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[Our students tell us about scientific integrity. - Scientific integrity on a daily basis: giving doctoral students a voice].

Haiech J, Forest C, Hervé C.

Med Sci (Paris). 2019 Jun-Jul;35(6-7):557. doi: 10.1051/medsci/2019100. Epub 2019 Jul 5. French. No abstract available.


Facts and conjectures on calmodulin and its cousin proteins, parvalbumin and troponin C.

Haiech J, Moreau M, Leclerc C, Kilhoffer MC.

Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1046-1053. doi: 10.1016/j.bbamcr.2019.01.014. Epub 2019 Feb 1. Review.


Using Data Mining to Explore Calmodulin Bibliography.

Haiech J, Kilhoffer MC.

Methods Mol Biol. 2019;1929:3-14. doi: 10.1007/978-1-4939-9030-6_1.


ECS meeting.

Haiech J, Heizmann CW, Krebs J.

Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1035-1036. doi: 10.1016/j.bbamcr.2019.01.006. Epub 2019 Jan 14. No abstract available.


Ca2+-Dependent Transcriptional Repressors KCNIP and Regulation of Prognosis Genes in Glioblastoma.

Néant I, Haiech J, Kilhoffer MC, Aulestia FJ, Moreau M, Leclerc C.

Front Mol Neurosci. 2018 Dec 18;11:472. doi: 10.3389/fnmol.2018.00472. eCollection 2018. Review.


Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia.

Regenass P, Abboud D, Daubeuf F, Lehalle C, Gizzi P, Riché S, Hachet-Haas M, Rohmer F, Gasparik V, Boeglin D, Haiech J, Knehans T, Rognan D, Heissler D, Marsol C, Villa P, Galzi JL, Hibert M, Frossard N, Bonnet D.

J Med Chem. 2018 Sep 13;61(17):7671-7686. doi: 10.1021/acs.jmedchem.8b00657. Epub 2018 Aug 28.


Quiescence status of glioblastoma stem-like cells involves remodelling of Ca2+ signalling and mitochondrial shape.

Aulestia FJ, Néant I, Dong J, Haiech J, Kilhoffer MC, Moreau M, Leclerc C.

Sci Rep. 2018 Jun 27;8(1):9731. doi: 10.1038/s41598-018-28157-8.


WNK1 kinase and its partners Akt, SGK1 and NBC-family Na+/HCO3- cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling.

Chen W, Zebaze LN, Dong J, Chézeau L, Inquimbert P, Hugel S, Niu S, Bihel F, Boutant E, Réal E, Villa P, Junier MP, Chneiweiss H, Hibert M, Haiech J, Kilhoffer MC, Zeniou M.

Oncotarget. 2018 Jun 5;9(43):27197-27219. doi: 10.18632/oncotarget.25509. eCollection 2018 Jun 5.


Efficient Modeling and Simulation of Space-Dependent Biological Systems.

Rosati E, Madec M, Kammerer JB, Hébrard L, Lallement C, Haiech J.

J Comput Biol. 2018 Aug;25(8):917-933. doi: 10.1089/cmb.2018.0012. Epub 2018 May 9.


Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness.

Bogeas A, Morvan-Dubois G, El-Habr EA, Lejeune FX, Defrance M, Narayanan A, Kuranda K, Burel-Vandenbos F, Sayd S, Delaunay V, Dubois LG, Parrinello H, Rialle S, Fabrega S, Idbaih A, Haiech J, Bièche I, Virolle T, Goodhardt M, Chneiweiss H, Junier MP.

Acta Neuropathol. 2018 Feb;135(2):267-283. doi: 10.1007/s00401-017-1783-x. Epub 2017 Nov 17.


Modeling and simulation of biological systems using SPICE language.

Madec M, Lallement C, Haiech J.

PLoS One. 2017 Aug 7;12(8):e0182385. doi: 10.1371/journal.pone.0182385. eCollection 2017.


The adaptors Grb10 and Grb14 are calmodulin-binding proteins.

García-Palmero I, Pompas-Veganzones N, Villalobo E, Gioria S, Haiech J, Villalobo A.

FEBS Lett. 2017 Apr;591(8):1176-1186. doi: 10.1002/1873-3468.12623. Epub 2017 Mar 26.


[Application of microelectronics CAD tools to synthetic biology].

Madec M, Haiech J, Rosati É, Rezgui A, Gendrault Y, Lallement C.

Med Sci (Paris). 2017 Feb;33(2):159-168. doi: 10.1051/medsci/20173302011. Epub 2017 Feb 27. Review. French.



Haiech J, Heizmann CW, Krebs J.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):841-842. doi: 10.1016/j.bbamcr.2017.02.006. Epub 2017 Feb 14. No abstract available.


Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells. Implication of inositol 1,4,5-triphosphate receptor dependent calcium signaling.

Dong J, Aulestia FJ, Assad Kahn S, Zeniou M, Dubois LG, El-Habr EA, Daubeuf F, Tounsi N, Cheshier SH, Frossard N, Junier MP, Chneiweiss H, Néant I, Moreau M, Leclerc C, Haiech J, Kilhoffer MC.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):1018-1027. doi: 10.1016/j.bbamcr.2017.01.010. Epub 2017 Jan 18.


Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy.

Chen W, Dong J, Haiech J, Kilhoffer MC, Zeniou M.

Stem Cells Int. 2016;2016:1740936. doi: 10.1155/2016/1740936. Epub 2016 Jun 21. Review.


[An ideal university? History of the university of Strasbourg from 1919 till 1939 (Françoise Olivier-Utard)].

Haiech J.

Med Sci (Paris). 2016 Jun-Jul;32(6-7):646-7. doi: 10.1051/medsci/20163206030. Epub 2016 Jul 12. French. No abstract available.


GeNeDA: An Open-Source Workflow for Design Automation of Gene Regulatory Networks Inspired from Microelectronics.

Madec M, Pecheux F, Gendrault Y, Rosati E, Lallement C, Haiech J.

J Comput Biol. 2016 Oct;23(10):841-55. doi: 10.1089/cmb.2015.0229. Epub 2016 Jun 20.


The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.

Assad Kahn S, Costa SL, Gholamin S, Nitta RT, Dubois LG, Fève M, Zeniou M, Coelho PL, El-Habr E, Cadusseau J, Varlet P, Mitra SS, Devaux B, Kilhoffer MC, Cheshier SH, Moura-Neto V, Haiech J, Junier MP, Chneiweiss H.

EMBO Mol Med. 2016 May 2;8(5):511-26. doi: 10.15252/emmm.201505421. Print 2016 May.


Calcium and Cell Fate.

Capiod T, Haiech J, Heizmann CW, Krebs J, Mignen O.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt B):1335-6. doi: 10.1016/j.bbamcr.2016.02.017. Epub 2016 Mar 2. No abstract available.


Glioblastoma and calcium signaling--analysis of calcium toolbox expression.

Robil N, Petel F, Kilhoffer MC, Haiech J.

Int J Dev Biol. 2015;59(7-9):407-15. doi: 10.1387/ijdb.150200jh.


A strategy to discover decoy chemokine ligands with an anti-inflammatory activity.

Abboud D, Daubeuf F, Do QT, Utard V, Villa P, Haiech J, Bonnet D, Hibert M, Bernard P, Galzi JL, Frossard N.

Sci Rep. 2015 Oct 7;5:14746. doi: 10.1038/srep14746.


Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells.

Zeniou M, Fève M, Mameri S, Dong J, Salomé C, Chen W, El-Habr EA, Bousson F, Sy M, Obszynski J, Boh A, Villa P, Assad Kahn S, Didier B, Bagnard D, Junier MP, Chneiweiss H, Haiech J, Hibert M, Kilhoffer MC.

PLoS One. 2015 Aug 13;10(8):e0134793. doi: 10.1371/journal.pone.0134793. eCollection 2015.


New fluorescein precursors for live bacteria detection.

Guilini C, Baehr C, Schaeffer E, Gizzi P, Rufi F, Haiech J, Weiss E, Bonnet D, Galzi JL.

Anal Chem. 2015 Sep 1;87(17):8858-66. doi: 10.1021/acs.analchem.5b02100. Epub 2015 Aug 20.



Haiech J, Heizmann CW, Krebs J.

Biochim Biophys Acta. 2015 Sep;1853(9):1919-20. doi: 10.1016/j.bbamcr.2015.04.019. Epub 2015 May 5. No abstract available.


Generation and behavior characterization of CaMKIIβ knockout mice.

Bachstetter AD, Webster SJ, Tu T, Goulding DS, Haiech J, Watterson DM, Van Eldik LJ.

PLoS One. 2014 Aug 15;9(8):e105191. doi: 10.1371/journal.pone.0105191. eCollection 2014.


Calcium signalling as a hub for translational medicine a starting point to model life.

Moreau M, Haiech J.

Biochim Biophys Acta. 2014 Oct;1843(10):2283. doi: 10.1016/j.bbamcr.2014.06.003. Epub 2014 Jun 12. No abstract available.


Comparative expression study of the endo-G protein coupled receptor (GPCR) repertoire in human glioblastoma cancer stem-like cells, U87-MG cells and non malignant cells of neural origin unveils new potential therapeutic targets.

Fève M, Saliou JM, Zeniou M, Lennon S, Carapito C, Dong J, Van Dorsselaer A, Junier MP, Chneiweiss H, Cianférani S, Haiech J, Kilhoffer MC.

PLoS One. 2014 Mar 24;9(3):e91519. doi: 10.1371/journal.pone.0091519. eCollection 2014.


Modeling biology with HDL languages: a first step toward a genetic design automation tool inspired from microelectronics.

Gendrault Y, Madec M, Lallement C, Haiech J.

IEEE Trans Biomed Eng. 2014 Apr;61(4):1231-40. doi: 10.1109/TBME.2014.2298559.


A general framework improving teaching ligand binding to a macromolecule.

Haiech J, Gendrault Y, Kilhoffer MC, Ranjeva R, Madec M, Lallement C.

Biochim Biophys Acta. 2014 Oct;1843(10):2348-55. doi: 10.1016/j.bbamcr.2014.03.013. Epub 2014 Mar 20.


Quantitative structure-property relationship modeling: a valuable support in high-throughput screening quality control.

Ruggiu F, Gizzi P, Galzi JL, Hibert M, Haiech J, Baskin I, Horvath D, Marcou G, Varnek A.

Anal Chem. 2014 Mar 4;86(5):2510-20. doi: 10.1021/ac403544k. Epub 2014 Feb 12.


[Evolution of biology seen by a biologist: from description to prediction].

Haiech J.

Med Sci (Paris). 2013 May;29 Spec No 2:43-6. doi: 10.1051/medsci/201329s212. Epub 2013 Jun 7. French. No abstract available.


[Too much evaluation kills evaluation].

Haiech J.

Med Sci (Paris). 2013 Feb;29(2):119-20. doi: 10.1051/medsci/2013292001. Epub 2013 Feb 28. French. No abstract available.


Using digital electronic design flow to create a Genetic Design Automation tool.

Gendrault Y, Madec M, Wlotzko V, Andraud M, Lallement C, Haiech J.

Conf Proc IEEE Eng Med Biol Soc. 2012;2012:5530-3. doi: 10.1109/EMBC.2012.6347247.


A game-of-life like simulator for design-oriented modeling of BioBricks in synthetic biology.

Madec M, Gendrault Y, Lallement C, Haiech J.

Conf Proc IEEE Eng Med Biol Soc. 2012;2012:5462-5. doi: 10.1109/EMBC.2012.6347230.


A general framework to characterize inhibitors of calmodulin: use of calmodulin inhibitors to study the interaction between calmodulin and its calmodulin binding domains.

Audran E, Dagher R, Gioria S, Tsvetkov PO, Kulikova AA, Didier B, Villa P, Makarov AA, Kilhoffer MC, Haiech J.

Biochim Biophys Acta. 2013 Jul;1833(7):1720-31. doi: 10.1016/j.bbamcr.2013.01.008. Epub 2013 Jan 17.


New aspects of calmodulin-calmodulin binding domains recognition.

Audran E, Dagher R, Gioria S, Kilhoffer MC, Haiech J.

Methods Mol Biol. 2013;963:57-72. doi: 10.1007/978-1-62703-230-8_4.


Personalized medicine and education: the challenge.

Haiech J, Kilhoffer MC.

Croat Med J. 2012 Aug;53(4):298-300.


[System biology and synthetic biology modify drug discovery and development].

Haiech J, Ranjeva R, Kilhoffer MC.

Med Sci (Paris). 2012 Feb;28(2):207-12. doi: 10.1051/medsci/2012282020. Epub 2012 Feb 27. Review. French.


Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo.

Gasparik V, Daubeuf F, Hachet-Haas M, Rohmer F, Gizzi P, Haiech J, Galzi JL, Hibert M, Bonnet D, Frossard N.

ACS Med Chem Lett. 2011 Dec 9;3(1):10-4. doi: 10.1021/ml200017d. eCollection 2012 Jan 12.


The calcium signal: a universal carrier to code, decode and transduce information.

Haiech J, Moreau M.

Biochimie. 2011 Dec;93(12):v. doi: 10.1016/S0300-9084(11)00406-8. No abstract available.


Synthetic biology methodology and model refinement based on microelectronic modeling tools and languages.

Gendrault Y, Madec M, Lallement C, Pecheux F, Haiech J.

Biotechnol J. 2011 Jul;6(7):796-806. doi: 10.1002/biot.201100083. Epub 2011 Jun 17.


Revisiting intracellular calcium signaling semantics.

Haiech J, Audran E, Fève M, Ranjeva R, Kilhoffer MC.

Biochimie. 2011 Dec;93(12):2029-37. doi: 10.1016/j.biochi.2011.05.003. Epub 2011 May 19. Review.


The 11(th) Meeting of the European Calcium Society.

Haiech J, Heizmann CW, Krebs J.

Biochim Biophys Acta. 2011 May;1813(5):908. doi: 10.1016/j.bbamcr.2011.03.014. No abstract available.


Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporter.

Zimmermann M, Atmanene C, Xu Q, Fouillen L, Van Dorsselaer A, Bonnet D, Marsol C, Hibert M, Sanglier-Cianferani S, Pigault C, McNamara LK, Watterson DM, Haiech J, Kilhoffer MC.

PLoS One. 2010 Nov 30;5(11):e14120. doi: 10.1371/journal.pone.0014120.


A general strategy to characterize calmodulin-calcium complexes involved in CaM-target recognition: DAPK and EGFR calmodulin binding domains interact with different calmodulin-calcium complexes.

Dagher R, Peng S, Gioria S, Fève M, Zeniou M, Zimmermann M, Pigault C, Haiech J, Kilhoffer MC.

Biochim Biophys Acta. 2011 May;1813(5):1059-67. doi: 10.1016/j.bbamcr.2010.11.004. Epub 2010 Nov 30.


Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme.

Kuhn I, Kellenberger E, Said-Hassane F, Villa P, Rognan D, Lobstein A, Haiech J, Hibert M, Schuber F, Muller-Steffner H.

Bioorg Med Chem. 2010 Nov 15;18(22):7900-10. doi: 10.1016/j.bmc.2010.09.041. Epub 2010 Sep 25.


Cryptogein, a fungal elicitor, remodels the phenylpropanoid metabolism of tobacco cell suspension cultures in a calcium-dependent manner.

Amelot N, Carrouche A, Danoun S, Bourque S, Haiech J, Pugin A, Ranjeva R, Grima-Pettenati J, Mazars C, Briere C.

Plant Cell Environ. 2011 Jan;34(1):149-61. doi: 10.1111/j.1365-3040.2010.02233.x. Epub 2010 Oct 15.


The plant nucleus. Editorial.

Ranjeva R, Zhou DX, Haiech J.

Mol Plant. 2010 Jul;3(4):641. doi: 10.1093/mp/ssq029. No abstract available.


CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors.

Patru C, Romao L, Varlet P, Coulombel L, Raponi E, Cadusseau J, Renault-Mihara F, Thirant C, Leonard N, Berhneim A, Mihalescu-Maingot M, Haiech J, Bièche I, Moura-Neto V, Daumas-Duport C, Junier MP, Chneiweiss H.

BMC Cancer. 2010 Feb 24;10:66. doi: 10.1186/1471-2407-10-66.

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