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Items: 46


An Overview of MicroRNAs as Biomarkers of ALS.

Joilin G, Leigh PN, Newbury SF, Hafezparast M.

Front Neurol. 2019 Mar 7;10:186. doi: 10.3389/fneur.2019.00186. eCollection 2019. Review.


FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress.

Martinez-Macias MI, Moore DA, Green RL, Gomez-Herreros F, Naumann M, Hermann A, Van Damme P, Hafezparast M, Caldecott KW.

Life Sci Alliance. 2019 Feb 26;2(2). pii: e201800222. doi: 10.26508/lsa.201800222. Print 2019 Apr.


A mathematical understanding of how cytoplasmic dynein walks on microtubules.

Trott L, Hafezparast M, Madzvamuse A.

R Soc Open Sci. 2018 Aug 8;5(8):171568. doi: 10.1098/rsos.171568. eCollection 2018 Aug.


Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.

Chiang SC, Meagher M, Kassouf N, Hafezparast M, McKinnon PJ, Haywood R, El-Khamisy SF.

Sci Adv. 2017 Apr 28;3(4):e1602506. doi: 10.1126/sciadv.1602506. eCollection 2017 Apr.


Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?

De Vos KJ, Hafezparast M.

Neurobiol Dis. 2017 Sep;105:283-299. doi: 10.1016/j.nbd.2017.02.004. Epub 2017 Feb 22. Review.


Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy.

Scoto M, Rossor AM, Harms MB, Cirak S, Calissano M, Robb S, Manzur AY, Martínez Arroyo A, Rodriguez Sanz A, Mansour S, Fallon P, Hadjikoumi I, Klein A, Yang M, De Visser M, Overweg-Plandsoen WC, Baas F, Taylor JP, Benatar M, Connolly AM, Al-Lozi MT, Nixon J, de Goede CG, Foley AR, Mcwilliam C, Pitt M, Sewry C, Phadke R, Hafezparast M, Chong WK, Mercuri E, Baloh RH, Reilly MM, Muntoni F.

Neurology. 2015 Feb 17;84(7):668-79. doi: 10.1212/WNL.0000000000001269. Epub 2015 Jan 21.


Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing.

Carroll J, Page TK, Chiang SC, Kalmar B, Bode D, Greensmith L, Mckinnon PJ, Thorpe JR, Hafezparast M, El-Khamisy SF.

Hum Mol Genet. 2015 Feb 1;24(3):828-40. doi: 10.1093/hmg/ddu500. Epub 2014 Sep 30.


DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy.

Garrett CA, Barri M, Kuta A, Soura V, Deng W, Fisher EM, Schiavo G, Hafezparast M.

Brain. 2014 Jul;137(Pt 7):1883-93. doi: 10.1093/brain/awu097. Epub 2014 Apr 22.


PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.

Rulten SL, Rotheray A, Green RL, Grundy GJ, Moore DA, Gómez-Herreros F, Hafezparast M, Caldecott KW.

Nucleic Acids Res. 2014 Jan;42(1):307-14. doi: 10.1093/nar/gkt835. Epub 2013 Sep 18.


Cytoplasmic dynein heavy chain: the servant of many masters.

Schiavo G, Greensmith L, Hafezparast M, Fisher EM.

Trends Neurosci. 2013 Nov;36(11):641-51. doi: 10.1016/j.tins.2013.08.001. Epub 2013 Sep 10. Review.


Mutations in BICD2 cause dominant congenital spinal muscular atrophy and hereditary spastic paraplegia.

Oates EC, Rossor AM, Hafezparast M, Gonzalez M, Speziani F, MacArthur DG, Lek M, Cottenie E, Scoto M, Foley AR, Hurles M, Houlden H, Greensmith L, Auer-Grumbach M, Pieber TR, Strom TM, Schule R, Herrmann DN, Sowden JE, Acsadi G, Menezes MP, Clarke NF, Züchner S; UK10K, Muntoni F, North KN, Reilly MM.

Am J Hum Genet. 2013 Jun 6;92(6):965-73. doi: 10.1016/j.ajhg.2013.04.018. Epub 2013 May 9.


From the cell membrane to the nucleus: unearthing transport mechanisms for dynein.

Crossley L, Garrett CA, Hafezparast M, Madzvamuse A.

Bull Math Biol. 2012 Sep;74(9):2032-61. doi: 10.1007/s11538-012-9745-x. Epub 2012 Jul 12.


Binding of dynein intermediate chain 2 to paxillin controls focal adhesion dynamics and migration.

Rosse C, Boeckeler K, Linch M, Radtke S, Frith D, Barnouin K, Morsi AS, Hafezparast M, Howell M, Parker PJ.

J Cell Sci. 2012 Aug 15;125(Pt 16):3733-8. doi: 10.1242/jcs.089557. Epub 2012 May 2.


A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis.

Acevedo-Arozena A, Kalmar B, Essa S, Ricketts T, Joyce P, Kent R, Rowe C, Parker A, Gray A, Hafezparast M, Thorpe JR, Greensmith L, Fisher EM.

Dis Model Mech. 2011 Sep;4(5):686-700. doi: 10.1242/dmm.007237. Epub 2011 May 2.


Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse.

Banks GT, Haas MA, Line S, Shepherd HL, Alqatari M, Stewart S, Rishal I, Philpott A, Kalmar B, Kuta A, Groves M, Parkinson N, Acevedo-Arozena A, Brandner S, Bannerman D, Greensmith L, Hafezparast M, Koltzenburg M, Deacon R, Fainzilber M, Fisher EM.

J Neurosci. 2011 Apr 6;31(14):5483-94. doi: 10.1523/JNEUROSCI.5244-10.2011.


Neurodegenerative mutation in cytoplasmic dynein alters its organization and dynein-dynactin and dynein-kinesin interactions.

Deng W, Garrett C, Dombert B, Soura V, Banks G, Fisher EM, van der Brug MP, Hafezparast M.

J Biol Chem. 2010 Dec 17;285(51):39922-34. doi: 10.1074/jbc.M110.178087. Epub 2010 Oct 2.


Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues.

Eschbach J, Fergani A, Oudart H, Robin JP, Rene F, Gonzalez de Aguilar JL, Larmet Y, Zoll J, Hafezparast M, Schwalenstocker B, Loeffler JP, Ludolph AC, Dupuis L.

Biochim Biophys Acta. 2011 Jan;1812(1):59-69. doi: 10.1016/j.bbadis.2010.09.009. Epub 2010 Sep 29.


Mouse cytoplasmic dynein intermediate chains: identification of new isoforms, alternative splicing and tissue distribution of transcripts.

Kuta A, Deng W, Morsi El-Kadi A, Banks GT, Hafezparast M, Pfister KK, Fisher EM.

PLoS One. 2010 Jul 21;5(7):e11682. doi: 10.1371/journal.pone.0011682. Erratum in: PLoS One. 2010;5(10). doi: 10.1371/annotation/59badad8-6e55-46f8-8bf1-7a8a957bc68e.


The legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease.

El-Kadi AM, Bros-Facer V, Deng W, Philpott A, Stoddart E, Banks G, Jackson GS, Fisher EM, Duchen MR, Greensmith L, Moore AL, Hafezparast M.

J Biol Chem. 2010 Jun 11;285(24):18627-39. doi: 10.1074/jbc.M110.129320. Epub 2010 Apr 9.


Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease.

Ateh DD, Hussain IK, Mustafa AH, Price KM, Gulati R, Nickols CD, Bird MM, Greensmith L, Hafezparast M, Fisher EM, Baker CS, Martin JE.

Neuropathol Appl Neurobiol. 2008 Feb;34(1):88-94. Epub 2007 Dec 10.


The phagocytic capacity of neurones.

Bowen S, Ateh DD, Deinhardt K, Bird MM, Price KM, Baker CS, Robson JC, Swash M, Shamsuddin W, Kawar S, El-Tawil T, Roos J, Hoyle A, Nickols CD, Knowles CH, Pullen AH, Luthert PJ, Weller RO, Hafezparast M, Franklin RJ, Revesz T, King RH, Berninghausen O, Fisher EM, Schiavo G, Martin JE.

Eur J Neurosci. 2007 May;25(10):2947-55.


Intermediate chain subunit as a probe for cytoplasmic dynein function: biochemical analyses and live cell imaging in PC12 cells.

Myers KR, Lo KW, Lye RJ, Kogoy JM, Soura V, Hafezparast M, Pfister KK.

J Neurosci Res. 2007 Sep;85(12):2640-7.


Defective axonal transport in motor neuron disease.

El-Kadi AM, Soura V, Hafezparast M.

J Neurosci Res. 2007 Sep;85(12):2557-66. Review.


The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12.

Achilli F, Boyle S, Kieran D, Chia R, Hafezparast M, Martin JE, Schiavo G, Greensmith L, Bickmore W, Fisher EM.

Amyotroph Lateral Scler Other Motor Neuron Disord. 2005 Jun;6(2):111-4.


A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice.

Kieran D, Hafezparast M, Bohnert S, Dick JR, Martin J, Schiavo G, Fisher EM, Greensmith L.

J Cell Biol. 2005 May 23;169(4):561-7.


Prion disease incubation time is not affected in mice heterozygous for a dynein mutation.

Hafezparast M, Brandner S, Linehan J, Martin JE, Collinge J, Fisher EM.

Biochem Biophys Res Commun. 2005 Jan 7;326(1):18-22.


Paradigms for the identification of new genes in motor neuron degeneration.

Hafezparast M, Ahmad-Annuar A, Hummerich H, Shah P, Ford M, Baker C, Bowen S, Martin JE, Fisher EM.

Amyotroph Lateral Scler Other Motor Neuron Disord. 2003 Dec;4(4):249-57.


No association with common Caucasian genotypes in exons 8, 13 and 14 of the human cytoplasmic dynein heavy chain gene (DNCHC1) and familial motor neuron disorders.

Ahmad-Annuar A, Shah P, Hafezparast M, Hummerich H, Witherden AS, Morrison KE, Shaw PJ, Kirby J, Warner TT, Crosby A, Proukakis C, Wilkinson P, Orrell RW, Bradley L, Martin JE, Fisher EM.

Amyotroph Lateral Scler Other Motor Neuron Disord. 2003 Sep;4(3):150-7.


Mouse models for neurological disease.

Hafezparast M, Ahmad-Annuar A, Wood NW, Tabrizi SJ, Fisher EM.

Lancet Neurol. 2002 Aug;1(4):215-24. Review.


Mutations in dynein link motor neuron degeneration to defects in retrograde transport.

Hafezparast M, Klocke R, Ruhrberg C, Marquardt A, Ahmad-Annuar A, Bowen S, Lalli G, Witherden AS, Hummerich H, Nicholson S, Morgan PJ, Oozageer R, Priestley JV, Averill S, King VR, Ball S, Peters J, Toda T, Yamamoto A, Hiraoka Y, Augustin M, Korthaus D, Wattler S, Wabnitz P, Dickneite C, Lampel S, Boehme F, Peraus G, Popp A, Rudelius M, Schlegel J, Fuchs H, Hrabe de Angelis M, Schiavo G, Shima DT, Russ AP, Stumm G, Martin JE, Fisher EM.

Science. 2003 May 2;300(5620):808-12.


A new mouse mutant, skijumper.

Hafezparast M, Ball S, Nicholson SJ, Witherden A, Arac D, Broadway N, Saggerson D, Cooper E, Naase M, Gokhale S, Quant P, Lascelles C, Nickols C, Baker CS, Peters J, Martin JE, Fisher EM.

Mamm Genome. 2002 Jul;13(7):359-364.


An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation.

Witherden AS, Hafezparast M, Nicholson SJ, Ahmad-Annuar A, Bermingham N, Arac D, Rankin J, Iravani M, Ball S, Peters J, Martin JE, Huntley D, Hummerich H, Sergot M, Fisher EM.

Gene. 2002 Jan 23;283(1-2):71-82.


NF1 mice: smaller brains but no tumours.

Hafezparast M.

Trends Mol Med. 2001 Jul;7(7):285. No abstract available.


SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice.

Rogers DC, Peters J, Martin JE, Ball S, Nicholson SJ, Witherden AS, Hafezparast M, Latcham J, Robinson TL, Quilter CA, Fisher EM.

Neurosci Lett. 2001 Jun 22;306(1-2):89-92.


Caspases and neurodegenerative diseases.

Hafezparast M.

Mol Med Today. 2000 Sep;6(9):338. No abstract available.


Mice, the motor system, and human motor neuron pathology.

Nicholson SJ, Witherden AS, Hafezparast M, Martin JE, Fisher EM.

Mamm Genome. 2000 Dec;11(12):1041-52. Review.


Genealogies of mouse inbred strains.

Beck JA, Lloyd S, Hafezparast M, Lennon-Pierce M, Eppig JT, Festing MF, Fisher EM.

Nat Genet. 2000 Jan;24(1):23-5.


The kinesin light chain gene: its mapping and exclusion in mouse and human forms of inherited motor neuron degeneration.

Hafezparast M, Witherden A, Nicholson S, Bermingham N, Mackin J, ten Asbroek A, Ball S, Peters J, Baas F, Martin JE, Fisher EM.

Neurosci Lett. 1999 Sep 24;273(1):49-52.


Wasted by an elongation factor.

Hafezparast M, Fisher E.

Trends Genet. 1998 Jun;14(6):215-7. No abstract available.


Complementation analysis of testis tumor cells.

Wang X, Hafezparast M, Masters JR.

Cancer Genet Cytogenet. 1997 Oct 1;98(1):56-62.


Genetic basis of drug sensitivity in human testis tumour cells.

Wang X, Hafezparast M, Masters JR.

Int J Cancer. 1996 Feb 8;65(4):426-31.


A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation of defective cells by YAC protoplast fusion.

Blunt T, Taccioli GE, Priestley A, Hafezparast M, McMillan T, Liu J, Cole CC, White J, Alt FW, Jackson SP, et al.

Genomics. 1995 Nov 20;30(2):320-8.


An extended panel of hamster-human hybrids for chromosome 2q.

Hafezparast M, Cole CG, Kaur GP, Athwal RS, Jeggo PA.

Somat Cell Mol Genet. 1994 Nov;20(6):541-8.


Subchromosomal localization of a gene (XRCC5) involved in double strand break repair to the region 2q34-36.

Hafezparast M, Kaur GP, Zdzienicka M, Athwal RS, Lehmann AR, Jeggo PA.

Somat Cell Mol Genet. 1993 Sep;19(5):413-21.


A hamster-human subchromosomal hybrid cell panel for chromosome 2.

Jeggo PA, Hafezparast M, Thompson AF, Kaur GP, Sandhu AK, Athwal RS.

Somat Cell Mol Genet. 1993 Jan;19(1):39-49.


Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2.

Jeggo PA, Hafezparast M, Thompson AF, Broughton BC, Kaur GP, Zdzienicka MZ, Athwal RS.

Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6423-7.

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