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Synthetic lethal mutations in the cyclin A interface of human cytomegalovirus.

Weisbach H, Schablowsky C, Vetter B, Gruska I, Hagemeier C, Wiebusch L.

PLoS Pathog. 2017 Jan 27;13(1):e1006193. doi: 10.1371/journal.ppat.1006193. eCollection 2017 Jan.


A rapid screening system evaluates novel inhibitors of DNA methylation and suggests F-box proteins as potential therapeutic targets for high-risk neuroblastoma.

Penter L, Maier B, Frede U, Hackner B, Carell T, Hagemeier C, Truss M.

Target Oncol. 2015 Dec;10(4):523-33. doi: 10.1007/s11523-014-0354-5. Epub 2015 Jan 6.


PUL21a-Cyclin A2 interaction is required to protect human cytomegalovirus-infected cells from the deleterious consequences of mitotic entry.

Eifler M, Uecker R, Weisbach H, Bogdanow B, Richter E, König L, Vetter B, Lenac-Rovis T, Jonjic S, Neitzel H, Hagemeier C, Wiebusch L.

PLoS Pathog. 2014 Nov 13;10(10):e1004514. doi: 10.1371/journal.ppat.1004514. eCollection 2014 Oct.


Use of 5-ethynyl-2'-deoxyuridine labelling and flow cytometry to study cell cycle-dependent regulation of human cytomegalovirus gene expression.

Wiebusch L, Hagemeier C.

Methods Mol Biol. 2014;1119:123-32. doi: 10.1007/978-1-62703-788-4_9.


Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state.

Bogdanow B, Weisbach H, von Einem J, Straschewski S, Voigt S, Winkler M, Hagemeier C, Wiebusch L.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17510-5. doi: 10.1073/pnas.1312235110. Epub 2013 Oct 7.


Inhibition of human cytomegalovirus immediate-early gene expression by cyclin A2-dependent kinase activity.

Oduro JD, Uecker R, Hagemeier C, Wiebusch L.

J Virol. 2012 Sep;86(17):9369-83. doi: 10.1128/JVI.07181-11. Epub 2012 Jun 20.


Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia.

Krentz S, Hof J, Mendioroz A, Vaggopoulou R, Dörge P, Lottaz C, Engelmann JC, Groeneveld TW, Körner G, Seeger K, Hagemeier C, Henze G, Eckert C, von Stackelberg A, Kirschner-Schwabe R.

Leukemia. 2013 Feb;27(2):295-304. doi: 10.1038/leu.2012.155. Epub 2012 Jun 13.


Mechanism and stem-cell activity of 5-carboxycytosine decarboxylation determined by isotope tracing.

Schiesser S, Hackner B, Pfaffeneder T, Müller M, Hagemeier C, Truss M, Carell T.

Angew Chem Int Ed Engl. 2012 Jun 25;51(26):6516-20. doi: 10.1002/anie.201202583. Epub 2012 May 29.


The latency-associated UL138 gene product of human cytomegalovirus sensitizes cells to tumor necrosis factor alpha (TNF-alpha) signaling by upregulating TNF-alpha receptor 1 cell surface expression.

Montag C, Wagner JA, Gruska I, Vetter B, Wiebusch L, Hagemeier C.

J Virol. 2011 Nov;85(21):11409-21. doi: 10.1128/JVI.05028-11. Epub 2011 Aug 31.


General blockade of human cytomegalovirus immediate-early mRNA expression in the S/G2 phase by a nuclear, Daxx- and PML-independent mechanism.

Zydek M, Uecker R, Tavalai N, Stamminger T, Hagemeier C, Wiebusch L.

J Gen Virol. 2011 Dec;92(Pt 12):2757-69. doi: 10.1099/vir.0.034173-0. Epub 2011 Aug 10.


Mutations and deletions of the TP53 gene predict nonresponse to treatment and poor outcome in first relapse of childhood acute lymphoblastic leukemia.

Hof J, Krentz S, van Schewick C, Körner G, Shalapour S, Rhein P, Karawajew L, Ludwig WD, Seeger K, Henze G, von Stackelberg A, Hagemeier C, Eckert C, Kirschner-Schwabe R.

J Clin Oncol. 2011 Aug 10;29(23):3185-93. doi: 10.1200/JCO.2011.34.8144. Epub 2011 Jul 11.


The discovery of 5-formylcytosine in embryonic stem cell DNA.

Pfaffeneder T, Hackner B, Truss M, Münzel M, Müller M, Deiml CA, Hagemeier C, Carell T.

Angew Chem Int Ed Engl. 2011 Jul 25;50(31):7008-12. doi: 10.1002/anie.201103899. Epub 2011 Jun 30. No abstract available.


Cyclin-dependent kinase activity controls the onset of the HCMV lytic cycle.

Zydek M, Hagemeier C, Wiebusch L.

PLoS Pathog. 2010 Sep 9;6(9):e1001096. doi: 10.1371/journal.ppat.1001096.


p53- and p21-dependent premature APC/C-Cdh1 activation in G2 is part of the long-term response to genotoxic stress.

Wiebusch L, Hagemeier C.

Oncogene. 2010 Jun 17;29(24):3477-89. doi: 10.1038/onc.2010.99. Epub 2010 Apr 12.


CD11b is a therapy resistance- and minimal residual disease-specific marker in precursor B-cell acute lymphoblastic leukemia.

Rhein P, Mitlohner R, Basso G, Gaipa G, Dworzak MN, Kirschner-Schwabe R, Hagemeier C, Stanulla M, Schrappe M, Ludwig WD, Karawajew L, Ratei R.

Blood. 2010 May 6;115(18):3763-71. doi: 10.1182/blood-2009-10-247585. Epub 2010 Mar 12.


Cell cycle-independent expression of immediate-early gene 3 results in G1 and G2 arrest in murine cytomegalovirus-infected cells.

Wiebusch L, Neuwirth A, Grabenhenrich L, Voigt S, Hagemeier C.

J Virol. 2008 Oct;82(20):10188-98. doi: 10.1128/JVI.01212-08. Epub 2008 Jul 30.


The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features.

Seedorf H, Fricke WF, Veith B, Brüggemann H, Liesegang H, Strittmatter A, Miethke M, Buckel W, Hinderberger J, Li F, Hagemeier C, Thauer RK, Gottschalk G.

Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2128-33. doi: 10.1073/pnas.0711093105. Epub 2008 Jan 24.


Hospitalization rates of generic metoprolol compared with the original beta-blocker in an epidemiological database study.

Ahrens W, Hagemeier C, Mühlbauer B, Pigeot I, Püntmann I, Reineke A, Steinbach M, Timm J.

Pharmacoepidemiol Drug Saf. 2007 Dec;16(12):1298-307.


Molecular cloning, characterisation and ligand-bound structure of an azoreductase from Pseudomonas aeruginosa.

Wang CJ, Hagemeier C, Rahman N, Lowe E, Noble M, Coughtrie M, Sim E, Westwood I.

J Mol Biol. 2007 Nov 9;373(5):1213-28. Epub 2007 Aug 25.


Down-regulation of the inhibitor of growth 1 (ING1) tumor suppressor sensitizes p53-deficient glioblastoma cells to cisplatin-induced cell death.

Tallen UG, Truss M, Kunitz F, Wellmann S, Unryn B, Sinn B, Lass U, Krabbe S, Holtkamp N, Hagemeier C, Wurm R, Henze G, Riabowol KT, von Deimling A.

J Neurooncol. 2008 Jan;86(1):23-30. Epub 2007 Sep 1.


Structure of coenzyme F420H2 oxidase (FprA), a di-iron flavoprotein from methanogenic Archaea catalyzing the reduction of O2 to H2O.

Seedorf H, Hagemeier CH, Shima S, Thauer RK, Warkentin E, Ermler U.

FEBS J. 2007 Mar;274(6):1588-99.


Gene expression shift towards normal B cells, decreased proliferative capacity and distinct surface receptors characterize leukemic blasts persisting during induction therapy in childhood acute lymphoblastic leukemia.

Rhein P, Scheid S, Ratei R, Hagemeier C, Seeger K, Kirschner-Schwabe R, Moericke A, Schrappe M, Spang R, Ludwig WD, Karawajew L.

Leukemia. 2007 May;21(5):897-905. Epub 2007 Mar 1.


Insight into the mechanism of biological methanol activation based on the crystal structure of the methanol-cobalamin methyltransferase complex.

Hagemeier CH, Krer M, Thauer RK, Warkentin E, Ermler U.

Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):18917-22. Epub 2006 Dec 1.


Human cytomegalovirus blocks tumor necrosis factor alpha- and interleukin-1beta-mediated NF-kappaB signaling.

Montag C, Wagner J, Gruska I, Hagemeier C.

J Virol. 2006 Dec;80(23):11686-98. Epub 2006 Sep 27.


Expression of late cell cycle genes and an increased proliferative capacity characterize very early relapse of childhood acute lymphoblastic leukemia.

Kirschner-Schwabe R, Lottaz C, Tödling J, Rhein P, Karawajew L, Eckert C, von Stackelberg A, Ungethüm U, Kostka D, Kulozik AE, Ludwig WD, Henze G, Spang R, Hagemeier C, Seeger K.

Clin Cancer Res. 2006 Aug 1;12(15):4553-61.


Combined effect of proteasome and calpain inhibition on cisplatin-resistant human melanoma cells.

Młynarczuk-Biały I, Roeckmann H, Kuckelkorn U, Schmidt B, Umbreen S, Gołab J, Ludwig A, Montag C, Wiebusch L, Hagemeier C, Schadendorf D, Kloetzel PM, Seifert U.

Cancer Res. 2006 Aug 1;66(15):7598-605.


The crystal structure of the apoenzyme of the iron-sulphur cluster-free hydrogenase.

Pilak O, Mamat B, Vogt S, Hagemeier CH, Thauer RK, Shima S, Vonrhein C, Warkentin E, Ermler U.

J Mol Biol. 2006 May 5;358(3):798-809. Epub 2006 Mar 2.


DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis.

Bhonde MR, Hanski ML, Budczies J, Cao M, Gillissen B, Moorthy D, Simonetta F, Scherübl H, Truss M, Hagemeier C, Mewes HW, Daniel PT, Zeitz M, Hanski C.

J Biol Chem. 2006 Mar 31;281(13):8675-85. Epub 2006 Jan 30.


Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3), which promotes viability of Hodgkin/Reed-Sternberg cells.

Janz M, Hummel M, Truss M, Wollert-Wulf B, Mathas S, Jöhrens K, Hagemeier C, Bommert K, Stein H, Dörken B, Bargou RC.

Blood. 2006 Mar 15;107(6):2536-9. Epub 2005 Nov 1.


Human cytomegalovirus inactivates the G0/G1-APC/C ubiquitin ligase by Cdh1 dissociation.

Wiebusch L, Bach M, Uecker R, Hagemeier C.

Cell Cycle. 2005 Oct;4(10):1435-9. Epub 2005 Oct 2.


MtdC, a novel class of methylene tetrahydromethanopterin dehydrogenases.

Vorholt JA, Kalyuzhnaya MG, Hagemeier CH, Lidstrom ME, Chistoserdova L.

J Bacteriol. 2005 Sep;187(17):6069-74.


A role for E2F6 in the restriction of male-germ-cell-specific gene expression.

Pohlers M, Truss M, Frede U, Scholz A, Strehle M, Kuban RJ, Hoffmann B, Morkel M, Birchmeier C, Hagemeier C.

Curr Biol. 2005 Jun 7;15(11):1051-7.


The structure of F420-dependent methylenetetrahydromethanopterin dehydrogenase: a crystallographic 'superstructure' of the selenomethionine-labelled protein crystal structure.

Warkentin E, Hagemeier CH, Shima S, Thauer RK, Ermler U.

Acta Crystallogr D Biol Crystallogr. 2005 Feb;61(Pt 2):198-202. Epub 2005 Jan 19.


How an enzyme binds the C1 carrier tetrahydromethanopterin. Structure of the tetrahydromethanopterin-dependent formaldehyde-activating enzyme (Fae) from Methylobacterium extorquens AM1.

Acharya P, Goenrich M, Hagemeier CH, Demmer U, Vorholt JA, Thauer RK, Ermler U.

J Biol Chem. 2005 Apr 8;280(14):13712-9. Epub 2005 Jan 4.


HuSiDa--the human siRNA database: an open-access database for published functional siRNA sequences and technical details of efficient transfer into recipient cells.

Truss M, Swat M, Kielbasa SM, Schäfer R, Herzel H, Hagemeier C.

Nucleic Acids Res. 2005 Jan 1;33(Database issue):D108-11.


Impact of pre-analytical handling on bone marrow mRNA gene expression.

Breit S, Nees M, Schaefer U, Pfoersich M, Hagemeier C, Muckenthaler M, Kulozik AE.

Br J Haematol. 2004 Jul;126(2):231-43.


Inhibition of human cytomegalovirus replication by small interfering RNAs.

Wiebusch L, Truss M, Hagemeier C.

J Gen Virol. 2004 Jan;85(Pt 1):179-84.


Coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase (Mtd) from Methanopyrus kandleri: a methanogenic enzyme with an unusual quarternary structure.

Hagemeier CH, Shima S, Thauer RK, Bourenkov G, Bartunik HD, Ermler U.

J Mol Biol. 2003 Oct 3;332(5):1047-57.


Coenzyme F420-dependent methylenetetrahydromethanopterin dehydrogenase from Methanopyrus kandleri: the selenomethionine-labelled and non-labelled enzyme crystallized in two different forms.

Hagemeier CH, Shima S, Warkentin E, Thauer RK, Ermler U.

Acta Crystallogr D Biol Crystallogr. 2003 Sep;59(Pt 9):1653-5. Epub 2003 Aug 19.


Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug-resistant T-cell leukemia.

Schroeder U, Bernt KM, Lange B, Wenkel J, Jikai J, Shabat D, Amir R, Huebener N, Niethammer AG, Hagemeier C, Wiebusch L, Gaedicke G, Wrasidlo W, Reisfeld RA, Lode HN.

Blood. 2003 Jul 1;102(1):246-53. Epub 2003 Mar 6.


TGGE screening of the entire FBN1 coding sequence in 126 individuals with marfan syndrome and related fibrillinopathies.

Katzke S, Booms P, Tiecke F, Palz M, Pletschacher A, Türkmen S, Neumann LM, Pregla R, Leitner C, Schramm C, Lorenz P, Hagemeier C, Fuchs J, Skovby F, Rosenberg T, Robinson PN.

Hum Mutat. 2002 Sep;20(3):197-208.


Structure of methylene-tetrahydromethanopterin dehydrogenase from methylobacterium extorquens AM1.

Ermler U, Hagemeier CH, Roth A, Demmer U, Grabarse W, Warkentin E, Vorholt JA.

Structure. 2002 Aug;10(8):1127-37.


A glutathione-dependent formaldehyde-activating enzyme (Gfa) from Paracoccus denitrificans detected and purified via two-dimensional proton exchange NMR spectroscopy.

Goenrich M, Bartoschek S, Hagemeier CH, Griesinger C, Vorholt JA.

J Biol Chem. 2002 Feb 1;277(5):3069-72. Epub 2001 Dec 10.


Evidence towards the role of arylamine N-acetyltransferase in Mycobacterium smegmatis and development of a specific antiserum against the homologous enzyme of Mycobacterium tuberculosis.

Payton M, Gifford C, Schartau P, Hagemeier C, Mushtaq A, Lucas S, Pinter K, Sim E.

Microbiology. 2001 Dec;147(Pt 12):3295-302.


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