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Pilot study of global endocrine disrupting activity in Iowa public drinking water utilities using cell-based assays.

Jones RR, Stavreva DA, Weyer PJ, Varticovski L, Inoue-Choi M, Medgyesi DN, Chavis N, Graubard BI, Cain T, Wichman M, Beane Freeman LE, Hager GL, Ward MH.

Sci Total Environ. 2020 Apr 20;714:136317. doi: 10.1016/j.scitotenv.2019.136317. Epub 2019 Dec 26.


Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library.

Paul-Friedman K, Martin M, Crofton KM, Hsu CW, Sakamuru S, Zhao J, Xia M, Huang R, Stavreva DA, Soni V, Varticovski L, Raziuddin R, Hager GL, Houck KA.

Environ Health Perspect. 2019 Sep;127(9):97009. doi: 10.1289/EHP5314. Epub 2019 Sep 30.


Meta-analysis of Chromatin Programming by Steroid Receptors.

Paakinaho V, Swinstead EE, Presman DM, Grøntved L, Hager GL.

Cell Rep. 2019 Sep 24;28(13):3523-3534.e2. doi: 10.1016/j.celrep.2019.08.039.


Transcriptional Bursting and Co-bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility.

Stavreva DA, Garcia DA, Fettweis G, Gudla PR, Zaki GF, Soni V, McGowan A, Williams G, Huynh A, Palangat M, Schiltz RL, Johnson TA, Presman DM, Ferguson ML, Pegoraro G, Upadhyaya A, Hager GL.

Mol Cell. 2019 Sep 19;75(6):1161-1177.e11. doi: 10.1016/j.molcel.2019.06.042. Epub 2019 Aug 14.


Glucocorticoid receptor quaternary structure drives chromatin occupancy and transcriptional outcome.

Paakinaho V, Johnson TA, Presman DM, Hager GL.

Genome Res. 2019 Aug;29(8):1223-1234. doi: 10.1101/gr.244814.118. Epub 2019 Jul 23.


Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus.

Taves MD, Mittelstadt PR, Presman DM, Hager GL, Ashwell JD.

Cell Rep. 2019 Mar 26;26(13):3629-3642.e4. doi: 10.1016/j.celrep.2019.02.108.


High Quality ATAC-Seq Data Recovered from Cryopreserved Breast Cell Lines and Tissue.

Fujiwara S, Baek S, Varticovski L, Kim S, Hager GL.

Sci Rep. 2019 Jan 24;9(1):516. doi: 10.1038/s41598-018-36927-7.


Corrigendum to "The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck" [Oral Oncol. 81 (2018) 100-108].

Saloura V, Vougiouklakis T, Burkitt K, Nakamura Y, Hager GL, van Waes C.

Oral Oncol. 2018 Nov;86:318. doi: 10.1016/j.oraloncology.2018.08.022. Epub 2018 Sep 7. No abstract available.


Dual Roles for Ikaros in Regulation of Macrophage Chromatin State and Inflammatory Gene Expression.

Oh KS, Gottschalk RA, Lounsbury NW, Sun J, Dorrington MG, Baek S, Sun G, Wang Z, Krauss KS, Milner JD, Dutta B, Hager GL, Sung MH, Fraser IDC.

J Immunol. 2018 Jul 15;201(2):757-771. doi: 10.4049/jimmunol.1800158. Epub 2018 Jun 13.


Chromatin reprogramming in breast cancer.

Swinstead EE, Paakinaho V, Hager GL.

Endocr Relat Cancer. 2018 Jul;25(7):R385-R404. doi: 10.1530/ERC-18-0033. Epub 2018 Apr 24. Review.


Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading.

Goldstein I, Paakinaho V, Baek S, Sung MH, Hager GL.

Nat Commun. 2017 Nov 29;8(1):1849. doi: 10.1038/s41467-017-02055-5.


Conventional and pioneer modes of glucocorticoid receptor interaction with enhancer chromatin in vivo.

Johnson TA, Chereji RV, Stavreva DA, Morris SA, Hager GL, Clark DJ.

Nucleic Acids Res. 2018 Jan 9;46(1):203-214. doi: 10.1093/nar/gkx1044.


The Three Ds of Transcription Activation by Glucagon: Direct, Delayed, and Dynamic.

Goldstein I, Hager GL.

Endocrinology. 2018 Jan 1;159(1):206-216. doi: 10.1210/en.2017-00521. Review.


Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action.

Oh KS, Patel H, Gottschalk RA, Lee WS, Baek S, Fraser IDC, Hager GL, Sung MH.

Immunity. 2017 Aug 15;47(2):298-309.e5. doi: 10.1016/j.immuni.2017.07.012. Epub 2017 Aug 8.


Single-molecule analysis of steroid receptor and cofactor action in living cells.

Paakinaho V, Presman DM, Ball DA, Johnson TA, Schiltz RL, Levitt P, Mazza D, Morisaki T, Karpova TS, Hager GL.

Nat Commun. 2017 Jun 21;8:15896. doi: 10.1038/ncomms15896.


Dynamic enhancer function in the chromatin context.

Goldstein I, Hager GL.

Wiley Interdiscip Rev Syst Biol Med. 2018 Jan;10(1). doi: 10.1002/wsbm.1390. Epub 2017 May 22. Review.


Bivariate Genomic Footprinting Detects Changes in Transcription Factor Activity.

Baek S, Goldstein I, Hager GL.

Cell Rep. 2017 May 23;19(8):1710-1722. doi: 10.1016/j.celrep.2017.05.003.


Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform.

Lynch C, Sakamuru S, Huang R, Stavreva DA, Varticovski L, Hager GL, Judson RS, Houck KA, Kleinstreuer NC, Casey W, Paules RS, Simeonov A, Xia M.

Toxicology. 2017 Jun 15;385:48-58. doi: 10.1016/j.tox.2017.05.001. Epub 2017 May 4.


Quantifying transcription factor binding dynamics at the single-molecule level in live cells.

Presman DM, Ball DA, Paakinaho V, Grimm JB, Lavis LD, Karpova TS, Hager GL.

Methods. 2017 Jul 1;123:76-88. doi: 10.1016/j.ymeth.2017.03.014. Epub 2017 Mar 15.


Genome-Wide Identification of Basic Helix-Loop-Helix and NF-1 Motifs Underlying GR Binding Sites in Male Rat Hippocampus.

Pooley JR, Flynn BP, Grøntved L, Baek S, Guertin MJ, Kershaw YM, Birnie MT, Pellatt A, Rivers CA, Schiltz RL, Hager GL, Lightman SL, Conway-Campbell BL.

Endocrinology. 2017 May 1;158(5):1486-1501. doi: 10.1210/en.2016-1929.


Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.

Veschi V, Liu Z, Voss TC, Ozbun L, Gryder B, Yan C, Hu Y, Ma A, Jin J, Mazur SJ, Lam N, Souza BK, Giannini G, Hager GL, Arrowsmith CH, Khan J, Appella E, Thiele CJ.

Cancer Cell. 2017 Jan 9;31(1):50-63. doi: 10.1016/j.ccell.2016.12.002.


High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss.

Siersbæk M, Varticovski L, Yang S, Baek S, Nielsen R, Mandrup S, Hager GL, Chung JH, Grøntved L.

Sci Rep. 2017 Jan 10;7:40220. doi: 10.1038/srep40220.


Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response.

Goldstein I, Baek S, Presman DM, Paakinaho V, Swinstead EE, Hager GL.

Genome Res. 2017 Mar;27(3):427-439. doi: 10.1101/gr.212175.116. Epub 2016 Dec 28.


Cajal body function in genome organization and transcriptome diversity.

Sawyer IA, Sturgill D, Sung MH, Hager GL, Dundr M.

Bioessays. 2016 Dec;38(12):1197-1208. doi: 10.1002/bies.201600144. Epub 2016 Oct 21. Review.


More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?

Presman DM, Hager GL.

Transcription. 2017 Jan;8(1):32-39. doi: 10.1080/21541264.2016.1249045. Epub 2016 Oct 20.


Novel cell-based assay for detection of thyroid receptor beta-interacting environmental contaminants.

Stavreva DA, Varticovski L, Levkova L, George AA, Davis L, Pegoraro G, Blazer V, Iwanowicz L, Hager GL.

Toxicology. 2016 Aug 10;368-369:69-79. doi: 10.1016/j.tox.2016.08.012. Epub 2016 Aug 12.


Specific genomic cues regulate Cajal body assembly.

Sawyer IA, Hager GL, Dundr M.

RNA Biol. 2017 Jun 3;14(6):791-803. doi: 10.1080/15476286.2016.1243648. Epub 2016 Oct 7. Review.


DNA binding triggers tetramerization of the glucocorticoid receptor in live cells.

Presman DM, Ganguly S, Schiltz RL, Johnson TA, Karpova TS, Hager GL.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8236-41. doi: 10.1073/pnas.1606774113. Epub 2016 Jul 5.


Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions.

Swinstead EE, Miranda TB, Paakinaho V, Baek S, Goldstein I, Hawkins M, Karpova TS, Ball D, Mazza D, Lavis LD, Grimm JB, Morisaki T, Grøntved L, Presman DM, Hager GL.

Cell. 2016 Apr 21;165(3):593-605. doi: 10.1016/j.cell.2016.02.067. Epub 2016 Apr 7.


Divergent Binding and Transactivation by Two Related Steroid Receptors at the Same Response Element.

Tesikova M, Dezitter X, Nenseth HZ, Klokk TI, Mueller F, Hager GL, Saatcioglu F.

J Biol Chem. 2016 May 27;291(22):11899-910. doi: 10.1074/jbc.M115.684480. Epub 2016 Apr 7.


Cajal bodies are linked to genome conformation.

Wang Q, Sawyer IA, Sung MH, Sturgill D, Shevtsov SP, Pegoraro G, Hakim O, Baek S, Hager GL, Dundr M.

Nat Commun. 2016 Mar 21;7:10966. doi: 10.1038/ncomms10966.


Genome-wide footprinting: ready for prime time?

Sung MH, Baek S, Hager GL.

Nat Methods. 2016 Mar;13(3):222-228. doi: 10.1038/nmeth.3766.


Genome-Wide Chromatin Landscape Transitions Identify Novel Pathways in Early Commitment to Osteoblast Differentiation.

Thompson B, Varticovski L, Baek S, Hager GL.

PLoS One. 2016 Feb 18;11(2):e0148619. doi: 10.1371/journal.pone.0148619. eCollection 2016.


Chromatin structure and gene regulation: a dynamic view of enhancer function.

Stavreva DA, Hager GL.

Nucleus. 2015;6(6):442-8. doi: 10.1080/19491034.2015.1107689. Epub 2016 Jan 14.


Transcriptional and Chromatin Regulation during Fasting - The Genomic Era.

Goldstein I, Hager GL.

Trends Endocrinol Metab. 2015 Dec;26(12):699-710. doi: 10.1016/j.tem.2015.09.005. Epub 2015 Oct 29. Review.


Structural Modeling of GR Interactions with the SWI/SNF Chromatin Remodeling Complex and C/EBP.

Muratcioglu S, Presman DM, Pooley JR, Grøntved L, Hager GL, Nussinov R, Keskin O, Gursoy A.

Biophys J. 2015 Sep 15;109(6):1227-39. doi: 10.1016/j.bpj.2015.06.044. Epub 2015 Aug 13.


Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling.

Grøntved L, Waterfall JJ, Kim DW, Baek S, Sung MH, Zhao L, Park JW, Nielsen R, Walker RL, Zhu YJ, Meltzer PS, Hager GL, Cheng SY.

Nat Commun. 2015 Apr 28;6:7048. doi: 10.1038/ncomms8048.


New Face for Chromatin-Related Mesenchymal Modulator: n-CHD9 Localizes to Nucleoli and Interacts With Ribosomal Genes.

Salomon-Kent R, Marom R, John S, Dundr M, Schiltz LR, Gutierrez J, Workman J, Benayahu D, Hager GL.

J Cell Physiol. 2015 Sep;230(9):2270-80. doi: 10.1002/jcp.24960.


Dynamics of chromatin accessibility and long-range interactions in response to glucocorticoid pulsing.

Stavreva DA, Coulon A, Baek S, Sung MH, John S, Stixova L, Tesikova M, Hakim O, Miranda T, Hawkins M, Stamatoyannopoulos JA, Chow CC, Hager GL.

Genome Res. 2015 Jun;25(6):845-57. doi: 10.1101/gr.184168.114. Epub 2015 Feb 12.


DNase footprint signatures are dictated by factor dynamics and DNA sequence.

Sung MH, Guertin MJ, Baek S, Hager GL.

Mol Cell. 2014 Oct 23;56(2):275-285. doi: 10.1016/j.molcel.2014.08.016. Epub 2014 Sep 18.


Targeted H3R26 deimination specifically facilitates estrogen receptor binding by modifying nucleosome structure.

Guertin MJ, Zhang X, Anguish L, Kim S, Varticovski L, Lis JT, Hager GL, Coonrod SA.

PLoS Genet. 2014 Sep 11;10(9):e1004613. doi: 10.1371/journal.pgen.1004613. eCollection 2014 Sep.


Distinctly different dynamics and kinetics of two steroid receptors at the same response elements in living cells.

Nenseth HZ, Dezitter X, Tesikova M, Mueller F, Klokk TI, Hager GL, Saatcioglu F.

PLoS One. 2014 Aug 18;9(8):e105204. doi: 10.1371/journal.pone.0105204. eCollection 2014.


Transient estrogen receptor binding and p300 redistribution support a squelching mechanism for estradiol-repressed genes.

Guertin MJ, Zhang X, Coonrod SA, Hager GL.

Mol Endocrinol. 2014 Sep;28(9):1522-33. doi: 10.1210/me.2014-1130. Epub 2014 Jul 22.


Molecular architecture of transcription factor hotspots in early adipogenesis.

Siersbæk R, Baek S, Rabiee A, Nielsen R, Traynor S, Clark N, Sandelin A, Jensen ON, Sung MH, Hager GL, Mandrup S.

Cell Rep. 2014 Jun 12;7(5):1434-1442. doi: 10.1016/j.celrep.2014.04.043. Epub 2014 May 22.


Live cell imaging unveils multiple domain requirements for in vivo dimerization of the glucocorticoid receptor.

Presman DM, Ogara MF, Stortz M, Alvarez LD, Pooley JR, Schiltz RL, Grøntved L, Johnson TA, Mittelstadt PR, Ashwell JD, Ganesan S, Burton G, Levi V, Hager GL, Pecci A.

PLoS Biol. 2014 Mar 18;12(3):e1001813. doi: 10.1371/journal.pbio.1001813. eCollection 2014 Mar.


Switching of the relative dominance between feedback mechanisms in lipopolysaccharide-induced NF-κB signaling.

Sung MH, Li N, Lao Q, Gottschalk RA, Hager GL, Fraser ID.

Sci Signal. 2014 Jan 14;7(308):ra6. doi: 10.1126/scisignal.2004764.


Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation.

Kieffer-Kwon KR, Tang Z, Mathe E, Qian J, Sung MH, Li G, Resch W, Baek S, Pruett N, Grøntved L, Vian L, Nelson S, Zare H, Hakim O, Reyon D, Yamane A, Nakahashi H, Kovalchuk AL, Zou J, Joung JK, Sartorelli V, Wei CL, Ruan X, Hager GL, Ruan Y, Casellas R.

Cell. 2013 Dec 19;155(7):1507-20. doi: 10.1016/j.cell.2013.11.039.


Dynamic regulation of transcriptional states by chromatin and transcription factors.

Voss TC, Hager GL.

Nat Rev Genet. 2014 Feb;15(2):69-81. doi: 10.1038/nrg3623. Epub 2013 Dec 17. Review.


Overlapping chromatin-remodeling systems collaborate genome wide at dynamic chromatin transitions.

Morris SA, Baek S, Sung MH, John S, Wiench M, Johnson TA, Schiltz RL, Hager GL.

Nat Struct Mol Biol. 2014 Jan;21(1):73-81. doi: 10.1038/nsmb.2718. Epub 2013 Dec 8.

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