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Items: 31

1.

Neuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neurons.

Winkler CW, Woods TA, Groveman BR, Carmody AB, Speranza EE, Martens CA, Best SM, Haigh CL, Peterson KE.

J Neuroinflammation. 2019 Nov 18;16(1):229. doi: 10.1186/s12974-019-1614-1.

2.

Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids.

Groveman BR, Foliaki ST, Orru CD, Zanusso G, Carroll JA, Race B, Haigh CL.

Acta Neuropathol Commun. 2019 Jun 14;7(1):90. doi: 10.1186/s40478-019-0742-2. Erratum in: Acta Neuropathol Commun. 2019 Aug 14;7(1):131.

3.

Prion protein cleavage fragments regulate adult neural stem cell quiescence through redox modulation of mitochondrial fission and SOD2 expression.

Collins SJ, Tumpach C, Groveman BR, Drew SC, Haigh CL.

Cell Mol Life Sci. 2018 Sep;75(17):3231-3249. doi: 10.1007/s00018-018-2790-3. Epub 2018 Mar 24.

4.

In Vivo-Near Infrared Imaging of Neurodegeneration.

Lawson VA, Tumpach C, Haigh CL, Drew SC.

Methods Mol Biol. 2017;1658:253-262. doi: 10.1007/978-1-4939-7244-9_17.

PMID:
28861794
5.

Cellular Analysis of Adult Neural Stem Cells for Investigating Prion Biology.

Haigh CL.

Methods Mol Biol. 2017;1658:133-145. doi: 10.1007/978-1-4939-7244-9_11.

PMID:
28861788
6.

Simplified Murine 3D Neuronal Cultures for Investigating Neuronal Activity and Neurodegeneration.

Collins SJ, Haigh CL.

Cell Biochem Biophys. 2017 Mar;75(1):3-13. doi: 10.1007/s12013-016-0768-z. Epub 2016 Oct 28.

PMID:
27796787
7.

A 2-Substituted 8-Hydroxyquinoline Stimulates Neural Stem Cell Proliferation by Modulating ROS Signalling.

Haigh CL, Tumpach C, Collins SJ, Drew SC.

Cell Biochem Biophys. 2016 Sep;74(3):297-306. doi: 10.1007/s12013-016-0747-4. Epub 2016 Jun 21.

PMID:
27329646
8.

Endoproteolytic cleavage as a molecular switch regulating and diversifying prion protein function.

Haigh CL, Collins SJ.

Neural Regen Res. 2016 Feb;11(2):238-9. doi: 10.4103/1673-5374.177726. No abstract available.

9.

The Prion Protein N1 and N2 Cleavage Fragments Bind to Phosphatidylserine and Phosphatidic Acid; Relevance to Stress-Protection Responses.

Haigh CL, Tumpach C, Drew SC, Collins SJ.

PLoS One. 2015 Aug 7;10(8):e0134680. doi: 10.1371/journal.pone.0134680. eCollection 2015.

10.

A Functional Role for Aβ in Metal Homeostasis? N-Truncation and High-Affinity Copper Binding.

Mital M, Wezynfeld NE, Frączyk T, Wiloch MZ, Wawrzyniak UE, Bonna A, Tumpach C, Barnham KJ, Haigh CL, Bal W, Drew SC.

Angew Chem Int Ed Engl. 2015 Sep 1;54(36):10460-4. doi: 10.1002/anie.201502644. Epub 2015 Jul 14.

PMID:
26178596
11.

Cavitation during the protein misfolding cyclic amplification (PMCA) method--The trigger for de novo prion generation?

Haigh CL, Drew SC.

Biochem Biophys Res Commun. 2015 Jun 5;461(3):494-500. doi: 10.1016/j.bbrc.2015.04.048. Epub 2015 Apr 17.

PMID:
25892519
12.

The prion protein regulates beta-amyloid-mediated self-renewal of neural stem cells in vitro.

Collins SJ, Tumpach C, Li QX, Lewis V, Ryan TM, Roberts B, Drew SC, Lawson VA, Haigh CL.

Stem Cell Res Ther. 2015 Apr 11;6:60. doi: 10.1186/s13287-015-0067-4.

13.

Neutron reflectometry studies define prion protein N-terminal peptide membrane binding.

Le Brun AP, Haigh CL, Drew SC, James M, Boland MP, Collins SJ.

Biophys J. 2014 Nov 18;107(10):2313-24. doi: 10.1016/j.bpj.2014.09.027.

14.

MEK1 transduces the prion protein N2 fragment antioxidant effects.

Haigh CL, McGlade AR, Collins SJ.

Cell Mol Life Sci. 2015 Apr;72(8):1613-29. doi: 10.1007/s00018-014-1777-y. Epub 2014 Nov 13.

PMID:
25391659
15.

Blood vessel cell death during prion disease: implications for disease management and infection control.

Haigh CL, Lawson VA, Drew SC.

Exp Hematol. 2014 Nov;42(11):939-40. doi: 10.1016/j.exphem.2014.06.009. Epub 2014 Jul 16. No abstract available.

PMID:
25038450
16.

Cytosolic caspases mediate mislocalised SOD2 depletion in an in vitro model of chronic prion infection.

Sinclair L, Lewis V, Collins SJ, Haigh CL.

Dis Model Mech. 2013 Jul;6(4):952-63. doi: 10.1242/dmm.010678. Epub 2013 Apr 4.

17.

Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity.

Lewis V, Haigh CL, Masters CL, Hill AF, Lawson VA, Collins SJ.

Mol Neurodegener. 2012 Apr 26;7:18. doi: 10.1186/1750-1326-7-18.

18.

Acute exposure to prion infection induces transient oxidative stress progressing to be cumulatively deleterious with chronic propagation in vitro.

Haigh CL, McGlade AR, Lewis V, Masters CL, Lawson VA, Collins SJ.

Free Radic Biol Med. 2011 Aug 1;51(3):594-608. doi: 10.1016/j.freeradbiomed.2011.03.035. Epub 2011 Apr 3.

PMID:
21466851
19.

Optical imaging detects apoptosis in the brain and peripheral organs of prion-infected mice.

Drew SC, Haigh CL, Klemm HM, Masters CL, Collins SJ, Barnham KJ, Lawson VA.

J Neuropathol Exp Neurol. 2011 Feb;70(2):143-50. doi: 10.1097/NEN.0b013e3182084a8c.

PMID:
21343883
20.

Near-infrared fluorescence imaging of apoptotic neuronal cell death in a live animal model of prion disease.

Lawson VA, Haigh CL, Roberts B, Kenche VB, Klemm HM, Masters CL, Collins SJ, Barnham KJ, Drew SC.

ACS Chem Neurosci. 2010 Nov 17;1(11):720-7. doi: 10.1021/cn100068x. Epub 2010 Sep 30.

21.

Anionic phospholipid interactions of the prion protein N terminus are minimally perturbing and not driven solely by the octapeptide repeat domain.

Boland MP, Hatty CR, Separovic F, Hill AF, Tew DJ, Barnham KJ, Haigh CL, James M, Masters CL, Collins SJ.

J Biol Chem. 2010 Oct 15;285(42):32282-92. doi: 10.1074/jbc.M110.123398. Epub 2010 Aug 2.

22.

Copper, endoproteolytic processing of the prion protein and cell signalling.

Haigh CL, Marom SY, Collins SJ.

Front Biosci (Landmark Ed). 2010 Jun 1;15:1086-104. Review.

PMID:
20515743
23.

Increased proportions of C1 truncated prion protein protect against cellular M1000 prion infection.

Lewis V, Hill AF, Haigh CL, Klug GM, Masters CL, Lawson VA, Collins SJ.

J Neuropathol Exp Neurol. 2009 Oct;68(10):1125-35. doi: 10.1097/NEN.0b013e3181b96981.

PMID:
19918124
24.

PrPC-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site.

Haigh CL, Lewis VA, Vella LJ, Masters CL, Hill AF, Lawson VA, Collins SJ.

Cell Res. 2009 Sep;19(9):1062-78. doi: 10.1038/cr.2009.86. Epub 2009 Jul 14.

PMID:
19597535
25.

Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response.

Haigh CL, Drew SC, Boland MP, Masters CL, Barnham KJ, Lawson VA, Collins SJ.

J Cell Sci. 2009 May 15;122(Pt 10):1518-28. doi: 10.1242/jcs.043604. Epub 2009 Apr 21.

26.

Investigation of PrPC metabolism and function in live cells : methods for studying individual cells and cell populations.

Haigh CL, Brown DR.

Methods Mol Biol. 2008;459:21-34. doi: 10.1007/978-1-59745-234-2_2.

PMID:
18576145
27.

Regulation of prion protein expression by noncoding regions of the Prnp gene.

Haigh CL, Wright JA, Brown DR.

J Mol Biol. 2007 May 11;368(4):915-27. Epub 2007 Mar 6.

PMID:
17376480
29.

Copper-dependent co-internalization of the prion protein and glypican-1.

Cheng F, Lindqvist J, Haigh CL, Brown DR, Mani K.

J Neurochem. 2006 Sep;98(5):1445-57.

30.

Prion protein reduces both oxidative and non-oxidative copper toxicity.

Haigh CL, Brown DR.

J Neurochem. 2006 Aug;98(3):677-89. Epub 2006 Jun 19.

31.

Copper binding is the governing determinant of prion protein turnover.

Haigh CL, Edwards K, Brown DR.

Mol Cell Neurosci. 2005 Oct;30(2):186-96.

PMID:
16084105

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