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Items: 11


First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway.

Hagel M, Miduturu C, Sheets M, Rubin N, Weng W, Stransky N, Bifulco N, Kim JL, Hodous B, Brooijmans N, Shutes A, Winter C, Lengauer C, Kohl NE, Guzi T.

Cancer Discov. 2015 Apr;5(4):424-37. doi: 10.1158/2159-8290.CD-14-1029. Epub 2015 Mar 16.


Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine.

Hagel M, Niu D, St Martin T, Sheets MP, Qiao L, Bernard H, Karp RM, Zhu Z, Labenski MT, Chaturvedi P, Nacht M, Westlin WF, Petter RC, Singh J.

Nat Chem Biol. 2011 Jan;7(1):22-4. doi: 10.1038/nchembio.492. Epub 2010 Nov 28.


Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).

Tremblay MR, Lescarbeau A, Grogan MJ, Tan E, Lin G, Austad BC, Yu LC, Behnke ML, Nair SJ, Hagel M, White K, Conley J, Manna JD, Alvarez-Diez TM, Hoyt J, Woodward CN, Sydor JR, Pink M, MacDougall J, Campbell MJ, Cushing J, Ferguson J, Curtis MS, McGovern K, Read MA, Palombella VJ, Adams J, Castro AC.

J Med Chem. 2009 Jul 23;52(14):4400-18. doi: 10.1021/jm900305z.


Inhibitory effect of estrogen on Rac1-expression in monocytes.

Adam O, Hagel M, Theobald K, Böhm M, Laufs U.

Biochem Biophys Res Commun. 2009 Aug 14;386(1):45-9. doi: 10.1016/j.bbrc.2009.05.126. Epub 2009 Jun 2.


Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists.

Tremblay MR, Nevalainen M, Nair SJ, Porter JR, Castro AC, Behnke ML, Yu LC, Hagel M, White K, Faia K, Grenier L, Campbell MJ, Cushing J, Woodward CN, Hoyt J, Foley MA, Read MA, Sydor JR, Tong JK, Palombella VJ, McGovern K, Adams J.

J Med Chem. 2008 Nov 13;51(21):6646-9. doi: 10.1021/jm8008508. Epub 2008 Oct 9.


Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila development.

Chen GC, Turano B, Ruest PJ, Hagel M, Settleman J, Thomas SM.

Mol Cell Biol. 2005 Feb;25(3):979-87.


Protection against anoikis and down-regulation of cadherin expression by a regulatable beta-catenin protein.

Weng Z, Xin M, Pablo L, Grueneberg D, Hagel M, Bain G, Müller T, Papkoff J.

J Biol Chem. 2002 May 24;277(21):18677-86. Epub 2002 Mar 19.


Molybdenum and tungsten complexes of sulfene (thioformaldehyde S,S-dioxide).

Schenk WA, Nielsen K, Burzlaff NI, Hagel M.

Inorg Chem. 2002 Mar 11;41(5):1079-85.


The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling.

Hagel M, George EL, Kim A, Tamimi R, Opitz SL, Turner CE, Imamoto A, Thomas SM.

Mol Cell Biol. 2002 Feb;22(3):901-15.


Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin.

Thomas SM, Hagel M, Turner CE.

J Cell Sci. 1999 Jan;112 ( Pt 2):181-90.


Naloxone and pentazocine given after morphine.

Cardan E, Hagel M, Roth A.

Acta Anaesthesiol Belg. 1984;35 Suppl:265-70.


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