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Items: 1 to 50 of 131

1.

A Pharmacokinetic Natural Product-Disease-Drug Interaction: A Double Hit of Silymarin and Nonalcoholic Steatohepatitis on Hepatic Transporters in a Rat Model.

Montonye ML, Tian DD, Arman T, Lynch KD, Hagenbuch B, Paine MF, Clarke JD.

J Pharmacol Exp Ther. 2019 Nov;371(2):385-393. doi: 10.1124/jpet.119.260489. Epub 2019 Aug 16.

PMID:
31420525
2.

Protein-protein interactions of drug uptake transporters that are important for liver and kidney.

Zhang Y, Hagenbuch B.

Biochem Pharmacol. 2019 Oct;168:384-391. doi: 10.1016/j.bcp.2019.07.026. Epub 2019 Aug 2. Review.

PMID:
31381872
3.

Gly45 and Phe555 in Transmembrane Domains 1 and 10 Are Critical for the Activation of Organic Anion Transporting Polypeptide 1B3 by Epigallocatechin Gallate.

Yue M, Yang J, Jin M, Steiert B, Xiang Y, Zhang H, Hagenbuch B, Gui C.

J Agric Food Chem. 2019 Aug 14;67(32):9079-9087. doi: 10.1021/acs.jafc.9b03812. Epub 2019 Aug 6.

PMID:
31353905
4.

Dynamic Contrast-Enhanced MRI of OATP Dysfunction in Diabetes.

Shuboni-Mulligan DD, Parys M, Blanco-Fernandez B, Mallett CL, Schnegelberger R, Takada M, Chakravarty S, Hagenbuch B, Shapiro EM.

Diabetes. 2019 Feb;68(2):271-280. doi: 10.2337/db18-0525. Epub 2018 Nov 28.

5.

Ligand-dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channel.

Boxberger KH, Hagenbuch B, Lampe JN.

Biochem Pharmacol. 2018 Oct;156:371-384. doi: 10.1016/j.bcp.2018.08.028. Epub 2018 Aug 20.

6.

Organic anion transporting polypeptide 1B3 can form homo- and hetero-oligomers.

Zhang Y, Boxberger KH, Hagenbuch B.

PLoS One. 2017 Jun 23;12(6):e0180257. doi: 10.1371/journal.pone.0180257. eCollection 2017.

7.

Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice.

Li J, Woolbright BL, Zhao W, Wang Y, Matye D, Hagenbuch B, Jaeschke H, Li T.

Toxicol Sci. 2018 Jan 1;161(1):34-47. doi: 10.1093/toxsci/kfx078.

8.

Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes.

Kreznar JH, Keller MP, Traeger LL, Rabaglia ME, Schueler KL, Stapleton DS, Zhao W, Vivas EI, Yandell BS, Broman AT, Hagenbuch B, Attie AD, Rey FE.

Cell Rep. 2017 Feb 14;18(7):1739-1750. doi: 10.1016/j.celrep.2017.01.062.

9.

Organic Anion Transporting Polypeptides Contribute to the Disposition of Perfluoroalkyl Acids in Humans and Rats.

Zhao W, Zitzow JD, Weaver Y, Ehresman DJ, Chang SC, Butenhoff JL, Hagenbuch B.

Toxicol Sci. 2017 Mar 1;156(1):84-95. doi: 10.1093/toxsci/kfw236.

10.

Recent advances in understanding hepatic drug transport.

Stieger B, Hagenbuch B.

F1000Res. 2016 Oct 6;5:2465. eCollection 2016. Review.

11.

Functional expression of the 11 human Organic Anion Transporting Polypeptides in insect cells reveals that sodium fluorescein is a general OATP substrate.

Patik I, Kovacsics D, Német O, Gera M, Várady G, Stieger B, Hagenbuch B, Szakács G, Özvegy-Laczka C.

Biochem Pharmacol. 2015 Dec 15;98(4):649-58. doi: 10.1016/j.bcp.2015.09.015. Epub 2015 Sep 28.

12.

Identification of the Bile Acid Transporter Slco1a6 as a Candidate Gene That Broadly Affects Gene Expression in Mouse Pancreatic Islets.

Tian J, Keller MP, Oler AT, Rabaglia ME, Schueler KL, Stapleton DS, Broman AT, Zhao W, Kendziorski C, Yandell BS, Hagenbuch B, Broman KW, Attie AD.

Genetics. 2015 Nov;201(3):1253-62. doi: 10.1534/genetics.115.179432. Epub 2015 Sep 18.

13.

Zebrafish Oatp-mediated transport of microcystin congeners.

Steiner K, Zimmermann L, Hagenbuch B, Dietrich D.

Arch Toxicol. 2016 May;90(5):1129-39. doi: 10.1007/s00204-015-1544-3. Epub 2015 Jun 9.

14.

Na+/Taurocholate Cotransporting Polypeptide and Apical Sodium-Dependent Bile Acid Transporter Are Involved in the Disposition of Perfluoroalkyl Sulfonates in Humans and Rats.

Zhao W, Zitzow JD, Ehresman DJ, Chang SC, Butenhoff JL, Forster J, Hagenbuch B.

Toxicol Sci. 2015 Aug;146(2):363-73. doi: 10.1093/toxsci/kfv102. Epub 2015 May 21.

15.

Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis.

Woolbright BL, Dorko K, Antoine DJ, Clarke JI, Gholami P, Li F, Kumer SC, Schmitt TM, Forster J, Fan F, Jenkins RE, Park BK, Hagenbuch B, Olyaee M, Jaeschke H.

Toxicol Appl Pharmacol. 2015 Mar 15;283(3):168-77. doi: 10.1016/j.taap.2015.01.015. Epub 2015 Jan 28.

16.

Molecular cloning and functional characterization of a rainbow trout liver Oatp.

Steiner K, Hagenbuch B, Dietrich DR.

Toxicol Appl Pharmacol. 2014 Nov 1;280(3):534-42. doi: 10.1016/j.taap.2014.08.031. Epub 2014 Sep 12.

17.

Influence of drug formulation on OATP1B-mediated transport of paclitaxel.

Nieuweboer AJ, Hu S, Gui C, Hagenbuch B, Ghobadi Moghaddam-Helmantel IM, Gibson AA, de Bruijn P, Mathijssen RH, Sparreboom A.

Cancer Res. 2014 Jun 1;74(11):3137-45. doi: 10.1158/0008-5472.CAN-13-3634. Epub 2014 Apr 22.

18.

Organic anion-transporting polypeptides.

Stieger B, Hagenbuch B.

Curr Top Membr. 2014;73:205-32. doi: 10.1016/B978-0-12-800223-0.00005-0. Review.

19.

Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake.

Boxberger KH, Hagenbuch B, Lampe JN.

Drug Metab Dispos. 2014 Jun;42(6):990-5. doi: 10.1124/dmd.113.055095. Epub 2014 Mar 31.

20.

Cysteine scanning mutagenesis of transmembrane domain 10 in organic anion transporting polypeptide 1B1.

Ohnishi S, Hays A, Hagenbuch B.

Biochemistry. 2014 Apr 15;53(14):2261-70. doi: 10.1021/bi500176e. Epub 2014 Apr 4.

21.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

22.

The SLCO (former SLC21) superfamily of transporters.

Hagenbuch B, Stieger B.

Mol Aspects Med. 2013 Apr-Jun;34(2-3):396-412. doi: 10.1016/j.mam.2012.10.009. Review.

23.

Transport by OATP1B1 and OATP1B3 enhances the cytotoxicity of epigallocatechin 3-O-gallate and several quercetin derivatives.

Zhang Y, Hays A, Noblett A, Thapa M, Hua DH, Hagenbuch B.

J Nat Prod. 2013 Mar 22;76(3):368-73. doi: 10.1021/np3007292. Epub 2013 Jan 17.

24.
25.

Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel.

de Graan AJ, Lancaster CS, Obaidat A, Hagenbuch B, Elens L, Friberg LE, de Bruijn P, Hu S, Gibson AA, Bruun GH, Corydon TJ, Mikkelsen TS, Walker AL, Du G, Loos WJ, van Schaik RH, Baker SD, Mathijssen RH, Sparreboom A.

Clin Cancer Res. 2012 Aug 15;18(16):4433-40. Epub 2012 Jun 18.

26.

OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies.

Roth M, Obaidat A, Hagenbuch B.

Br J Pharmacol. 2012 Mar;165(5):1260-87. doi: 10.1111/j.1476-5381.2011.01724.x. Review.

27.

Organic anion transporting polypeptides in the hepatic uptake of PBDE congeners in mice.

Pacyniak E, Hagenbuch B, Klaassen CD, Lehman-McKeeman L, Guo GL.

Toxicol Appl Pharmacol. 2011 Nov 15;257(1):23-31. doi: 10.1016/j.taap.2011.08.014. Epub 2011 Aug 22.

28.

The expression and function of organic anion transporting polypeptides in normal tissues and in cancer.

Obaidat A, Roth M, Hagenbuch B.

Annu Rev Pharmacol Toxicol. 2012;52:135-51. doi: 10.1146/annurev-pharmtox-010510-100556. Epub 2011 Aug 15. Review.

29.

Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (Annonaceae).

Roth M, Araya JJ, Timmermann BN, Hagenbuch B.

J Pharmacol Exp Ther. 2011 Nov;339(2):624-32. doi: 10.1124/jpet.111.184564. Epub 2011 Aug 16.

30.

Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs.

Obaidat A, Weiss J, Wahlgren B, Manam RR, Macherla VR, McArthur K, Chao TH, Palladino MA, Lloyd GK, Potts BC, Enna SJ, Neuteboom ST, Hagenbuch B.

J Pharmacol Exp Ther. 2011 May;337(2):479-86. doi: 10.1124/jpet.110.177824. Epub 2011 Feb 8.

31.

Interactions of green tea catechins with organic anion-transporting polypeptides.

Roth M, Timmermann BN, Hagenbuch B.

Drug Metab Dispos. 2011 May;39(5):920-6. doi: 10.1124/dmd.110.036640. Epub 2011 Jan 28.

32.

Several conserved positively charged amino acids in OATP1B1 are involved in binding or translocation of different substrates.

Weaver YM, Hagenbuch B.

J Membr Biol. 2010 Aug;236(3):279-90. doi: 10.1007/s00232-010-9300-3. Epub 2010 Sep 4.

33.

Development of a cell-based high-throughput assay to screen for inhibitors of organic anion transporting polypeptides 1B1 and 1B3.

Gui C, Obaidat A, Chaguturu R, Hagenbuch B.

Curr Chem Genomics. 2010 Mar 1;4:1-8. doi: 10.2174/1875397301004010001.

34.

Mechanism of polybrominated diphenyl ether uptake into the liver: PBDE congeners are substrates of human hepatic OATP transporters.

Pacyniak E, Roth M, Hagenbuch B, Guo GL.

Toxicol Sci. 2010 Jun;115(2):344-53. doi: 10.1093/toxsci/kfq059. Epub 2010 Feb 22.

35.

Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1).

Huang J, Bathena SP, Tong J, Roth M, Hagenbuch B, Alnouti Y.

Xenobiotica. 2010 Mar;40(3):184-94. doi: 10.3109/00498250903514607.

PMID:
20102295
36.

Cloning/characterization of the canine organic anion transporting polypeptide 1b4 (Oatp1b4) and classification of the canine OATP/SLCO members.

Gui C, Hagenbuch B.

Comp Biochem Physiol C Toxicol Pharmacol. 2010 Apr;151(3):393-9. doi: 10.1016/j.cbpc.2010.01.005. Epub 2010 Jan 14.

37.

Drug uptake systems in liver and kidney: a historic perspective.

Hagenbuch B.

Clin Pharmacol Ther. 2010 Jan;87(1):39-47. doi: 10.1038/clpt.2009.235. Epub 2009 Nov 18. Review.

38.

Dynamic cytotoxic response to microcystins using microelectronic sensor arrays.

Huang DY, Mock M, Hagenbuch B, Chan S, Dmitrovic J, Gabos S, Kinniburgh D.

Environ Sci Technol. 2009 Oct 15;43(20):7803-9. doi: 10.1021/es901189c.

PMID:
19921897
39.

Roles of rat renal organic anion transporters in transporting perfluorinated carboxylates with different chain lengths.

Weaver YM, Ehresman DJ, Butenhoff JL, Hagenbuch B.

Toxicol Sci. 2010 Feb;113(2):305-14. doi: 10.1093/toxsci/kfp275. Epub 2009 Nov 13.

40.

Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1.

Gui C, Hagenbuch B.

Protein Sci. 2009 Nov;18(11):2298-306. doi: 10.1002/pro.240.

41.

Identification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17beta-glucuronide transport.

Gui C, Wahlgren B, Lushington GH, Hagenbuch B.

Pharmacol Res. 2009 Jul;60(1):50-6. doi: 10.1016/j.phrs.2009.03.004. Epub 2009 Mar 17.

42.

Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.

Leuthold S, Hagenbuch B, Mohebbi N, Wagner CA, Meier PJ, Stieger B.

Am J Physiol Cell Physiol. 2009 Mar;296(3):C570-82. doi: 10.1152/ajpcell.00436.2008. Epub 2009 Jan 7.

43.

Stable expression and functional characterization of a Na+-taurocholate cotransporting green fluorescent protein in human hepatoblastoma HepG2 cells.

Kullak-Ublick GA, Ismair MG, Kubitz R, Schmitt M, Häussinger D, Stieger B, Hagenbuch B, Meier PJ, Beuers U, Paumgartner G.

Cytotechnology. 2000 Oct;34(1-2):1-9. doi: 10.1023/A:1008152729133.

44.
45.

Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family.

Hagenbuch B, Gui C.

Xenobiotica. 2008 Jul;38(7-8):778-801. doi: 10.1080/00498250801986951 . Review.

PMID:
18668430
46.

Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3.

Gui C, Miao Y, Thompson L, Wahlgren B, Mock M, Stieger B, Hagenbuch B.

Eur J Pharmacol. 2008 Apr 14;584(1):57-65. doi: 10.1016/j.ejphar.2008.01.042. Epub 2008 Feb 8.

47.

Cellular entry of thyroid hormones by organic anion transporting polypeptides.

Hagenbuch B.

Best Pract Res Clin Endocrinol Metab. 2007 Jun;21(2):209-21. Review.

PMID:
17574004
48.

Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain.

Huber RD, Gao B, Sidler Pfändler MA, Zhang-Fu W, Leuthold S, Hagenbuch B, Folkers G, Meier PJ, Stieger B.

Am J Physiol Cell Physiol. 2007 Feb;292(2):C795-806. Epub 2006 Sep 13.

49.

Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin.

Fischer WJ, Altheimer S, Cattori V, Meier PJ, Dietrich DR, Hagenbuch B.

Toxicol Appl Pharmacol. 2005 Mar 15;203(3):257-63.

PMID:
15737679
50.

Application of QSAR analysis to organic anion transporting polypeptide 1a5 (Oatp1a5) substrates.

Yarim M, Moro S, Huber R, Meier PJ, Kaseda C, Kashima T, Hagenbuch B, Folkers G.

Bioorg Med Chem. 2005 Jan 17;13(2):463-71.

PMID:
15598568

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