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Items: 27


Xenon-helium gas mixture at equimolar concentration of 37.5% protects against oxygen and glucose deprivation-induced injury and inhibits tissue plasminogen activator.

David HN, Haelewyn B, Blatteau JÉ, Risso JJ, Vallée N, Abraini JH.

Med Gas Res. 2017 Oct 17;7(3):181-185. doi: 10.4103/2045-9912.215747. eCollection 2017 Jul-Sep.


Molecular magnetic resonance imaging discloses endothelial activation after transient ischaemic attack.

Quenault A, Martinez de Lizarrondo S, Etard O, Gauberti M, Orset C, Haelewyn B, Segal HC, Rothwell PM, Vivien D, Touzé E, Ali C.

Brain. 2017 Jan;140(1):146-157. doi: 10.1093/brain/aww260. Epub 2016 Nov 8.


Hyperbaric oxygen increases tissue-plasminogen activator-induced thrombolysis in vitro, and reduces ischemic brain damage and edema in rats subjected to thromboembolic brain ischemia.

Chazalviel L, Haelewyn B, Degoulet M, Blatteau JE, Vallée N, Risso JJ, Besnard S, Abraini JH.

Med Gas Res. 2016 Jul 11;6(2):64-69. eCollection 2016 Apr-Jun.


Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis.

Macrez R, Ortega MC, Bardou I, Mehra A, Fournier A, Van der Pol SM, Haelewyn B, Maubert E, Lesept F, Chevilley A, de Castro F, De Vries HE, Vivien D, Clemente D, Docagne F.

Brain. 2016 Sep;139(Pt 9):2406-19. doi: 10.1093/brain/aww172. Epub 2016 Jul 19.


The underestimated effect of normobaric hyperoxia on cerebral blood flow and its relationship to neuroprotection.

Chazalviel L, David HN, Haelewyn B, Blatteau JE, Vallée N, Risso JJ, Besnard S, Abraini JH.

Brain. 2016 Nov 1;139(11):e62. doi: 10.1093/brain/aww178. No abstract available.


Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis.

Orset C, Haelewyn B, Allan SM, Ansar S, Campos F, Cho TH, Durand A, El Amki M, Fatar M, Garcia-Yébenes I, Gauberti M, Grudzenski S, Lizasoain I, Lo E, Macrez R, Margaill I, Maysami S, Meairs S, Nighoghossian N, Orbe J, Paramo JA, Parienti JJ, Rothwell NJ, Rubio M, Waeber C, Young AR, Touzé E, Vivien D.

Stroke. 2016 May;47(5):1312-1318. doi: 10.1161/STROKEAHA.116.012238. Epub 2016 Mar 31.


Modulation by the Noble Gas Helium of Tissue Plasminogen Activator: Effects in a Rat Model of Thromboembolic Stroke.

Haelewyn B, David HN, Blatteau JE, Vallée N, Meckler C, Risso JJ, Abraini JH.

Crit Care Med. 2016 Jun;44(6):e383-9. doi: 10.1097/CCM.0000000000001424.


Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia.

Llovera G, Hofmann K, Roth S, Salas-Pérdomo A, Ferrer-Ferrer M, Perego C, Zanier ER, Mamrak U, Rex A, Party H, Agin V, Fauchon C, Orset C, Haelewyn B, De Simoni MG, Dirnagl U, Grittner U, Planas AM, Plesnila N, Vivien D, Liesz A.

Sci Transl Med. 2015 Aug 5;7(299):299ra121. doi: 10.1126/scitranslmed.aaa9853.


Stressed neurons protect themselves by a tissue-type plasminogen activator-mediated EGFR-dependent mechanism.

Lemarchand E, Maubert E, Haelewyn B, Ali C, Rubio M, Vivien D.

Cell Death Differ. 2016 Jan;23(1):123-31. doi: 10.1038/cdd.2015.76. Epub 2015 Jun 12.


Object recognition test in mice.

Leger M, Quiedeville A, Bouet V, Haelewyn B, Boulouard M, Schumann-Bard P, Freret T.

Nat Protoc. 2013 Dec;8(12):2531-7. doi: 10.1038/nprot.2013.155. Epub 2013 Nov 21.


Modulation by the noble gas argon of the catalytic and thrombolytic efficiency of tissue plasminogen activator.

David HN, Haelewyn B, Risso JJ, Abraini JH.

Naunyn Schmiedebergs Arch Pharmacol. 2013 Jan;386(1):91-5. doi: 10.1007/s00210-012-0809-0. Epub 2012 Nov 11.


Ultra-sensitive molecular MRI of cerebrovascular cell activation enables early detection of chronic central nervous system disorders.

Montagne A, Gauberti M, Macrez R, Jullienne A, Briens A, Raynaud JS, Louin G, Buisson A, Haelewyn B, Docagne F, Defer G, Vivien D, Maubert E.

Neuroimage. 2012 Nov 1;63(2):760-70. doi: 10.1016/j.neuroimage.2012.07.018. Epub 2012 Jul 17.


Prothrombolytic action of normobaric oxygen given alone or in combination with recombinant tissue-plasminogen activator in a rat model of thromboembolic stroke.

David HN, Haelewyn B, Degoulet M, Colomb DG Jr, Risso JJ, Abraini JH.

J Appl Physiol (1985). 2012 Jun;112(12):2068-76. doi: 10.1152/japplphysiol.00092.2012. Epub 2012 Apr 5.


Ex vivo and in vivo neuroprotection induced by argon when given after an excitotoxic or ischemic insult.

David HN, Haelewyn B, Degoulet M, Colomb DG Jr, Risso JJ, Abraini JH.

PLoS One. 2012;7(2):e30934. doi: 10.1371/journal.pone.0030934. Epub 2012 Feb 22.


Moderately delayed post-insult treatment with normobaric hyperoxia reduces excitotoxin-induced neuronal degeneration but increases ischemia-induced brain damage.

Haelewyn B, Chazalviel L, Nicole O, Lecocq M, Risso JJ, Abraini JH.

Med Gas Res. 2011 Apr 27;1(1):2. doi: 10.1186/2045-9912-1-2.


Interactions between nitrous oxide and tissue plasminogen activator in a rat model of thromboembolic stroke.

Haelewyn B, David HN, Colloc'h N, Colomb DG Jr, Risso JJ, Abraini JH.

Anesthesiology. 2011 Nov;115(5):1044-53. doi: 10.1097/ALN.0b013e3182342860.


Human recombinant tissue-plasminogen activator (alteplase): why not use the 'human' dose for stroke studies in rats?

Haelewyn B, Risso JJ, Abraini JH.

J Cereb Blood Flow Metab. 2010 May;30(5):900-3. doi: 10.1038/jcbfm.2010.33. Epub 2010 Mar 10.


Xenon is an inhibitor of tissue-plasminogen activator: adverse and beneficial effects in a rat model of thromboembolic stroke.

David HN, Haelewyn B, Risso JJ, Colloc'h N, Abraini JH.

J Cereb Blood Flow Metab. 2010 Apr;30(4):718-28. doi: 10.1038/jcbfm.2009.275. Epub 2010 Jan 20.


Post-ischemic helium provides neuroprotection in rats subjected to middle cerebral artery occlusion-induced ischemia by producing hypothermia.

David HN, Haelewyn B, Chazalviel L, Lecocq M, Degoulet M, Risso JJ, Abraini JH.

J Cereb Blood Flow Metab. 2009 Jun;29(6):1159-65. doi: 10.1038/jcbfm.2009.40. Epub 2009 Apr 22.


Neuroprotection by nitrous oxide: facts and evidence.

Haelewyn B, David HN, Rouillon C, Chazalviel L, Lecocq M, Risso JJ, Lemaire M, Abraini JH.

Crit Care Med. 2008 Sep;36(9):2651-9. doi: 10.1097/CCM.0b013e318183f646.


Functional (neurologic) recovery following transient focal cerebral ischemia in the rat requires at least 80% of ipsilateral cortical and subcortical integrity.

Haelewyn B, Rouillon C, Risso JJ, Abraini JH.

Exp Neurol. 2008 Sep;213(1):238-40. doi: 10.1016/j.expneurol.2008.05.012. Epub 2008 May 27.


NMDA-induced striatal brain damage and time-dependence reliability of thionin staining in rats.

Haelewyn B, Alix P, Maubert E, Abraini JH.

J Neurosci Methods. 2008 Mar 15;168(2):479-82. Epub 2007 Nov 1.


Neuroprotective effects of xenon: a therapeutic window of opportunity in rats subjected to transient cerebral ischemia.

David HN, Haelewyn B, Rouillon C, Lecoq M, Chazalviel L, Apiou G, Risso JJ, Lemaire M, Abraini JH.

FASEB J. 2008 Apr;22(4):1275-86. Epub 2007 Nov 16.


Long-term evaluation of sensorimotor and mnesic behaviour following striatal NMDA-induced unilateral excitotoxic lesion in the mouse.

Haelewyn B, Freret T, Pacary E, Schumann-Bard P, Boulouard M, Bernaudin M, Bouët V.

Behav Brain Res. 2007 Mar 28;178(2):235-43. Epub 2007 Jan 23.


Cardioprotective effects of desflurane: effect of timing and duration of administration in rat myocardium.

Haelewyn B, Zhu L, Hanouz JL, Persehaye E, Roussel S, Ducouret P, Gérard JL.

Br J Anaesth. 2004 Apr;92(4):552-7. Epub 2004 Feb 20.


Desflurane affords greater protection than halothane against focal cerebral ischaemia in the rat.

Haelewyn B, Yvon A, Hanouz JL, MacKenzie ET, Ducouret P, Gérard JL, Roussel S.

Br J Anaesth. 2003 Sep;91(3):390-6.


Mechanisms of sevoflurane-induced myocardial preconditioning in isolated human right atria in vitro.

Yvon A, Hanouz JL, Haelewyn B, Terrien X, Massetti M, Babatasi G, Khayat A, Ducouret P, Bricard H, Gérard JL.

Anesthesiology. 2003 Jul;99(1):27-33.


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