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Items: 1 to 50 of 390

1.

Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma.

Bronner SM, Merrick KA, Murray J, Salphati L, Moffat JG, Pang J, Sneeringer CJ, Dompe N, Cyr P, Purkey H, Boenig GL, Li J, Kolesnikov A, Larouche-Gauthier R, Lai KW, Shen X, Aubert-Nicol S, Chen YC, Cheong J, Crawford JJ, Hafner M, Haghshenas P, Jakalian A, Leclerc JP, Lim NK, O'Brien T, Plise EG, Shalan H, Sturino C, Wai J, Xiao Y, Yin J, Zhao L, Gould S, Olivero A, Heffron TP.

Bioorg Med Chem Lett. 2019 Jun 26. pii: S0960-894X(19)30401-9. doi: 10.1016/j.bmcl.2019.06.021. [Epub ahead of print]

PMID:
31307887
2.

A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines.

Niepel M, Hafner M, Mills CE, Subramanian K, Williams EH, Chung M, Gaudio B, Barrette AM, Stern AD, Hu B, Korkola JE; LINCS Consortium, Gray JW, Birtwistle MR, Heiser LM, Sorger PK.

Cell Syst. 2019 Jul 5. pii: S2405-4712(19)30200-5. doi: 10.1016/j.cels.2019.06.005. [Epub ahead of print]

PMID:
31302153
3.

Differential response of esophageal cancer cells to particle irradiation.

Hartfiel S, Häfner M, Perez RL, Rühle A, Trinh T, Debus J, Huber PE, Nicolay NH.

Radiat Oncol. 2019 Jul 8;14(1):119. doi: 10.1186/s13014-019-1326-9.

4.

Optimizing the month of the year backwards test for delirium screening of older patients in the emergency department.

Hasemann W, Grossmann FF, Bingisser R, Hafner M, Breil D, Kressig RW, Nickel CH.

Am J Emerg Med. 2019 Jun 21. pii: S0735-6757(19)30416-4. doi: 10.1016/j.ajem.2019.06.035. [Epub ahead of print]

PMID:
31262626
5.

Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3.

Wang S, Chim B, Su Y, Khil P, Wong M, Wang X, Foroushani A, Smith PT, Liu X, Li R, Ganesan S, Kanellopoulou C, Hafner M, Muljo SA.

Genes Dev. 2019 Jun 20. doi: 10.1101/gad.325100.119. [Epub ahead of print]

PMID:
31221665
6.

Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity.

Hafner M, Mills CE, Subramanian K, Chen C, Chung M, Boswell SA, Everley RA, Liu C, Walmsley CS, Juric D, Sorger PK.

Cell Chem Biol. 2019 Jun 6. pii: S2451-9456(19)30174-6. doi: 10.1016/j.chembiol.2019.05.005. [Epub ahead of print]

PMID:
31178407
7.

Acute Toxicity and Early Oncological Outcomes After Intraoperative Electron Radiotherapy (IOERT) as Boost Followed by Whole Breast Irradiation in 157 Early Stage Breast Cancer Patients-First Clinical Results From a Single Center.

König L, Lang K, Heil J, Golatta M, Major G, Krug D, Hörner-Rieber J, Häfner MF, Koerber SA, Harrabi S, Bostel T, Debus J, Uhl M.

Front Oncol. 2019 May 21;9:384. doi: 10.3389/fonc.2019.00384. eCollection 2019.

8.

DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions.

Sauer M, Juranek SA, Marks J, De Magis A, Kazemier HG, Hilbig D, Benhalevy D, Wang X, Hafner M, Paeschke K.

Nat Commun. 2019 Jun 3;10(1):2421. doi: 10.1038/s41467-019-10432-5.

9.

miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism.

Muys BR, Sousa JF, Plaça JR, de Araújo LF, Sarshad AA, Anastasakis DG, Wang X, Li XL, de Molfetta GA, Ramão A, Lal A, Vidal DO, Hafner M, Silva WA.

Cancer Res. 2019 Jul 1;79(13):3294-3305. doi: 10.1158/0008-5472.CAN-19-0490. Epub 2019 May 17.

PMID:
31101765
10.

A novel spheroid-based co-culture model mimics loss of keratinocyte differentiation, melanoma cell invasion, and drug-induced selection of ABCB5-expressing cells.

Klicks J, Maßlo C, Kluth A, Rudolf R, Hafner M.

BMC Cancer. 2019 Apr 29;19(1):402. doi: 10.1186/s12885-019-5606-4.

11.

Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries.

Moret N, Clark NA, Hafner M, Wang Y, Lounkine E, Medvedovic M, Wang J, Gray N, Jenkins J, Sorger PK.

Cell Chem Biol. 2019 May 16;26(5):765-777.e3. doi: 10.1016/j.chembiol.2019.02.018. Epub 2019 Apr 4.

12.

Quest for the best endoscopic imaging modality for computer-assisted colonic polyp staging.

Wimmer G, Gadermayr M, Wolkersdörfer G, Kwitt R, Tamaki T, Tischendorf J, Häfner M, Yoshida S, Tanaka S, Merhof D, Uhl A.

World J Gastroenterol. 2019 Mar 14;25(10):1197-1209. doi: 10.3748/wjg.v25.i10.1197.

13.

Bimodal Radiotherapy with Active Raster-Scanning Carbon Ion Radiotherapy and Intensity-Modulated Radiotherapy in High-Risk Nasopharyngeal Carcinoma Results in Excellent Local Control.

Akbaba S, Held T, Lang K, Forster T, Federspil P, Herfarth K, Häfner M, Plinkert P, Rieken S, Debus J, Adeberg S.

Cancers (Basel). 2019 Mar 17;11(3). pii: E379. doi: 10.3390/cancers11030379.

14.

A Novel Optical Tissue Clearing Protocol for Mouse Skeletal Muscle to Visualize Endplates in Their Tissue Context.

Williams MPI, Rigon M, Straka T, Hörner SJ, Thiel M, Gretz N, Hafner M, Reischl M, Rudolf R.

Front Cell Neurosci. 2019 Feb 27;13:49. doi: 10.3389/fncel.2019.00049. eCollection 2019.

15.

A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers.

Rao S, Du G, Hafner M, Subramanian K, Sorger PK, Gray NS.

J Biol Chem. 2019 May 24;294(21):8664-8673. doi: 10.1074/jbc.RA118.006805. Epub 2019 Mar 11.

16.

The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation.

Palangat M, Anastasakis DG, Fei DL, Lindblad KE, Bradley R, Hourigan CS, Hafner M, Larson DR.

Genes Dev. 2019 May 1;33(9-10):482-497. doi: 10.1101/gad.319590.118. Epub 2019 Mar 6.

PMID:
30842218
17.

Fisher encoding of convolutional neural network features for endoscopic image classification.

Wimmer G, Vécsei A, Häfner M, Uhl A.

J Med Imaging (Bellingham). 2018 Jul;5(3):034504. doi: 10.1117/1.JMI.5.3.034504. Epub 2018 Sep 24.

PMID:
30840751
18.

Bone Sialoprotein Shows Enhanced Expression in Early, High-Proliferation Stages of Three-Dimensional Spheroid Cell Cultures of Breast Cancer Cell Line MDA-MB-231.

Rustamov V, Keller F, Klicks J, Hafner M, Rudolf R.

Front Oncol. 2019 Feb 5;9:36. doi: 10.3389/fonc.2019.00036. eCollection 2019.

19.

Loss of genetic diversity, recovery and allele surfing in a colonizing parasite, Geomydoecus aurei.

Demastes JW, Hafner DJ, Hafner MS, Light JE, Spradling TA.

Mol Ecol. 2019 Feb;28(4):703-720. doi: 10.1111/mec.14997. Epub 2019 Feb 21.

PMID:
30589151
20.

Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis.

Li J, Wang X, Ackerman WE 4th, Batty AJ, Kirk SG, White WM, Wang X, Anastasakis D, Samavati L, Buhimschi I, Nelin LD, Hafner M, Liu Y.

Int J Mol Sci. 2018 Dec 6;19(12). pii: E3904. doi: 10.3390/ijms19123904.

21.

Positive results of patch tests with fragrance markers: analysis of a 15-year period at a Brazilian dermatology center.

Hafner MFS, Munhoz SDG, Jeldes AG, Lazzarini R.

An Bras Dermatol. 2018 Nov/Dec;93(6):910-912. doi: 10.1590/abd1806-4841.20187743.

22.

Proximity-CLIP provides a snapshot of protein-occupied RNA elements in subcellular compartments.

Benhalevy D, Anastasakis DG, Hafner M.

Nat Methods. 2018 Dec;15(12):1074-1082. doi: 10.1038/s41592-018-0220-y. Epub 2018 Nov 26.

23.

6mer seed toxicity in tumor suppressive microRNAs.

Gao QQ, Putzbach WE, Murmann AE, Chen S, Sarshad AA, Peter JM, Bartom ET, Hafner M, Peter ME.

Nat Commun. 2018 Oct 29;9(1):4504. doi: 10.1038/s41467-018-06526-1.

24.

CD95/Fas ligand mRNA is toxic to cells.

Putzbach W, Haluck-Kangas A, Gao QQ, Sarshad AA, Bartom ET, Stults A, Qadir AS, Hafner M, Peter ME.

Elife. 2018 Oct 16;7. pii: e38621. doi: 10.7554/eLife.38621.

25.

Allergic contact dermatitis to shoes: contribution of a specific series to the diagnosis.

Lazzarini R, Mendonça RF, Hafner MFS.

An Bras Dermatol. 2018 Sep-Oct;93(5):696-700. doi: 10.1590/abd1806-4841.20187370.

26.

Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells.

Sarshad AA, Juan AH, Muler AIC, Anastasakis DG, Wang X, Genzor P, Feng X, Tsai PF, Sun HW, Haase AD, Sartorelli V, Hafner M.

Mol Cell. 2018 Sep 20;71(6):1040-1050.e8. doi: 10.1016/j.molcel.2018.07.020. Epub 2018 Aug 23.

PMID:
30146314
27.

Human proteins that interact with RNA/DNA hybrids.

Wang IX, Grunseich C, Fox J, Burdick J, Zhu Z, Ravazian N, Hafner M, Cheung VG.

Genome Res. 2018 Sep;28(9):1405-1414. doi: 10.1101/gr.237362.118. Epub 2018 Aug 14.

28.

A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans.

Tsai PF, Dell'Orso S, Rodriguez J, Vivanco KO, Ko KD, Jiang K, Juan AH, Sarshad AA, Vian L, Tran M, Wangsa D, Wang AH, Perovanovic J, Anastasakis D, Ralston E, Ried T, Sun HW, Hafner M, Larson DR, Sartorelli V.

Mol Cell. 2018 Jul 5;71(1):129-141.e8. doi: 10.1016/j.molcel.2018.06.008.

29.

Postnatal Development and Distribution of Sympathetic Innervation in Mouse Skeletal Muscle.

Straka T, Vita V, Prokshi K, Hörner SJ, Khan MM, Pirazzini M, Williams MPI, Hafner M, Zaglia T, Rudolf R.

Int J Mol Sci. 2018 Jul 1;19(7). pii: E1935. doi: 10.3390/ijms19071935.

30.

Evaluation of the presence of allergens in children's products available for sale in a big city.

Lazzarini R, Hafner MFS, Rangel MG.

An Bras Dermatol. 2018 Jun;93(3):457-459. doi: 10.1590/abd1806-4841.20187111.

31.

Training of polyp staging systems using mixed imaging modalities.

Wimmer G, Gadermayr M, Kwitt R, Häfner M, Tamaki T, Yoshida S, Tanaka S, Merhof D, Uhl A.

Comput Biol Med. 2018 Nov 1;102:251-259. doi: 10.1016/j.compbiomed.2018.05.003. Epub 2018 May 4.

PMID:
29773226
32.

Improving Fluid Management in Critical Care - Towards the ICU of the Future.

Bergmoser K, Pflanzl-Knizacek L, Hafner M, Schilcher G, Baumgartner C.

Stud Health Technol Inform. 2018;248:47-54.

PMID:
29726418
33.

ONC201 kills breast cancer cells in vitro by targeting mitochondria.

Greer YE, Porat-Shliom N, Nagashima K, Stuelten C, Crooks D, Koparde VN, Gilbert SF, Islam C, Ubaldini A, Ji Y, Gattinoni L, Soheilian F, Wang X, Hafner M, Shetty J, Tran B, Jailwala P, Cam M, Lang M, Voeller D, Reinhold WC, Rajapakse V, Pommier Y, Weigert R, Linehan WM, Lipkowitz S.

Oncotarget. 2018 Apr 6;9(26):18454-18479. doi: 10.18632/oncotarget.24862. eCollection 2018 Apr 6.

34.

Evaluation of nickel and cobalt release from mobile phone devices used in Brazil.

Hafner MFS, Chen JCS, Lazzarini R.

An Bras Dermatol. 2018 Jan-Feb;93(1):151-153. doi: 10.1590/abd1806-4841.20186800.

35.

Nickel, chromium and cobalt: the relevant allergens in allergic contact dermatitis. Comparative study between two periods: 1995-2002 and 2003-2015.

Duarte I, Mendonça RF, Korkes KL, Lazzarini R, Hafner MFS.

An Bras Dermatol. 2018 Jan-Feb;93(1):59-62. doi: 10.1590/abd1806-4841.20186047.

36.

Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability.

Min KW, Zealy RW, Davila S, Fomin M, Cummings JC, Makowsky D, Mcdowell CH, Thigpen H, Hafner M, Kwon SH, Georgescu C, Wren JD, Yoon JH.

Aging Cell. 2018 Jun;17(3):e12753. doi: 10.1111/acel.12753. Epub 2018 Mar 23.

37.

Analyses of Synthetic N-Acyl Dopamine Derivatives Revealing Different Structural Requirements for Their Anti-inflammatory and Transient-Receptor-Potential-Channel-of-the-Vanilloid-Receptor-Subfamily-Subtype-1 (TRPV1)-Activating Properties.

Pallavi P, Pretze M, Caballero J, Li Y, Hofmann BB, Stamellou E, Klotz S, Wängler C, Wängler B, Loesel R, Roth S, Theisinger B, Moerz H, Binzen U, Greffrath W, Treede RD, Harmsen MC, Krämer BK, Hafner M, Yard BA, Kälsch AI.

J Med Chem. 2018 Apr 12;61(7):3126-3137. doi: 10.1021/acs.jmedchem.8b00156. Epub 2018 Apr 2.

PMID:
29543451
38.

Active pump-seed-pulse synchronization for OPCPA with sub-2-fs residual timing jitter: erratum.

Prinz S, Häfner M, Schultze M, Teisset CY, Bessing R, Michel K, Kienberger R, Metzger T.

Opt Express. 2018 Mar 5;26(5):5512-5513. doi: 10.1364/OE.26.005512.

PMID:
29529754
39.

Modeling and simulation of protein elution in linear pH and salt gradients on weak, strong and mixed cation exchange resins applying an extended Donnan ion exchange model.

Wittkopp F, Peeck L, Hafner M, Frech C.

J Chromatogr A. 2018 Apr 13;1545:32-47. doi: 10.1016/j.chroma.2018.02.020. Epub 2018 Feb 12.

PMID:
29525127
40.

Allergic contact dermatitis caused by topical ketoconazole: a relevant issue? Review of ketoconazole-positive patch tests.

Lazzarini R, Hafner MFS, Miguel BAF, Kawakami NT, Nakagome BHY.

Contact Dermatitis. 2018 Mar;78(3):234-236. doi: 10.1111/cod.12919. No abstract available.

PMID:
29430708
41.

Thin-disk pumped optical parametric chirped pulse amplifier delivering CEP-stable multi-mJ few-cycle pulses at 6 kHz.

Prinz S, Schnitzenbaumer M, Potamianos D, Schultze M, Stark S, Häfner M, Teisset CY, Wandt C, Michel K, Kienberger R, Bernhardt B, Metzger T.

Opt Express. 2018 Jan 22;26(2):1108-1124. doi: 10.1364/OE.26.001108.

PMID:
29401989
42.

Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors.

Giannelou A, Wang H, Zhou Q, Park YH, Abu-Asab MS, Ylaya K, Stone DL, Sediva A, Sleiman R, Sramkova L, Bhatla D, Serti E, Tsai WL, Yang D, Bishop K, Carrington B, Pei W, Deuitch N, Brooks S, Edwan JH, Joshi S, Prader S, Kaiser D, Owen WC, Sonbul AA, Zhang Y, Niemela JE, Burgess SM, Boehm M, Rehermann B, Chae J, Quezado MM, Ombrello AK, Buckley RH, Grom AA, Remmers EF, Pachlopnik JM, Su HC, Gutierrez-Cruz G, Hewitt SM, Sood R, Risma K, Calvo KR, Rosenzweig SD, Gadina M, Hafner M, Sun HW, Kastner DL, Aksentijevich I.

Ann Rheum Dis. 2018 Apr;77(4):612-619. doi: 10.1136/annrheumdis-2017-212401. Epub 2018 Jan 22.

43.

Screening and detection of delirium in older ED patients: performance of the modified Confusion Assessment Method for the Emergency Department (mCAM-ED). A two-step tool.

Hasemann W, Grossmann FF, Stadler R, Bingisser R, Breil D, Hafner M, Kressig RW, Nickel CH.

Intern Emerg Med. 2018 Sep;13(6):915-922. doi: 10.1007/s11739-017-1781-y. Epub 2017 Dec 30.

PMID:
29290048
44.

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.

Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, Lachmann A, Kuleshov MV, Ma'ayan A, Stathias V, Terryn R, Cooper D, Forlin M, Koleti A, Vidovic D, Chung C, Schürer SC, Vasiliauskas J, Pilarczyk M, Shamsaei B, Fazel M, Ren Y, Niu W, Clark NA, White S, Mahi N, Zhang L, Kouril M, Reichard JF, Sivaganesan S, Medvedovic M, Meller J, Koch RJ, Birtwistle MR, Iyengar R, Sobie EA, Azeloglu EU, Kaye J, Osterloh J, Haston K, Kalra J, Finkbiener S, Li J, Milani P, Adam M, Escalante-Chong R, Sachs K, Lenail A, Ramamoorthy D, Fraenkel E, Daigle G, Hussain U, Coye A, Rothstein J, Sareen D, Ornelas L, Banuelos M, Mandefro B, Ho R, Svendsen CN, Lim RG, Stocksdale J, Casale MS, Thompson TG, Wu J, Thompson LM, Dardov V, Venkatraman V, Matlock A, Van Eyk JE, Jaffe JD, Papanastasiou M, Subramanian A, Golub TR, Erickson SD, Fallahi-Sichani M, Hafner M, Gray NS, Lin JR, Mills CE, Muhlich JL, Niepel M, Shamu CE, Williams EH, Wrobel D, Sorger PK, Heiser LM, Gray JW, Korkola JE, Mills GB, LaBarge M, Feiler HS, Dane MA, Bucher E, Nederlof M, Sudar D, Gross S, Kilburn DF, Smith R, Devlin K, Margolis R, Derr L, Lee A, Pillai A.

Cell Syst. 2018 Jan 24;6(1):13-24. doi: 10.1016/j.cels.2017.11.001. Epub 2017 Nov 29. Review.

45.

Allergy to hypoallergenic nail polish: does this exist?

Lazzarini R, Hafner MFS, Lopes ASA, Oliari CB.

An Bras Dermatol. 2017 May-Jun;92(3):421-422. doi: 10.1590/abd1806-4841.20175889.

46.

Nickel exposure from keys: a Brazilian issue.

Suzuki NM, Duarte IAG, Hafner MFS, Lazzarini R.

An Bras Dermatol. 2017 Sep-Oct;92(5):734-735. doi: 10.1590/abd1806-4841.20175754.

47.

The economic implications of later school start times in the United States.

Hafner M, Stepanek M, Troxel WM.

Sleep Health. 2017 Dec;3(6):451-457. doi: 10.1016/j.sleh.2017.08.007. Epub 2017 Oct 10.

PMID:
29157639
48.

Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics.

Hafner M, Heiser LM, Williams EH, Niepel M, Wang NJ, Korkola JE, Gray JW, Sorger PK.

Sci Data. 2017 Nov 7;4:170166. doi: 10.1038/sdata.2017.166.

49.

Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling.

Niepel M, Hafner M, Duan Q, Wang Z, Paull EO, Chung M, Lu X, Stuart JM, Golub TR, Subramanian A, Ma'ayan A, Sorger PK.

Nat Commun. 2017 Oct 30;8(1):1186. doi: 10.1038/s41467-017-01383-w.

50.

GRcalculator: an online tool for calculating and mining dose-response data.

Clark NA, Hafner M, Kouril M, Williams EH, Muhlich JL, Pilarczyk M, Niepel M, Sorger PK, Medvedovic M.

BMC Cancer. 2017 Oct 24;17(1):698. doi: 10.1186/s12885-017-3689-3.

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