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Items: 41


Ormeloxifene nanotherapy for cervical cancer treatment.

Chauhan N, Maher DM, Hafeez BB, Mandil H, Singh MM, Yallapu MM, Jaggi M, Chauhan SC.

Int J Nanomedicine. 2019 Sep 3;14:7107-7121. doi: 10.2147/IJN.S200944. eCollection 2019.


Next-generation paclitaxel-nanoparticle formulation for pancreatic cancer treatment.

Massey AE, Sikander M, Chauhan N, Kumari S, Setua S, Shetty AB, Mandil H, Kashyap VK, Khan S, Jaggi M, Yallapu MM, Hafeez BB, Chauhan SC.

Nanomedicine. 2019 Aug;20:102027. doi: 10.1016/j.nano.2019.102027. Epub 2019 Jun 4.


Superparamagnetic iron oxide nanoparticles of curcumin enhance gemcitabine therapeutic response in pancreatic cancer.

Khan S, Setua S, Kumari S, Dan N, Massey A, Hafeez BB, Yallapu MM, Stiles ZE, Alabkaa A, Yue J, Ganju A, Behrman S, Jaggi M, Chauhan SC.

Biomaterials. 2019 Jul;208:83-97. doi: 10.1016/j.biomaterials.2019.04.005. Epub 2019 Apr 8.


Therapeutic efficacy of a novel βIII/βIV-tubulin inhibitor (VERU-111) in pancreatic cancer.

Kashyap VK, Wang Q, Setua S, Nagesh PKB, Chauhan N, Kumari S, Chowdhury P, Miller DD, Yallapu MM, Li W, Jaggi M, Hafeez BB, Chauhan SC.

J Exp Clin Cancer Res. 2019 Jan 23;38(1):29. doi: 10.1186/s13046-018-1009-7.


Tannic acid-inspired paclitaxel nanoparticles for enhanced anticancer effects in breast cancer cells.

Chowdhury P, Nagesh PKB, Hatami E, Wagh S, Dan N, Tripathi MK, Khan S, Hafeez BB, Meibohm B, Chauhan SC, Jaggi M, Yallapu MM.

J Colloid Interface Sci. 2019 Feb 1;535:133-148. doi: 10.1016/j.jcis.2018.09.072. Epub 2018 Sep 22.


miRNA-205 Nanoformulation Sensitizes Prostate Cancer Cells to Chemotherapy.

Nagesh PKB, Chowdhury P, Hatami E, Boya VKN, Kashyap VK, Khan S, Hafeez BB, Chauhan SC, Jaggi M, Yallapu MM.

Cancers (Basel). 2018 Aug 25;10(9). pii: E289. doi: 10.3390/cancers10090289.


Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer.

Chowdhury P, Nagesh PKB, Khan S, Hafeez BB, Chauhan SC, Jaggi M, Yallapu MM.

Acta Pharm Sin B. 2018 Jul;8(4):602-614. doi: 10.1016/j.apsb.2017.10.004. Epub 2017 Dec 10.


Tannic Acid Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Prostate Cancer.

Nagesh PKB, Hatami E, Chowdhury P, Kashyap VK, Khan S, Hafeez BB, Chauhan SC, Jaggi M, Yallapu MM.

Cancers (Basel). 2018 Mar 7;10(3). pii: E68. doi: 10.3390/cancers10030068.


Protein kinase D1 regulates subcellular localisation and metastatic function of metastasis-associated protein 1.

Ganju A, Chauhan SC, Hafeez BB, Doxtater K, Tripathi MK, Zafar N, Yallapu MM, Kumar R, Jaggi M.

Br J Cancer. 2018 Feb 20;118(4):587-599. doi: 10.1038/bjc.2017.431. Epub 2018 Feb 20.


Ormeloxifene Suppresses Prostate Tumor Growth and Metastatic Phenotypes via Inhibition of Oncogenic β-catenin Signaling and EMT Progression.

Hafeez BB, Ganju A, Sikander M, Kashyap VK, Hafeez ZB, Chauhan N, Malik S, Massey AE, Tripathi MK, Halaweish FT, Zafar N, Singh MM, Yallapu MM, Chauhan SC, Jaggi M.

Mol Cancer Ther. 2017 Oct;16(10):2267-2280. doi: 10.1158/1535-7163.MCT-17-0157. Epub 2017 Jun 14.


Magnetic nanoformulations for prostate cancer.

Chowdhury P, Roberts AM, Khan S, Hafeez BB, Chauhan SC, Jaggi M, Yallapu MM.

Drug Discov Today. 2017 Aug;22(8):1233-1241. doi: 10.1016/j.drudis.2017.04.018. Epub 2017 May 16. Review.


Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer.

Sikander M, Hafeez BB, Malik S, Alsayari A, Halaweish FT, Yallapu MM, Chauhan SC, Jaggi M.

Sci Rep. 2016 Nov 8;6:36594. doi: 10.1038/srep36594.


miRNA nanotherapeutics for cancer.

Ganju A, Khan S, Hafeez BB, Behrman SW, Yallapu MM, Chauhan SC, Jaggi M.

Drug Discov Today. 2017 Feb;22(2):424-432. doi: 10.1016/j.drudis.2016.10.014. Epub 2016 Nov 1. Review.


MUC13 interaction with receptor tyrosine kinase HER2 drives pancreatic ductal adenocarcinoma progression.

Khan S, Sikander M, Ebeling MC, Ganju A, Kumari S, Yallapu MM, Hafeez BB, Ise T, Nagata S, Zafar N, Behrman SW, Wan JY, Ghimire HM, Sahay P, Pradhan P, Chauhan SC, Jaggi M.

Oncogene. 2017 Jan 26;36(4):491-500. doi: 10.1038/onc.2016.218. Epub 2016 Jun 20.


Tissue-specific conditional PKCε knockout mice: a model to precisely reveal PKCε functional role in initiation, promotion and progression of cancer.

Hafeez BB, Meske L, Singh A, Singh A, Zhong W, Powers P, John M, Griep AE, Verma AK.

Oncotarget. 2016 May 31;7(22):33069-80. doi: 10.18632/oncotarget.8850.


PSMA targeted docetaxel-loaded superparamagnetic iron oxide nanoparticles for prostate cancer.

Nagesh PKB, Johnson NR, Boya VKN, Chowdhury P, Othman SF, Khalilzad-Sharghi V, Hafeez BB, Ganju A, Khan S, Behrman SW, Zafar N, Chauhan SC, Jaggi M, Yallapu MM.

Colloids Surf B Biointerfaces. 2016 Aug 1;144:8-20. doi: 10.1016/j.colsurfb.2016.03.071. Epub 2016 Mar 26.


Ultraviolet radiation-induced tumor necrosis factor alpha, which is linked to the development of cutaneous SCC, modulates differential epidermal microRNAs expression.

Singh A, Willems E, Singh A, Hafeez BB, Ong IM, Mehta SL, Verma AK.

Oncotarget. 2016 Apr 5;7(14):17945-56. doi: 10.18632/oncotarget.7595.


Plumbagin Inhibits Prostate Carcinogenesis in Intact and Castrated PTEN Knockout Mice via Targeting PKCε, Stat3, and Epithelial-to-Mesenchymal Transition Markers.

Hafeez BB, Fischer JW, Singh A, Zhong W, Mustafa A, Meske L, Sheikhani MO, Verma AK.

Cancer Prev Res (Phila). 2015 May;8(5):375-86. doi: 10.1158/1940-6207.CAPR-14-0231. Epub 2015 Jan 27.


Topically applied Hsp90 inhibitor 17AAG inhibits UVR-induced cutaneous squamous cell carcinomas.

Singh A, Singh A, Sand JM, Bauer SJ, Hafeez BB, Meske L, Verma AK.

J Invest Dermatol. 2015 Apr;135(4):1098-1107. doi: 10.1038/jid.2014.460. Epub 2014 Oct 22.


α-Mangostin: a dietary antioxidant derived from the pericarp of Garcinia mangostana L. inhibits pancreatic tumor growth in xenograft mouse model.

Hafeez BB, Mustafa A, Fischer JW, Singh A, Zhong W, Shekhani MO, Meske L, Havighurst T, Kim K, Verma AK.

Antioxid Redox Signal. 2014 Aug 10;21(5):682-99. doi: 10.1089/ars.2013.5212. Epub 2014 Feb 6.


Protein Kinase C ε , Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells.

Singh A, Singh A, Sand JM, Heninger E, Hafeez BB, Verma AK.

J Skin Cancer. 2013;2013:452425. doi: 10.1155/2013/452425. Epub 2013 Apr 29.


Plumbagin, a medicinal plant (Plumbago zeylanica)-derived 1,4-naphthoquinone, inhibits growth and metastasis of human prostate cancer PC-3M-luciferase cells in an orthotopic xenograft mouse model.

Hafeez BB, Zhong W, Fischer JW, Mustafa A, Shi X, Meske L, Hong H, Cai W, Havighurst T, Kim K, Verma AK.

Mol Oncol. 2013 Jun;7(3):428-39. doi: 10.1016/j.molonc.2012.12.001. Epub 2012 Dec 14.


Plumbagin inhibits prostate cancer development in TRAMP mice via targeting PKCε, Stat3 and neuroendocrine markers.

Hafeez BB, Zhong W, Mustafa A, Fischer JW, Witkowsky O, Verma AK.

Carcinogenesis. 2012 Dec;33(12):2586-92. doi: 10.1093/carcin/bgs291. Epub 2012 Sep 13.


Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-κB signaling pathways.

Hafeez BB, Jamal MS, Fischer JW, Mustafa A, Verma AK.

Int J Cancer. 2012 Nov 1;131(9):2175-86. doi: 10.1002/ijc.27478. Epub 2012 Mar 20.


Ligand-dependent corepressor acts as a novel androgen receptor corepressor, inhibits prostate cancer growth, and is functionally inactivated by the Src protein kinase.

Asim M, Hafeez BB, Siddiqui IA, Gerlach C, Patz M, Mukhtar H, Baniahmad A.

J Biol Chem. 2011 Oct 28;286(43):37108-17. doi: 10.1074/jbc.M111.292771. Epub 2011 Aug 19.


Genetic ablation of PKC epsilon inhibits prostate cancer development and metastasis in transgenic mouse model of prostate adenocarcinoma.

Hafeez BB, Zhong W, Weichert J, Dreckschmidt NE, Jamal MS, Verma AK.

Cancer Res. 2011 Mar 15;71(6):2318-27. doi: 10.1158/0008-5472.CAN-10-4170.


Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer.

Siddiqui IA, Asim M, Hafeez BB, Adhami VM, Tarapore RS, Mukhtar H.

FASEB J. 2011 Apr;25(4):1198-207. doi: 10.1096/fj.10-167924. Epub 2010 Dec 21.


Protein kinase Cvarepsilon mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression, and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2, and ERK1/2).

Aziz MH, Hafeez BB, Sand JM, Pierce DB, Aziz SW, Dreckschmidt NE, Verma AK.

Oncogene. 2010 May 27;29(21):3100-9. doi: 10.1038/onc.2010.63. Epub 2010 Mar 15.


Dietary zinc and prostate cancer in the TRAMP mouse model.

Prasad AS, Mukhtar H, Beck FW, Adhami VM, Siddiqui IA, Din M, Hafeez BB, Kucuk O.

J Med Food. 2010 Feb;13(1):70-6. doi: 10.1089/jmf.2009.0042.


Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB.

Murtaza I, Adhami VM, Hafeez BB, Saleem M, Mukhtar H.

Int J Cancer. 2009 Nov 15;125(10):2465-73. doi: 10.1002/ijc.24628.


Effective prostate cancer chemopreventive intervention with green tea polyphenols in the TRAMP model depends on the stage of the disease.

Adhami VM, Siddiqui IA, Sarfaraz S, Khwaja SI, Hafeez BB, Ahmad N, Mukhtar H.

Clin Cancer Res. 2009 Mar 15;15(6):1947-53. doi: 10.1158/1078-0432.CCR-08-2332. Epub 2009 Mar 10.


Lupeol inhibits proliferation of human prostate cancer cells by targeting beta-catenin signaling.

Saleem M, Murtaza I, Tarapore RS, Suh Y, Adhami VM, Johnson JJ, Siddiqui IA, Khan N, Asim M, Hafeez BB, Shekhani MT, Li B, Mukhtar H.

Carcinogenesis. 2009 May;30(5):808-17. doi: 10.1093/carcin/bgp044. Epub 2009 Feb 20.


Introducing nanochemoprevention as a novel approach for cancer control: proof of principle with green tea polyphenol epigallocatechin-3-gallate.

Siddiqui IA, Adhami VM, Bharali DJ, Hafeez BB, Asim M, Khwaja SI, Ahmad N, Cui H, Mousa SA, Mukhtar H.

Cancer Res. 2009 Mar 1;69(5):1712-6. doi: 10.1158/0008-5472.CAN-08-3978. Epub 2009 Feb 17.


Suppression of cFLIP by lupeol, a dietary triterpene, is sufficient to overcome resistance to TRAIL-mediated apoptosis in chemoresistant human pancreatic cancer cells.

Murtaza I, Saleem M, Adhami VM, Hafeez BB, Mukhtar H.

Cancer Res. 2009 Feb 1;69(3):1156-65. doi: 10.1158/0008-5472.CAN-08-2917. Epub 2009 Jan 27.


A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: involvement of nuclear factor-kappaB signaling.

Hafeez BB, Siddiqui IA, Asim M, Malik A, Afaq F, Adhami VM, Saleem M, Din M, Mukhtar H.

Cancer Res. 2008 Oct 15;68(20):8564-72. doi: 10.1158/0008-5472.CAN-08-2232.


Suppression of NFkappaB and its regulated gene products by oral administration of green tea polyphenols in an autochthonous mouse prostate cancer model.

Siddiqui IA, Shukla Y, Adhami VM, Sarfaraz S, Asim M, Hafeez BB, Mukhtar H.

Pharm Res. 2008 Sep;25(9):2135-42. doi: 10.1007/s11095-008-9553-z. Epub 2008 Mar 4.


Src kinase potentiates androgen receptor transactivation function and invasion of androgen-independent prostate cancer C4-2 cells.

Asim M, Siddiqui IA, Hafeez BB, Baniahmad A, Mukhtar H.

Oncogene. 2008 Jun 5;27(25):3596-604. doi: 10.1038/sj.onc.1211016. Epub 2008 Jan 28.


Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis.

Siddiqui IA, Malik A, Adhami VM, Asim M, Hafeez BB, Sarfaraz S, Mukhtar H.

Oncogene. 2008 Mar 27;27(14):2055-63. Epub 2007 Nov 12.


Green tea polyphenols-induced apoptosis in human osteosarcoma SAOS-2 cells involves a caspase-dependent mechanism with downregulation of nuclear factor-kappaB.

Hafeez BB, Ahmed S, Wang N, Gupta S, Zhang A, Haqqi TM.

Toxicol Appl Pharmacol. 2006 Oct 1;216(1):11-9. Epub 2006 May 17.


Doxorubicin plus interleukin-2 chemoimmunotherapy against breast cancer in mice.

Ewens A, Luo L, Berleth E, Alderfer J, Wollman R, Hafeez BB, Kanter P, Mihich E, Ehrke MJ.

Cancer Res. 2006 May 15;66(10):5419-26.

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