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Dabigatran-induced anticoagulant-related nephropathy with undiagnosed IgA nephropathy in a patient with normal baseline renal function.

Ikeda M, Tanaka M, Shimoda S, Saita H, Nishikawa S, Shimada H, Taniguchi K, Hagihara K, Iwanari S, Takeoka H.

CEN Case Rep. 2019 Nov;8(4):292-296. doi: 10.1007/s13730-019-00410-7. Epub 2019 Jul 25.


Renin-angiotensin System Blockade Therapy for Early Renal Involvement in MYH9-related Disease with an E1841K Mutation.

Tanaka M, Miki S, Saita H, Shimada H, Nishikawa S, Taniguchi K, Hagihara K, Iwanari S, Ikeda M, Kunishima S, Takeoka H.

Intern Med. 2019 Oct 15;58(20):2983-2988. doi: 10.2169/internalmedicine.2997-19. Epub 2019 Jun 27.


Quantitative ultrasound (QUS) axial transmission method reflects anisotropy in micro-arrangement of apatite crystallites in human long bones: A study with 3-MHz-frequency ultrasound.

Ishimoto T, Suetoshi R, Cretin D, Hagihara K, Hashimoto J, Kobayashi A, Nakano T.

Bone. 2019 Oct;127:82-90. doi: 10.1016/j.bone.2019.05.034. Epub 2019 Jun 3.


Clonal Deletion of Tumor-Specific T Cells by Interferon-γ Confers Therapeutic Resistance to Combination Immune Checkpoint Blockade.

Pai CS, Huang JT, Lu X, Simons DM, Park C, Chang A, Tamaki W, Liu E, Roybal KT, Seagal J, Chen M, Hagihara K, Wei XX, DuPage M, Kwek SS, Oh DY, Daud A, Tsai KK, Wu C, Zhang L, Fasso M, Sachidanandam R, Jayaprakash A, Lin I, Casbon AJ, Kinsbury GA, Fong L.

Immunity. 2019 Feb 19;50(2):477-492.e8. doi: 10.1016/j.immuni.2019.01.006. Epub 2019 Feb 5.


Cell-Type-Specific Thalamocortical Inputs Constrain Direction Map Formation in Visual Cortex.

Nishiyama M, Matsui T, Murakami T, Hagihara KM, Ohki K.

Cell Rep. 2019 Jan 29;26(5):1082-1088.e3. doi: 10.1016/j.celrep.2019.01.008.


Neoadjuvant sipuleucel-T induces both Th1 activation and immune regulation in localized prostate cancer.

Hagihara K, Chan S, Zhang L, Oh DY, Wei XX, Simko J, Fong L.

Oncoimmunology. 2018 Oct 1;8(1):e1486953. doi: 10.1080/2162402X.2018.1486953. eCollection 2019.


[Aging-related frailty and sarcopenia. Kampo medicine for frailty and sarcopenia.]

Kajimoto K, Nakata H, Hagihara K.

Clin Calcium. 2018;28(9):1257-1262. doi: CliCa180912571262. Japanese.


Enhancement of ghrelin-signaling system by Rikkunshi-To attenuates teriparatide-induced pica in rats.

Yamamoto K, Isogai Y, Ishida T, Hagihara K.

J Pharmacol Sci. 2018 Jun;137(2):137-145. doi: 10.1016/j.jphs.2018.05.003. Epub 2018 May 17.


Interaction of Nevirapine with the Peptide Binding Groove of HLA-DRB1*01:01 and Its Effect on the Conformation of HLA-Peptide Complex.

Hirasawa M, Hagihara K, Abe K, Ando O, Hirayama N.

Int J Mol Sci. 2018 Jun 4;19(6). pii: E1660. doi: 10.3390/ijms19061660.


More than Just an Immunosuppressant: The Emerging Role of FTY720 as a Novel Inducer of ROS and Apoptosis.

Takasaki T, Hagihara K, Satoh R, Sugiura R.

Oxid Med Cell Longev. 2018 Mar 28;2018:4397159. doi: 10.1155/2018/4397159. eCollection 2018. Review.


Case of laparoscopic right hemicolectomy for ascending colon cancer after aortic graft replacement and revascularization of the superior mesenteric artery.

Hagihara K, Takahashi H, Miyoshi N, Haraguchi N, Hata T, Matsuda C, Mizushima T, Yamamoto H, Doki Y, Mori M.

Asian J Endosc Surg. 2018 Aug;11(3):266-269. doi: 10.1111/ases.12461. Epub 2018 Jan 11.


Fiber type-specific afferent nerve activity induced by transient contractions of rat bladder smooth muscle in pathological states.

Kuga N, Tanioka A, Hagihara K, Kawai T.

PLoS One. 2017 Dec 21;12(12):e0189941. doi: 10.1371/journal.pone.0189941. eCollection 2017.


A genome-wide screen for FTY720-sensitive mutants reveals genes required for ROS homeostasis.

Hagihara K, Kinoshita K, Ishida K, Hojo S, Kameoka Y, Satoh R, Takasaki T, Sugiura R.

Microb Cell. 2017 Nov 27;4(12):390-401. doi: 10.15698/mic2017.12.601.


Unusual dynamic precipitation softening induced by dislocation glide in biomedical beta-titanium alloys.

Hagihara K, Nakano T, Todai M.

Sci Rep. 2017 Aug 14;7(1):8056. doi: 10.1038/s41598-017-08211-7.


Rae1-mediated nuclear export of Rnc1 is an important determinant in controlling MAPK signaling.

Satoh R, Hagihara K, Sugiura R.

Curr Genet. 2018 Feb;64(1):103-108. doi: 10.1007/s00294-017-0732-5. Epub 2017 Aug 10. Review.


Peripheral T-cell lymphoma, not otherwise specified accompanied by central nervous system involvement with features of lymphomatosis cerebri.

Fuseya H, Nakao T, Hashimura M, Horiuchi M, Hayashi Y, Hagihara K, Kanashima H, Okuno T, Fukushima H, Inoue T, Manabe T, Yamane T.

Rinsho Ketsueki. 2017;58(7):760-765. doi: 10.11406/rinketsu.58.760. Japanese.


Assessment of the effects of switching oral bisphosphonates to denosumab or daily teriparatide in patients with rheumatoid arthritis.

Ebina K, Hirao M, Hashimoto J, Hagihara K, Kashii M, Kitaguchi K, Matsuoka H, Iwahashi T, Chijimatsu R, Yoshikawa H.

J Bone Miner Metab. 2018 Jul;36(4):478-487. doi: 10.1007/s00774-017-0861-4. Epub 2017 Aug 1.


Outstanding compressive creep strength in Cr/Ir-codoped (Mo0.85Nb0.15)Si2 crystals with the unique cross-lamellar microstructure.

Hagihara K, Ikenishi T, Araki H, Nakano T.

Sci Rep. 2017 Jun 21;7(1):3936. doi: 10.1038/s41598-017-04163-0.


Pregnancy Is a Risk Factor for Secondary Focal Segmental Glomerulosclerosis in Women with a History of Very Low Birth Weight.

Tanaka M, Iwanari S, Tsujimoto Y, Taniguchi K, Hagihara K, Fumihara D, Miki S, Shimoda S, Ikeda M, Takeoka H.

Intern Med. 2017;56(12):1537-1541. doi: 10.2169/internalmedicine.56.8032. Epub 2017 Jun 15.


Identification of ACA-28, a 1'-acetoxychavicol acetate analogue compound, as a novel modulator of ERK MAPK signaling, which preferentially kills human melanoma cells.

Satoh R, Hagihara K, Matsuura K, Manse Y, Kita A, Kunoh T, Masuko T, Moriyama M, Moriyama H, Tanabe G, Muraoka O, Sugiura R.

Genes Cells. 2017 Jul;22(7):608-618. doi: 10.1111/gtc.12499. Epub 2017 May 9.


Cellular and humoral immunity after vaccination or natural mumps infection.

Terada K, Hagihara K, Oishi T, Miyata I, Akaike H, Ogita S, Ohno N, Ouchi K.

Pediatr Int. 2017 Aug;59(8):885-890. doi: 10.1111/ped.13306. Epub 2017 Jul 14.


In Silico and In Vitro Analysis of Interaction between Ximelagatran and Human Leukocyte Antigen (HLA)-DRB1*07:01.

Hirasawa M, Hagihara K, Abe K, Ando O, Hirayama N.

Int J Mol Sci. 2017 Mar 24;18(4). pii: E694. doi: 10.3390/ijms18040694.


Spatial regulation of the KH domain RNA-binding protein Rnc1 mediated by a Crm1-independent nuclear export system in Schizosaccharomyces pombe.

Satoh R, Matsumura Y, Tanaka A, Takada M, Ito Y, Hagihara K, Inari M, Kita A, Fukao A, Fujiwara T, Hirai S, Tani T, Sugiura R.

Mol Microbiol. 2017 May;104(3):428-448. doi: 10.1111/mmi.13636. Epub 2017 Feb 24.


[Effectiveness of Irinotecan, S-1, and Bevacizumab for Rectal Cancer with Lung and Skin Metastases after Adjuvant Chemotherapy].

Hagihara K, Ikeda M, Maeda S, Uemura M, Yamamoto K, Miyake M, Hama N, Nishikawa K, Miyamoto A, Omiya H, Miyazaki M, Hirao M, Takami K, Nakamori S, Sekimoto M.

Gan To Kagaku Ryoho. 2016 Nov;43(12):2313-2315. Japanese.


[A Case of Pulmonary Embolism Developed during Combination Chemotherapy with S-1 and Cisplatin in a Young Female Patient with Type 4Gastric Cancer].

Kobayashi N, Yamamoto K, Hagihara K, Nishikawa K, Hirao M, Maeda S, Uemura M, Miyake M, Hama N, Miyamoto A, Miyazaki M, Ikeda M, Nakamori S, Sekimoto M.

Gan To Kagaku Ryoho. 2016 Nov;43(12):1914-1916. Japanese.


[Double-Hit Follicular Lymphoma with BCL2 and MYC Translocations].

Horiuchi M, Fuseya H, Tsutsumi M, Hayashi Y, Hagihara K, Kanashima H, Nakao T, Fukushima Y, Inoue T, Yamane T.

Gan To Kagaku Ryoho. 2016 Sep;43(9):1135-8. Japanese.


Erratum: Isotropic plasticity of β-type Ti-29Nb-13Ta-4.6Zr alloy single crystals for the development of single crystalline β-Ti implants.

Hagihara K, Nakano T, Maki H, Umakoshi Y, Niinomi M.

Sci Rep. 2016 Aug 16;6:31681. doi: 10.1038/srep31681. No abstract available.


Skb5, an SH3 adaptor protein, regulates Pmk1 MAPK signaling by controlling the intracellular localization of the MAPKKK Mkh1.

Kanda Y, Satoh R, Matsumoto S, Ikeda C, Inutsuka N, Hagihara K, Matzno S, Tsujimoto S, Kita A, Sugiura R.

J Cell Sci. 2016 Aug 15;129(16):3189-202. doi: 10.1242/jcs.188854. Epub 2016 Jul 22.


Isotropic plasticity of β-type Ti-29Nb-13Ta-4.6Zr alloy single crystals for the development of single crystalline β-Ti implants.

Hagihara K, Nakano T, Maki H, Umakoshi Y, Niinomi M.

Sci Rep. 2016 Jul 15;6:29779. doi: 10.1038/srep29779. Erratum in: Sci Rep. 2016 Aug 16;6:31681.


[What do RNAs chat about when they gather at granules?].

Hagihara K.

Nihon Yakurigaku Zasshi. 2016 Jun;147(6):370. doi: 10.1254/fpj.147.370. Japanese. No abstract available.


[The role of RNA granules as signaling hubs].

Satoh R, Hagihara K, Kita A, Sugiura R.

Nihon Yakurigaku Zasshi. 2016 Jun;147(6):340-5. doi: 10.1254/fpj.147.340. Japanese. No abstract available.


Go-sha-jinki-Gan (GJG) ameliorates allodynia in chronic constriction injury-model mice via suppression of TNF-α expression in the spinal cord.

Nakanishi M, Nakae A, Kishida Y, Baba K, Sakashita N, Shibata M, Yoshikawa H, Hagihara K.

Mol Pain. 2016 Jun 13;12. pii: 1744806916656382. doi: 10.1177/1744806916656382. Print 2016.


Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate.

Ohtoyo M, Machinaga N, Inoue R, Hagihara K, Yuita H, Tamura M, Hashimoto R, Chiba J, Muro F, Watanabe J, Kobayashi Y, Abe K, Kita Y, Nagasaki M, Shimozato T.

Cell Chem Biol. 2016 May 19;23(5):555-560. doi: 10.1016/j.chembiol.2016.04.007. Epub 2016 May 12.


Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity.

Ogitani Y, Hagihara K, Oitate M, Naito H, Agatsuma T.

Cancer Sci. 2016 Jul;107(7):1039-46. doi: 10.1111/cas.12966. Epub 2016 Jun 22.


DS-8201a, A Novel HER2-Targeting ADC with a Novel DNA Topoisomerase I Inhibitor, Demonstrates a Promising Antitumor Efficacy with Differentiation from T-DM1.

Ogitani Y, Aida T, Hagihara K, Yamaguchi J, Ishii C, Harada N, Soma M, Okamoto H, Oitate M, Arakawa S, Hirai T, Atsumi R, Nakada T, Hayakawa I, Abe Y, Agatsuma T.

Clin Cancer Res. 2016 Oct 15;22(20):5097-5108. Epub 2016 Mar 29.


Reply to comment on: Dietary yeasts reduce inflammation in central nervous system via microflora.

Takata K, Tomita T, Okuno T, Kinoshita M, Koda T, Honorat JA, Takei M, Hagihara K, Sugimoto T, Mochizuki H, Sakoda S, Nakatsuji Y.

Ann Clin Transl Neurol. 2015 Oct 16;2(11):1040. doi: 10.1002/acn3.258. eCollection 2015 Nov. No abstract available.


Modulation of afferent nerve activity by prostaglandin E2 upon urinary bladder distension in rats.

Kuga N, Tanioka A, Hagihara K, Kawai T.

Exp Physiol. 2016 May 1;101(5):577-87. doi: 10.1113/EP085418. Epub 2016 Mar 15.


[A Case of Lateral Lymph Node Recurrence Five-Years after Curative Surgery for Rectal Cancer].

Hagihara K, Miyake M, Uemura M, Miyazaki M, Ikeda M, Maeda S, Yamamoto K, Hama N, Miyamoto A, Omiya H, Nishikawa K, Hirao M, Takami K, Nakamori S, Sekimoto M.

Gan To Kagaku Ryoho. 2015 Nov;42(12):1606-7. Japanese.


[Peripheral T-Cell Lymphoma, Not Otherwise Specified Occurring After the Treatment of Relapsed Follicular Lymphoma].

Fukushima H, Inoue T, Ishi N, Okuno T, Son R, Soejima C, Horiuchi M, Ueda H, Yoshida M, Hagihara K, Kanashima H, Nakao T, Yamane T.

Rinsho Byori. 2015 Sep;63(9):1029-34. Japanese.


[Spatial regulation of calcineurin by RNA granules].

Satoh R, Hagihara K, Kita A, Sugiura R.

Seikagaku. 2015 Oct;87(5):517-24. Japanese. No abstract available.


Human Intestinal Raf Kinase Inhibitor Protein (RKIP) Catalyzes Prasugrel as a Bioactivation Hydrolase.

Kazui M, Ogura Y, Hagihara K, Kubota K, Kurihara A.

Drug Metab Dispos. 2016 Jan;44(1):115-23. doi: 10.1124/dmd.115.066290. Epub 2015 Nov 11.


Neuronal activity is not required for the initial formation and maturation of visual selectivity.

Hagihara KM, Murakami T, Yoshida T, Tagawa Y, Ohki K.

Nat Neurosci. 2015 Dec;18(12):1780-8. doi: 10.1038/nn.4155. Epub 2015 Nov 2.


Accelerating the Smith-Waterman algorithm with interpair pruning and band optimization for the all-pairs comparison of base sequences.

Okada D, Ino F, Hagihara K.

BMC Bioinformatics. 2015 Oct 6;16:321. doi: 10.1186/s12859-015-0744-4.


[Cutaneous extramedullary hematopoiesis associated with myelodysplastic/myeloproliferative neoplasm, unclassifiable].

Yoshida M, Horiuchi M, Ueda H, Hagihara K, Kanashima H, Nakao T, Hirata C, Inoue T, Yamane T.

Rinsho Ketsueki. 2015 Jul;56(7):911-4. doi: 10.11406/rinketsu.56.911. Japanese.


[Leukostasis during Chronic Myelogenous Leukemia Resolved Following Leukapheresis].

Yoshida M, Ueda H, Imaizumi J, Horiuchi M, Hagihara K, Kanashima H, Nakao T, Azuma K, Itoi J, Yamane T.

Gan To Kagaku Ryoho. 2015 Jun;42(6):763-5. Japanese.


The Possible Mechanism of Idiosyncratic Lapatinib-Induced Liver Injury in Patients Carrying Human Leukocyte Antigen-DRB1*07:01.

Hirasawa M, Hagihara K, Okudaira N, Izumi T.

PLoS One. 2015 Jun 22;10(6):e0130928. doi: 10.1371/journal.pone.0130928. eCollection 2015.


Analysis of elderly patients with diffuse large B-cell lymphoma: aggressive therapy is a reasonable approach for 'unfit' patients classified by comprehensive geriatric assessment.

Yoshida M, Nakao T, Horiuchi M, Ueda H, Hagihara K, Kanashima H, Inoue T, Sakamoto E, Hirai M, Koh H, Nakane T, Hino M, Yamane T.

Eur J Haematol. 2016 Apr;96(4):409-16. doi: 10.1111/ejh.12608. Epub 2015 Jul 6.


Effects of a traditional herbal medicine on peripheral blood flow in women experiencing peripheral coldness: a randomized controlled trial.

Nishida S, Eguchi E, Ohira T, Kitamura A, Kato YH, Hagihara K, Iso H.

BMC Complement Altern Med. 2015 Apr 2;15:105. doi: 10.1186/s12906-015-0617-4.


Dietary Yeasts Reduce Inflammation in Central Nerve System via Microflora.

Takata K, Tomita T, Okuno T, Kinoshita M, Koda T, Honorat JA, Takei M, Hagihara K, Sugimoto T, Mochizuki H, Sakoda S, Nakatsuji Y.

Ann Clin Transl Neurol. 2015 Jan;2(1):56-66. doi: 10.1002/acn3.153. Epub 2014 Dec 3.

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