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Items: 1 to 50 of 95

1.

Mathematical Modeling of Tumor-Tumor Distant Interactions Supports a Systemic Control of Tumor Growth.

Benzekry S, Lamont C, Barbolosi D, Hlatky L, Hahnfeldt P.

Cancer Res. 2017 Sep 15;77(18):5183-5193. doi: 10.1158/0008-5472.CAN-17-0564. Epub 2017 Jul 20.

2.

Modeling the Dichotomy of the Immune Response to Cancer: Cytotoxic Effects and Tumor-Promoting Inflammation.

Wilkie KP, Hahnfeldt P.

Bull Math Biol. 2017 Jun;79(6):1426-1448. doi: 10.1007/s11538-017-0291-4. Epub 2017 Jun 5.

3.

Capturing the Driving Role of Tumor-Host Crosstalk in a Dynamical Model of Tumor Growth.

Benzekry S, Beheshti A, Hahnfeldt P, Hlatky L.

Bio Protoc. 2015 Nov 5;5(21). pii: e1644.

4.

Radiation-Induced Reprogramming of Pre-Senescent Mammary Epithelial Cells Enriches Putative CD44(+)/CD24(-/low) Stem Cell Phenotype.

Gao X, Sishc BJ, Nelson CB, Hahnfeldt P, Bailey SM, Hlatky L.

Front Oncol. 2016 Jun 14;6:138. doi: 10.3389/fonc.2016.00138. eCollection 2016.

5.

Evaluating biomarkers to model cancer risk post cosmic ray exposure.

Sridharan DM, Asaithamby A, Blattnig SR, Costes SV, Doetsch PW, Dynan WS, Hahnfeldt P, Hlatky L, Kidane Y, Kronenberg A, Naidu MD, Peterson LE, Plante I, Ponomarev AL, Saha J, Snijders AM, Srinivasan K, Tang J, Werner E, Pluth JM.

Life Sci Space Res (Amst). 2016 Jun;9:19-47. doi: 10.1016/j.lssr.2016.05.004. Epub 2016 May 21. Review.

6.

Tumor-host signaling interaction reveals a systemic, age-dependent splenic immune influence on tumor development.

Beheshti A, Wage J, McDonald JT, Lamont C, Peluso M, Hahnfeldt P, Hlatky L.

Oncotarget. 2015 Nov 3;6(34):35419-32. doi: 10.18632/oncotarget.6214.

7.

Proton irradiation impacts age-driven modulations of cancer progression influenced by immune system transcriptome modifications from splenic tissue.

Wage J, Ma L, Peluso M, Lamont C, Evens AM, Hahnfeldt P, Hlatky L, Beheshti A.

J Radiat Res. 2015 Sep;56(5):792-803. doi: 10.1093/jrr/rrv043. Epub 2015 Aug 7.

8.

Therapeutic implications from sensitivity analysis of tumor angiogenesis models.

Poleszczuk J, Hahnfeldt P, Enderling H.

PLoS One. 2015 Mar 18;10(3):e0120007. doi: 10.1371/journal.pone.0120007. eCollection 2015.

9.

Evolution and phenotypic selection of cancer stem cells.

Poleszczuk J, Hahnfeldt P, Enderling H.

PLoS Comput Biol. 2015 Mar 5;11(3):e1004025. doi: 10.1371/journal.pcbi.1004025. eCollection 2015 Mar.

10.

Host age is a systemic regulator of gene expression impacting cancer progression.

Beheshti A, Benzekry S, McDonald JT, Ma L, Peluso M, Hahnfeldt P, Hlatky L.

Cancer Res. 2015 Mar 15;75(6):1134-43. doi: 10.1158/0008-5472.CAN-14-1053. Epub 2015 Mar 2.

11.

Classical mathematical models for description and prediction of experimental tumor growth.

Benzekry S, Lamont C, Beheshti A, Tracz A, Ebos JM, Hlatky L, Hahnfeldt P.

PLoS Comput Biol. 2014 Aug 28;10(8):e1003800. doi: 10.1371/journal.pcbi.1003800. eCollection 2014 Aug.

12.

A proposed quantitative index for assessing the potential contribution of reprogramming to cancer stem cell kinetics.

Gao X, McDonald JT, Naidu M, Hahnfeldt P, Hlatky L.

Stem Cells Int. 2014;2014:249309. doi: 10.1155/2014/249309. Epub 2014 May 12.

13.

A multicompartment mathematical model of cancer stem cell-driven tumor growth dynamics.

Weekes SL, Barker B, Bober S, Cisneros K, Cline J, Thompson A, Hlatky L, Hahnfeldt P, Enderling H.

Bull Math Biol. 2014 Jul;76(7):1762-82. doi: 10.1007/s11538-014-9976-0. Epub 2014 May 20.

14.

Biphasic modulation of cancer stem cell-driven solid tumour dynamics in response to reactivated replicative senescence.

Poleszczuk J, Hahnfeldt P, Enderling H.

Cell Prolif. 2014 Jun;47(3):267-76. doi: 10.1111/cpr.12101. Epub 2014 Mar 25.

PMID:
24666838
15.

Proton irradiation augments the suppression of tumor progression observed with advanced age.

Beheshti A, Peluso M, Lamont C, Hahnfeldt P, Hlatky L.

Radiat Res. 2014 Mar;181(3):272-83. doi: 10.1667/RR13538.1. Epub 2014 Feb 25.

16.

Mathematical models of immune-induced cancer dormancy and the emergence of immune evasion.

Wilkie KP, Hahnfeldt P.

Interface Focus. 2013 Aug 6;3(4):20130010. doi: 10.1098/rsfs.2013.0010.

17.

Global dormancy of metastases due to systemic inhibition of angiogenesis.

Benzekry S, Gandolfi A, Hahnfeldt P.

PLoS One. 2014 Jan 21;9(1):e84249. doi: 10.1371/journal.pone.0084249. eCollection 2014.

18.

Beyond the cancer cell: progression-level determinants highlight the multiscale nature of carcinogenesis risk.

Hlatky L, Hahnfeldt P.

Cancer Res. 2014 Feb 1;74(3):659-64. doi: 10.1158/0008-5472.CAN-13-2508. Epub 2013 Nov 22. Review.

19.

Maximum tolerated dose versus metronomic scheduling in the treatment of metastatic cancers.

Benzekry S, Hahnfeldt P.

J Theor Biol. 2013 Oct 21;335:235-44. doi: 10.1016/j.jtbi.2013.06.036. Epub 2013 Jul 11.

20.

An integrated multidisciplinary model describing initiation of cancer and the Warburg hypothesis.

Rietman EA, Friesen DE, Hahnfeldt P, Gatenby R, Hlatky L, Tuszynski JA.

Theor Biol Med Model. 2013 Jun 10;10:39. doi: 10.1186/1742-4682-10-39.

21.

Cancer Stem Cells: A Minor Cancer Subpopulation that Redefines Global Cancer Features.

Enderling H, Hlatky L, Hahnfeldt P.

Front Oncol. 2013 Apr 15;3:76. doi: 10.3389/fonc.2013.00076. eCollection 2013.

22.

Tumor-immune dynamics regulated in the microenvironment inform the transient nature of immune-induced tumor dormancy.

Wilkie KP, Hahnfeldt P.

Cancer Res. 2013 Jun 15;73(12):3534-44. doi: 10.1158/0008-5472.CAN-12-4590. Epub 2013 Mar 27.

23.

Center of cancer systems biology second annual workshop--tumor metronomics: timing and dose level dynamics.

Hahnfeldt P, Hlatky L, Klement GL.

Cancer Res. 2013 May 15;73(10):2949-54. doi: 10.1158/0008-5472.CAN-12-3807. Epub 2013 Mar 14.

24.

The emerging "hallmarks" of metabolic reprogramming and immune evasion: distinct or linked?

Kareva I, Hahnfeldt P.

Cancer Res. 2013 May 1;73(9):2737-42. doi: 10.1158/0008-5472.CAN-12-3696. Epub 2013 Feb 19.

25.

Age and space irradiation modulate tumor progression: implications for carcinogenesis risk.

Beheshti A, Sachs RK, Peluso M, Rietman E, Hahnfeldt P, Hlatky L.

Radiat Res. 2013 Feb;179(2):208-20. doi: 10.1667/RR3100.1. Epub 2013 Jan 4.

PMID:
23289386
26.

The tumor growth paradox and immune system-mediated selection for cancer stem cells.

Hillen T, Enderling H, Hahnfeldt P.

Bull Math Biol. 2013 Jan;75(1):161-84. doi: 10.1007/s11538-012-9798-x. Epub 2012 Nov 30.

PMID:
23196354
27.

The host support niche as a control point for tumor dormancy: implications for tumor development and beyond.

Hahnfeldt P.

Adv Exp Med Biol. 2013;734:19-35. doi: 10.1007/978-1-4614-1445-2_2.

PMID:
23143973
28.

Immunoediting: evidence of the multifaceted role of the immune system in self-metastatic tumor growth.

Enderling H, Hlatky L, Hahnfeldt P.

Theor Biol Med Model. 2012 Jul 28;9:31. doi: 10.1186/1742-4682-9-31.

29.

Proton irradiation suppresses angiogenic genes and impairs cell invasion and tumor growth.

Girdhani S, Lamont C, Hahnfeldt P, Abdollahi A, Hlatky L.

Radiat Res. 2012 Jul;178(1):33-45. Epub 2012 Jun 14.

PMID:
22702646
30.

Systems biology of tumor dormancy: linking biology and mathematics on multiple scales to improve cancer therapy.

Enderling H, Hahnfeldt P, Hlatky L, Almog N.

Cancer Res. 2012 May 1;72(9):2172-5. doi: 10.1158/0008-5472.CAN-11-3269. Epub 2012 Mar 13.

31.

Non-stem cancer cell kinetics modulate solid tumor progression.

Morton CI, Hlatky L, Hahnfeldt P, Enderling H.

Theor Biol Med Model. 2011 Dec 30;8:48. doi: 10.1186/1742-4682-8-48.

32.

A multicellular basis for the origination of blast crisis in chronic myeloid leukemia.

Sachs RK, Johnsson K, Hahnfeldt P, Luo J, Chen A, Hlatky L.

Cancer Res. 2011 Apr 15;71(8):2838-47. doi: 10.1158/0008-5472.CAN-10-4600. Epub 2011 Apr 12.

33.

Cancer stem cells in solid tumors: is 'evading apoptosis' a hallmark of cancer?

Enderling H, Hahnfeldt P.

Prog Biophys Mol Biol. 2011 Aug;106(2):391-9. doi: 10.1016/j.pbiomolbio.2011.03.007. Epub 2011 Apr 5.

PMID:
21473880
34.

The promoting role of a tumour-secreted chemorepellent in self-metastatic tumour progression.

Enderling H, Hlatky L, Hahnfeldt P.

Math Med Biol. 2012 Mar;29(1):21-9. doi: 10.1093/imammb/dqq015. Epub 2010 Oct 6.

PMID:
20929852
35.

Quantitative modeling of tumor dynamics and radiotherapy.

Enderling H, Chaplain MA, Hahnfeldt P.

Acta Biotheor. 2010 Dec;58(4):341-53. doi: 10.1007/s10441-010-9111-z. Epub 2010 Jul 24.

PMID:
20658170
36.

Significance of tumor self-seeding as an augmentation to the classic metastasis paradigm.

Hahnfeldt P.

Future Oncol. 2010 May;6(5):681-5. doi: 10.2217/fon.10.43. No abstract available.

37.

Tumor morphological evolution: directed migration and gain and loss of the self-metastatic phenotype.

Enderling H, Hlatky L, Hahnfeldt P.

Biol Direct. 2010 Apr 20;5:23. doi: 10.1186/1745-6150-5-23.

38.

Paradoxical dependencies of tumor dormancy and progression on basic cell kinetics.

Enderling H, Anderson AR, Chaplain MA, Beheshti A, Hlatky L, Hahnfeldt P.

Cancer Res. 2009 Nov 15;69(22):8814-21. doi: 10.1158/0008-5472.CAN-09-2115. Epub 2009 Nov 3.

39.

Stochastic population dynamic effects for lung cancer progression.

Fakir H, Tan WY, Hlatky L, Hahnfeldt P, Sachs RK.

Radiat Res. 2009 Sep;172(3):383-93. doi: 10.1667/RR1621.1.

PMID:
19708787
40.

A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approach.

Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ.

Radiat Environ Biophys. 2009 Aug;48(3):263-74. doi: 10.1007/s00411-009-0230-3. Epub 2009 Jun 18. Erratum in: Radiat Environ Biophys. 2011 Nov;50(4):607-8.

41.

A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation.

Shuryak I, Hahnfeldt P, Hlatky L, Sachs RK, Brenner DJ.

Radiat Environ Biophys. 2009 Aug;48(3):275-86. doi: 10.1007/s00411-009-0231-2. Epub 2009 Jun 5. Erratum in: Radiat Environ Biophys. 2011 Nov;50(4):607-8.

42.

Migration rules: tumours are conglomerates of self-metastases.

Enderling H, Hlatky L, Hahnfeldt P.

Br J Cancer. 2009 Jun 16;100(12):1917-25. doi: 10.1038/sj.bjc.6605071. Epub 2009 May 19.

43.

Systems biology and its potential role in radiobiology.

Feinendegen L, Hahnfeldt P, Schadt EE, Stumpf M, Voit EO.

Radiat Environ Biophys. 2008 Feb;47(1):5-23. Epub 2007 Dec 18. Review.

PMID:
18087710
44.

Second cancers after fractionated radiotherapy: stochastic population dynamics effects.

Sachs RK, Shuryak I, Brenner D, Fakir H, Hlatky L, Hahnfeldt P.

J Theor Biol. 2007 Dec 7;249(3):518-31. Epub 2007 Aug 12.

45.

Transcriptional network governing the angiogenic switch in human pancreatic cancer.

Abdollahi A, Schwager C, Kleeff J, Esposito I, Domhan S, Peschke P, Hauser K, Hahnfeldt P, Hlatky L, Debus J, Peters JM, Friess H, Folkman J, Huber PE.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12890-5. Epub 2007 Jul 24.

46.

Subtraction of background damage in PFGE experiments on DNA fragment-size distributions.

Ponomarev AL, Belli M, Hahnfeldt PJ, Hlatky L, Sachs RK, Cucinotta FA.

Radiat Environ Biophys. 2007 Jun;46(2):155-60. Epub 2007 Apr 4.

PMID:
17406880
47.

Radiation-induced leukemia at doses relevant to radiation therapy: modeling mechanisms and estimating risks.

Shuryak I, Sachs RK, Hlatky L, Little MP, Hahnfeldt P, Brenner DJ.

J Natl Cancer Inst. 2006 Dec 20;98(24):1794-806.

PMID:
17179481
48.

A robust procedure for removing background damage in assays of radiation-induced DNA fragment distributions.

Ponomarev AL, Belli M, Hahnfeldt PJ, Hlatky L, Sachs RK, Cucinotta FA.

Radiat Res. 2006 Dec;166(6):908-16.

PMID:
17149980
49.

Full-color painting reveals an excess of radiation-induced dicentrics involving homologous chromosomes.

Plan Y, Hlatky L, Hahnfeldt P, Sachs R, Loucas B, Cornforth M.

Int J Radiat Biol. 2005 Aug;81(8):613-20.

PMID:
16298942
50.

Modeling intercellular interactions during carcinogenesis.

Sachs RK, Chan M, Hlatky L, Hahnfeldt P.

Radiat Res. 2005 Sep;164(3):324-31.

PMID:
16137206

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