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Items: 14


LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis.

Morishima T, Krahl AC, Nasri M, Xu Y, Aghaallaei N, Findik B, Klimiankou M, Ritter M, Hartmann MD, Gloeckner CJ, Stefanczyk S, Lindner C, Oswald B, Bernhard R, Hähnel K, Hermanutz-Klein U, Ebinger M, Handgretinger R, Casadei N, Welte K, Andre M, Müller P, Bajoghli B, Skokowa J.

Blood. 2019 Oct 3;134(14):1159-1175. doi: 10.1182/blood.2019000095. Epub 2019 Jul 31.


CRISPR/Cas9 mediated ELANE knockout enables neutrophilic maturation of primary hematopoietic stem and progenitor cells and induced pluripotent stem cells of severe congenital neutropenia patients.

Nasri M, Ritter M, Mir P, Dannenmann B, Aghaallaei N, Amend D, Makaryan V, Xu Y, Fletcher B, Bernhard R, Steiert I, Hahnel K, Berger J, Koch I, Sailer B, Hipp K, Zeidler C, Klimiankou M, Bajoghli B, Dale DC, Welte K, Skokowa J.

Haematologica. 2019 Jun 27. pii: haematol.2019.221804. doi: 10.3324/haematol.2019.221804. [Epub ahead of print]


Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function.

Petri RM, Hackel A, Hahnel K, Dumitru CA, Bruderek K, Flohe SB, Paschen A, Lang S, Brandau S.

Stem Cell Reports. 2017 Sep 12;9(3):985-998. doi: 10.1016/j.stemcr.2017.06.020. Epub 2017 Aug 3.


CCR4+ Regulatory T Cells Accumulate in the Very Elderly and Correlate With Superior 8-Year Survival.

Derhovanessian E, Chen S, Maier AB, Hähnel K, de Craen AJ, Roelofs H, Westendorp R, Pawelec G.

J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):917-23. doi: 10.1093/gerona/glu128. Epub 2015 Apr 7.


Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly.

Derhovanessian E, Maier AB, Hähnel K, McElhaney JE, Slagboom EP, Pawelec G.

J Immunol. 2014 Oct 1;193(7):3624-31. doi: 10.4049/jimmunol.1303361. Epub 2014 Sep 3.


Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination.

Derhovanessian E, Theeten H, Hähnel K, Van Damme P, Cools N, Pawelec G.

Vaccine. 2013 Jan 11;31(4):685-90. doi: 10.1016/j.vaccine.2012.11.041. Epub 2012 Nov 26.


Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people.

Derhovanessian E, Maier AB, Hähnel K, Zelba H, de Craen AJ, Roelofs H, Slagboom EP, Westendorp RG, Pawelec G.

Age (Dordr). 2013 Aug;35(4):1387-99. doi: 10.1007/s11357-012-9425-7. Epub 2012 Jun 4.


Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans.

Derhovanessian E, Maier AB, Hähnel K, Beck R, de Craen AJ, Slagboom EP, Westendorp RG, Pawelec G.

J Gen Virol. 2011 Dec;92(Pt 12):2746-56. doi: 10.1099/vir.0.036004-0. Epub 2011 Aug 3.


Hallmark features of immunosenescence are absent in familial longevity.

Derhovanessian E, Maier AB, Beck R, Jahn G, Hähnel K, Slagboom PE, de Craen AJ, Westendorp RG, Pawelec G.

J Immunol. 2010 Oct 15;185(8):4618-24. doi: 10.4049/jimmunol.1001629. Epub 2010 Sep 20.


Pretreatment frequency of circulating IL-17+ CD4+ T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients.

Derhovanessian E, Adams V, Hähnel K, Groeger A, Pandha H, Ward S, Pawelec G.

Int J Cancer. 2009 Sep 15;125(6):1372-9. doi: 10.1002/ijc.24497.


Immunosenescence, suppression and tumour progression.

Pawelec G, Koch S, Griesemann H, Rehbein A, Hähnel K, Gouttefangeas C.

Cancer Immunol Immunother. 2006 Aug;55(8):981-6. Epub 2005 Dec 6. Review.


In vitro senescence models for human T lymphocytes.

Pawelec G, Adibzadeh M, Rehbein A, Hähnel K, Wagner W, Engel A.

Vaccine. 2000 Feb 25;18(16):1666-74. Review.


Finite lifespans of T cell clones derived from CD34+ human haematopoietic stem cells in vitro.

Pawelec G, Müller R, Rehbein A, Hähnel K, Ziegler BL.

Exp Gerontol. 1999 Jan;34(1):69-77.


Extrathymic T cell differentiation in vitro from human CD34+ stem cells.

Pawelec G, Müller R, Rehbein A, Hähnel K, Ziegler BL.

J Leukoc Biol. 1998 Dec;64(6):733-9.


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