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Items: 1 to 50 of 96

1.

Glutathione maintenance mitigates age-related susceptibility to redox cycling agents.

Thomas NO, Shay KP, Kelley AR, Butler JA, Hagen TM.

Redox Biol. 2016 Dec;10:45-52. doi: 10.1016/j.redox.2016.09.010. Epub 2016 Sep 22.

2.

Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a.

Smith EJ, Shay KP, Thomas NO, Butler JA, Finlay LF, Hagen TM.

Free Radic Biol Med. 2015 Dec;89:1184-91. doi: 10.1016/j.freeradbiomed.2015.11.003. Epub 2015 Nov 5.

3.

Tools for a better supervisor. Utilize NEMSMA-curated leadership pillars.

Hagen TM.

JEMS. 2014 Nov;39(11):69. No abstract available.

PMID:
25630165
4.

Quality patient care.

Hagen TM.

JEMS. 2014 Jul;39(7):79. No abstract available.

PMID:
25163206
5.

Leading edge.

Hagen TM.

JEMS. 2014 May;39(5):61. No abstract available.

PMID:
24984442
6.

Compassion for our own.

Hagen TM.

JEMS. 2014 Mar;39(3):63. No abstract available.

PMID:
24724340
7.

The circle of life: Preparing a leadership succession plan.

Hagen TM.

JEMS. 2014 Jan;39(1):67. No abstract available.

PMID:
24640634
8.

It's a dangerous world: preventing violence against EMS.

Hagen TM.

JEMS. 2013 Dec;38(12):65. No abstract available.

PMID:
24592573
9.

Laundry bins. Basic needs, pay raises & other morale measures.

Hagen TM.

JEMS. 2013 Nov;38(11):84. No abstract available.

PMID:
24475631
10.

Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function.

Michels AJ, Hagen TM, Frei B.

Annu Rev Nutr. 2013;33:45-70. doi: 10.1146/annurev-nutr-071812-161246. Epub 2013 Apr 29. Review.

11.

Stepping up: there are many ways you can impact the delivery of patient care.

Hagen TM.

EMS World. 2013 Feb;42(2):20. No abstract available.

PMID:
23469457
12.

Maximizing team performance: key actions will help you improve operations.

Hagen TM.

EMS World. 2012 Nov;41(11):38. No abstract available.

PMID:
23213717
13.

The value of EMS. The time to change EMS reimbursement models is now.

Hagen TM.

EMS World. 2012 Sep;41(9):60. No abstract available.

PMID:
23033618
14.

What's your EMS story? Advocating for EMS means educating about EMS.

Hagen TM.

EMS World. 2012 Jun;41(6):47. No abstract available.

PMID:
22830188
15.

Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study.

Keith DJ, Butler JA, Bemer B, Dixon B, Johnson S, Garrard M, Sudakin DL, Christensen JM, Pereira C, Hagen TM.

Pharmacol Res. 2012 Sep;66(3):199-206. doi: 10.1016/j.phrs.2012.05.002. Epub 2012 May 16.

16.

Moving toward regionalization. A viable means to improve patient outcomes while reducing costs.

Hagen TM.

EMS World. 2012 Apr;41(4):55. No abstract available.

PMID:
22567793
17.

Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response.

Shay KP, Michels AJ, Li W, Kong AN, Hagen TM.

Biochim Biophys Acta. 2012 Jun;1823(6):1102-9. doi: 10.1016/j.bbamcr.2012.04.002. Epub 2012 Apr 13.

18.

Age-related decline in mitochondrial bioenergetics: does supercomplex destabilization determine lower oxidative capacity and higher superoxide production?

Gómez LA, Hagen TM.

Semin Cell Dev Biol. 2012 Sep;23(7):758-67. doi: 10.1016/j.semcdb.2012.04.002. Epub 2012 Apr 12. Review.

19.

Learning from history: How will you lead EMS into the future?

Hagen TM.

EMS World. 2012 Feb;41(2):24-5. No abstract available.

PMID:
22413694
20.
21.
22.

OLAM: A wearable, non-contact sensor for continuous heart-rate and activity monitoring.

Albright RK, Goska BJ, Hagen TM, Chi MY, Cauwenberghs G, Chiang PY.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:5625-8. doi: 10.1109/IEMBS.2011.6091361.

PMID:
22255615
23.
24.

R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.

Finlay LA, Michels AJ, Butler JA, Smith EJ, Monette JS, Moreau RF, Petersen SK, Frei B, Hagen TM.

Am J Physiol Regul Integr Comp Physiol. 2012 Mar 1;302(5):R587-97. doi: 10.1152/ajpregu.00393.2011. Epub 2011 Nov 2.

25.

The executive EMS officer. What values and competencies does an EMS executive need to succeed?

Hagen TM.

EMS World. 2011 Oct;40(10):26. No abstract available.

PMID:
22046894
26.

The managing EMS officer: managers often get a bad rap, but without them, where would we be?

Hagen TM.

EMS World. 2011 Sep;40(9):34. No abstract available.

PMID:
21961424
27.

The supervising EMS officer. What values and competencies does an EMS supervisor need to succeed?

Hagen TM.

EMS World. 2011 Aug;40(8):35. No abstract available.

PMID:
21877477
28.

Antioxidants to enhance fertility: role of eNOS and potential benefits.

Visioli F, Hagen TM.

Pharmacol Res. 2011 Nov;64(5):431-7. doi: 10.1016/j.phrs.2011.06.021. Epub 2011 Jul 1. Review.

PMID:
21745572
29.

What's a leader to do? When it comes to good leadership, actions speak louder than words.

Hagen TM.

EMS World. 2011 May;40(5):34. No abstract available.

PMID:
21650104
30.

The making of a leader. NEMSMA sets out to define standard levels, competencies.

Hagen TM.

EMS World. 2011 Mar;40(3):36. No abstract available.

PMID:
21456456
31.

(R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria.

Monette JS, Gómez LA, Moreau RF, Dunn KC, Butler JA, Finlay LA, Michels AJ, Shay KP, Smith EJ, Hagen TM.

Pharmacol Res. 2011 Jan;63(1):23-9. doi: 10.1016/j.phrs.2010.09.007. Epub 2010 Oct 8.

32.

Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.

Li L, Smith A, Hagen TM, Frei B.

Ann N Y Acad Sci. 2010 Aug;1203:151-9. doi: 10.1111/j.1749-6632.2010.05555.x.

PMID:
20716298
33.

Transcription factor Nrf2: examination of nuclear protein levels by immunoblotting and promoter response element binding by chromatin immunoprecipitation (ChIP).

Shay KP, Smith EJ, Hagen TM.

Curr Protoc Toxicol. 2010 Aug;Chapter 17:Unit17.13. doi: 10.1002/0471140856.tx1713s45.

PMID:
23045018
34.

Altered mitochondrial membrane potential, mass, and morphology in the mononuclear cells of humans with type 2 diabetes.

Widlansky ME, Wang J, Shenouda SM, Hagen TM, Smith AR, Kizhakekuttu TJ, Kluge MA, Weihrauch D, Gutterman DD, Vita JA.

Transl Res. 2010 Jul;156(1):15-25. doi: 10.1016/j.trsl.2010.04.001. Epub 2010 May 11.

35.

Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations.

Monette JS, Gómez LA, Moreau RF, Bemer BA, Taylor AW, Hagen TM.

Biochem Biophys Res Commun. 2010 Jul 23;398(2):272-7. doi: 10.1016/j.bbrc.2010.06.077. Epub 2010 Jun 25. Erratum in: Biochem Biophys Res Commun. 2011 Jan 28;404(4):1111.

36.

A new twist on an old vitamin: human polymorphisms in the gene encoding the sodium-dependent vitamin C transporter 1.

Michels AJ, Hagen TM, Frei B.

Am J Clin Nutr. 2010 Aug;92(2):271-2. doi: 10.3945/ajcn.2010.29979. Epub 2010 Jun 30. No abstract available.

PMID:
20592130
37.

Hepatocyte nuclear factor 1 is essential for transcription of sodium-dependent vitamin C transporter protein 1.

Michels AJ, Hagen TM.

Am J Physiol Cell Physiol. 2009 Nov;297(5):C1220-7. doi: 10.1152/ajpcell.00348.2009. Epub 2009 Sep 9.

38.

Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart.

Gómez LA, Monette JS, Chavez JD, Maier CS, Hagen TM.

Arch Biochem Biophys. 2009 Oct 1;490(1):30-5. doi: 10.1016/j.abb.2009.08.002. Epub 2009 Aug 11.

39.

Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.

Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM.

Biochim Biophys Acta. 2009 Oct;1790(10):1149-60. doi: 10.1016/j.bbagen.2009.07.026. Epub 2009 Aug 4. Review.

40.

Transcriptional regulation of rat gamma-glutamate cysteine ligase catalytic subunit gene is mediated through a distal antioxidant response element.

Shenvi SV, Smith EJ, Hagen TM.

Pharmacol Res. 2009 Oct;60(4):229-36. doi: 10.1016/j.phrs.2009.06.003. Epub 2009 Jun 18.

41.

Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion.

Butler JA, Hagen TM, Moreau R.

Arch Biochem Biophys. 2009 May 1;485(1):63-71. doi: 10.1016/j.abb.2009.01.024. Epub 2009 Feb 20.

42.

Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.

Shay KP, Hagen TM.

Biogerontology. 2009 Aug;10(4):443-56. doi: 10.1007/s10522-008-9187-x. Epub 2008 Oct 18.

43.

A rat primary hepatocyte culture model for aging studies.

Shenvi SV, Dixon BM, Petersen Shay K, Hagen TM.

Curr Protoc Toxicol. 2008 Aug;Chapter 14:Unit 14.7. doi: 10.1002/0471140856.tx1407s37.

44.
45.

Lipoic acid significantly restores, in rats, the age-related decline in vasomotion.

Smith AR, Visioli F, Frei B, Hagen TM.

Br J Pharmacol. 2008 Apr;153(8):1615-22. doi: 10.1038/bjp.2008.28. Epub 2008 Feb 25.

46.

Assessment of endoplasmic reticulum glutathione redox status is confounded by extensive ex vivo oxidation.

Dixon BM, Heath SH, Kim R, Suh JH, Hagen TM.

Antioxid Redox Signal. 2008 May;10(5):963-72. doi: 10.1089/ars.2007.1869.

47.
48.

Thiol supplementation inhibits metalloproteinase activity independent of glutathione status.

Bogani P, Canavesi M, Hagen TM, Visioli F, Bellosta S.

Biochem Biophys Res Commun. 2007 Nov 23;363(3):651-5. Epub 2007 Sep 18.

PMID:
17900531
49.

Mitochondrial superoxide production and nuclear factor erythroid 2-related factor 2 activation in p75 neurotrophin receptor-induced motor neuron apoptosis.

Pehar M, Vargas MR, Robinson KM, Cassina P, Díaz-Amarilla PJ, Hagen TM, Radi R, Barbeito L, Beckman JS.

J Neurosci. 2007 Jul 18;27(29):7777-85.

50.

Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests.

Milgram NW, Araujo JA, Hagen TM, Treadwell BV, Ames BN.

FASEB J. 2007 Nov;21(13):3756-62. Epub 2007 Jul 10.

PMID:
17622567

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