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APRIL Induces a Novel Subset of IgA+ Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1.

Fehres CM, van Uden NO, Yeremenko NG, Fernandez L, Franco Salinas G, van Duivenvoorde LM, Huard B, Morel J, Spits H, Hahne M, Baeten DLP.

Front Immunol. 2019 Jun 14;10:1368. doi: 10.3389/fimmu.2019.01368. eCollection 2019.


A proliferation-inducing ligand-mediated anti-inflammatory response of astrocytes in multiple sclerosis.

Baert L, Benkhoucha M, Popa N, Ahmed MC, Manfroi B, Boutonnat J, Sturm N, Raguenez G, Tessier M, Casez O, Marignier R, Ahmadi M, Broisat A, Ghezzi C, Rivat C, Sonrier C, Hahne M, Baeten D, Vives RR, Lortat-Jacob H, Marche PN, Schneider P, Lassmann HP, Boucraut J, Lalive PH, Huard B.

Ann Neurol. 2019 Mar;85(3):406-420. doi: 10.1002/ana.25415. Epub 2019 Feb 4.


Mixed signals from the cell's antennae: primary cilia in cancer.

Eguether T, Hahne M.

EMBO Rep. 2018 Nov;19(11). pii: e46589. doi: 10.15252/embr.201846589. Epub 2018 Oct 22. Review.


IL-10 Producing B Cells Ability to Induce Regulatory T Cells Is Maintained in Rheumatoid Arthritis.

Mielle J, Audo R, Hahne M, Macia L, Combe B, Morel J, Daien C.

Front Immunol. 2018 May 3;9:961. doi: 10.3389/fimmu.2018.00961. eCollection 2018.


PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity.

Audo R, Deckert V, Daien CI, Che H, Elhmioui J, Lemaire S, Pais de Barros JP, Desrumaux C, Combe B, Hahne M, Lagrost L, Morel J.

PLoS One. 2018 Mar 22;13(3):e0193815. doi: 10.1371/journal.pone.0193815. eCollection 2018.


mTOR intersects antibody-inducing signals from TACI in marginal zone B cells.

Sintes J, Gentile M, Zhang S, Garcia-Carmona Y, Magri G, Cassis L, Segura-Garzón D, Ciociola A, Grasset EK, Bascones S, Comerma L, Pybus M, Lligé D, Puga I, Gutzeit C, He B, DuBois W, Crespo M, Pascual J, Mensa A, Aróstegui JI, Juan M, Yagüe J, Serrano S, Lloreta J, Meffre E, Hahne M, Cunningham-Rundles C, Mock BA, Cerutti A.

Nat Commun. 2017 Nov 13;8(1):1462. doi: 10.1038/s41467-017-01602-4.


RNA sequencing analysis of activated macrophages treated with the anti-HIV ABX464 in intestinal inflammation.

Manchon L, Chebli K, Papon L, Paul C, Garcel A, Campos N, Scherrer D, Ehrlich H, Hahne M, Tazi J.

Sci Data. 2017 Oct 17;4:170150. doi: 10.1038/sdata.2017.150.


Unraveling the role of hypoxia-inducible factor (HIF)-1α and HIF-2α in the adaption process of human microvascular endothelial cells (HMEC-1) to hypoxia: Redundant HIF-dependent regulation of macrophage migration inhibitory factor.

Hahne M, Schumann P, Mursell M, Strehl C, Hoff P, Buttgereit F, Gaber T.

Microvasc Res. 2018 Mar;116:34-44. doi: 10.1016/j.mvr.2017.09.004. Epub 2017 Oct 6.



Page-Karjian A, Hahne M, Leach K, Murphy H, Lock B, Rivera S.

J Zoo Wildl Med. 2017 Jun;48(2):521-524. doi: 10.1638/2016-0101R1.1.


The Anti-Hiv Candidate Abx464 Dampens Intestinal Inflammation by Triggering Il-22 Production in Activated Macrophages.

Chebli K, Papon L, Paul C, Garcel A, Campos N, Scherrer D, J Ehrlich H, Hahne M, Tazi J.

Sci Rep. 2017 Jul 7;7(1):4860. doi: 10.1038/s41598-017-04071-3.


A New Animal Model of Gastric Lymphomagenesis: APRIL Transgenic Mice Infected by Helicobacter Species.

Floch P, Izotte J, Guillemaud J, Sifré E, Costet P, Rousseau B, Laur AM, Giese A, Korolik V, Mégraud F, Dubus P, Hahne M, Lehours P.

Am J Pathol. 2017 Jul;187(7):1473-1484. doi: 10.1016/j.ajpath.2017.03.004. Epub 2017 Apr 29.


Phosphatidylserine Outer Layer Translocation Is Implicated in IL-10 Secretion by Human Regulatory B Cells.

Audo R, Hua C, Hahne M, Combe B, Morel J, Daien CI.

PLoS One. 2017 Jan 10;12(1):e0169755. doi: 10.1371/journal.pone.0169755. eCollection 2017.


Impact of the B Cell Growth Factor APRIL on the Qualitative and Immunological Characteristics of Atherosclerotic Plaques.

Bernelot Moens SJ, van Leuven SI, Zheng KH, Havik SR, Versloot MV, van Duivenvoorde LM, Hahne M, Stroes ES, Baeten DL, Hamers AA.

PLoS One. 2016 Nov 7;11(11):e0164690. doi: 10.1371/journal.pone.0164690. eCollection 2016.


A proliferation inducing ligand (APRIL) promotes IL-10 production and regulatory functions of human B cells.

Hua C, Audo R, Yeremenko N, Baeten D, Hahne M, Combe B, Morel J, Daïen C.

J Autoimmun. 2016 Sep;73:64-72. doi: 10.1016/j.jaut.2016.06.002. Epub 2016 Jun 29.


[Parkinson's Disease at the Border Between Inpatient and Outpatient Care].

Buhmann C, Bass H, Hahne M, Jost W, Redecker C, Schwarz M, Woitalla D.

Fortschr Neurol Psychiatr. 2016 Jul;84 Suppl 1:S36-40. doi: 10.1055/s-0042-103325. Epub 2016 Jun 8. Review. German.


Th17 and regulatory T cells are increased in blood of patients with birdshot chorioretinopathy.

Daien V, Mura F, Martin G, Audo R, Rivière S, Konate A, Morel J, Villain M, Hahne M, Schneider C, Daien C.

Acta Ophthalmol. 2017 Mar;95(2):e161-e163. doi: 10.1111/aos.12949. Epub 2016 Mar 24. No abstract available.


SNX9 promotes metastasis by enhancing cancer cell invasion via differential regulation of RhoGTPases.

Bendris N, Williams KC, Reis CR, Welf ES, Chen PH, Lemmers B, Hahne M, Leong HS, Schmid SL.

Mol Biol Cell. 2016 Mar 9. pii: mbc.E16-02-0101. [Epub ahead of print]


Disentangling the effects of tocilizumab on neutrophil survival and function.

Gaber T, Hahne M, Strehl C, Hoff P, Dörffel Y, Feist E, Burmester GR, Buttgereit F.

Immunol Res. 2016 Jun;64(3):665-76. doi: 10.1007/s12026-015-8770-x.


BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.

Rosati A, Basile A, D'Auria R, d'Avenia M, De Marco M, Falco A, Festa M, Guerriero L, Iorio V, Parente R, Pascale M, Marzullo L, Franco R, Arra C, Barbieri A, Rea D, Menichini G, Hahne M, Bijlsma M, Barcaroli D, Sala G, di Mola FF, di Sebastiano P, Todoric J, Antonucci L, Corvest V, Jawhari A, Firpo MA, Tuveson DA, Capunzo M, Karin M, De Laurenzi V, Turco MC.

Nat Commun. 2015 Nov 2;6:8695. doi: 10.1038/ncomms9695.


A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy.

d'Avenia M, Citro R, De Marco M, Veronese A, Rosati A, Visone R, Leptidis S, Philippen L, Vitale G, Cavallo A, Silverio A, Prota C, Gravina P, De Cola A, Carletti E, Coppola G, Gallo S, Provenza G, Bossone E, Piscione F, Hahne M, De Windt LJ, Turco MC, De Laurenzi V.

Cell Death Dis. 2015 Oct 29;6:e1948. doi: 10.1038/cddis.2015.280.


Decreased Circulating Levels of APRIL: Questioning Its Role in Diabetes.

Carvalho-Santos A, Ribeiro-Alves M, Cardoso-Weide LC, Nunes J, Kuhnert LR, Xavier AR, Cunha S, Hahne M, Villa-Verde DM, Carvalho-Pinto CE.

PLoS One. 2015 Oct 15;10(10):e0140150. doi: 10.1371/journal.pone.0140150. eCollection 2015.


The atomic structure of low-index surfaces of the intermetallic compound InPd.

McGuirk GM, Ledieu J, Gaudry É, de Weerd MC, Hahne M, Gille P, Ivarsson DC, Armbrüster M, Ardini J, Held G, Maccherozzi F, Bayer A, Lowe M, Pussi K, Diehl RD, Fournée V.

J Chem Phys. 2015 Aug 21;143(7):074705. doi: 10.1063/1.4928650.


Identification of genes regulating TRAIL-induced apoptosis in rheumatoid arthritis fibroblasts-like synoviocytes.

Audo R, Hegglin A, Severac D, Dantec C, Combe B, Hahne M, Morel J.

Genes Immun. 2015 Oct;16(7):462-9. doi: 10.1038/gene.2015.31. Epub 2015 Aug 6.


Osteoprotegerin and tumor necrosis factor-related apoptosis-inducing ligand as prognostic factors in rheumatoid arthritis: results from the ESPOIR cohort.

Audo R, Daien C, Papon L, Lukas C, Vittecoq O, Hahne M, Combe B, Morel J.

Arthritis Res Ther. 2015 Jul 29;17:193. doi: 10.1186/s13075-015-0705-3.


Advanced stages of PD: interventional therapies and related patient-centered care.

Krüger R, Hilker R, Winkler C, Lorrain M, Hahne M, Redecker C, Lingor P, Jost WH.

J Neural Transm (Vienna). 2016 Jan;123(1):31-43. doi: 10.1007/s00702-015-1418-0. Epub 2015 Jul 3. Review.


Effects of PVA coated nanoparticles on human immune cells.

Strehl C, Gaber T, Maurizi L, Hahne M, Rauch R, Hoff P, Häupl T, Hofmann-Amtenbrink M, Poole AR, Hofmann H, Buttgereit F.

Int J Nanomedicine. 2015 May 8;10:3429-45. doi: 10.2147/IJN.S75936. eCollection 2015.


Cyclin A2 modulates EMT via β-catenin and phospholipase C pathways.

Cheung CT, Bendris N, Paul C, Hamieh A, Anouar Y, Hahne M, Blanchard JM, Lemmers B.

Carcinogenesis. 2015 Aug;36(8):914-24. doi: 10.1093/carcin/bgv069. Epub 2015 May 19.


BAG3 regulates formation of the SNARE complex and insulin secretion.

Iorio V, Festa M, Rosati A, Hahne M, Tiberti C, Capunzo M, De Laurenzi V, Turco MC.

Cell Death Dis. 2015 Mar 12;6:e1684. doi: 10.1038/cddis.2015.53.


APRIL promotes breast tumor growth and metastasis and is associated with aggressive basal breast cancer.

García-Castro A, Zonca M, Florindo-Pinheiro D, Carvalho-Pinto CE, Cordero A, Gutiérrez del Fernando B, García-Grande A, Mañes S, Hahne M, González-Suárez E, Planelles L.

Carcinogenesis. 2015 May;36(5):574-84. doi: 10.1093/carcin/bgv020. Epub 2015 Mar 6.


In Silico Identification of Novel APRIL Peptide Antagonists and Binding Insights by Molecular Modeling and Immunosorbent Assays.

Silva JH, Calmon-Hamaty F, Savino W, Hahne M, Caffarena ER.

Protein Pept Lett. 2015;22(5):432-42.


Circulating APRIL levels are correlated with advanced disease and prognosis in rectal cancer patients.

Lascano V, Hahne M, Papon L, Cameron K, Röeder C, Schafmayer C, Driessen L, van Eenennaam H, Kalthoff H, Medema JP.

Oncogenesis. 2015 Jan 26;4:e136. doi: 10.1038/oncsis.2014.50.


Circadian rhythms of cellular immunity in rheumatoid arthritis: a hypothesis-generating study.

Spies CM, Hoff P, Mazuch J, Gaber T, Maier B, Strehl C, Hahne M, Jakstadt M, Huscher D, Burmester GR, Detert J, Kramer A, Buttgereit F.

Clin Exp Rheumatol. 2015 Jan-Feb;33(1):34-43. Epub 2014 Dec 22.


Targeting the Fas/FasL system in Rheumatoid Arthritis therapy: Promising or risky?

Calmon-Hamaty F, Audo R, Combe B, Morel J, Hahne M.

Cytokine. 2015 Oct;75(2):228-33. doi: 10.1016/j.cyto.2014.10.004. Epub 2014 Dec 4. Review.


Effects of 60-day bed rest with and without exercise on cellular and humoral immunological parameters.

Hoff P, Belavý DL, Huscher D, Lang A, Hahne M, Kuhlmey AK, Maschmeyer P, Armbrecht G, Fitzner R, Perschel FH, Gaber T, Burmester GR, Straub RH, Felsenberg D, Buttgereit F.

Cell Mol Immunol. 2015 Jul;12(4):483-92. doi: 10.1038/cmi.2014.106. Epub 2014 Nov 10.


High levels of natural killer cells are associated with response to tocilizumab in patients with severe rheumatoid arthritis.

Daïen CI, Gailhac S, Audo R, Mura T, Hahne M, Combe B, Morel J.

Rheumatology (Oxford). 2015 Apr;54(4):601-8. doi: 10.1093/rheumatology/keu363. Epub 2014 Sep 16.


Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon.

Rocha C, Papon L, Cacheux W, Marques Sousa P, Lascano V, Tort O, Giordano T, Vacher S, Lemmers B, Mariani P, Meseure D, Medema JP, Bièche I, Hahne M, Janke C.

EMBO J. 2014 Oct 1;33(19):2247-60. doi: 10.15252/embj.201488466. Epub 2014 Sep 1. Erratum in: EMBO J. 2014 Nov 18;33(22):2735.


Distinct effects of soluble and membrane-bound fas ligand on fibroblast-like synoviocytes from rheumatoid arthritis patients.

Audo R, Calmon-Hamaty F, Papon L, Combe B, Morel J, Hahne M.

Arthritis Rheumatol. 2014 Dec;66(12):3289-99. doi: 10.1002/art.38806.


[Median nerve neuropathy after perilunate dislocation injuries].

Mühldorfer-Fodor M, Hohendorff B, Saalabian AA, Hahne M, van Schoonhoven J, Prommersberger KJ.

Handchir Mikrochir Plast Chir. 2014 Jun;46(3):163-8. doi: 10.1055/s-0034-1370959. Epub 2014 Jun 18. German.


Regulatory B10 cells are decreased in patients with rheumatoid arthritis and are inversely correlated with disease activity.

Daien CI, Gailhac S, Mura T, Audo R, Combe B, Hahne M, Morel J.

Arthritis Rheumatol. 2014 Aug;66(8):2037-46. doi: 10.1002/art.38666.


Chronic lymphocytic leukemia disease progression is accelerated by APRIL-TACI interaction in the TCL1 transgenic mouse model.

Lascano V, Guadagnoli M, Schot JG, Luijks DM, Guikema JE, Cameron K, Hahne M, Pals S, Slinger E, Kipps TJ, van Oers MH, Eldering E, Medema JP, Kater AP.

Blood. 2013 Dec 5;122(24):3960-3. doi: 10.1182/blood-2013-04-497693. Epub 2013 Oct 7.


The two directions of TNF-related apoptosis-inducing ligand in rheumatoid arthritis.

Audo R, Combe B, Hahne M, Morel J.

Cytokine. 2013 Aug;63(2):81-90. doi: 10.1016/j.cyto.2013.04.011. Epub 2013 May 4. Review.


Preoperative irradiation for the prevention of heterotopic ossification induces local inflammation in humans.

Hoff P, Rakow A, Gaber T, Hahne M, Sentürk U, Strehl C, Fangradt M, Schmidt-Bleek K, Huscher D, Winkler T, Matziolis D, Matziolis G, Badakhshi H, Burmester GR, Duda GN, Perka C, Buttgereit F.

Bone. 2013 Jul;55(1):93-101. doi: 10.1016/j.bone.2013.03.020. Epub 2013 Apr 6.


Pathophysiological hypoxia affects the redox state and IL-2 signalling of human CD4+ T cells and concomitantly impairs survival and proliferation.

Gaber T, Tran CL, Schellmann S, Hahne M, Strehl C, Hoff P, Radbruch A, Burmester GR, Buttgereit F.

Eur J Immunol. 2013 Jun;43(6):1588-97. doi: 10.1002/eji.201242754. Epub 2013 May 17.


Gene expression of catalytic proteasome subunits and resistance toward proteasome inhibition of B lymphocytes from patients with primary sjogren syndrome.

Martinez-Gamboa L, Lesemann K, Kuckelkorn U, Scheffler S, Ghannam K, Hahne M, Gaber-Elsner T, Egerer K, Naumann L, Buttgereit F, Dörner T, Kloetzel PM, Burmester GR, Faustman DL, Feist E.

J Rheumatol. 2013 May;40(5):663-73. doi: 10.3899/jrheum.120680. Epub 2013 Mar 15.


To target or not to target APRIL in systemic lupus erythematosus: that is the question!

Morel J, Hahne M.

Arthritis Res Ther. 2013 Feb 25;15(1):107. doi: 10.1186/ar4160.


Detection of soluble BAG3 and anti-BAG3 antibodies in patients with chronic heart failure.

De Marco M, Falco A, Basile A, Rosati A, Festa M, d'Avenia M, Pascale M, Dal Piaz F, Bisogni R, Barcaroli D, Coppola G, Piscione F, Gigantino A, Citro R, De Rosa R, Vitulano G, Virtuoso N, Manganelli F, Palermo E, Siano F, Rosato G, Hahne M, Tiberti C, De Laurenzi V, Turco MC.

Cell Death Dis. 2013 Feb 14;4:e495. doi: 10.1038/cddis.2013.8. No abstract available.


High-sensitivity immunofluorescence staining: a comparison of the liposome procedure and the FASER technique on mGR detection.

Strehl C, Gaber T, Jakstadt M, Hahne M, Hoff P, Spies CM, Scheffold A, Burmester GR, Buttgereit F.

J Fluoresc. 2013 May;23(3):509-18. doi: 10.1007/s10895-013-1163-4. Epub 2013 Feb 14.


Structural investigation of the (010) surface of the Al13 Fe4 catalyst.

Ledieu J, Gaudry É, Loli LN, Villaseca SA, de Weerd MC, Hahne M, Gille P, Grin Y, Dubois JM, Fournée V.

Phys Rev Lett. 2013 Feb 15;110(7):076102. Epub 2013 Feb 15.


The TNF family member APRIL dampens collagen-induced arthritis.

Fernandez L, Salinas GF, Rocha C, Carvalho-Pinto CE, Yeremenko N, Papon L, Medema JP, Combe B, Morel J, Baeten D, Hahne M.

Ann Rheum Dis. 2013 Aug;72(8):1367-74. doi: 10.1136/annrheumdis-2012-202382. Epub 2012 Nov 24.


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