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Items: 1 to 50 of 390

1.

TIGIT signaling restores suppressor function of Th1 Tregs.

Lucca LE, Axisa PP, Singer ER, Nolan NM, Dominguez-Villar M, Hafler DA.

JCI Insight. 2019 Feb 7;4(3). pii: 124427. doi: 10.1172/jci.insight.124427. [Epub ahead of print]

2.

Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis.

Ponath G, Lincoln MR, Levine-Ritterman M, Park C, Dahlawi S, Mubarak M, Sumida T, Airas L, Zhang S, Isitan C, Nguyen TD, Raine CS, Hafler DA, Pitt D.

Nat Commun. 2018 Dec 17;9(1):5337. doi: 10.1038/s41467-018-07785-8.

3.

Correction: Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting.

Murray C, Miwa H, Dhar M, Park DE, Pao E, Martinez J, Kaanumale S, Loghin E, Graf J, Raddassi K, Kwok WW, Hafler D, Puleo C, Di Carlo D.

Lab Chip. 2018 Dec 7;18(23):3703. doi: 10.1039/c8lc90095g. Epub 2018 Nov 13.

PMID:
30420988
4.

Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity.

Sumida T, Lincoln MR, Ukeje CM, Rodriguez DM, Akazawa H, Noda T, Naito AT, Komuro I, Dominguez-Villar M, Hafler DA.

Nat Immunol. 2018 Dec;19(12):1391-1402. doi: 10.1038/s41590-018-0236-6. Epub 2018 Oct 29.

PMID:
30374130
5.

Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV.

Farhadian SF, Mehta SS, Zografou C, Robertson K, Price RW, Pappalardo J, Chiarella J, Hafler DA, Spudich SS.

JCI Insight. 2018 Sep 20;3(18). pii: 121718. doi: 10.1172/jci.insight.121718. [Epub ahead of print]

6.

Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo.

Dominguez-Villar M, Raddassi K, Danielsen AC, Guarnaccia J, Hafler DA.

J Autoimmun. 2019 Jan;96:40-49. doi: 10.1016/j.jaut.2018.08.002. Epub 2018 Aug 16.

PMID:
30122421
7.

Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting.

Murray C, Miwa H, Dhar M, Park DE, Pao E, Martinez J, Kaanumale S, Loghin E, Graf J, Raddassi K, Kwok WW, Hafler D, Puleo C, Di Carlo D.

Lab Chip. 2018 Aug 7;18(16):2396-2409. doi: 10.1039/c8lc00518d. Erratum in: Lab Chip. 2018 Nov 13;:.

PMID:
30039125
8.

Regulatory T cells in autoimmune disease.

Dominguez-Villar M, Hafler DA.

Nat Immunol. 2018 Jul;19(7):665-673. doi: 10.1038/s41590-018-0120-4. Epub 2018 Jun 20. Review.

PMID:
29925983
9.

Multiple sclerosis.

Cotsapas C, Mitrovic M, Hafler D.

Handb Clin Neurol. 2018;148:723-730. doi: 10.1016/B978-0-444-64076-5.00046-6. Review.

PMID:
29478610
10.

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.

Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P.

Front Immunol. 2018 Jan 15;8:1844. doi: 10.3389/fimmu.2017.01844. eCollection 2017.

11.

Regulatory T Cells: From Discovery to Autoimmunity.

Kitz A, Singer E, Hafler D.

Cold Spring Harb Perspect Med. 2018 Dec 3;8(12). pii: a029041. doi: 10.1101/cshperspect.a029041. Review.

PMID:
29311129
12.

Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme.

Goods BA, Hernandez AL, Lowther DE, Lucca LE, Lerner BA, Gunel M, Raddassi K, Coric V, Hafler DA, Love JC.

PLoS One. 2017 Sep 7;12(9):e0181538. doi: 10.1371/journal.pone.0181538. eCollection 2017.

13.

Podoplanin is a negative regulator of Th17 inflammation.

Nylander AN, Ponath GD, Axisa PP, Mubarak M, Tomayko M, Kuchroo VK, Pitt D, Hafler DA.

JCI Insight. 2017 Sep 7;2(17). pii: 92321. doi: 10.1172/jci.insight.92321. [Epub ahead of print]

14.

Resisting fatal attraction: a glioma oncometabolite prevents CD8+ T cell recruitment.

Lucca LE, Hafler DA.

J Clin Invest. 2017 Apr 3;127(4):1218-1220. doi: 10.1172/JCI93565. Epub 2017 Mar 20.

15.

Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma.

Lucca LE, Hafler DA.

Immunol Rev. 2017 Mar;276(1):9-25. doi: 10.1111/imr.12529. Review.

16.

Solving Immunology?

Vodovotz Y, Xia A, Read EL, Bassaganya-Riera J, Hafler DA, Sontag E, Wang J, Tsang JS, Day JD, Kleinstein SH, Butte AJ, Altman MC, Hammond R, Sealfon SC.

Trends Immunol. 2017 Feb;38(2):116-127. doi: 10.1016/j.it.2016.11.006. Epub 2016 Dec 13. Review.

17.

TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage.

Taylor RA, Chang CF, Goods BA, Hammond MD, Mac Grory B, Ai Y, Steinschneider AF, Renfroe SC, Askenase MH, McCullough LD, Kasner SE, Mullen MT, Hafler DA, Love JC, Sansing LH.

J Clin Invest. 2017 Jan 3;127(1):280-292. doi: 10.1172/JCI88647. Epub 2016 Nov 28.

18.

The Human Functional Genomics Project: Understanding Generation of Diversity.

Pappalardo JL, Hafler DA.

Cell. 2016 Nov 3;167(4):894-896. doi: 10.1016/j.cell.2016.10.040.

19.

National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness: Building on the Current Scientific Evidence.

Oh YS, Appel LJ, Galis ZS, Hafler DA, He J, Hernandez AL, Joe B, Karumanchi SA, Maric-Bilkan C, Mattson D, Mehta NN, Randolph G, Ryan M, Sandberg K, Titze J, Tolunay E, Toney GM, Harrison DG.

Hypertension. 2016 Aug;68(2):281-8. doi: 10.1161/HYPERTENSIONAHA.116.07415. Epub 2016 Jun 20. Review. No abstract available.

20.

AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease.

Kitz A, de Marcken M, Gautron AS, Mitrovic M, Hafler DA, Dominguez-Villar M.

EMBO Rep. 2016 Aug;17(8):1169-83. doi: 10.15252/embr.201541905. Epub 2016 Jun 16.

21.

Linking Genotype to Clinical Phenotype in Multiple Sclerosis: In Search of the Holy Grail.

Longbrake EE, Hafler DA.

JAMA Neurol. 2016 Jul 1;73(7):777-8. doi: 10.1001/jamaneurol.2016.1227. No abstract available.

22.

Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells.

Arterbery AS, Osafo-Addo A, Avitzur Y, Ciarleglio M, Deng Y, Lobritto SJ, Martinez M, Hafler DA, Kleinewietfeld M, Ekong UD.

J Immunol. 2016 May 15;196(10):4040-51. doi: 10.4049/jimmunol.1502276. Epub 2016 Apr 18.

23.

PD-1 marks dysfunctional regulatory T cells in malignant gliomas.

Lowther DE, Goods BA, Lucca LE, Lerner BA, Raddassi K, van Dijk D, Hernandez AL, Duan X, Gunel M, Coric V, Krishnaswamy S, Love JC, Hafler DA.

JCI Insight. 2016 Apr 21;1(5). pii: e85935.

24.

Evaluation of KIR4.1 as an Immune Target in Multiple Sclerosis.

Chastre A, Hafler DA, O'Connor KC.

N Engl J Med. 2016 Apr 14;374(15):1495-6. doi: 10.1056/NEJMc1513302. No abstract available.

25.

Multiple sclerosis: genetics, biomarkers, treatments.

Axisa PP, Hafler DA.

Curr Opin Neurol. 2016 Jun;29(3):345-53. doi: 10.1097/WCO.0000000000000319. Review.

PMID:
27058221
26.

Power estimation for non-standardized multisite studies.

Keshavan A, Paul F, Beyer MK, Zhu AH, Papinutto N, Shinohara RT, Stern W, Amann M, Bakshi R, Bischof A, Carriero A, Comabella M, Crane JC, D'Alfonso S, Demaerel P, Dubois B, Filippi M, Fleischer V, Fontaine B, Gaetano L, Goris A, Graetz C, Gröger A, Groppa S, Hafler DA, Harbo HF, Hemmer B, Jordan K, Kappos L, Kirkish G, Llufriu S, Magon S, Martinelli-Boneschi F, McCauley JL, Montalban X, Mühlau M, Pelletier D, Pattany PM, Pericak-Vance M, Cournu-Rebeix I, Rocca MA, Rovira A, Schlaeger R, Saiz A, Sprenger T, Stecco A, Uitdehaag BMJ, Villoslada P, Wattjes MP, Weiner H, Wuerfel J, Zimmer C, Zipp F; International Multiple Sclerosis Genetics Consortium. Electronic address: AIVINSON@PARTNERS.ORG, Hauser SL, Oksenberg JR, Henry RG.

Neuroimage. 2016 Jul 1;134:281-294. doi: 10.1016/j.neuroimage.2016.03.051. Epub 2016 Apr 1.

27.

CNS demyelination and enhanced myelin-reactive responses after ipilimumab treatment.

Cao Y, Nylander A, Ramanan S, Goods BA, Ponath G, Zabad R, Chiang VL, Vortmeyer AO, Hafler DA, Pitt D.

Neurology. 2016 Apr 19;86(16):1553-6. doi: 10.1212/WNL.0000000000002594. Epub 2016 Mar 16. No abstract available.

28.

The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations.

Kofler DM, Farkas A, von Bergwelt-Baildon M, Hafler DA.

Curr Drug Targets. 2016;17(6):651-65. Review.

PMID:
26844569
29.

Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived Immunoglobulins.

Willis SN, Stathopoulos P, Chastre A, Compton SD, Hafler DA, O'Connor KC.

Front Immunol. 2015 Nov 25;6:600. doi: 10.3389/fimmu.2015.00600. eCollection 2015.

30.

Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.

Hernandez AL, Kitz A, Wu C, Lowther DE, Rodriguez DM, Vudattu N, Deng S, Herold KC, Kuchroo VK, Kleinewietfeld M, Hafler DA.

J Clin Invest. 2015 Nov 2;125(11):4212-22. doi: 10.1172/JCI81151. Epub 2015 Oct 20.

31.

Class II HLA interactions modulate genetic risk for multiple sclerosis.

Moutsianas L, Jostins L, Beecham AH, Dilthey AT, Xifara DK, Ban M, Shah TS, Patsopoulos NA, Alfredsson L, Anderson CA, Attfield KE, Baranzini SE, Barrett J, Binder TMC, Booth D, Buck D, Celius EG, Cotsapas C, D'Alfonso S, Dendrou CA, Donnelly P, Dubois B, Fontaine B, Fugger L, Goris A, Gourraud PA, Graetz C, Hemmer B, Hillert J; International IBD Genetics Consortium (IIBDGC), Kockum I, Leslie S, Lill CM, Martinelli-Boneschi F, Oksenberg JR, Olsson T, Oturai A, Saarela J, Søndergaard HB, Spurkland A, Taylor B, Winkelmann J, Zipp F, Haines JL, Pericak-Vance MA, Spencer CCA, Stewart G, Hafler DA, Ivinson AJ, Harbo HF, Hauser SL, De Jager PL, Compston A, McCauley JL, Sawcer S, McVean G.

Nat Genet. 2015 Oct;47(10):1107-1113. doi: 10.1038/ng.3395. Epub 2015 Sep 7.

32.

Prospects of immune checkpoint modulators in the treatment of glioblastoma.

Preusser M, Lim M, Hafler DA, Reardon DA, Sampson JH.

Nat Rev Neurol. 2015 Sep;11(9):504-14. doi: 10.1038/nrneurol.2015.139. Epub 2015 Aug 11. Review.

33.

Sodium-activated macrophages: the salt mine expands.

Lucca LE, Hafler DA.

Cell Res. 2015 Aug;25(8):885-6. doi: 10.1038/cr.2015.91. Epub 2015 Jul 28.

34.

Biomarkers in multiple sclerosis.

Housley WJ, Pitt D, Hafler DA.

Clin Immunol. 2015 Nov;161(1):51-8. doi: 10.1016/j.clim.2015.06.015. Epub 2015 Jul 2. Review.

PMID:
26143623
35.

Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli.

Housley WJ, Fernandez SD, Vera K, Murikinati SR, Grutzendler J, Cuerdon N, Glick L, De Jager PL, Mitrovic M, Cotsapas C, Hafler DA.

Sci Transl Med. 2015 Jun 10;7(291):291ra93. doi: 10.1126/scitranslmed.aaa9223.

36.

Genetic basis of autoimmunity.

Marson A, Housley WJ, Hafler DA.

J Clin Invest. 2015 Jun;125(6):2234-41. doi: 10.1172/JCI78086. Epub 2015 Jun 1. Review.

37.

Editorial: T cell regulation by the environment.

Hafler DA, Astier AL.

Front Immunol. 2015 May 13;6:229. doi: 10.3389/fimmu.2015.00229. eCollection 2015. No abstract available.

38.

Thymic selection: to thine own self be true.

Kitz A, Hafler DA.

Immunity. 2015 May 19;42(5):788-9. doi: 10.1016/j.immuni.2015.05.007.

39.

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis.

Cao Y, Goods BA, Raddassi K, Nepom GT, Kwok WW, Love JC, Hafler DA.

Sci Transl Med. 2015 May 13;7(287):287ra74. doi: 10.1126/scitranslmed.aaa8038.

40.

Corrigendum: multiple sclerosis-a quiet revolution.

Ransohoff RM, Hafler DA, Lucchinetti CF.

Nat Rev Neurol. 2015 May;11(5):246. doi: 10.1038/nrneurol.2015.49. Epub 2015 Mar 24. No abstract available.

PMID:
25799926
41.

Multiple sclerosis-a quiet revolution.

Ransohoff RM, Hafler DA, Lucchinetti CF.

Nat Rev Neurol. 2015 Mar;11(3):134-42. doi: 10.1038/nrneurol.2015.14. Epub 2015 Feb 17. Review. Erratum in: Nat Rev Neurol. 2015 May;11(5):246.

42.

Monoallelic expression of the human FOXP2 speech gene.

Adegbola AA, Cox GF, Bradshaw EM, Hafler DA, Gimelbrant A, Chess A.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6848-54. doi: 10.1073/pnas.1411270111. Epub 2014 Nov 24.

43.

TLR7 induces anergy in human CD4(+) T cells.

Dominguez-Villar M, Gautron AS, de Marcken M, Keller MJ, Hafler DA.

Nat Immunol. 2015 Jan;16(1):118-28. doi: 10.1038/ni.3036. Epub 2014 Nov 17.

44.

Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults.

Mohanty S, Joshi SR, Ueda I, Wilson J, Blevins TP, Siconolfi B, Meng H, Devine L, Raddassi K, Tsang S, Belshe RB, Hafler DA, Kaech SM, Kleinstein SH, Trentalange M, Allore HG, Shaw AC.

J Infect Dis. 2015 Apr 1;211(7):1174-84. doi: 10.1093/infdis/jiu573. Epub 2014 Nov 2.

45.

Genetic and epigenetic fine mapping of causal autoimmune disease variants.

Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE.

Nature. 2015 Feb 19;518(7539):337-43. doi: 10.1038/nature13835. Epub 2014 Oct 29.

46.

Systems immunology reveals markers of susceptibility to West Nile virus infection.

Qian F, Goel G, Meng H, Wang X, You F, Devine L, Raddassi K, Garcia MN, Murray KO, Bolen CR, Gaujoux R, Shen-Orr SS, Hafler D, Fikrig E, Xavier R, Kleinstein SH, Montgomery RR.

Clin Vaccine Immunol. 2015 Jan;22(1):6-16. doi: 10.1128/CVI.00508-14. Epub 2014 Oct 29.

47.

B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes.

Stern JN, Yaari G, Vander Heiden JA, Church G, Donahue WF, Hintzen RQ, Huttner AJ, Laman JD, Nagra RM, Nylander A, Pitt D, Ramanan S, Siddiqui BA, Vigneault F, Kleinstein SH, Hafler DA, O'Connor KC.

Sci Transl Med. 2014 Aug 6;6(248):248ra107. doi: 10.1126/scitranslmed.3008879.

48.

Joint modeling and registration of cell populations in cohorts of high-dimensional flow cytometric data.

Pyne S, Lee SX, Wang K, Irish J, Tamayo P, Nazaire MD, Duong T, Ng SK, Hafler D, Levy R, Nolan GP, Mesirov J, McLachlan GJ.

PLoS One. 2014 Jul 1;9(7):e100334. doi: 10.1371/journal.pone.0100334. eCollection 2014.

49.

Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells.

Gautron AS, Dominguez-Villar M, de Marcken M, Hafler DA.

Eur J Immunol. 2014 Sep;44(9):2703-2711. doi: 10.1002/eji.201344392. Epub 2014 Jun 16.

50.

Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.

Kofler DM, Marson A, Dominguez-Villar M, Xiao S, Kuchroo VK, Hafler DA.

J Clin Invest. 2014 Jun;124(6):2513-22. doi: 10.1172/JCI72973. Epub 2014 May 8.

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