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Items: 1 to 50 of 121

1.

Controlling protein conformation with light.

Dagliyan O, Hahn KM.

Curr Opin Struct Biol. 2019 Mar 5;57:17-22. doi: 10.1016/j.sbi.2019.01.012. [Epub ahead of print] Review.

PMID:
30849716
2.

High Rac1 activity is functionally translated into cytosolic structures with unique nanoscale cytoskeletal architecture.

Marston DJ, Anderson KL, Swift MF, Rougie M, Page C, Hahn KM, Volkmann N, Hanein D.

Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1267-1272. doi: 10.1073/pnas.1808830116. Epub 2019 Jan 10.

PMID:
30630946
3.

Computational design of chemogenetic and optogenetic split proteins.

Dagliyan O, Krokhotin A, Ozkan-Dagliyan I, Deiters A, Der CJ, Hahn KM, Dokholyan NV.

Nat Commun. 2018 Oct 2;9(1):4042. doi: 10.1038/s41467-018-06531-4.

4.

Functional redundancy between RAP1 isoforms in murine platelet production and function.

Stefanini L, Lee RH, Paul DS, O'Shaughnessy EC, Ghalloussi D, Jones CI, Boulaftali Y, Poe KO, Piatt R, Kechele DO, Caron KM, Hahn KM, Gibbins JM, Bergmeier W.

Blood. 2018 Nov 1;132(18):1951-1962. doi: 10.1182/blood-2018-03-838714. Epub 2018 Aug 21.

PMID:
30131434
5.

Profiling cellular morphodynamics by spatiotemporal spectrum decomposition.

Ma X, Dagliyan O, Hahn KM, Danuser G.

PLoS Comput Biol. 2018 Aug 2;14(8):e1006321. doi: 10.1371/journal.pcbi.1006321. eCollection 2018 Aug.

6.

EdgeProps: A Computational Platform for Correlative Analysis of Cell Dynamics and Near-Edge Protein Activity.

Zhurikhina A, Qi T, Hahn KM, Elston TC, Tsygankov D.

Methods Mol Biol. 2018;1821:47-56. doi: 10.1007/978-1-4939-8612-5_4.

PMID:
30062404
7.

STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.

Woroniuk A, Porter A, White G, Newman DT, Diamantopoulou Z, Waring T, Rooney C, Strathdee D, Marston DJ, Hahn KM, Sansom OJ, Zech T, Malliri A.

Nat Commun. 2018 May 29;9(1):2124. doi: 10.1038/s41467-018-04404-4.

8.

An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration.

Tajadura-Ortega V, Garg R, Allen R, Owczarek C, Bright MD, Kean S, Mohd-Noor A, Grigoriadis A, Elston TC, Hahn KM, Ridley AJ.

BMC Biol. 2018 Mar 6;16(1):29. doi: 10.1186/s12915-018-0489-4.

9.

Local control of intracellular microtubule dynamics by EB1 photodissociation.

van Haren J, Charafeddine RA, Ettinger A, Wang H, Hahn KM, Wittmann T.

Nat Cell Biol. 2018 Mar;20(3):252-261. doi: 10.1038/s41556-017-0028-5. Epub 2018 Jan 29.

10.

Discovery of long-range inhibitory signaling to ensure single axon formation.

Takano T, Wu M, Nakamuta S, Naoki H, Ishizawa N, Namba T, Watanabe T, Xu C, Hamaguchi T, Yura Y, Amano M, Hahn KM, Kaibuchi K.

Nat Commun. 2017 Jun 26;8(1):33. doi: 10.1038/s41467-017-00044-2.

11.

Spatial analysis of Cdc42 activity reveals a role for plasma membrane-associated Cdc42 in centrosome regulation.

Herrington KA, Trinh AL, Dang C, O'Shaughnessy E, Hahn KM, Gratton E, Digman MA, Sütterlin C.

Mol Biol Cell. 2017 Jul 15;28(15):2135-2145. doi: 10.1091/mbc.E16-09-0665. Epub 2017 May 24.

12.

Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains.

Ye F, Yang C, Kim J, MacNevin CJ, Hahn KM, Park D, Ginsberg MH, Kim C.

J Biol Chem. 2017 Jun 16;292(24):9858-9864. doi: 10.1074/jbc.C117.787309. Epub 2017 May 9.

13.

Engineering Pak1 Allosteric Switches.

Dagliyan O, Karginov AV, Yagishita S, Gale ME, Wang H, DerMardirossian C, Wells CM, Dokholyan NV, Kasai H, Hahn KM.

ACS Synth Biol. 2017 Jul 21;6(7):1257-1262. doi: 10.1021/acssynbio.6b00359. Epub 2017 Apr 6.

14.

Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin.

Woodham EF, Paul NR, Tyrrell B, Spence HJ, Swaminathan K, Scribner MR, Giampazolias E, Hedley A, Clark W, Kage F, Marston DJ, Hahn KM, Tait SW, Larue L, Brakebusch CH, Insall RH, Machesky LM.

Curr Biol. 2017 Mar 6;27(5):624-637. doi: 10.1016/j.cub.2017.01.033. Epub 2017 Feb 23.

15.

Engineering extrinsic disorder to control protein activity in living cells.

Dagliyan O, Tarnawski M, Chu PH, Shirvanyants D, Schlichting I, Dokholyan NV, Hahn KM.

Science. 2016 Dec 16;354(6318):1441-1444.

16.

LOVTRAP: A Versatile Method to Control Protein Function with Light.

Wang H, Hahn KM.

Curr Protoc Cell Biol. 2016 Dec 1;73:21.10.1-21.10.14. doi: 10.1002/cpcb.12.

17.

PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front.

Nguyen TT, Park WS, Park BO, Kim CY, Oh Y, Kim JM, Choi H, Kyung T, Kim CH, Lee G, Hahn KM, Meyer T, Heo WD.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10091-6. doi: 10.1073/pnas.1604720113. Epub 2016 Aug 23.

18.

FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions.

Hodgson L, Spiering D, Sabouri-Ghomi M, Dagliyan O, DerMardirossian C, Danuser G, Hahn KM.

Nat Chem Biol. 2016 Oct;12(10):802-809. doi: 10.1038/nchembio.2145. Epub 2016 Aug 8.

19.

LOVTRAP: an optogenetic system for photoinduced protein dissociation.

Wang H, Vilela M, Winkler A, Tarnawski M, Schlichting I, Yumerefendi H, Kuhlman B, Liu R, Danuser G, Hahn KM.

Nat Methods. 2016 Sep;13(9):755-8. doi: 10.1038/nmeth.3926. Epub 2016 Jul 18.

20.

Ratiometric Imaging Using a Single Dye Enables Simultaneous Visualization of Rac1 and Cdc42 Activation.

MacNevin CJ, Toutchkine A, Marston DJ, Hsu CW, Tsygankov D, Li L, Liu B, Qi T, Nguyen DV, Hahn KM.

J Am Chem Soc. 2016 Mar 2;138(8):2571-5. doi: 10.1021/jacs.5b09764. Epub 2016 Feb 19.

21.

Characterization of an Engineered Src Kinase to Study Src Signaling and Biology.

Gentry LR, Karginov AV, Hahn KM, Der CJ.

Methods Mol Biol. 2016;1360:157-67. doi: 10.1007/978-1-4939-3073-9_12.

22.

Labelling and optical erasure of synaptic memory traces in the motor cortex.

Hayashi-Takagi A, Yagishita S, Nakamura M, Shirai F, Wu YI, Loshbaugh AL, Kuhlman B, Hahn KM, Kasai H.

Nature. 2015 Sep 17;525(7569):333-8. doi: 10.1038/nature15257. Epub 2015 Sep 9.

23.

An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A.

Yi JJ, Berrios J, Newbern JM, Snider WD, Philpot BD, Hahn KM, Zylka MJ.

Cell. 2015 Aug 13;162(4):795-807. doi: 10.1016/j.cell.2015.06.045. Epub 2015 Aug 6.

24.

Automated pain intervention for underserved minority women with breast cancer.

Anderson KO, Palos GR, Mendoza TR, Cleeland CS, Liao KP, Fisch MJ, Garcia-Gonzalez A, Rieber AG, Nazario LA, Valero V, Hahn KM, Person CL, Payne R.

Cancer. 2015 Jun 1;121(11):1882-90. doi: 10.1002/cncr.29204. Epub 2015 Feb 24.

25.

A High-Content Assay for Biosensor Validation and for Examining Stimuli that Affect Biosensor Activity.

Slattery SD, Hahn KM.

Curr Protoc Cell Biol. 2014 Dec 1;65:14.15.1-31. doi: 10.1002/0471143030.cb1415s65. Review.

26.

A novel fluorescent sensor protein for detecting changes in airway surface liquid glucose concentration.

Helassa N, Garnett JP, Farrant M, Khan F, Pickup JC, Hahn KM, MacNevin CJ, Tarran R, Baines DL.

Biochem J. 2014 Dec 1;464(2):213-20. doi: 10.1042/BJ20141041.

27.

Optogenetic approaches to cell migration and beyond.

Weitzman M, Hahn KM.

Curr Opin Cell Biol. 2014 Oct;30:112-20. doi: 10.1016/j.ceb.2014.08.004. Epub 2014 Sep 15. Review.

28.

Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms.

Chu PH, Tsygankov D, Berginski ME, Dagliyan O, Gomez SM, Elston TC, Karginov AV, Hahn KM.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12420-5. doi: 10.1073/pnas.1404487111. Epub 2014 Aug 12.

29.

User-friendly tools for quantifying the dynamics of cellular morphology and intracellular protein clusters.

Tsygankov D, Chu PH, Chen H, Elston TC, Hahn KM.

Methods Cell Biol. 2014;123:409-27. doi: 10.1016/B978-0-12-420138-5.00022-7.

30.

Manipulation of endogenous kinase activity in living cells using photoswitchable inhibitory peptides.

Yi JJ, Wang H, Vilela M, Danuser G, Hahn KM.

ACS Synth Biol. 2014 Nov 21;3(11):788-95. doi: 10.1021/sb5001356. Epub 2014 Jun 13.

31.

Optochemical activation of kinase function in live cells.

Karginov AV, Hahn KM, Deiters A.

Methods Mol Biol. 2014;1148:31-43. doi: 10.1007/978-1-4939-0470-9_3.

32.

Dissecting motility signaling through activation of specific Src-effector complexes.

Karginov AV, Tsygankov D, Berginski M, Chu PH, Trudeau ED, Yi JJ, Gomez S, Elston TC, Hahn KM.

Nat Chem Biol. 2014 Apr;10(4):286-90. doi: 10.1038/nchembio.1477. Epub 2014 Mar 9. Erratum in: Nat Chem Biol. 2014 Aug;10(8):692.

33.

Fluctuation-based imaging of nuclear Rac1 activation by protein oligomerisation.

Hinde E, Yokomori K, Gaus K, Hahn KM, Gratton E.

Sci Rep. 2014 Feb 27;4:4219. doi: 10.1038/srep04219.

34.

CellGeo: a computational platform for the analysis of shape changes in cells with complex geometries.

Tsygankov D, Bilancia CG, Vitriol EA, Hahn KM, Peifer M, Elston TC.

J Cell Biol. 2014 Feb 3;204(3):443-60. doi: 10.1083/jcb.201306067.

35.

Effect of age and race on quality of life in young breast cancer survivors.

Morrow PK, Broxson AC, Munsell MF, Basen-Enquist K, Rosenblum CK, Schover LR, Nguyen LH, Hsu L, Castillo L, Hahn KM, Litton JK, Kwiatkowski DN, Hortobagyi GN.

Clin Breast Cancer. 2014 Apr;14(2):e21-31. doi: 10.1016/j.clbc.2013.10.003. Epub 2013 Oct 25. Review.

36.

The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility.

Khalil BD, Hanna S, Saykali BA, El-Sitt S, Nasrallah A, Marston D, El-Sabban M, Hahn KM, Symons M, El-Sibai M.

Exp Cell Res. 2014 Feb 15;321(2):109-22. doi: 10.1016/j.yexcr.2013.11.023. Epub 2013 Dec 10.

37.

A RhoC biosensor reveals differences in the activation kinetics of RhoA and RhoC in migrating cells.

Zawistowski JS, Sabouri-Ghomi M, Danuser G, Hahn KM, Hodgson L.

PLoS One. 2013 Nov 5;8(11):e79877. doi: 10.1371/journal.pone.0079877. eCollection 2013.

38.

[Phosphate restriction in chronic renal failure - yes].

Hahn KM.

Dtsch Med Wochenschr. 2013 Sep;138(38):1900. doi: 10.1055/s-0033-1349442. Epub 2013 Sep 10. German. No abstract available.

PMID:
24022455
39.

Automated line scan analysis to quantify biosensor activity at the cell edge.

Allen RJ, Tsygankov D, Zawistowski JS, Elston TC, Hahn KM.

Methods. 2014 Mar 15;66(2):162-7. doi: 10.1016/j.ymeth.2013.08.025. Epub 2013 Aug 30.

40.

Knowledge-based design of a biosensor to quantify localized ERK activation in living cells.

Kummer L, Hsu CW, Dagliyan O, MacNevin C, Kaufholz M, Zimmermann B, Dokholyan NV, Hahn KM, Plückthun A.

Chem Biol. 2013 Jun 20;20(6):847-56. doi: 10.1016/j.chembiol.2013.04.016.

41.

[Importance of the different i.v. iron generations for everyday medical practice].

Biggar P, Hahn KM.

MMW Fortschr Med. 2013 Mar 21;155 Suppl 1:18-24. Review. German.

PMID:
23678667
42.

An optogenetic tool for the activation of endogenous diaphanous-related formins induces thickening of stress fibers without an increase in contractility.

Rao MV, Chu PH, Hahn KM, Zaidel-Bar R.

Cytoskeleton (Hoboken). 2013 Jul;70(7):394-407. doi: 10.1002/cm.21115. Epub 2013 May 24.

43.

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.

Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, Roth BL, Brown PJ, Frye SV, Arrowsmith CH, Hahn KM, Wang GG, Vedadi M, Jin J.

ACS Chem Biol. 2013;8(6):1324-34. doi: 10.1021/cb400133j. Epub 2013 Apr 24.

44.

Case control study of women treated with chemotherapy for breast cancer during pregnancy as compared with nonpregnant patients with breast cancer.

Litton JK, Warneke CL, Hahn KM, Palla SL, Kuerer HM, Perkins GH, Mittendorf EA, Barnett C, Gonzalez-Angulo AM, Hortobágyi GN, Theriault RL.

Oncologist. 2013;18(4):369-76. doi: 10.1634/theoncologist.2012-0340. Epub 2013 Apr 10.

45.

Rational design of a ligand-controlled protein conformational switch.

Dagliyan O, Shirvanyants D, Karginov AV, Ding F, Fee L, Chandrasekaran SN, Freisinger CM, Smolen GA, Huttenlocher A, Hahn KM, Dokholyan NV.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6800-4. doi: 10.1073/pnas.1218319110. Epub 2013 Apr 8.

46.

Environment-sensing merocyanine dyes for live cell imaging applications.

MacNevin CJ, Gremyachinskiy D, Hsu CW, Li L, Rougie M, Davis TT, Hahn KM.

Bioconjug Chem. 2013 Feb 20;24(2):215-23. doi: 10.1021/bc3005073. Epub 2013 Jan 16.

47.

Millisecond spatiotemporal dynamics of FRET biosensors by the pair correlation function and the phasor approach to FLIM.

Hinde E, Digman MA, Hahn KM, Gratton E.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):135-40. doi: 10.1073/pnas.1211882110. Epub 2012 Dec 17.

48.

External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane.

Galic M, Jeong S, Tsai FC, Joubert LM, Wu YI, Hahn KM, Cui Y, Meyer T.

Nat Cell Biol. 2012 Aug;14(8):874-81. doi: 10.1038/ncb2533. Epub 2012 Jul 1.

49.

Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons.

Dietz DM, Sun H, Lobo MK, Cahill ME, Chadwick B, Gao V, Koo JW, Mazei-Robison MS, Dias C, Maze I, Damez-Werno D, Dietz KC, Scobie KN, Ferguson D, Christoffel D, Ohnishi Y, Hodes GE, Zheng Y, Neve RL, Hahn KM, Russo SJ, Nestler EJ.

Nat Neurosci. 2012 Jun;15(6):891-6. doi: 10.1038/nn.3094.

50.

Designing photoswitchable peptides using the AsLOV2 domain.

Lungu OI, Hallett RA, Choi EJ, Aiken MJ, Hahn KM, Kuhlman B.

Chem Biol. 2012 Apr 20;19(4):507-17. doi: 10.1016/j.chembiol.2012.02.006. Erratum in: Chem Biol. 2012 Jul 27;19(7):926.

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