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Items: 9


The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors.

Hagenbeek TJ, Webster JD, Kljavin NM, Chang MT, Pham T, Lee HJ, Klijn C, Cai AG, Totpal K, Ravishankar B, Yang N, Lee DH, Walsh KB, Hatzivassiliou G, de la Cruz CC, Gould SE, Wu X, Lee WP, Yang S, Zhang Z, Gu Q, Ji Q, Jackson EL, Lim DS, Dey A.

Sci Signal. 2018 Sep 11;11(547). pii: eaaj1757. doi: 10.1126/scisignal.aaj1757.


Constitutive NOTCH3 Signaling Promotes the Growth of Basal Breast Cancers.

Choy L, Hagenbeek TJ, Solon M, French D, Finkle D, Shelton A, Venook R, Brauer MJ, Siebel CW.

Cancer Res. 2017 Mar 15;77(6):1439-1452. doi: 10.1158/0008-5472.CAN-16-1022. Epub 2017 Jan 20.


Murine Pten(-/-) T-ALL requires non-redundant PI3K/mTOR and DLL4/Notch1 signals for maintenance and γc/TCR signals for thymic exit.

Hagenbeek TJ, Wu X, Choy L, Sanchez-Irizarry C, Seshagiri S, Stinson J, Siebel CW, Spits H.

Cancer Lett. 2014 May 1;346(2):237-48. doi: 10.1016/j.canlet.2013.12.027. Epub 2013 Dec 30.


Pharmacological inhibition of carbonic anhydrase XII interferes with cell proliferation and induces cell apoptosis in T-cell lymphomas.

Lounnas N, Rosilio C, Nebout M, Mary D, Griessinger E, Neffati Z, Chiche J, Spits H, Hagenbeek TJ, Asnafi V, Poulsen SA, Supuran CT, Peyron JF, Imbert V.

Cancer Lett. 2013 Jun 1;333(1):76-88. doi: 10.1016/j.canlet.2013.01.020. Epub 2013 Jan 21.


Therapeutic antibody targeting of individual Notch receptors.

Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, Finkle D, Venook R, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Shelton A, Stawicki S, Watts RJ, Zhang J, Choy R, Howard P, Kadyk L, Yan M, Zha J, Callahan CA, Hymowitz SG, Siebel CW.

Nature. 2010 Apr 15;464(7291):1052-7. doi: 10.1038/nature08878.


Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes.

Finlay DK, Sinclair LV, Feijoo C, Waugh CM, Hagenbeek TJ, Spits H, Cantrell DA.

J Exp Med. 2009 Oct 26;206(11):2441-54. doi: 10.1084/jem.20090219. Epub 2009 Oct 5.


Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking.

Sinclair LV, Finlay D, Feijoo C, Cornish GH, Gray A, Ager A, Okkenhaug K, Hagenbeek TJ, Spits H, Cantrell DA.

Nat Immunol. 2008 May;9(5):513-21. doi: 10.1038/ni.1603. Epub 2008 Apr 6. Erratum in: Nat Immunol. 2008 Jun;9(6):692.


T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus.

Hagenbeek TJ, Spits H.

Leukemia. 2008 Mar;22(3):608-19. Epub 2007 Nov 29.


The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling.

Hagenbeek TJ, Naspetti M, Malergue F, Garçon F, Nunès JA, Cleutjens KB, Trapman J, Krimpenfort P, Spits H.

J Exp Med. 2004 Oct 4;200(7):883-94. Epub 2004 Sep 27.

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