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Engineering Antibodies with C-Terminal Sortase-Mediated Modification for Targeted Nanomedicine.

Hashad RA, Lange JL, Tan NCW, Alt K, Hagemeyer CE.

Methods Mol Biol. 2019;2033:67-80. doi: 10.1007/978-1-4939-9654-4_6.


Functional Brush Poly(2-ethyl-2-oxazine)s: Synthesis by CROP and RAFT, Thermoresponsiveness and Grafting onto Iron Oxide Nanoparticles.

Klein T, Parkin J, de Jongh PAJM, Esser L, Sepehrizadeh T, Zheng G, De Veer M, Alt K, Hagemeyer CE, Haddleton DM, Davis TP, Thelakkat M, Kempe K.

Macromol Rapid Commun. 2019 May;40(10):e1800911. doi: 10.1002/marc.201800911. Epub 2019 Feb 12.


Self-Assembled Metal-Phenolic Networks on Emulsions as Low-Fouling and pH-Responsive Particles.

Besford QA, Ju Y, Wang TY, Yun G, Cherepanov P, Hagemeyer CE, Cavalieri F, Caruso F.

Small. 2018 Sep;14(39):e1802342. doi: 10.1002/smll.201802342. Epub 2018 Aug 29.


Platelet-targeted dual pathway antithrombotic inhibits thrombosis with preserved hemostasis.

Hanjaya-Putra D, Haller C, Wang X, Dai E, Lim B, Liu L, Jaminet P, Yao J, Searle A, Bonnard T, Hagemeyer CE, Peter K, Chaikof EL.

JCI Insight. 2018 Aug 9;3(15). pii: 99329. doi: 10.1172/jci.insight.99329. eCollection 2018 Aug 9.


Psammomys obesus: a Natural Diet-Controlled Model for Diabetes and Cardiovascular Diseases.

Chaudhary R, Walder KR, Hagemeyer CE, Kanwar JR.

Curr Atheroscler Rep. 2018 Jul 17;20(9):46. doi: 10.1007/s11883-018-0746-6. Review.


Low-Fouling and Biodegradable Protein-Based Particles for Thrombus Imaging.

Bonnard T, Jayapadman A, Putri JA, Cui J, Ju Y, Carmichael C, Angelovich TA, Cody SH, French S, Pascaud K, Pearce HA, Jagdale S, Caruso F, Hagemeyer CE.

ACS Nano. 2018 Jul 24;12(7):6988-6996. doi: 10.1021/acsnano.8b02588. Epub 2018 Jun 7.


Magnetic fibrinolysis: putting the therapeutic wheels in a corkscrew motion.

Medcalf RL, Hagemeyer CE, Alt K.

J Thromb Haemost. 2018 Apr;16(4):615-617. doi: 10.1111/jth.13969. No abstract available.


High-density lipoprotein delivered after myocardial infarction increases cardiac glucose uptake and function in mice.

Heywood SE, Richart AL, Henstridge DC, Alt K, Kiriazis H, Zammit C, Carey AL, Kammoun HL, Delbridge LM, Reddy M, Chen YC, Du XJ, Hagemeyer CE, Febbraio MA, Siebel AL, Kingwell BA.

Sci Transl Med. 2017 Oct 11;9(411). pii: eaam6084. doi: 10.1126/scitranslmed.aam6084.


Platelet-Targeted Delivery of Peripheral Blood Mononuclear Cells to the Ischemic Heart Restores Cardiac Function after Ischemia-Reperfusion Injury.

Ziegler M, Wang X, Lim B, Leitner E, Klingberg F, Ching V, Yao Y, Huang D, Gao XM, Kiriazis H, Du XJ, Haigh JJ, Bobik A, Hagemeyer CE, Ahrens I, Peter K.

Theranostics. 2017 Jul 22;7(13):3192-3206. doi: 10.7150/thno.19698. eCollection 2017.


Development and validation of a high throughput whole blood thrombolysis plate assay.

Bonnard T, Law LS, Tennant Z, Hagemeyer CE.

Sci Rep. 2017 May 24;7(1):2346. doi: 10.1038/s41598-017-02498-2.


Self-Assembled Nanoparticles from Phenolic Derivatives for Cancer Therapy.

Dai Y, Guo J, Wang TY, Ju Y, Mitchell AJ, Bonnard T, Cui J, Richardson JJ, Hagemeyer CE, Alt K, Caruso F.

Adv Healthc Mater. 2017 Aug;6(16). doi: 10.1002/adhm.201700467. Epub 2017 May 16.


Triggered and Tunable Hydrogen Sulfide Release from Photogenerated Thiobenzaldehydes.

Xiao Z, Bonnard T, Shakouri-Motlagh A, Wylie RAL, Collins J, White J, Heath DE, Hagemeyer CE, Connal LA.

Chemistry. 2017 Aug 22;23(47):11294-11300. doi: 10.1002/chem.201701206. Epub 2017 Jul 27.


Molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual MRI contrast.

Ta HT, Li Z, Hagemeyer CE, Cowin G, Zhang S, Palasubramaniam J, Alt K, Wang X, Peter K, Whittaker AK.

Biomaterials. 2017 Jul;134:31-42. doi: 10.1016/j.biomaterials.2017.04.037. Epub 2017 Apr 22.


Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation.

Molloy CP, Yao Y, Kammoun H, Bonnard T, Hoefer T, Alt K, Tovar-Lopez F, Rosengarten G, Ramsland PA, van der Meer AD, van den Berg A, Murphy AJ, Hagemeyer CE, Peter K, Westein E.

J Thromb Haemost. 2017 May;15(5):972-982. doi: 10.1111/jth.13666. Epub 2017 Apr 9.


Novel Thrombolytic Drug Based on Thrombin Cleavable Microplasminogen Coupled to a Single-Chain Antibody Specific for Activated GPIIb/IIIa.

Bonnard T, Tennant Z, Niego B, Kanojia R, Alt K, Jagdale S, Law LS, Rigby S, Medcalf RL, Peter K, Hagemeyer CE.

J Am Heart Assoc. 2017 Feb 3;6(2). pii: e004535. doi: 10.1161/JAHA.116.004535.


Highly Sensitive Detection of Minimal Cardiac Ischemia using Positron Emission Tomography Imaging of Activated Platelets.

Ziegler M, Alt K, Paterson BM, Kanellakis P, Bobik A, Donnelly PS, Hagemeyer CE, Peter K.

Sci Rep. 2016 Dec 2;6:38161. doi: 10.1038/srep38161.


Polymer Capsules for Plaque-Targeted In Vivo Delivery.

Richardson JJ, Choy MY, Guo J, Liang K, Alt K, Ping Y, Cui J, Law LS, Hagemeyer CE, Caruso F.

Adv Mater. 2016 Sep;28(36):7820. doi: 10.1002/adma.201603952. No abstract available.


Polymer Capsules for Plaque-Targeted In Vivo Delivery.

Richardson JJ, Choy MY, Guo J, Liang K, Alt K, Ping Y, Cui J, Law LS, Hagemeyer CE, Caruso F.

Adv Mater. 2016 Sep;28(35):7703-7. doi: 10.1002/adma.201601754. Epub 2016 Jun 30. Erratum in: Adv Mater. 2016 Sep;28(36):7820.


Molecular Imaging of Activated Platelets Allows the Detection of Pulmonary Embolism with Magnetic Resonance Imaging.

Heidt T, Ehrismann S, Hövener JB, Neudorfer I, Hilgendorf I, Reisert M, Hagemeyer CE, Zirlik A, Reinöhl J, Bode C, Peter K, von Elverfeldt D, von Zur Muhlen C.

Sci Rep. 2016 May 3;6:25044. doi: 10.1038/srep25044.


Thrombus-Targeted Theranostic Microbubbles: A New Technology towards Concurrent Rapid Ultrasound Diagnosis and Bleeding-free Fibrinolytic Treatment of Thrombosis.

Wang X, Gkanatsas Y, Palasubramaniam J, Hohmann JD, Chen YC, Lim B, Hagemeyer CE, Peter K.

Theranostics. 2016 Mar 20;6(5):726-38. doi: 10.7150/thno.14514. eCollection 2016.


Nanoporous Metal-Phenolic Particles as Ultrasound Imaging Probes for Hydrogen Peroxide.

Guo J, Wang X, Henstridge DC, Richardson JJ, Cui J, Sharma A, Febbraio MA, Peter K, de Haan JB, Hagemeyer CE, Caruso F.

Adv Healthc Mater. 2015 Oct;4(14):2170-2175. doi: 10.1002/adhm.201500528. Epub 2015 Sep 1.


High Affinity Binders to EphA2 Isolated from Abdurin Scaffold Libraries; Characterization, Binding and Tumor Targeting.

Ullman C, Mathonet P, Oleksy A, Diamandakis A, Tomei L, Demartis A, Nardi C, Sambucini S, Missineo A, Alt K, Hagemeyer CE, Harris M, Hedt A, Weis R, Gehlsen KR.

PLoS One. 2015 Aug 27;10(8):e0135278. doi: 10.1371/journal.pone.0135278. eCollection 2015.


Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets.

Gunawan ST, Kempe K, Bonnard T, Cui J, Alt K, Law LS, Wang X, Westein E, Such GK, Peter K, Hagemeyer CE, Caruso F.

Adv Mater. 2015 Sep 16;27(35):5153-7. doi: 10.1002/adma.201502243. Epub 2015 Aug 3.


HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi.

Ahrens I, Chen YC, Topcic D, Bode M, Haenel D, Hagemeyer CE, Seeba H, Duerschmied D, Bassler N, Jandeleit-Dahm KA, Sweet MJ, Agrotis A, Bobik A, Peter K.

Thromb Haemost. 2015 Nov;114(5):994-1003. doi: 10.1160/TH14-12-1073. Epub 2015 Jul 23.


Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel.

Bonnard T, Hagemeyer CE.

J Vis Exp. 2015 Jun 29;(100):e52838. doi: 10.3791/52838.


Boronate-Phenolic Network Capsules with Dual Response to Acidic pH and cis-Diols.

Guo J, Sun H, Alt K, Tardy BL, Richardson JJ, Suma T, Ejima H, Cui J, Hagemeyer CE, Caruso F.

Adv Healthc Mater. 2015 Aug 26;4(12):1796-801. doi: 10.1002/adhm.201500332. Epub 2015 Jun 18.


A versatile approach for the site-specific modification of recombinant antibodies using a combination of enzyme-mediated bioconjugation and click chemistry.

Alt K, Paterson BM, Westein E, Rudd SE, Poniger SS, Jagdale S, Ardipradja K, Connell TU, Krippner GY, Nair AK, Wang X, Tochon-Danguy HJ, Donnelly PS, Peter K, Hagemeyer CE.

Angew Chem Int Ed Engl. 2015 Jun 22;54(26):7515-9. doi: 10.1002/anie.201411507. Epub 2015 May 11.


Immuno-magnetoliposomes targeting activated platelets as a potentially human-compatible MRI contrast agent for targeting atherothrombosis.

Meier S, Pütz G, Massing U, Hagemeyer CE, von Elverfeldt D, Meissner M, Ardipradja K, Barnert S, Peter K, Bode C, Schubert R, von zur Muhlen C.

Biomaterials. 2015 Jun;53:137-48. doi: 10.1016/j.biomaterials.2015.02.088. Epub 2015 Mar 12.


Engineering poly(ethylene glycol) particles for improved biodistribution.

Cui J, De Rose R, Alt K, Alcantara S, Paterson BM, Liang K, Hu M, Richardson JJ, Yan Y, Jeffery CM, Price RI, Peter K, Hagemeyer CE, Donnelly PS, Kent SJ, Caruso F.

ACS Nano. 2015 Feb 24;9(2):1571-80. doi: 10.1021/nn5061578. Epub 2015 Jan 21.


Versatile Loading of Diverse Cargo into Functional Polymer Capsules.

Richardson JJ, Maina JW, Ejima H, Hu M, Guo J, Choy MY, Gunawan ST, Lybaert L, Hagemeyer CE, De Geest BG, Caruso F.

Adv Sci (Weinh). 2015 Jan 29;2(1-2):1400007. eCollection 2015 Feb.


Targeted antithrombotic protein micelles.

Kim W, Haller C, Dai E, Wang X, Hagemeyer CE, Liu DR, Peter K, Chaikof EL.

Angew Chem Int Ed Engl. 2015 Jan 26;54(5):1461-5. doi: 10.1002/anie.201408529. Epub 2014 Dec 10.


Particle generation, functionalization and sortase A-mediated modification with targeting of single-chain antibodies for diagnostic and therapeutic use.

Hagemeyer CE, Alt K, Johnston AP, Such GK, Ta HT, Leung MK, Prabhu S, Wang X, Caruso F, Peter K.

Nat Protoc. 2015 Jan;10(1):90-105. doi: 10.1038/nprot.2014.177. Epub 2014 Dec 11.


Single-chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets.

Alt K, Paterson BM, Ardipradja K, Schieber C, Buncic G, Lim B, Poniger SS, Jakoby B, Wang X, O'Keefe GJ, Tochon-Danguy HJ, Scott AM, Ackermann U, Peter K, Donnelly PS, Hagemeyer CE.

Mol Pharm. 2014 Aug 4;11(8):2855-63. doi: 10.1021/mp500209a. Epub 2014 Jul 14.


Enzyme-mediated site-specific bioconjugation of metal complexes to proteins: sortase-mediated coupling of copper-64 to a single-chain antibody.

Paterson BM, Alt K, Jeffery CM, Price RI, Jagdale S, Rigby S, Williams CC, Peter K, Hagemeyer CE, Donnelly PS.

Angew Chem Int Ed Engl. 2014 Jun 10;53(24):6115-9. doi: 10.1002/anie.201402613. Epub 2014 Apr 28.


Engineering multifunctional capsules through the assembly of metal-phenolic networks.

Guo J, Ping Y, Ejima H, Alt K, Meissner M, Richardson JJ, Yan Y, Peter K, von Elverfeldt D, Hagemeyer CE, Caruso F.

Angew Chem Int Ed Engl. 2014 May 26;53(22):5546-51. doi: 10.1002/anie.201311136. Epub 2014 Apr 2.


Towards effective and safe thrombolysis and thromboprophylaxis: preclinical testing of a novel antibody-targeted recombinant plasminogen activator directed against activated platelets.

Wang X, Palasubramaniam J, Gkanatsas Y, Hohmann JD, Westein E, Kanojia R, Alt K, Huang D, Jia F, Ahrens I, Medcalf RL, Peter K, Hagemeyer CE.

Circ Res. 2014 Mar 28;114(7):1083-93. doi: 10.1161/CIRCRESAHA.114.302514. Epub 2014 Feb 9.


Detection of activated platelets in a mouse model of carotid artery thrombosis with 18 F-labeled single-chain antibodies.

Ardipradja K, Yeoh SD, Alt K, O'Keefe G, Rigopoulos A, Howells DW, Scott AM, Peter K, Ackerman U, Hagemeyer CE.

Nucl Med Biol. 2014 Mar;41(3):229-37. doi: 10.1016/j.nucmedbio.2013.12.006. Epub 2013 Dec 18.


A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling.

Chen YC, Bui AV, Diesch J, Manasseh R, Hausding C, Rivera J, Haviv I, Agrotis A, Htun NM, Jowett J, Hagemeyer CE, Hannan RD, Bobik A, Peter K.

Circ Res. 2013 Jul 19;113(3):252-65. doi: 10.1161/CIRCRESAHA.113.301562. Epub 2013 Jun 7.


Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?

Hohmann JD, Wang X, Krajewski S, Selan C, Haller CA, Straub A, Chaikof EL, Nandurkar HH, Hagemeyer CE, Peter K.

Blood. 2013 Apr 18;121(16):3067-75. doi: 10.1182/blood-2012-08-449694. Epub 2013 Feb 4.


Enzymatic antibody tagging: toward a universal biocompatible targeting tool.

Ta HT, Peter K, Hagemeyer CE.

Trends Cardiovasc Med. 2012 May;22(4):105-11. doi: 10.1016/j.tcm.2012.07.004. Epub 2012 Aug 11. Review.


Bio-click chemistry: enzymatic functionalization of PEGylated capsules for targeting applications.

Leung MK, Hagemeyer CE, Johnston AP, Gonzales C, Kamphuis MM, Ardipradja K, Such GK, Peter K, Caruso F.

Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7132-6. doi: 10.1002/anie.201203612. Epub 2012 Jun 28.


Novel single-chain antibody-targeted microbubbles for molecular ultrasound imaging of thrombosis: validation of a unique noninvasive method for rapid and sensitive detection of thrombi and monitoring of success or failure of thrombolysis in mice.

Wang X, Hagemeyer CE, Hohmann JD, Leitner E, Armstrong PC, Jia F, Olschewski M, Needles A, Peter K, Ahrens I.

Circulation. 2012 Jun 26;125(25):3117-26. doi: 10.1161/CIRCULATIONAHA.111.030312. Epub 2012 May 30.


Enzymatic single-chain antibody tagging: a universal approach to targeted molecular imaging and cell homing in cardiovascular disease.

Ta HT, Prabhu S, Leitner E, Jia F, von Elverfeldt D, Jackson KE, Heidt T, Nair AK, Pearce H, von Zur Muhlen C, Wang X, Peter K, Hagemeyer CE.

Circ Res. 2011 Aug 5;109(4):365-73. doi: 10.1161/CIRCRESAHA.111.249375. Epub 2011 Jun 23.


An activation-specific platelet inhibitor that can be turned on/off by medically used hypothermia.

Topcic D, Kim W, Holien JK, Jia F, Armstrong PC, Hohmann JD, Straub A, Krippner G, Haller CA, Domeij H, Hagemeyer CE, Parker MW, Chaikof EL, Peter K.

Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):2015-23. doi: 10.1161/ATVBAHA.111.226241. Epub 2011 Jun 9.


GPVI and GPIbα mediate staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors.

Hu H, Armstrong PC, Khalil E, Chen YC, Straub A, Li M, Soosairajah J, Hagemeyer CE, Bassler N, Huang D, Ahrens I, Krippner G, Gardiner E, Peter K.

PLoS One. 2011 Apr 28;6(4):e19190. doi: 10.1371/journal.pone.0019190.


Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody.

Heidt T, Deininger F, Peter K, Goldschmidt J, Pethe A, Hagemeyer CE, Neudorfer I, Zirlik A, Weber WA, Bode C, Meyer PT, Behe M, von Zur Mühlen C.

PLoS One. 2011 Mar 30;6(3):e18446. doi: 10.1371/journal.pone.0018446.


Targeting the platelet integrin GPIIb/IIIa.

Hagemeyer CE, Peter K.

Curr Pharm Des. 2010;16(37):4119-33. Review.


MRI of inducible P-selectin expression in human activated platelets involved in the early stages of atherosclerosis.

Jacobin-Valat MJ, Deramchia K, Mornet S, Hagemeyer CE, Bonetto S, Robert R, Biran M, Massot P, Miraux S, Sanchez S, Bouzier-Sore AK, Franconi JM, Duguet E, Clofent-Sanchez G.

NMR Biomed. 2011 May;24(4):413-24. doi: 10.1002/nbm.1606. Epub 2010 Dec 29.


Genetic transfer of fusion proteins effectively inhibits VCAM-1-mediated cell adhesion and transmigration via inhibition of cytoskeletal anchorage.

Hagemeyer CE, Ahrens I, Bassler N, Dschachutaschwili N, Chen YC, Eisenhardt SU, Bode C, Peter K.

J Cell Mol Med. 2010 Jan;14(1-2):290-302. doi: 10.1111/j.1582-4934.2008.00409.x.


7-Benzyloxyresorufin-O-dealkylase activity as a marker for measuring cytochrome P450 CYP3A induction in mouse liver.

Hagemeyer CE, Bürck C, Schwab R, Knoth R, Meyer RP.

Anal Biochem. 2010 Mar 1;398(1):104-11. doi: 10.1016/j.ab.2009.11.004. Epub 2009 Nov 10.


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