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Items: 1 to 50 of 103

1.

CADASIL brain vessels show a HTRA1 loss-of-function profile.

Zellner A, Scharrer E, Arzberger T, Oka C, Domenga-Denier V, Joutel A, Lichtenthaler SF, Müller SA, Dichgans M, Haffner C.

Acta Neuropathol. 2018 Jul;136(1):111-125. doi: 10.1007/s00401-018-1853-8. Epub 2018 May 3.

PMID:
29725820
2.

Low-loss plasmon-assisted electro-optic modulator.

Haffner C, Chelladurai D, Fedoryshyn Y, Josten A, Baeuerle B, Heni W, Watanabe T, Cui T, Cheng B, Saha S, Elder DL, Dalton LR, Boltasseva A, Shalaev VM, Kinsey N, Leuthold J.

Nature. 2018 Apr;556(7702):483-486. doi: 10.1038/s41586-018-0031-4. Epub 2018 Apr 25.

PMID:
29695845
3.

2,4-Diamino-8-quinazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationships.

Deaton DN, Haffner CD, Henke BR, Jeune MR, Shearer BG, Stewart EL, Stuart JD, Ulrich JC.

Bioorg Med Chem. 2018 May 1;26(8):2107-2150. doi: 10.1016/j.bmc.2018.03.021. Epub 2018 Mar 15.

PMID:
29576271
4.

Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke.

Roth S, Singh V, Tiedt S, Schindler L, Huber G, Geerlof A, Antoine DJ, Anfray A, Orset C, Gauberti M, Fournier A, Holdt LM, Harris HE, Engelhardt B, Bianchi ME, Vivien D, Haffner C, Bernhagen J, Dichgans M, Liesz A.

Sci Transl Med. 2018 Mar 14;10(432). pii: eaao1313. doi: 10.1126/scitranslmed.aao1313.

PMID:
29540615
5.

Nonlinearities of organic electro-optic materials in nanoscale slots and implications for the optimum modulator design.

Heni W, Haffner C, Elder DL, Tillack AF, Fedoryshyn Y, Cottier R, Salamin Y, Hoessbacher C, Koch U, Cheng B, Robinson B, Dalton LR, Leuthold J.

Opt Express. 2017 Feb 6;25(3):2627-2653. doi: 10.1364/OE.25.002627.

PMID:
29519106
6.

Plasmonic modulator with >170 GHz bandwidth demonstrated at 100 GBd NRZ.

Hoessbacher C, Josten A, Baeuerle B, Fedoryshyn Y, Hettrich H, Salamin Y, Heni W, Haffner C, Kaiser C, Schmid R, Elder DL, Hillerkuss D, Möller M, Dalton LR, Leuthold J.

Opt Express. 2017 Feb 6;25(3):1762-1768. doi: 10.1364/OE.25.001762.

PMID:
29519029
7.

Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7.

Tavano S, Taverna E, Kalebic N, Haffner C, Namba T, Dahl A, Wilsch-Bräuninger M, Paridaen JTML, Huttner WB.

Neuron. 2018 Mar 21;97(6):1299-1314.e8. doi: 10.1016/j.neuron.2018.01.052. Epub 2018 Mar 1.

PMID:
29503187
8.

High-speed plasmonic modulator in a single metal layer.

Ayata M, Fedoryshyn Y, Heni W, Baeuerle B, Josten A, Zahner M, Koch U, Salamin Y, Hoessbacher C, Haffner C, Elder DL, Dalton LR, Leuthold J.

Science. 2017 Nov 3;358(6363):630-632. doi: 10.1126/science.aan5953.

PMID:
29097545
9.

Epigenome profiling and editing of neocortical progenitor cells during development.

Albert M, Kalebic N, Florio M, Lakshmanaperumal N, Haffner C, Brandl H, Henry I, Huttner WB.

EMBO J. 2017 Sep 1;36(17):2642-2658. doi: 10.15252/embj.201796764. Epub 2017 Aug 1.

10.

The choroid plexus is a key cerebral invasion route for T cells after stroke.

Llovera G, Benakis C, Enzmann G, Cai R, Arzberger T, Ghasemigharagoz A, Mao X, Malik R, Lazarevic I, Liebscher S, Ertürk A, Meissner L, Vivien D, Haffner C, Plesnila N, Montaner J, Engelhardt B, Liesz A.

Acta Neuropathol. 2017 Dec;134(6):851-868. doi: 10.1007/s00401-017-1758-y. Epub 2017 Jul 31.

PMID:
28762187
11.

A Novel Biomarker Panel to Identify Steroid Resistance in Childhood Idiopathic Nephrotic Syndrome.

Bennett MR, Pleasant L, Haffner C, Ma Q, Haffey WD, Ying J, Wagner M, Greis KD, Devarajan P.

Biomark Insights. 2017 Mar 8;12:1177271917695832. doi: 10.1177/1177271917695832. eCollection 2017.

12.

Plasmonic phased array feeder enabling ultra-fast beam steering at millimeter waves.

Bonjour R, Burla M, Abrecht FC, Welschen S, Hoessbacher C, Heni W, Gebrewold SA, Baeuerle B, Josten A, Salamin Y, Haffner C, Johnston PV, Elder DL, Leuchtmann P, Hillerkuss D, Fedoryshyn Y, Dalton LR, Hafner C, Leuthold J.

Opt Express. 2016 Oct 31;24(22):25608-25618. doi: 10.1364/OE.24.025608.

PMID:
27828496
13.

CADASIL, CARASIL, CARASAL: The linguistic subtleties of cerebral small vessel disease.

Haffner C, Vinters HV.

Neurology. 2016 Oct 25;87(17):1752-1753. Epub 2016 Sep 24. No abstract available.

PMID:
27664986
14.

Urinary kidney injury biomarkers and tobramycin clearance among children and young adults with cystic fibrosis: a population pharmacokinetic analysis.

Downes KJ, Dong M, Fukuda T, Clancy JP, Haffner C, Bennett MR, Vinks AA, Goldstein SL.

J Antimicrob Chemother. 2017 Jan;72(1):254-260. Epub 2016 Sep 1.

15.

Novel urinary tubular injury markers reveal an evidence of underlying kidney injury in children with reduced left ventricular systolic function: a pilot study.

Kaddourah A, Goldstein SL, Basu R, Nehus EJ, Terrell TC, Brunner L, Bennett MR, Haffner C, Jefferies JL.

Pediatr Nephrol. 2016 Oct;31(10):1637-45. doi: 10.1007/s00467-016-3360-2. Epub 2016 May 2.

16.

Therapeutic NOTCH3 cysteine correction in CADASIL using exon skipping: in vitro proof of concept.

Rutten JW, Dauwerse HG, Peters DJ, Goldfarb A, Venselaar H, Haffner C, van Ommen GJ, Aartsma-Rus AM, Lesnik Oberstein SA.

Brain. 2016 Apr;139(Pt 4):1123-35. doi: 10.1093/brain/aww011. Epub 2016 Feb 19.

PMID:
26912635
17.

Non-canonical features of the Golgi apparatus in bipolar epithelial neural stem cells.

Taverna E, Mora-Bermúdez F, Strzyz PJ, Florio M, Icha J, Haffner C, Norden C, Wilsch-Bräuninger M, Huttner WB.

Sci Rep. 2016 Feb 16;6:21206. doi: 10.1038/srep21206.

18.

Urinary Vitamin D-Binding Protein as a Biomarker of Steroid-Resistant Nephrotic Syndrome.

Bennett MR, Pordal A, Haffner C, Pleasant L, Ma Q, Devarajan P.

Biomark Insights. 2016 Jan 13;11:1-6. doi: 10.4137/BMI.S31633. eCollection 2016.

19.

Prospective validation of a novel renal activity index of lupus nephritis.

Gulati G, Bennett MR, Abulaban K, Song H, Zhang X, Ma Q, Brodsky SV, Nadasdy T, Haffner C, Wiley K, Ardoin SP, Devarajan P, Ying J, Rovin BH, Brunner HI.

Lupus. 2017 Aug;26(9):927-936. doi: 10.1177/0961203316684212. Epub 2016 Dec 19.

20.

High speed plasmonic modulator array enabling dense optical interconnect solutions.

Heni W, Hoessbacher C, Haffner C, Fedoryshyn Y, Baeuerle B, Josten A, Hillerkuss D, Salamin Y, Bonjour R, Melikyan A, Kohl M, Elder DL, Dalton LR, Hafner C, Leuthold J.

Opt Express. 2015 Nov 16;23(23):29746-57. doi: 10.1364/OE.23.029746.

PMID:
26698457
21.

Atomic Scale Plasmonic Switch.

Emboras A, Niegemann J, Ma P, Haffner C, Pedersen A, Luisier M, Hafner C, Schimmel T, Leuthold J.

Nano Lett. 2016 Jan 13;16(1):709-14. doi: 10.1021/acs.nanolett.5b04537. Epub 2015 Dec 29.

PMID:
26670551
22.

Direct Conversion of Free Space Millimeter Waves to Optical Domain by Plasmonic Modulator Antenna.

Salamin Y, Heni W, Haffner C, Fedoryshyn Y, Hoessbacher C, Bonjour R, Zahner M, Hillerkuss D, Leuchtmann P, Elder DL, Dalton LR, Hafner C, Leuthold J.

Nano Lett. 2015 Dec 9;15(12):8342-6. doi: 10.1021/acs.nanolett.5b04025. Epub 2015 Nov 19.

23.

Lipidome of midbody released from neural stem and progenitor cells during mammalian cortical neurogenesis.

Arai Y, Sampaio JL, Wilsch-Bräuninger M, Ettinger AW, Haffner C, Huttner WB.

Front Cell Neurosci. 2015 Aug 28;9:325. doi: 10.3389/fncel.2015.00325. eCollection 2015.

24.

Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility.

Chiang SH, Harrington WW, Luo G, Milliken NO, Ulrich JC, Chen J, Rajpal DK, Qian Y, Carpenter T, Murray R, Geske RS, Stimpson SA, Kramer HF, Haffner CD, Becherer JD, Preugschat F, Billin AN.

PLoS One. 2015 Aug 19;10(8):e0134927. doi: 10.1371/journal.pone.0134927. eCollection 2015.

25.

Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38.

Becherer JD, Boros EE, Carpenter TY, Cowan DJ, Deaton DN, Haffner CD, Jeune MR, Kaldor IW, Poole JC, Preugschat F, Rheault TR, Schulte CA, Shearer BG, Shearer TW, Shewchuk LM, Smalley TL Jr, Stewart EL, Stuart JD, Ulrich JC.

J Med Chem. 2015 Sep 10;58(17):7021-56. doi: 10.1021/acs.jmedchem.5b00992. Epub 2015 Aug 24.

PMID:
26267483
26.

Sustained Pax6 Expression Generates Primate-like Basal Radial Glia in Developing Mouse Neocortex.

Wong FK, Fei JF, Mora-Bermúdez F, Taverna E, Haffner C, Fu J, Anastassiadis K, Stewart AF, Huttner WB.

PLoS Biol. 2015 Aug 7;13(8):e1002217. doi: 10.1371/journal.pbio.1002217. eCollection 2015 Aug.

27.

Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease.

Verdura E, Hervé D, Scharrer E, Amador Mdel M, Guyant-Maréchal L, Philippi A, Corlobé A, Bergametti F, Gazal S, Prieto-Morin C, Beaufort N, Le Bail B, Viakhireva I, Dichgans M, Chabriat H, Haffner C, Tournier-Lasserve E.

Brain. 2015 Aug;138(Pt 8):2347-58. doi: 10.1093/brain/awv155. Epub 2015 Jun 10.

PMID:
26063658
28.

Long-term Stability of Urinary Biomarkers of Acute Kidney Injury in Children.

Schuh MP, Nehus E, Ma Q, Haffner C, Bennett M, Krawczeski CD, Devarajan P.

Am J Kidney Dis. 2016 Jan;67(1):56-61. doi: 10.1053/j.ajkd.2015.04.040. Epub 2015 May 29.

29.

Plasmonic-organic hybrid (POH) modulators for OOK and BPSK signaling at 40 Gbit/s.

Melikyan A, Koehnle K, Lauermann M, Palmer R, Koeber S, Muehlbrandt S, Schindler PC, Elder DL, Wolf S, Heni W, Haffner C, Fedoryshyn Y, Hillerkuss D, Sommer M, Dalton LR, Van Thourhout D, Freude W, Kohl M, Leuthold J, Koos C.

Opt Express. 2015 Apr 20;23(8):9938-46. doi: 10.1364/OE.23.009938.

PMID:
25969035
30.

A novel HTRA1 exon 2 mutation causes loss of protease activity in a Pakistani CARASIL patient.

Khaleeli Z, Jaunmuktane Z, Beaufort N, Houlden H, Haffner C, Brandner S, Dichgans M, Werring D.

J Neurol. 2015 May;262(5):1369-72. doi: 10.1007/s00415-015-7769-5. Epub 2015 May 10. No abstract available.

PMID:
25957642
31.

Response to Letter Regarding Article, "Cysteine-Sparing CADASIL Mutations in NOTCH3 Show Proaggregatory Properties In Vitro".

Wollenweber FA, Haffner C, Duering M.

Stroke. 2015 Jun;46(6):e154. doi: 10.1161/STROKEAHA.115.009473. Epub 2015 Apr 28. No abstract available.

PMID:
25922512
32.

Genetic factors in cerebral small vessel disease and their impact on stroke and dementia.

Haffner C, Malik R, Dichgans M.

J Cereb Blood Flow Metab. 2016 Jan;36(1):158-71. Review.

33.

Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors.

Haffner CD, Becherer JD, Boros EE, Cadilla R, Carpenter T, Cowan D, Deaton DN, Guo Y, Harrington W, Henke BR, Jeune MR, Kaldor I, Milliken N, Petrov KG, Preugschat F, Schulte C, Shearer BG, Shearer T, Smalley TL Jr, Stewart EL, Stuart JD, Ulrich JC.

J Med Chem. 2015 Apr 23;58(8):3548-71. doi: 10.1021/jm502009h. Epub 2015 Apr 10.

PMID:
25828863
34.

Reply to Liu et al.: Loss of TGF-β signaling in CARASIL pathogenesis.

Beaufort N, Scharrer E, Lux V, Ehrmann M, Haffner C, Dichgans M.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1694. doi: 10.1073/pnas.1501817112. Epub 2015 Mar 13. No abstract available.

35.

Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion.

Florio M, Albert M, Taverna E, Namba T, Brandl H, Lewitus E, Haffner C, Sykes A, Wong FK, Peters J, Guhr E, Klemroth S, Prüfer K, Kelso J, Naumann R, Nüsslein I, Dahl A, Lachmann R, Pääbo S, Huttner WB.

Science. 2015 Mar 27;347(6229):1465-70. doi: 10.1126/science.aaa1975. Epub 2015 Feb 26.

36.

Cysteine-sparing CADASIL mutations in NOTCH3 show proaggregatory properties in vitro.

Wollenweber FA, Hanecker P, Bayer-Karpinska A, Malik R, Bäzner H, Moreton F, Muir KW, Müller S, Giese A, Opherk C, Dichgans M, Haffner C, Duering M.

Stroke. 2015 Mar;46(3):786-92. doi: 10.1161/STROKEAHA.114.007472. Epub 2015 Jan 20.

PMID:
25604251
37.

Deficiency of the stroke relevant HDAC9 gene attenuates atherosclerosis in accord with allele-specific effects at 7p21.1.

Azghandi S, Prell C, van der Laan SW, Schneider M, Malik R, Berer K, Gerdes N, Pasterkamp G, Weber C, Haffner C, Dichgans M.

Stroke. 2015 Jan;46(1):197-202. doi: 10.1161/STROKEAHA.114.007213. Epub 2014 Nov 11.

PMID:
25388417
38.

Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling.

Beaufort N, Scharrer E, Kremmer E, Lux V, Ehrmann M, Huber R, Houlden H, Werring D, Haffner C, Dichgans M.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16496-501. doi: 10.1073/pnas.1418087111. Epub 2014 Nov 4.

39.

Pediatric reference ranges for acute kidney injury biomarkers.

Bennett MR, Nehus E, Haffner C, Ma Q, Devarajan P.

Pediatr Nephrol. 2015 Apr;30(4):677-85. doi: 10.1007/s00467-014-2989-y. Epub 2014 Oct 28.

40.

Sequestration of latent TGF-β binding protein 1 into CADASIL-related Notch3-ECD deposits.

Kast J, Hanecker P, Beaufort N, Giese A, Joutel A, Dichgans M, Opherk C, Haffner C.

Acta Neuropathol Commun. 2014 Aug 13;2:96. doi: 10.1186/s40478-014-0096-8.

41.

Microinjection of membrane-impermeable molecules into single neural stem cells in brain tissue.

Wong FK, Haffner C, Huttner WB, Taverna E.

Nat Protoc. 2014 May;9(5):1170-82. doi: 10.1038/nprot.2014.074. Epub 2014 Apr 24.

PMID:
24762784
42.

3' UTR-dependent, miR-92-mediated restriction of Tis21 expression maintains asymmetric neural stem cell division to ensure proper neocortex size.

Fei JF, Haffner C, Huttner WB.

Cell Rep. 2014 Apr 24;7(2):398-411. doi: 10.1016/j.celrep.2014.03.033. Epub 2014 Apr 13.

43.

Thrombosis of the left subclavian vein complicating SAPHO syndrome: a case report.

Sanges S, Ducoulombier V, Sivery B, Delhaye N, Haffner C, Houvenagel E.

Joint Bone Spine. 2014 Oct;81(5):460-1. doi: 10.1016/j.jbspin.2014.02.002. Epub 2014 Apr 2. No abstract available.

PMID:
24703398
44.

Urinary NGAL levels correlate with differential renal function in patients with ureteropelvic junction obstruction undergoing pyeloplasty.

Cost NG, Noh PH, Devarajan P, Ivancic V, Reddy PP, Minevich E, Bennett M, Haffner C, Schulte M, DeFoor WR Jr.

J Urol. 2013 Oct;190(4 Suppl):1462-7. doi: 10.1016/j.juro.2013.05.003. Epub 2013 Jun 20.

45.

A new approach to manipulate the fate of single neural stem cells in tissue.

Taverna E, Haffner C, Pepperkok R, Huttner WB.

Nat Neurosci. 2011 Dec 18;15(2):329-37. doi: 10.1038/nn.3008.

PMID:
22179113
46.

Co-aggregate formation of CADASIL-mutant NOTCH3: a single-particle analysis.

Duering M, Karpinska A, Rosner S, Hopfner F, Zechmeister M, Peters N, Kremmer E, Haffner C, Giese A, Dichgans M, Opherk C.

Hum Mol Genet. 2011 Aug 15;20(16):3256-65. doi: 10.1093/hmg/ddr237. Epub 2011 May 30.

PMID:
21628316
47.

Neural stem and progenitor cells shorten S-phase on commitment to neuron production.

Arai Y, Pulvers JN, Haffner C, Schilling B, Nüsslein I, Calegari F, Huttner WB.

Nat Commun. 2011 Jan 11;2:154.

48.

Substituted N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 ion channel blockers. Part 2.

Haffner CD, Thomson SA, Guo Y, Petrov K, Larkin A, Banker P, Schaaf G, Dickerson S, Gobel J, Gillie D, Condreay JP, Poole C, Carpenter T, Ulrich J.

Bioorg Med Chem Lett. 2010 Dec 1;20(23):6989-92. doi: 10.1016/j.bmcl.2010.09.131. Epub 2010 Oct 23.

PMID:
20974533
49.

N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 inhibitors. Part 1.

Haffner CD, Thomson SA, Guo Y, Schaller LT, Boggs S, Dickerson S, Gobel J, Gillie D, Condreay JP.

Bioorg Med Chem Lett. 2010 Dec 1;20(23):6983-8. doi: 10.1016/j.bmcl.2010.09.132. Epub 2010 Oct 7.

PMID:
20971642
50.

Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex.

Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Krüger M, Kremmer E, Haass C, Haffner C.

J Biol Chem. 2010 Aug 20;285(34):26174-81. doi: 10.1074/jbc.M110.132548. Epub 2010 Jun 10.

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