;17(6):804-15. doi: 10.1038/ncb3175. Epub 2015 May 25.

19.

Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.

Bender RH, Haigis KM, Gutmann DH.

Stem Cells. 2015 Jun;33(6):1998-2010. doi: 10.1002/stem.1990.

20.

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif.

Tsai FD, Lopes MS, Zhou M, Court H, Ponce O, Fiordalisi JJ, Gierut JJ, Cox AD, Haigis KM, Philips MR.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):779-84. doi: 10.1073/pnas.1412811112. Epub 2015 Jan 5.

21.

Preclinical efficacy of MEK inhibition in Nras-mutant AML.

Burgess MR, Hwang E, Firestone AJ, Huang T, Xu J, Zuber J, Bohin N, Wen T, Kogan SC, Haigis KM, Sampath D, Lowe S, Shannon K, Li Q.

Blood. 2014 Dec 18;124(26):3947-55. doi: 10.1182/blood-2014-05-574582. Epub 2014 Oct 31.

22.

ROS1 signaling regulates epithelial differentiation in the epididymis.

Jun HJ, Roy J, Smith TB, Wood LB, Lane K, Woolfenden S, Punko D, Bronson RT, Haigis KM, Breton S, Charest A.

Endocrinology. 2014 Sep;155(9):3661-73. doi: 10.1210/en.2014-1341. Epub 2014 Jun 27.

23.

Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review.

Imamura Y, Lochhead P, Yamauchi M, Kuchiba A, Qian ZR, Liao X, Nishihara R, Jung S, Wu K, Nosho K, Wang YE, Peng S, Bass AJ, Haigis KM, Meyerhardt JA, Chan AT, Fuchs CS, Ogino S.

Mol Cancer. 2014 May 31;13:135. doi: 10.1186/1476-4598-13-135.

24.

Whole-mount X-Gal staining of mouse tissues.

Gierut JJ, Jacks TE, Haigis KM.

Cold Spring Harb Protoc. 2014 Apr 1;2014(4):417-9. doi: 10.1101/pdb.prot073452.

25.

Strategies to achieve conditional gene mutation in mice.

Gierut JJ, Jacks TE, Haigis KM.

Cold Spring Harb Protoc. 2014 Apr 1;2014(4):339-49. doi: 10.1101/pdb.top069807. Review.

26.

In vivo delivery of lenti-Cre or adeno-Cre into mice using intranasal instillation.

Gierut JJ, Jacks TE, Haigis KM.

Cold Spring Harb Protoc. 2014 Mar 1;2014(3):307-9. doi: 10.1101/pdb.prot073445.

27.

Producing and concentrating lenti-Cre for mouse infections.

Gierut JJ, Jacks TE, Haigis KM.

Cold Spring Harb Protoc. 2014 Mar 1;2014(3):304-6. doi: 10.1101/pdb.prot073437.

28.

Mutational analysis and clinical correlation of metastatic colorectal cancer.

Russo AL, Borger DR, Szymonifka J, Ryan DP, Wo JY, Blaszkowsky LS, Kwak EL, Allen JN, Wadlow RC, Zhu AX, Murphy JE, Faris JE, Dias-Santagata D, Haigis KM, Ellisen LW, Iafrate AJ, Hong TS.

Cancer. 2014 May 15;120(10):1482-90. doi: 10.1002/cncr.28599. Epub 2014 Feb 5.

29.

Comparative analysis of radiosensitizers for K-RAS mutant rectal cancers.

Kleiman LB, Krebs AM, Kim SY, Hong TS, Haigis KM.

PLoS One. 2013 Dec 12;8(12):e82982. doi: 10.1371/journal.pone.0082982. eCollection 2013.

30.

Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α.

Lau KS, Schrier SB, Gierut J, Lyons J, Lauffenburger DA, Haigis KM.

Integr Biol (Camb). 2013 Nov;5(11):1355-65. doi: 10.1039/c3ib40062j. Epub 2013 Oct 2.

31.

Mutational and clinical predictors of pathologic complete response in the treatment of locally advanced rectal cancer.

Russo AL, Ryan DP, Borger DR, Wo JY, Szymonifka J, Liang WY, Kwak EL, Blaszkowsky LS, Clark JW, Allen JN, Zhu AX, Berger DL, Cusack JC, Mamon HJ, Haigis KM, Hong TS.

J Gastrointest Cancer. 2014 Mar;45(1):34-9. doi: 10.1007/s12029-013-9546-y.

32.

Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation.

Xu J, Haigis KM, Firestone AJ, McNerney ME, Li Q, Davis E, Chen SC, Nakitandwe J, Downing J, Jacks T, Le Beau MM, Shannon K.

Cancer Discov. 2013 Sep;3(9):993-1001. doi: 10.1158/2159-8290.CD-13-0096. Epub 2013 Jun 3.

33.

HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS.

Yang MH, Laurent G, Bause AS, Spang R, German N, Haigis MC, Haigis KM.

Mol Cancer Res. 2013 Sep;11(9):1072-7. doi: 10.1158/1541-7786.MCR-13-0040-T. Epub 2013 May 30.

34.

Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice.

Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM.

Integr Biol (Camb). 2013 Jul 24;5(7):940-63. doi: 10.1039/c3ib40013a. Epub 2013 May 20.

35.

Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-β on microglial accumulation.

Cho H, Hashimoto T, Wong E, Hori Y, Wood LB, Zhao L, Haigis KM, Hyman BT, Irimia D.

Sci Rep. 2013;3:1823. doi: 10.1038/srep01823.

36.

Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression.

Wang Y, Velho S, Vakiani E, Peng S, Bass AJ, Chu GC, Gierut J, Bugni JM, Der CJ, Philips M, Solit DB, Haigis KM.

Cancer Discov. 2013 Mar;3(3):294-307. doi: 10.1158/2159-8290.CD-12-0198. Epub 2012 Dec 28.

37.

An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background.

Mitra D, Luo X, Morgan A, Wang J, Hoang MP, Lo J, Guerrero CR, Lennerz JK, Mihm MC, Wargo JA, Robinson KC, Devi SP, Vanover JC, D'Orazio JA, McMahon M, Bosenberg MW, Haigis KM, Haber DA, Wang Y, Fisher DE.

Nature. 2012 Nov 15;491(7424):449-53. doi: 10.1038/nature11624. Epub 2012 Oct 31.

38.

Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium.

Lau KS, Cortez-Retamozo V, Philips SR, Pittet MJ, Lauffenburger DA, Haigis KM.

PLoS Biol. 2012;10(9):e1001393. doi: 10.1371/journal.pbio.1001393. Epub 2012 Sep 25.

39.

BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner.

Lau KS, Zhang T, Kendall KR, Lauffenburger D, Gray NS, Haigis KM.

PLoS One. 2012;7(7):e41343. doi: 10.1371/journal.pone.0041343. Epub 2012 Jul 18.

40.

Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF wild-type colorectal cancers.

Imamura Y, Morikawa T, Liao X, Lochhead P, Kuchiba A, Yamauchi M, Qian ZR, Nishihara R, Meyerhardt JA, Haigis KM, Fuchs CS, Ogino S.

Clin Cancer Res. 2012 Sep 1;18(17):4753-63. doi: 10.1158/1078-0432.CCR-11-3210. Epub 2012 Jul 2.

41.

Regulation of RAS oncogenicity by acetylation.

Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10843-8. doi: 10.1073/pnas.1201487109. Epub 2012 Jun 18.

42.

Cancers of the colon and rectum: identical or fraternal twins?

Hong TS, Clark JW, Haigis KM.

Cancer Discov. 2012 Feb;2(2):117-21. doi: 10.1158/2159-8290.CD-11-0315.

43.

The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor.

Powell AE, Wang Y, Li Y, Poulin EJ, Means AL, Washington MK, Higginbotham JN, Juchheim A, Prasad N, Levy SE, Guo Y, Shyr Y, Aronow BJ, Haigis KM, Franklin JL, Coffey RJ.

Cell. 2012 Mar 30;149(1):146-58. doi: 10.1016/j.cell.2012.02.042.

44.

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras.

Xu J, Hedberg C, Dekker FJ, Li Q, Haigis KM, Hwang E, Waldmann H, Shannon K.

Blood. 2012 Jan 26;119(4):1032-5. doi: 10.1182/blood-2011-06-358960. Epub 2011 Dec 5.

45.

Regulation of homeostasis and oncogenesis in the intestinal epithelium by Ras.

Velho S, Haigis KM.

Exp Cell Res. 2011 Nov 15;317(19):2732-9. doi: 10.1016/j.yexcr.2011.06.002. Epub 2011 Jun 17. Review.

46.

In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs.

Lau KS, Juchheim AM, Cavaliere KR, Philips SR, Lauffenburger DA, Haigis KM.

Sci Signal. 2011 Mar 22;4(165):ra16. doi: 10.1126/scisignal.2001338.

47.

New insights into oncogenic stress.

Haigis KM, Sweet-Cordero A.

Nat Genet. 2011 Mar;43(3):177-8. doi: 10.1038/ng0311-177.

PMID:
21350495
48.

Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.

Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K.

Blood. 2011 Feb 10;117(6):2022-32. doi: 10.1182/blood-2010-04-280750. Epub 2010 Dec 16.

49.

Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer.

Tanaka N, Huttenhower C, Nosho K, Baba Y, Shima K, Quackenbush J, Haigis KM, Giovannucci E, Fuchs CS, Ogino S.

Am J Pathol. 2010 Dec;177(6):2731-40. doi: 10.2353/ajpath.2010.100361. Epub 2010 Oct 29.

50.

NRAS mutations are rare in colorectal cancer.

Irahara N, Baba Y, Nosho K, Shima K, Yan L, Dias-Santagata D, Iafrate AJ, Fuchs CS, Haigis KM, Ogino S.

Diagn Mol Pathol. 2010 Sep;19(3):157-63. doi: 10.1097/PDM.0b013e3181c93fd1.

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