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Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations.

Hucke A, Park GY, Bauer OB, Beyer G, Köppen C, Zeeh D, Wehe CA, Sperling M, Schröter R, Kantauskaitè M, Hagos Y, Karst U, Lippard SJ, Ciarimboli G.

Front Chem. 2018 May 25;6:180. doi: 10.3389/fchem.2018.00180. eCollection 2018.


Serological investigation of visceral Leishmania infection in human and its associated risk factors in Welkait District, Western Tigray, Ethiopia.

Bsrat A, Berhe M, Gadissa E, Taddele H, Tekle Y, Hagos Y, Abera A, G/Micael M, Alemayhu T, Gugsa G, Aseffa A.

Parasite Epidemiol Control. 2017 Nov 4;3(1):13-20. doi: 10.1016/j.parepi.2017.10.004. eCollection 2018 Feb.


Differential Interaction of Dantrolene, Glafenine, Nalidixic Acid, and Prazosin with Human Organic Anion Transporters 1 and 3.

Burckhardt BC, Henjakovic M, Hagos Y, Burckhardt G.

J Pharmacol Exp Ther. 2017 Sep;362(3):450-458. doi: 10.1124/jpet.117.241406. Epub 2017 Jun 19.


Standard Operating Procedure Utilization for Tuberculosis Microscopy in Mekelle City, North Ethiopia.

Weldu Y, Gebru H, Kahsay G, Teweldemedhn G, Hagos Y, Kahsay A.

Am J Clin Pathol. 2017 Jan 1;147(1):83-88. doi: 10.1093/ajcp/aqw196.


Erratum to: Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3).

Burckhardt BC, Henjakovic M, Hagos Y, Burckhardt G.

Pflugers Arch. 2016 Nov;468(11-12):1919-1920. No abstract available.


Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3).

Burckhardt BC, Henjakovic M, Hagos Y, Burckhardt G.

Pflugers Arch. 2016 Nov;468(11-12):1909-1918. Epub 2016 Nov 3. Erratum in: Pflugers Arch. 2016 Nov;468(11-12):1919-1920.


Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron.

Breljak D, Ljubojević M, Hagos Y, Micek V, Balen Eror D, Vrhovac Madunić I, Brzica H, Karaica D, Radović N, Kraus O, Anzai N, Koepsell H, Burckhardt G, Burckhardt BC, Sabolić I.

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F227-38. doi: 10.1152/ajprenal.00113.2016. Epub 2016 Apr 6.


The Isoquinolone Derived Prolyl Hydroxylase Inhibitor ICA Is a Potent Substrate of the Organic Anion Transporters 1 and 3.

Schulz K, Hagos Y, Burckhardt G, Schley G, Burzlaff N, Willam C, Burckhardt BC.

Nephron. 2015;131(4):285-9. doi: 10.1159/000442531. Epub 2015 Dec 8.


Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function.

Henjakovic M, Hagos Y, Krick W, Burckhardt G, Burckhardt BC.

Am J Physiol Renal Physiol. 2015 Nov 15;309(10):F843-51. doi: 10.1152/ajprenal.00140.2015. Epub 2015 Sep 16.


Pre-slaughter, slaughter and post-slaughter defects of skins and hides at the Sheba Tannery and Leather Industry, Tigray region, northern Ethiopia.

Kahsay T, Negash G, Hagos Y, Hadush B.

Onderstepoort J Vet Res. 2015 Aug 21;82(1):E1-7. doi: 10.4102/ojvr.v82i1.931.


Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis.

Lovisa S, LeBleu VS, Tampe B, Sugimoto H, Vadnagara K, Carstens JL, Wu CC, Hagos Y, Burckhardt BC, Pentcheva-Hoang T, Nischal H, Allison JP, Zeisberg M, Kalluri R.

Nat Med. 2015 Sep;21(9):998-1009. doi: 10.1038/nm.3902. Epub 2015 Aug 3.


Beta-2 Adrenergic Agonists Are Substrates and Inhibitors of Human Organic Cation Transporter 1.

Salomon JJ, Hagos Y, Petzke S, Kühne A, Gausterer JC, Hosoya K, Ehrhardt C.

Mol Pharm. 2015 Aug 3;12(8):2633-41. doi: 10.1021/mp500854e. Epub 2015 Mar 18.


Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds.

Marada VV, Flörl S, Kühne A, Burckhardt G, Hagos Y.

Eur J Med Chem. 2015 Mar 6;92:723-31. doi: 10.1016/j.ejmech.2015.01.011. Epub 2015 Jan 8.


Interaction of human organic anion transporter 2 (OAT2) and sodium taurocholate cotransporting polypeptide (NTCP) with antineoplastic drugs.

Marada VV, Flörl S, Kühne A, Müller J, Burckhardt G, Hagos Y.

Pharmacol Res. 2015 Jan;91:78-87. doi: 10.1016/j.phrs.2014.11.002. Epub 2014 Dec 4.


Renal human organic anion transporter 3 increases the susceptibility of lymphoma cells to bendamustine uptake.

Hagos Y, Hundertmark P, Shnitsar V, Marada VV, Wulf G, Burckhardt G.

Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F330-8. doi: 10.1152/ajprenal.00467.2014. Epub 2014 Dec 4.


Transporters involved in renal excretion of N-carbamoylglutamate, an orphan drug to treat inborn n-acetylglutamate synthase deficiency.

Schwob E, Hagos Y, Burckhardt G, Burckhardt BC.

Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1373-9. doi: 10.1152/ajprenal.00482.2014. Epub 2014 Oct 29.


HNF4α induced chemosensitivity to oxaliplatin and 5-FU mediated by OCT1 and CNT3 in renal cell carcinoma.

Hagos Y, Wegner W, Kuehne A, Floerl S, Marada VV, Burckhardt G, Henjakovic M.

J Pharm Sci. 2014 Oct;103(10):3326-34. doi: 10.1002/jps.24128. Epub 2014 Aug 29.


The elephants of Gash-Barka, Eritrea: nuclear and mitochondrial genetic patterns.

Brandt AL, Hagos Y, Yacob Y, David VA, Georgiadis NJ, Shoshani J, Roca AL.

J Hered. 2014 Jan-Feb;105(1):82-90. doi: 10.1093/jhered/est078. Epub 2013 Nov 27.


The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes.

Schnell C, Shahmoradi A, Wichert SP, Mayerl S, Hagos Y, Heuer H, Rossner MJ, Hülsmann S.

Brain Struct Funct. 2015 Jan;220(1):193-203. doi: 10.1007/s00429-013-0645-0. Epub 2013 Oct 16.


Human organic anion transporter OAT1 is not responsible for glutathione transport but mediates transport of glutamate derivatives.

Hagos Y, Burckhardt G, Burckhardt BC.

Am J Physiol Renal Physiol. 2013 Feb 15;304(4):F403-9. doi: 10.1152/ajprenal.00412.2012. Epub 2012 Dec 19.


Active sulforhodamine 101 uptake into hippocampal astrocytes.

Schnell C, Hagos Y, Hülsmann S.

PLoS One. 2012;7(11):e49398. doi: 10.1371/journal.pone.0049398. Epub 2012 Nov 26.


Selective stabilization of HIF-1α in renal tubular cells by 2-oxoglutarate analogues.

Schley G, Klanke B, Schödel J, Kröning S, Türkoglu G, Beyer A, Hagos Y, Amann K, Burckhardt BC, Burzlaff N, Eckardt KU, Willam C.

Am J Pathol. 2012 Nov;181(5):1595-606. doi: 10.1016/j.ajpath.2012.07.010. Epub 2012 Aug 31.


α-Ketoglutarate-related inhibitors of HIF prolyl hydroxylases are substrates of renal organic anion transporters 1 (OAT1) and 4 (OAT4).

Hagos Y, Schley G, Schödel J, Krick W, Burckhardt G, Willam C, Burckhardt BC.

Pflugers Arch. 2012 Oct;464(4):367-74. Epub 2012 Aug 9.


Human organic cation transporter 1 is expressed in lymphoma cells and increases susceptibility to irinotecan and paclitaxel.

Gupta S, Wulf G, Henjakovic M, Koepsell H, Burckhardt G, Hagos Y.

J Pharmacol Exp Ther. 2012 Apr;341(1):16-23. doi: 10.1124/jpet.111.190561. Epub 2011 Dec 27.


Interaction of human multidrug and toxin extrusion 1 (MATE1) transporter with antineoplastic agents.

Grottker J, Rosenberger A, Burckhardt G, Hagos Y.

Drug Metabol Drug Interact. 2011;26(4):181-9. doi: 10.1515/DMDI.2011.024. Epub 2011 Nov 7.


Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3.

Kaufhold M, Schulz K, Breljak D, Gupta S, Henjakovic M, Krick W, Hagos Y, Sabolic I, Burckhardt BC, Burckhardt G.

Am J Physiol Renal Physiol. 2011 Nov;301(5):F1026-34. doi: 10.1152/ajprenal.00169.2011. Epub 2011 Aug 24.


SLC22 transporter family proteins as targets for cytostatic uptake into tumor cells.

Gupta S, Burckhardt G, Hagos Y.

Biol Chem. 2011 Jan;392(1-2):117-24. doi: 10.1515/BC.2011.014. Review.


New clues for nephrotoxicity induced by ifosfamide: preferential renal uptake via the human organic cation transporter 2.

Ciarimboli G, Holle SK, Vollenbröcker B, Hagos Y, Reuter S, Burckhardt G, Bierer S, Herrmann E, Pavenstädt H, Rossi R, Kleta R, Schlatter E.

Mol Pharm. 2011 Feb 7;8(1):270-9. doi: 10.1021/mp100329u. Epub 2010 Dec 2.


Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity.

Hagos Y, Wolff NA.

Toxins (Basel). 2010 Aug;2(8):2055-82. doi: 10.3390/toxins2082055. Epub 2010 Aug 9. Review.


Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes.

Brökers N, Le-Huu S, Vogel S, Hagos Y, Katschinski DM, Kleinschmidt M.

Cancer Sci. 2010 Jan;101(1):129-36. doi: 10.1111/j.1349-7006.2009.01367.x. Epub 2009 Sep 14.


Influx and efflux transport as determinants of melphalan cytotoxicity: Resistance to melphalan in MDR1 overexpressing tumor cell lines.

Kühne A, Tzvetkov MV, Hagos Y, Lage H, Burckhardt G, Brockmöller J.

Biochem Pharmacol. 2009 Jul 1;78(1):45-53. doi: 10.1016/j.bcp.2009.03.026. Epub 2009 Apr 5.


Expression of human organic cation transporter 3 in kidney carcinoma cell lines increases chemosensitivity to melphalan, irinotecan, and vincristine.

Shnitsar V, Eckardt R, Gupta S, Grottker J, Müller GA, Koepsell H, Burckhardt G, Hagos Y.

Cancer Res. 2009 Feb 15;69(4):1494-501. doi: 10.1158/0008-5472.CAN-08-2483. Epub 2009 Feb 3.


Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13).

Bahn A, Hagos Y, Reuter S, Balen D, Brzica H, Krick W, Burckhardt BC, Sabolic I, Burckhardt G.

J Biol Chem. 2008 Jun 13;283(24):16332-41. doi: 10.1074/jbc.M800737200. Epub 2008 Apr 14.


Membrane translocation of glutaric acid and its derivatives.

Mühlhausen C, Burckhardt BC, Hagos Y, Burckhardt G, Keyser B, Lukacs Z, Ullrich K, Braulke T.

J Inherit Metab Dis. 2008 Apr;31(2):188-93. doi: 10.1007/s10545-008-0825-x. Epub 2008 Apr 4. Review.


Organic anion transporters OAT1 and OAT4 mediate the high affinity transport of glutarate derivatives accumulating in patients with glutaric acidurias.

Hagos Y, Krick W, Braulke T, Mühlhausen C, Burckhardt G, Burckhardt BC.

Pflugers Arch. 2008 Oct;457(1):223-31. doi: 10.1007/s00424-008-0489-2. Epub 2008 Mar 26.


Torasemide transport by organic anion transporters contributes to hyperuricemia.

Hagos Y, Bahn A, Vormfelde SV, Brockmöller J, Burckhardt G.

J Am Soc Nephrol. 2007 Dec;18(12):3101-9. Epub 2007 Oct 31. No abstract available.


Human renal organic anion transporter 4 operates as an asymmetric urate transporter.

Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A.

J Am Soc Nephrol. 2007 Feb;18(2):430-9. Epub 2007 Jan 17.


Torsemide renal clearance and genetic variation in luminal and basolateral organic anion transporters.

Vormfelde SV, Schirmer M, Hagos Y, Toliat MR, Engelhardt S, Meineke I, Burckhardt G, Nürnberg P, Brockmöller J.

Br J Clin Pharmacol. 2006 Sep;62(3):323-35.


Regulation of steroid hormone biosynthesis enzymes and organic anion transporters by forskolin and DHEA-S treatment in adrenocortical cells.

Asif AR, Ljubojevic M, Sabolic I, Shnitsar V, Metten M, Anzai N, Müller GA, Burckhardt G, Hagos Y.

Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1351-9. Epub 2006 Jul 11.


Functional roles of cationic amino acid residues in the sodium-dicarboxylate cotransporter 3 (NaDC-3) from winter flounder.

Hagos Y, Steffgen J, Rizwan AN, Langheit D, Knoll A, Burckhardt G, Burckhardt BC.

Am J Physiol Renal Physiol. 2006 Dec;291(6):F1224-31. Epub 2006 May 30.


Localization of the sulfate/anion exchanger in the rat liver.

Quondamatteo F, Krick W, Hagos Y, Krüger MH, Neubauer-Saile K, Herken R, Ramadori G, Burckhardt G, Burckhardt BC.

Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G1075-81. Epub 2005 Dec 15.


Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites.

Bahn A, Ljubojevic M, Lorenz H, Schultz C, Ghebremedhin E, Ugele B, Sabolic I, Burckhardt G, Hagos Y.

Am J Physiol Cell Physiol. 2005 Nov;289(5):C1075-84. Epub 2005 Jun 8.


Presence of organic anion transporters 3 (OAT3) and 4 (OAT4) in human adrenocortical cells.

Asif AR, Steffgen J, Metten M, Grunewald RW, Müller GA, Bahn A, Burckhardt G, Hagos Y.

Pflugers Arch. 2005 May;450(2):88-95. Epub 2004 Dec 10.


Functional expression of pig renal organic anion transporter 3 (pOAT3).

Hagos Y, Braun IM, Krick W, Burckhardt G, Bahn A.

Biochimie. 2005 May;87(5):421-4.


Expression studies and functional characterization of renal human organic anion transporter 1 isoforms.

Bahn A, Ebbinghaus C, Ebbinghaus D, Ponimaskin EG, Fuzesï L, Burckhardt G, Hagos Y.

Drug Metab Dispos. 2004 Apr;32(4):424-30.


Mutation of amino acid 475 of rat organic cation transporter 2 (rOCT2) impairs organic cation transport.

Bahn A, Hagos Y, Rudolph T, Burckhardt G.

Biochimie. 2004 Feb;86(2):133-6.


Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition.

Ljubojevic M, Herak-Kramberger CM, Hagos Y, Bahn A, Endou H, Burckhardt G, Sabolic I.

Am J Physiol Renal Physiol. 2004 Jul;287(1):F124-38. Epub 2004 Mar 9.


Regulation of sodium-dicarboxylate cotransporter-3 from winter flounder kidney by protein kinase C.

Hagos Y, Burckhardt BC, Larsen A, Mathys C, Gronow T, Bahn A, Wolff NA, Burckhardt G, Steffgen J.

Am J Physiol Renal Physiol. 2004 Jan;286(1):F86-93. Epub 2003 Sep 16.


Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin-regulated zonal expression.

Béery E, Middel P, Bahn A, Willenberg HS, Hagos Y, Koepsell H, Bornstein SR, Müller GA, Burckhardt G, Steffgen J.

Endocrinology. 2003 Oct;144(10):4519-26. Epub 2003 Jun 26.


RT-PCR-based evidence for the in vivo stimulation of renal tubularp-aminohippurate (PAH) transport by triiodothyronine (T3) or dexamethasone (DEXA) in kidney tissue of immature and adult rats.

Bahn A, Hauss A, Appenroth D, Ebbinghaus D, Hagos Y, Steinmetzer P, Burckhardt G, Fleck C.

Exp Toxicol Pathol. 2003 Jun;54(5-6):367-73.


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