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Items: 1 to 50 of 88

1.

Tanycyte-Like Cells Derived From Mouse Embryonic Stem Culture Show Hypothalamic Neural Stem/Progenitor Cell Functions.

Kano M, Suga H, Ishihara T, Sakakibara M, Soen M, Yamada T, Ozaki H, Mitsumoto K, Kasai T, Sugiyama M, Onoue T, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Iwama S, Goto M, Banno R, Arima H.

Endocrinology. 2019 Jul 1;160(7):1701-1718. doi: 10.1210/en.2019-00105.

PMID:
31135891
2.

Nutritional Heterogeneity Among Aspergillus fumigatus Strains Has Consequences for Virulence in a Strain- and Host-Dependent Manner.

Ries LNA, Steenwyk JL, de Castro PA, de Lima PBA, Almeida F, de Assis LJ, Manfiolli AO, Takahashi-Nakaguchi A, Kusuya Y, Hagiwara D, Takahashi H, Wang X, Obar JJ, Rokas A, Goldman GH.

Front Microbiol. 2019 Apr 24;10:854. doi: 10.3389/fmicb.2019.00854. eCollection 2019.

3.

Novel Antifungal Compound Z-705 Specifically Inhibits Protein Kinase C of Filamentous Fungi.

Sugahara A, Yoshimi A, Shoji F, Fujioka T, Kawai K, Umeyama H, Komatsu K, Enomoto M, Kuwahara S, Hagiwara D, Katayama T, Horiuchi H, Miyazawa K, Nakayama M, Abe K.

Appl Environ Microbiol. 2019 May 2;85(10). pii: e02923-18. doi: 10.1128/AEM.02923-18. Print 2019 May 15.

PMID:
30902853
4.

AtrR Is an Essential Determinant of Azole Resistance in Aspergillus fumigatus.

Paul S, Stamnes M, Thomas GH, Liu H, Hagiwara D, Gomi K, Filler SG, Moye-Rowley WS.

MBio. 2019 Mar 12;10(2). pii: e02563-18. doi: 10.1128/mBio.02563-18.

5.

Short-Term Steroid Regimen for Adult Steroid-Sensitive Minimal Change Disease.

Ozeki T, Katsuno T, Hayashi H, Kato S, Yasuda Y, Ando M, Tsuboi N, Hagiwara D, Arima H, Maruyama S.

Am J Nephrol. 2019;49(1):54-63. doi: 10.1159/000495352. Epub 2018 Dec 17.

PMID:
30557879
6.

Protein Kinase A and High-Osmolarity Glycerol Response Pathways Cooperatively Control Cell Wall Carbohydrate Mobilization in Aspergillus fumigatus.

de Assis LJ, Manfiolli A, Mattos E, Fabri JHTM, Malavazi I, Jacobsen ID, Brock M, Cramer RA, Thammahong A, Hagiwara D, Ries LNA, Goldman GH.

MBio. 2018 Dec 11;9(6). pii: e01952-18. doi: 10.1128/mBio.01952-18.

7.

Current Status of Azole-resistant Aspergillus fumigatus Isolates in East Asia.

Hagiwara D.

Med Mycol J. 2018;59(4):E71-E76. doi: 10.3314/mmj.18.010.

8.

Heterogeneity in Pathogenicity-related Properties and Stress Tolerance in Aspergillus fumigatus Clinical Isolates.

Hagiwara D, Takahashi H, Takagi H, Watanabe A, Kamei K.

Med Mycol J. 2018;59(4):E63-E70. doi: 10.3314/mmj.18-00007.

9.

Identification of Two Mannosyltransferases Contributing to Biosynthesis of the Fungal-type Galactomannan α-Core-Mannan Structure in Aspergillus fumigatus.

Onoue T, Tanaka Y, Hagiwara D, Ekino K, Watanabe A, Ohta K, Kamei K, Shibata N, Goto M, Oka T.

Sci Rep. 2018 Nov 16;8(1):16918. doi: 10.1038/s41598-018-35059-2.

10.

The impact of earlier intervention by an antimicrobial stewardship team for specific antimicrobials in a single weekly intervention.

Hagiwara D, Sato K, Miyazaki M, Kamada M, Moriwaki N, Nakano T, Shiotsuka S, Tokushige C, Toh H, Kamimura H, Togawa A, Takata T.

Int J Infect Dis. 2018 Dec;77:34-39. doi: 10.1016/j.ijid.2018.09.025. Epub 2018 Oct 4.

11.

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase.

Hagiwara D, Arai T, Takahashi H, Kusuya Y, Watanabe A, Kamei K.

Emerg Infect Dis. 2018 Oct;24(10):1889-1897. doi: 10.3201/eid2410.180730.

12.

A novel mechanism of autophagy-associated cell death of vasopressin neurons in familial neurohypophysial diabetes insipidus.

Hagiwara D, Grinevich V, Arima H.

Cell Tissue Res. 2019 Jan;375(1):259-266. doi: 10.1007/s00441-018-2872-4. Epub 2018 Jun 30. Review.

PMID:
29961215
13.

Chemical chaperone 4-phenylbutylate reduces mutant protein accumulation in the endoplasmic reticulum of arginine vasopressin neurons in a mouse model for familial neurohypophysial diabetes insipidus.

Tochiya M, Hagiwara D, Azuma Y, Miyata T, Morishita Y, Suga H, Onoue T, Tsunekawa T, Takagi H, Ito Y, Iwama S, Goto M, Banno R, Arima H.

Neurosci Lett. 2018 Aug 24;682:50-55. doi: 10.1016/j.neulet.2018.06.013. Epub 2018 Jun 7.

PMID:
29886132
14.

[Investigation of Virulence Factors by "Omics" Approaches].

Takahashi-Nakaguchi A, Hagiwara D, Takahashi H, Sakai K, Toyotome T, Watanabe A, Kamei K, Gonoi T.

Med Mycol J. 2018;59(2):J35-J40. doi: 10.3314/mmj.18.005. Review. Japanese.

15.

Patients With Antithyroid Antibodies Are Prone To Develop Destructive Thyroiditis by Nivolumab: A Prospective Study.

Kobayashi T, Iwama S, Yasuda Y, Okada N, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Morishita Y, Goto M, Suga H, Banno R, Yokota K, Hase T, Morise M, Hashimoto N, Ando M, Kiyoi H, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Arima H.

J Endocr Soc. 2018 Feb 6;2(3):241-251. doi: 10.1210/js.2017-00432. eCollection 2018 Mar 1.

16.

Vasopressin-secreting neurons derived from human embryonic stem cells through specific induction of dorsal hypothalamic progenitors.

Ogawa K, Suga H, Ozone C, Sakakibara M, Yamada T, Kano M, Mitsumoto K, Kasai T, Kodani Y, Nagasaki H, Yamamoto N, Hagiwara D, Goto M, Banno R, Sugimura Y, Arima H.

Sci Rep. 2018 Feb 26;8(1):3615. doi: 10.1038/s41598-018-22053-x.

17.

A simple method to detect the tandem repeat of the cyp51A promoter in azole-resistant strains of Aspergillus fumigatus.

Toyotome T, Hagiwara D, Watanabe A, Kamei K.

Med Mycol. 2018 Nov 1;56(8):1042-1044. doi: 10.1093/mmy/myx149.

PMID:
29340615
18.

Global gene expression reveals stress-responsive genes in Aspergillus fumigatus mycelia.

Takahashi H, Kusuya Y, Hagiwara D, Takahashi-Nakaguchi A, Sakai K, Gonoi T.

BMC Genomics. 2017 Dec 4;18(1):942. doi: 10.1186/s12864-017-4316-z.

19.

Aspergillus fumigatus adhesion factors in dormant conidia revealed through comparative phenotypic and transcriptomic analyses.

Takahashi-Nakaguchi A, Sakai K, Takahashi H, Hagiwara D, Toyotome T, Chibana H, Watanabe A, Yaguchi T, Yamaguchi M, Kamei K, Gonoi T.

Cell Microbiol. 2018 Mar;20(3). doi: 10.1111/cmi.12802. Epub 2017 Dec 22.

20.

Sequestosome 1 (SQSTM1/p62) maintains protein folding capacity under endoplasmic reticulum stress in mouse hypothalamic organotypic culture.

Tominaga T, Goto M, Onoue T, Mizoguchi A, Sugiyama M, Tsunekawa T, Hagiwara D, Morishita Y, Ito Y, Iwama S, Suga H, Banno R, Arima H.

Neurosci Lett. 2017 Aug 24;656:103-107. doi: 10.1016/j.neulet.2017.06.014. Epub 2017 Jun 13.

PMID:
28619261
21.

Drug Sensitivity and Resistance Mechanism in Aspergillus Section Nigri Strains from Japan.

Hashimoto A, Hagiwara D, Watanabe A, Yahiro M, Yikelamu A, Yaguchi T, Kamei K.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e02583-16. doi: 10.1128/AAC.02583-16. Print 2017 Aug.

22.

Azole-resistant Aspergillus fumigatus Containing a 34-bp Tandem Repeat in cyp51A Promoter is Isolated from the Environment in Japan.

Onishi K, Muhammad Sarumoh B, Hagiwara D, Watanabe A, Kamei K, Toyotome T.

Med Mycol J. 2017;58(2):E67-E70. doi: 10.3314/mmj.17-00002. Erratum in: Med Mycol J. 2017;58(3):J98.

23.

Temperature during conidiation affects stress tolerance, pigmentation, and trypacidin accumulation in the conidia of the airborne pathogen Aspergillus fumigatus.

Hagiwara D, Sakai K, Suzuki S, Umemura M, Nogawa T, Kato N, Osada H, Watanabe A, Kawamoto S, Gonoi T, Kamei K.

PLoS One. 2017 May 9;12(5):e0177050. doi: 10.1371/journal.pone.0177050. eCollection 2017.

24.

PTP1B deficiency improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under high-fat diet conditions.

Sugiyama M, Banno R, Mizoguchi A, Tominaga T, Tsunekawa T, Onoue T, Hagiwara D, Ito Y, Morishita Y, Iwama S, Goto M, Suga H, Arima H.

Biochem Biophys Res Commun. 2017 Jun 17;488(1):116-121. doi: 10.1016/j.bbrc.2017.05.019. Epub 2017 May 4.

PMID:
28479249
25.

Transcription factor Afmac1 controls copper import machinery in Aspergillus fumigatus.

Kusuya Y, Hagiwara D, Sakai K, Yaguchi T, Gonoi T, Takahashi H.

Curr Genet. 2017 Aug;63(4):777-789. doi: 10.1007/s00294-017-0681-z. Epub 2017 Feb 18.

PMID:
28215034
26.

First clinical isolation report of azole-resistant Aspergillus fumigatus with TR34/L98H-type mutation in Japan.

Toyotome T, Hagiwara D, Kida H, Ogi T, Watanabe A, Wada T, Komatsu R, Kamei K.

J Infect Chemother. 2017 Aug;23(8):579-581. doi: 10.1016/j.jiac.2016.12.004. Epub 2017 Jan 19.

PMID:
28109740
27.

Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia.

Tsunekawa T, Banno R, Mizoguchi A, Sugiyama M, Tominaga T, Onoue T, Hagiwara D, Ito Y, Iwama S, Goto M, Suga H, Sugimura Y, Arima H.

EBioMedicine. 2017 Feb;16:172-183. doi: 10.1016/j.ebiom.2017.01.007. Epub 2017 Jan 9.

28.

A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions.

Hagiwara D, Miura D, Shimizu K, Paul S, Ohba A, Gonoi T, Watanabe A, Kamei K, Shintani T, Moye-Rowley WS, Kawamoto S, Gomi K.

PLoS Pathog. 2017 Jan 4;13(1):e1006096. doi: 10.1371/journal.ppat.1006096. eCollection 2017 Jan.

29.

Central diabetes insipidus.

Arima H, Azuma Y, Morishita Y, Hagiwara D.

Nagoya J Med Sci. 2016 Dec;78(4):349-358. doi: 10.18999/nagjms.78.4.349. Review.

30.
31.

Anti-pituitary antibodies against corticotrophs in IgG4-related hypophysitis.

Iwata N, Iwama S, Sugimura Y, Yasuda Y, Nakashima K, Takeuchi S, Hagiwara D, Ito Y, Suga H, Goto M, Banno R, Caturegli P, Koike T, Oshida Y, Arima H.

Pituitary. 2017 Jun;20(3):301-310. doi: 10.1007/s11102-016-0780-8.

PMID:
27896569
32.

Genome-wide transcriptome analysis of Aspergillus fumigatus exposed to osmotic stress reveals regulators of osmotic and cell wall stresses that are SakAHOG1 and MpkC dependent.

Pereira Silva L, Alves de Castro P, Dos Reis TF, Paziani MH, Von Zeska Kress MR, Riaño-Pachón DM, Hagiwara D, Ries LN, Brown NA, Goldman GH.

Cell Microbiol. 2017 Apr;19(4). doi: 10.1111/cmi.12681. Epub 2016 Oct 27.

PMID:
27706915
33.

Epidemiological and Genomic Landscape of Azole Resistance Mechanisms in Aspergillus Fungi.

Hagiwara D, Watanabe A, Kamei K, Goldman GH.

Front Microbiol. 2016 Sep 21;7:1382. eCollection 2016. Review.

34.

The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence.

Alves de Castro P, Dos Reis TF, Dolan SK, Oliveira Manfiolli A, Brown NA, Jones GW, Doyle S, Riaño-Pachón DM, Squina FM, Caldana C, Singh A, Del Poeta M, Hagiwara D, Silva-Rocha R, Goldman GH.

Mol Microbiol. 2016 Nov;102(4):642-671. doi: 10.1111/mmi.13484. Epub 2016 Oct 7.

35.

Comparative transcriptome analysis revealing dormant conidia and germination associated genes in Aspergillus species: an essential role for AtfA in conidial dormancy.

Hagiwara D, Takahashi H, Kusuya Y, Kawamoto S, Kamei K, Gonoi T.

BMC Genomics. 2016 May 17;17:358. doi: 10.1186/s12864-016-2689-z.

36.

Signaling pathways for stress responses and adaptation in Aspergillus species: stress biology in the post-genomic era.

Hagiwara D, Sakamoto K, Abe K, Gomi K.

Biosci Biotechnol Biochem. 2016 Sep;80(9):1667-80. doi: 10.1080/09168451.2016.1162085. Epub 2016 Mar 23. Review.

PMID:
27007956
37.

Reactive oxygen species mediate insulin signal transduction in mouse hypothalamus.

Onoue T, Goto M, Tominaga T, Sugiyama M, Tsunekawa T, Hagiwara D, Banno R, Suga H, Sugimura Y, Arima H.

Neurosci Lett. 2016 Apr 21;619:1-7. doi: 10.1016/j.neulet.2016.03.011. Epub 2016 Mar 9.

PMID:
26968348
38.

Regulation of genes encoding cellulolytic enzymes by Pal-PacC signaling in Aspergillus nidulans.

Kunitake E, Hagiwara D, Miyamoto K, Kanamaru K, Kimura M, Kobayashi T.

Appl Microbiol Biotechnol. 2016 Apr;100(8):3621-35. doi: 10.1007/s00253-016-7409-8. Epub 2016 Mar 5.

PMID:
26946171
39.

Multi-azole resistant Aspergillus fumigatus harboring Cyp51A TR46/Y121F/T289A isolated in Japan.

Hagiwara D, Takahashi H, Fujimoto M, Sugahara M, Misawa Y, Gonoi T, Itoyama S, Watanabe A, Kamei K.

J Infect Chemother. 2016 Aug;22(8):577-9. doi: 10.1016/j.jiac.2016.01.015. Epub 2016 Feb 16.

PMID:
26898666
40.

AgRP Neuron-Specific Deletion of Glucocorticoid Receptor Leads to Increased Energy Expenditure and Decreased Body Weight in Female Mice on a High-Fat Diet.

Shibata M, Banno R, Sugiyama M, Tominaga T, Onoue T, Tsunekawa T, Azuma Y, Hagiwara D, Lu W, Ito Y, Goto M, Suga H, Sugimura Y, Oiso Y, Arima H.

Endocrinology. 2016 Apr;157(4):1457-66. doi: 10.1210/en.2015-1430. Epub 2016 Feb 18.

PMID:
26889940
41.

Mitogen activated protein kinases SakA(HOG1) and MpkC collaborate for Aspergillus fumigatus virulence.

Bruder Nascimento AC, Dos Reis TF, de Castro PA, Hori JI, Bom VL, de Assis LJ, Ramalho LN, Rocha MC, Malavazi I, Brown NA, Valiante V, Brakhage AA, Hagiwara D, Goldman GH.

Mol Microbiol. 2016 Jun;100(5):841-59. doi: 10.1111/mmi.13354. Epub 2016 Mar 23.

42.

Unfolded protein response in hypothalamic cultures of wild-type and ATF6α-knockout mice.

Lu W, Hagiwara D, Morishita Y, Tochiya M, Azuma Y, Suga H, Goto M, Banno R, Sugimura Y, Oyadomari S, Mori K, Arima H.

Neurosci Lett. 2016 Jan 26;612:199-203. doi: 10.1016/j.neulet.2015.12.031. Epub 2015 Dec 18.

PMID:
26708632
43.

Functional Analysis of Sterol Transporter Orthologues in the Filamentous Fungus Aspergillus nidulans.

Bühler N, Hagiwara D, Takeshita N.

Eukaryot Cell. 2015 Sep;14(9):908-21. doi: 10.1128/EC.00027-15. Epub 2015 Jun 26.

44.

Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus.

Winkelströter LK, Dolan SK, Fernanda Dos Reis T, Bom VL, Alves de Castro P, Hagiwara D, Alowni R, Jones GW, Doyle S, Brown NA, Goldman GH.

G3 (Bethesda). 2015 May 5;5(7):1525-39. doi: 10.1534/g3.115.016766.

45.

The Aspergillus fumigatus sitA Phosphatase Homologue Is Important for Adhesion, Cell Wall Integrity, Biofilm Formation, and Virulence.

Bom VL, de Castro PA, Winkelströter LK, Marine M, Hori JI, Ramalho LN, dos Reis TF, Goldman MH, Brown NA, Rajendran R, Ramage G, Walker LA, Munro CA, Rocha MC, Malavazi I, Hagiwara D, Goldman GH.

Eukaryot Cell. 2015 Aug;14(8):728-44. doi: 10.1128/EC.00008-15. Epub 2015 Apr 24.

46.

Genome sequence comparison of Aspergillus fumigatus strains isolated from patients with pulmonary aspergilloma and chronic necrotizing pulmonary aspergillosis.

Takahashi-Nakaguchi A, Muraosa Y, Hagiwara D, Sakai K, Toyotome T, Watanabe A, Kawamoto S, Kamei K, Gonoi T, Takahashi H.

Med Mycol. 2015 May;53(4):353-60. doi: 10.1093/mmy/myv003.

PMID:
25851262
47.

Mitogen-activated protein kinases MpkA and MpkB independently affect micafungin sensitivity in Aspergillus nidulans.

Yoshimi A, Fujioka T, Mizutani O, Marui J, Hagiwara D, Abe K.

Biosci Biotechnol Biochem. 2015;79(5):836-44. doi: 10.1080/09168451.2014.998619. Epub 2015 Mar 2.

PMID:
25727969
48.

High osmolarity glycerol response PtcB phosphatase is important for Aspergillus fumigatus virulence.

Winkelströter LK, Bom VL, de Castro PA, Ramalho LN, Goldman MH, Brown NA, Rajendran R, Ramage G, Bovier E, Dos Reis TF, Savoldi M, Hagiwara D, Goldman GH.

Mol Microbiol. 2015 Apr;96(1):42-54. doi: 10.1111/mmi.12919. Epub 2015 Feb 11.

49.

The role of AtfA and HOG MAPK pathway in stress tolerance in conidia of Aspergillus fumigatus.

Hagiwara D, Suzuki S, Kamei K, Gonoi T, Kawamoto S.

Fungal Genet Biol. 2014 Dec;73:138-49. doi: 10.1016/j.fgb.2014.10.011. Epub 2014 Oct 22.

PMID:
25459537
50.

Whole-genome comparison of Aspergillus fumigatus strains serially isolated from patients with aspergillosis.

Hagiwara D, Takahashi H, Watanabe A, Takahashi-Nakaguchi A, Kawamoto S, Kamei K, Gonoi T.

J Clin Microbiol. 2014 Dec;52(12):4202-9. doi: 10.1128/JCM.01105-14. Epub 2014 Sep 17.

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