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Mycobacterium tuberculosis whole genome sequencing provides insights into the Manila strain and drug-resistance mutations in the Philippines.

Phelan JE, Lim DR, Mitarai S, de Sessions PF, Tujan MAA, Reyes LT, Medado IAP, Palparan AG, Naim ANM, Jie S, Segubre-Mercado E, Simoes B, Campino S, Hafalla JC, Murase Y, Morishige Y, Hibberd ML, Kato S, Ama MCG, Clark TG.

Sci Rep. 2019 Jun 26;9(1):9305. doi: 10.1038/s41598-019-45566-5.


Mosquito and human hepatocyte infections with Plasmodium ovale curtisi and Plasmodium ovale wallikeri.

Kristan M, Thorburn SG, Hafalla JC, Sutherland CJ, Oguike MC.

Trans R Soc Trop Med Hyg. 2019 Oct 11;113(10):617-622. doi: 10.1093/trstmh/trz048.


The ecology of immune state in a wild mammal, Mus musculus domesticus.

Abolins S, Lazarou L, Weldon L, Hughes L, King EC, Drescher P, Pocock MJO, Hafalla JCR, Riley EM, Viney M.

PLoS Biol. 2018 Apr 13;16(4):e2003538. doi: 10.1371/journal.pbio.2003538. eCollection 2018 Apr.


Tissue-specific cellular immune responses to malaria pre-erythrocytic stages.

Silvie O, Amino R, Hafalla JC.

Curr Opin Microbiol. 2017 Dec;40:160-167. doi: 10.1016/j.mib.2017.12.001. Epub 2017 Dec 5. Review.


An in vitro assay to measure antibody-mediated inhibition of P. berghei sporozoite invasion against P. falciparum antigens.

Rodríguez-Galán A, Salman AM, Bowyer G, Collins KA, Longley RJ, Brod F, Ulaszewska M, Ewer KJ, Janse CJ, Khan SM, Hafalla JC, Hill AVS, Spencer AJ.

Sci Rep. 2017 Dec 5;7(1):17011. doi: 10.1038/s41598-017-17274-5.


The comparative immunology of wild and laboratory mice, Mus musculus domesticus.

Abolins S, King EC, Lazarou L, Weldon L, Hughes L, Drescher P, Raynes JG, Hafalla JCR, Viney ME, Riley EM.

Nat Commun. 2017 May 3;8:14811. doi: 10.1038/ncomms14811.


Host Resistance to Plasmodium-Induced Acute Immune Pathology Is Regulated by Interleukin-10 Receptor Signaling.

Claser C, De Souza JB, Thorburn SG, Grau GE, Riley EM, Rénia L, Hafalla JCR.

Infect Immun. 2017 May 23;85(6). pii: e00941-16. doi: 10.1128/IAI.00941-16. Print 2017 Jun.


Evidence of cross-stage CD8+ T cell epitopes in malaria pre-erythrocytic and blood stage infections.

Müller K, Gibbins MP, Matuschewski K, Hafalla JCR.

Parasite Immunol. 2017 Jul;39(7). doi: 10.1111/pim.12434.


Type I Interferon in Malaria: A Balancing Act.

Mooney JP, Wassmer SC, Hafalla JC.

Trends Parasitol. 2017 Apr;33(4):257-260. doi: 10.1016/ Epub 2017 Jan 13.


Signatures of malaria vaccine efficacy in ageing murine immune memory.

Haussig JM, Burgold J, Hafalla JC, Matuschewski K, Kooij TW.

Parasite Immunol. 2014 May;36(5):199-206. doi: 10.1111/pim.12104.


Identification of targets of CD8⁺ T cell responses to malaria liver stages by genome-wide epitope profiling.

Hafalla JC, Bauza K, Friesen J, Gonzalez-Aseguinolaza G, Hill AV, Matuschewski K.

PLoS Pathog. 2013 May;9(5):e1003303. doi: 10.1371/journal.ppat.1003303. Epub 2013 May 9.


Long-lived memory B-cell responses following BCG vaccination.

Sebina I, Cliff JM, Smith SG, Nogaro S, Webb EL, Riley EM, Dockrell HM, Elliott AM, Hafalla JC, Cose S.

PLoS One. 2012;7(12):e51381. doi: 10.1371/journal.pone.0051381. Epub 2012 Dec 11.


IFN-γ-producing CD4+ T cells promote experimental cerebral malaria by modulating CD8+ T cell accumulation within the brain.

Villegas-Mendez A, Greig R, Shaw TN, de Souza JB, Gwyer Findlay E, Stumhofer JS, Hafalla JC, Blount DG, Hunter CA, Riley EM, Couper KN.

J Immunol. 2012 Jul 15;189(2):968-79. doi: 10.4049/jimmunol.1200688. Epub 2012 Jun 20.


Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine.

Horowitz A, Hafalla JC, King E, Lusingu J, Dekker D, Leach A, Moris P, Cohen J, Vekemans J, Villafana T, Corran PH, Bejon P, Drakeley CJ, von Seidlein L, Riley EM.

J Immunol. 2012 May 15;188(10):5054-62. doi: 10.4049/jimmunol.1102710. Epub 2012 Apr 13.


The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology.

Hafalla JC, Claser C, Couper KN, Grau GE, Renia L, de Souza JB, Riley EM.

PLoS Pathog. 2012 Feb;8(2):e1002504. doi: 10.1371/journal.ppat.1002504. Epub 2012 Feb 2.


Experimental cerebral malaria develops independently of caspase recruitment domain-containing protein 9 signaling.

Hafalla JC, Burgold J, Dorhoi A, Gross O, Ruland J, Kaufmann SH, Matuschewski K.

Infect Immun. 2012 Mar;80(3):1274-9. doi: 10.1128/IAI.06033-11. Epub 2011 Dec 12.


The breadth, but not the magnitude, of circulating memory B cell responses to P. falciparum increases with age/exposure in an area of low transmission.

Nogaro SI, Hafalla JC, Walther B, Remarque EJ, Tetteh KK, Conway DJ, Riley EM, Walther M.

PLoS One. 2011;6(10):e25582. doi: 10.1371/journal.pone.0025582. Epub 2011 Oct 4.


Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.

Villegas-Mendez A, de Souza JB, Murungi L, Hafalla JC, Shaw TN, Greig R, Riley EM, Couper KN.

J Immunol. 2011 Sep 15;187(6):2885-97. doi: 10.4049/jimmunol.1100241. Epub 2011 Aug 31.


Caspase-1 activation of interleukin-1β (IL-1β) and IL-18 is dispensable for induction of experimental cerebral malaria.

Kordes M, Matuschewski K, Hafalla JC.

Infect Immun. 2011 Sep;79(9):3633-41. doi: 10.1128/IAI.05459-11. Epub 2011 Jun 27.


Cell biology and immunology of malaria.

Hafalla JC, Silvie O, Matuschewski K.

Immunol Rev. 2011 Mar;240(1):297-316. doi: 10.1111/j.1600-065X.2010.00988.x. Review.


Short-lived IFN-γ effector responses, but long-lived IL-10 memory responses, to malaria in an area of low malaria endemicity.

Wipasa J, Okell L, Sakkhachornphop S, Suphavilai C, Chawansuntati K, Liewsaree W, Hafalla JC, Riley EM.

PLoS Pathog. 2011 Feb 10;7(2):e1001281. doi: 10.1371/journal.ppat.1001281.


Arrested Plasmodium liver stages as experimental anti-malaria vaccines.

Matuschewski K, Hafalla JC, Borrmann S, Friesen J.

Hum Vaccin. 2011 Jan-Feb;7 Suppl:16-21. Epub 2011 Jan 1. Review.


Measures of immune function of wild mice, Mus musculus.

Abolins SR, Pocock MJ, Hafalla JC, Riley EM, Viney ME.

Mol Ecol. 2011 Mar;20(5):881-92. doi: 10.1111/j.1365-294X.2010.04910.x. Epub 2010 Nov 12.


Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection.

Findlay EG, Greig R, Stumhofer JS, Hafalla JC, de Souza JB, Saris CJ, Hunter CA, Riley EM, Couper KN.

J Immunol. 2010 Aug 15;185(4):2482-92. doi: 10.4049/jimmunol.0904019. Epub 2010 Jul 14.


Natural immunization against malaria: causal prophylaxis with antibiotics.

Friesen J, Silvie O, Putrianti ED, Hafalla JC, Matuschewski K, Borrmann S.

Sci Transl Med. 2010 Jul 14;2(40):40ra49. doi: 10.1126/scitranslmed.3001058.


Neuropathogenesis of human and murine malaria.

Riley EM, Couper KN, Helmby H, Hafalla JC, de Souza JB, Langhorne J, Jarra WB, Zavala F.

Trends Parasitol. 2010 Jun;26(6):277-8. doi: 10.1016/ Epub 2010 Mar 24. No abstract available.


Long-lived antibody and B Cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivax.

Wipasa J, Suphavilai C, Okell LC, Cook J, Corran PH, Thaikla K, Liewsaree W, Riley EM, Hafalla JC.

PLoS Pathog. 2010 Feb 19;6(2):e1000770. doi: 10.1371/journal.ppat.1000770.


Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation.

Couper KN, Barnes T, Hafalla JC, Combes V, Ryffel B, Secher T, Grau GE, Riley EM, de Souza JB.

PLoS Pathog. 2010 Jan 29;6(1):e1000744. doi: 10.1371/journal.ppat.1000744.


Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease.

de Souza JB, Hafalla JC, Riley EM, Couper KN.

Parasitology. 2010 Apr;137(5):755-72. doi: 10.1017/S0031182009991715. Epub 2009 Dec 23. Review.


IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection.

Couper KN, Blount DG, Wilson MS, Hafalla JC, Belkaid Y, Kamanaka M, Flavell RA, de Souza JB, Riley EM.

PLoS Pathog. 2008 Feb 29;4(2):e1000004. doi: 10.1371/journal.ppat.1000004.


Efficient development of plasmodium liver stage-specific memory CD8+ T cells during the course of blood-stage malarial infection.

Hafalla JC, Rai U, Bernal-Rubio D, Rodriguez A, Zavala F.

J Infect Dis. 2007 Dec 15;196(12):1827-35. doi: 10.1086/522965.


Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia.

Couper KN, Blount DG, Hafalla JC, van Rooijen N, de Souza JB, Riley EM.

Infect Immun. 2007 Dec;75(12):5806-18. Epub 2007 Oct 8.


Priming of CD8+ T cell responses following immunization with heat-killed Plasmodium sporozoites.

Hafalla JC, Rai U, Morrot A, Bernal-Rubio D, Zavala F, Rodriguez A.

Eur J Immunol. 2006 May;36(5):1179-86.


Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses.

Boscardin SB, Hafalla JC, Masilamani RF, Kamphorst AO, Zebroski HA, Rai U, Morrot A, Zavala F, Steinman RM, Nussenzweig RS, Nussenzweig MC.

J Exp Med. 2006 Mar 20;203(3):599-606. Epub 2006 Feb 27.


Protective and pathogenic roles of CD8+ T cells during malaria infection.

Hafalla JC, Cockburn IA, Zavala F.

Parasite Immunol. 2006 Jan-Feb;28(1-2):15-24. Review.


IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites.

Morrot A, Hafalla JC, Cockburn IA, Carvalho LH, Zavala F.

J Exp Med. 2005 Aug 15;202(4):551-60. Epub 2005 Aug 8.


Early self-regulatory mechanisms control the magnitude of CD8+ T cell responses against liver stages of murine malaria.

Hafalla JC, Morrot A, Sano G, Milon G, Lafaille JJ, Zavala F.

J Immunol. 2003 Jul 15;171(2):964-70.


Migration through host cells activates Plasmodium sporozoites for infection.

Mota MM, Hafalla JC, Rodriguez A.

Nat Med. 2002 Nov;8(11):1318-22. Epub 2002 Oct 15. Erratum in: Nat Med. 2003 Jan;9(1):146..


Short-term antigen presentation and single clonal burst limit the magnitude of the CD8(+) T cell responses to malaria liver stages.

Hafalla JC, Sano G, Carvalho LH, Morrot A, Zavala F.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11819-24. Epub 2002 Aug 15. Erratum in: Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14611.


IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.

Carvalho LH, Sano G, Hafalla JC, Morrot A, Curotto de Lafaille MA, Zavala F.

Nat Med. 2002 Feb;8(2):166-70.


Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR.

Bruña-Romero O, Hafalla JC, González-Aseguinolaza G, Sano G, Tsuji M, Zavala F.

Int J Parasitol. 2001 Nov;31(13):1499-502.


Complete, long-lasting protection against malaria of mice primed and boosted with two distinct viral vectors expressing the same plasmodial antigen.

Bruña-Romero O, González-Aseguinolaza G, Hafalla JC, Tsuji M, Nussenzweig RS.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11491-6. Epub 2001 Sep 11.


Detection of bancroftian filariasis in human blood samples from Sorsogon province, the Philippines by polymerase chain reaction.

Torres EP, Ramirez BL, Salazar F, Pasay MC, Alamares JG, Santiago ML, Hafalla JC.

Parasitol Res. 2001 Aug;87(8):677-9.


Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stages.

Sano G, Hafalla JC, Morrot A, Abe R, Lafaille JJ, Zavala F.

J Exp Med. 2001 Jul 16;194(2):173-80.


Fluorescent Plasmodium berghei sporozoites and pre-erythrocytic stages: a new tool to study mosquito and mammalian host interactions with malaria parasites.

Natarajan R, Thathy V, Mota MM, Hafalla JC, Ménard R, Vernick KD.

Cell Microbiol. 2001 Jun;3(6):371-9.


ELISPOT assay to measure antigen-specific murine CD8(+) T cell responses.

Carvalho LH, Hafalla JC, Zavala F.

J Immunol Methods. 2001 Jun 1;252(1-2):207-18.


Migration of Plasmodium sporozoites through cells before infection.

Mota MM, Pradel G, Vanderberg JP, Hafalla JC, Frevert U, Nussenzweig RS, Nussenzweig V, Rodríguez A.

Science. 2001 Jan 5;291(5501):141-4.


Paramyosin is a major target of the human IgA response against Schistosoma japonicum.

Hernandez MG, Hafalla JC, Acosta LP, Aligui FF, Aligui GD, Ramirez BL, Dunne DW, Santiago ML.

Parasite Immunol. 1999 Dec;21(12):641-7.


Molecular identification of a 21.7 kDa schistosoma japonicum antigen as a target of the human IgE response.

Hafalla JC, Alamares JG 2nd, Acosta LP, Dunne DW, Ramirez BL, Santiago ML.

Mol Biochem Parasitol. 1999 Jan 5;98(1):157-61. No abstract available.


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