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Items: 1 to 50 of 178

1.

Identification of differentially methylated BRCA1 and CRISP2 DNA regions as blood surrogate markers for cardiovascular disease.

Istas G, Declerck K, Pudenz M, Szic KSV, Lendinez-Tortajada V, Leon-Latre M, Heyninck K, Haegeman G, Casasnovas JA, Tellez-Plaza M, Gerhauser C, Heiss C, Rodriguez-Mateos A, Berghe WV.

Sci Rep. 2017 Jul 11;7(1):5120. doi: 10.1038/s41598-017-03434-0.

2.

Bullous pemphigoid outcome is associated with CXCL10-induced matrix metalloproteinase 9 secretion from monocytes and neutrophils but not lymphocytes.

Riani M, Le Jan S, Plée J, Durlach A, Le Naour R, Haegeman G, Bernard P, Antonicelli F.

J Allergy Clin Immunol. 2017 Mar;139(3):863-872.e3. doi: 10.1016/j.jaci.2016.08.012. Epub 2016 Sep 13.

PMID:
27637385
3.

Adipose Stromal Cells from Visceral and Subcutaneous Fat Facilitate Migration of Ovarian Cancer Cells via IL-6/JAK2/STAT3 Pathway.

Kim B, Kim HS, Kim S, Haegeman G, Tsang BK, Dhanasekaran DN, Song YS.

Cancer Res Treat. 2017 Apr;49(2):338-349. doi: 10.4143/crt.2016.175. Epub 2016 Jul 18.

4.

Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway.

Heyninck K, Sabbe L, Chirumamilla CS, Szarc Vel Szic K, Vander Veken P, Lemmens KJA, Lahtela-Kakkonen M, Naulaerts S, Op de Beeck K, Laukens K, Van Camp G, Weseler AR, Bast A, Haenen GRMM, Haegeman G, Vanden Berghe W.

Biochem Pharmacol. 2016 Jun 1;109:48-61. doi: 10.1016/j.bcp.2016.03.026. Epub 2016 Apr 1.

PMID:
27045103
5.

Selective Activator of the Glucocorticoid Receptor Compound A Dissociates Therapeutic and Atrophogenic Effects of Glucocorticoid Receptor Signaling in Skin.

Klopot A, Baida G, Bhalla P, Haegeman G, Budunova I.

J Cancer Prev. 2015 Dec;20(4):250-9. doi: 10.15430/JCP.2015.20.4.250. Epub 2015 Dec 30.

6.

Inhibition of dengue virus production and cytokine/chemokine expression by ribavirin and compound A.

Rattanaburee T, Junking M, Panya A, Sawasdee N, Songprakhon P, Suttitheptumrong A, Limjindaporn T, Haegeman G, Yenchitsomanus PT.

Antiviral Res. 2015 Dec;124:83-92. doi: 10.1016/j.antiviral.2015.10.005. Epub 2015 Nov 2.

PMID:
26542647
7.

Discovery of Compound A--a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity.

Lesovaya E, Yemelyanov A, Swart AC, Swart P, Haegeman G, Budunova I.

Oncotarget. 2015 Oct 13;6(31):30730-44. doi: 10.18632/oncotarget.5078. Review.

8.

Epigenetic control of cardiovascular health by nutritional polyphenols involves multiple chromatin-modifying writer-reader-eraser proteins.

Declerck K, Szarc vel Szic K, Palagani A, Heyninck K, Haegeman G, Morand C, Milenkovic D, Vanden Berghe W.

Curr Top Med Chem. 2016;16(7):788-806. Review.

PMID:
26303416
9.

Anakoinosis: Communicative Reprogramming of Tumor Systems - for Rescuing from Chemorefractory Neoplasia.

Hart C, Vogelhuber M, Wolff D, Klobuch S, Ghibelli L, Foell J, Corbacioglu S, Rehe K, Haegeman G, Thomas S, Herr W, Reichle A.

Cancer Microenviron. 2015 Aug;8(2):75-92. doi: 10.1007/s12307-015-0170-1. Epub 2015 Aug 11.

10.

Inhibition of the NF-κB signaling pathway by a novel heterocyclic curcumin analogue.

Katsori AM, Palagani A, Bougarne N, Hadjipavlou-Litina D, Haegeman G, Vanden Berghe W.

Molecules. 2015 Jan 8;20(1):863-78. doi: 10.3390/molecules20010863.

11.

NF-κB is required for dengue virus NS5-induced RANTES expression.

Khunchai S, Junking M, Suttitheptumrong A, Kooptiwut S, Haegeman G, Limjindaporn T, Yenchitsomanus PT.

Virus Res. 2015 Feb 2;197:92-100. doi: 10.1016/j.virusres.2014.12.007. Epub 2014 Dec 16.

PMID:
25523420
12.

Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs: involvement of MAPK and NF-κB pathways.

Achoui M, Heyninck K, Looi CY, Mustafa AM, Haegeman G, Mustafa MR.

Drug Des Devel Ther. 2014 Oct 20;8:1993-2007. doi: 10.2147/DDDT.S68659. eCollection 2014.

13.

Inhibition of corticosteroid-binding globulin gene expression by glucocorticoids involves C/EBPβ.

Verhoog N, Allie-Reid F, Vanden Berghe W, Smith C, Haegeman G, Hapgood J, Louw A.

PLoS One. 2014 Oct 21;9(10):e110702. doi: 10.1371/journal.pone.0110702. eCollection 2014.

14.

Cancer-specific interruption of glucose metabolism by resveratrol is mediated through inhibition of Akt/GLUT1 axis in ovarian cancer cells.

Gwak H, Haegeman G, Tsang BK, Song YS.

Mol Carcinog. 2015 Dec;54(12):1529-40. doi: 10.1002/mc.22227. Epub 2014 Oct 12.

PMID:
25307508
15.

Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ.

Heyninck K, Lahtela-Kakkonen M, Van der Veken P, Haegeman G, Vanden Berghe W.

Biochem Pharmacol. 2014 Oct 15;91(4):501-9. doi: 10.1016/j.bcp.2014.08.004. Epub 2014 Aug 23.

PMID:
25159986
16.

Compound A, a selective glucocorticoid receptor agonist, inhibits immunoinflammatory diabetes, induced by multiple low doses of streptozotocin in mice.

Saksida T, Vujicic M, Nikolic I, Stojanovic I, Haegeman G, Stosic-Grujicic S.

Br J Pharmacol. 2014 Dec;171(24):5898-909. doi: 10.1111/bph.12892. Epub 2014 Nov 24.

17.

How the venom from the ectoparasitoid Wasp nasonia vitripennis exhibits anti-inflammatory properties on mammalian cell lines.

Danneels EL, Gerlo S, Heyninck K, Van Craenenbroeck K, De Bosscher K, Haegeman G, de Graaf DC.

PLoS One. 2014 May 12;9(5):e96825. doi: 10.1371/journal.pone.0096825. eCollection 2014.

18.

Dietary flavanols modulate the transcription of genes associated with cardiovascular pathology without changes in their DNA methylation state.

Milenkovic D, Vanden Berghe W, Boby C, Leroux C, Declerck K, Szarc vel Szic K, Heyninck K, Laukens K, Bizet M, Defrance M, Dedeurwaerder S, Calonne E, Fuks F, Haegeman G, Haenen GR, Bast A, Weseler AR.

PLoS One. 2014 Apr 24;9(4):e95527. doi: 10.1371/journal.pone.0095527. eCollection 2014.

19.

Genistein inhibits phorbol ester-induced NF-κB transcriptional activity and COX-2 expression by blocking the phosphorylation of p65/RelA in human mammary epithelial cells.

Chung MH, Kim DH, Na HK, Kim JH, Kim HN, Haegeman G, Surh YJ.

Mutat Res. 2014 Oct;768:74-83. doi: 10.1016/j.mrfmmm.2014.04.003. Epub 2014 Apr 15.

PMID:
24742714
20.

β-agonists selectively modulate proinflammatory gene expression in skeletal muscle cells via non-canonical nuclear crosstalk mechanisms.

Kolmus K, Van Troys M, Van Wesemael K, Ampe C, Haegeman G, Tavernier J, Gerlo S.

PLoS One. 2014 Mar 6;9(6):e90649. doi: 10.1371/journal.pone.0090649. eCollection 2014.

21.

The serotonin 5-HT7 receptors: two decades of research.

Gellynck E, Heyninck K, Andressen KW, Haegeman G, Levy FO, Vanhoenacker P, Van Craenenbroeck K.

Exp Brain Res. 2013 Oct;230(4):555-68. doi: 10.1007/s00221-013-3694-y. Epub 2013 Sep 17. Review.

PMID:
24042216
22.

Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation.

Beck IM, Drebert ZJ, Hoya-Arias R, Bahar AA, Devos M, Clarisse D, Desmet S, Bougarne N, Ruttens B, Gossye V, Denecker G, Lievens S, Bracke M, Tavernier J, Declercq W, Gevaert K, Vanden Berghe W, Haegeman G, De Bosscher K.

PLoS One. 2013 Jul 30;8(7):e69115. doi: 10.1371/journal.pone.0069115. Print 2013.

23.

Effects of the selective glucocorticoid receptor modulator compound A on bone metabolism and inflammation in male mice with collagen-induced arthritis.

Rauner M, Thiele S, Sinningen K, Winzer M, Salbach-Hirsch J, Gloe I, Peschke K, Haegeman G, Tuckermann JP, Hofbauer LC.

Endocrinology. 2013 Oct;154(10):3719-28. doi: 10.1210/en.2012-2221. Epub 2013 Jul 24.

PMID:
23885015
24.

Mitogen- and stress-activated protein kinase 1 MSK1 regulates glucocorticoid response element promoter activity in a glucocorticoid concentration-dependent manner.

Beck IM, Clarisse D, Bougarne N, Okret S, Haegeman G, De Bosscher K.

Eur J Pharmacol. 2013 Sep 5;715(1-3):1-9. doi: 10.1016/j.ejphar.2013.06.032. Epub 2013 Jul 4.

PMID:
23831393
25.

Selective modulation through the glucocorticoid receptor ameliorates muscle pathology in mdx mice.

Huynh T, Uaesoontrachoon K, Quinn JL, Tatem KS, Heier CR, Van Der Meulen JH, Yu Q, Harris M, Nolan CJ, Haegeman G, Grounds MD, Nagaraju K.

J Pathol. 2013 Oct;231(2):223-35. doi: 10.1002/path.4231.

26.

Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1.

De Bosscher K, Beck IM, Dejager L, Bougarne N, Gaigneaux A, Chateauvieux S, Ratman D, Bracke M, Tavernier J, Vanden Berghe W, Libert C, Diederich M, Haegeman G.

Cell Mol Life Sci. 2014 Jan;71(1):143-63. doi: 10.1007/s00018-013-1367-4. Epub 2013 Jun 20.

27.

Compound A, a dissociated glucocorticoid receptor modulator, reduces dengue virus-induced cytokine secretion and dengue virus production.

Suttitheptumrong A, Khunchai S, Panaampon J, Yasamut U, Morchang A, Puttikhunt C, Noisakran S, Haegeman G, Yenchitsomanus PT, Limjindaporn T.

Biochem Biophys Res Commun. 2013 Jun 28;436(2):283-8. doi: 10.1016/j.bbrc.2013.05.094. Epub 2013 Jun 4.

PMID:
23743190
28.

In vitro inhibition of the transcription factor NF-κB and cyclooxygenase by bamboo extracts.

Van Hoyweghen L, De Bosscher K, Haegeman G, Deforce D, Heyerick A.

Phytother Res. 2014 Feb;28(2):224-30. doi: 10.1002/ptr.4978. Epub 2013 Apr 5.

PMID:
23559516
29.

Molecular insight in the multifunctional activities of Withaferin A.

Vanden Berghe W, Sabbe L, Kaileh M, Haegeman G, Heyninck K.

Biochem Pharmacol. 2012 Nov 15;84(10):1282-91. doi: 10.1016/j.bcp.2012.08.027. Epub 2012 Sep 6. Review.

PMID:
22981382
30.

Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells.

Liberman AC, Antunica-Noguerol M, Ferraz-de-Paula V, Palermo-Neto J, Castro CN, Druker J, Holsboer F, Perone MJ, Gerlo S, De Bosscher K, Haegeman G, Arzt E.

PLoS One. 2012;7(4):e35155. doi: 10.1371/journal.pone.0035155. Epub 2012 Apr 9. Erratum in: PLoS One. 2012;7(5): doi/10.1371/annotation/12a8fc89-5f47-4bad-8863-863d99a0e52d.

31.

Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT₇a receptor.

Gellynck E, Andressen KW, Lintermans B, Haegeman G, Levy FO, Vanhoenacker P, Van Craenenbroeck K.

FEBS J. 2012 Jun;279(11):1994-2003. doi: 10.1111/j.1742-4658.2012.08581.x. Epub 2012 Apr 25.

32.

A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma.

Reber LL, Daubeuf F, Plantinga M, De Cauwer L, Gerlo S, Waelput W, Van Calenbergh S, Tavernier J, Haegeman G, Lambrecht BN, Frossard N, De Bosscher K.

J Immunol. 2012 Apr 1;188(7):3478-87. doi: 10.4049/jimmunol.1004227. Epub 2012 Mar 5.

33.

RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation.

Matthys A, Van Craenenbroeck K, Lintermans B, Haegeman G, Vanhoenacker P.

Cell Signal. 2012 May;24(5):1053-63. doi: 10.1016/j.cellsig.2011.12.027. Epub 2012 Jan 5.

PMID:
22245496
34.

Attenuation of ERK/RSK2-driven NFκB gene expression and cancer cell proliferation by kurarinone, a lavandulyl flavanone isolated from Sophora flavescens ait. roots.

Berghe WV, De Naeyer A, Dijsselbloem N, David JP, De Keukeleire D, Haegeman G.

Endocr Metab Immune Disord Drug Targets. 2011 Sep 1;11(3):247-61.

PMID:
21831037
35.

Cyclic AMP: a selective modulator of NF-κB action.

Gerlo S, Kooijman R, Beck IM, Kolmus K, Spooren A, Haegeman G.

Cell Mol Life Sci. 2011 Dec;68(23):3823-41. doi: 10.1007/s00018-011-0757-8. Epub 2011 Jul 9. Review.

PMID:
21744067
36.

Glucocorticoid receptor mutants: man-made tools for functional research.

Beck IM, De Bosscher K, Haegeman G.

Trends Endocrinol Metab. 2011 Aug;22(8):295-310. doi: 10.1016/j.tem.2011.03.009. Epub 2011 May 5. Review.

PMID:
21549614
37.

Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives.

Matthys A, Haegeman G, Van Craenenbroeck K, Vanhoenacker P.

Mol Neurobiol. 2011 Jun;43(3):228-53. doi: 10.1007/s12035-011-8175-3. Epub 2011 Mar 22. Review.

PMID:
21424680
38.

Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells.

García-Rivera D, Delgado R, Bougarne N, Haegeman G, Berghe WV.

Cancer Lett. 2011 Jun 1;305(1):21-31. doi: 10.1016/j.canlet.2011.02.011. Epub 2011 Mar 21.

PMID:
21420233
39.

Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes.

Verstraete K, Remmerie B, Elegheert J, Lintermans B, Haegeman G, Vanhoenacker P, Van Craenenbroeck K, Savvides SN.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Mar 1;67(Pt 3):325-31. doi: 10.1107/S1744309111003319. Epub 2011 Feb 23.

40.

Dopamine D4 receptor oligomerization--contribution to receptor biogenesis.

Van Craenenbroeck K, Borroto-Escuela DO, Romero-Fernandez W, Skieterska K, Rondou P, Lintermans B, Vanhoenacker P, Fuxe K, Ciruela F, Haegeman G.

FEBS J. 2011 Apr;278(8):1333-44. doi: 10.1111/j.1742-4658.2011.08052.x. Epub 2011 Mar 10.

41.

IL-1β potently stabilizes IL-6 mRNA in human astrocytes.

Spooren A, Mestdagh P, Rondou P, Kolmus K, Haegeman G, Gerlo S.

Biochem Pharmacol. 2011 Apr 15;81(8):1004-15. doi: 10.1016/j.bcp.2011.01.019. Epub 2011 Feb 12.

PMID:
21300032
42.

Interleukin-6, a mental cytokine.

Spooren A, Kolmus K, Laureys G, Clinckers R, De Keyser J, Haegeman G, Gerlo S.

Brain Res Rev. 2011 Jun 24;67(1-2):157-83. doi: 10.1016/j.brainresrev.2011.01.002. Epub 2011 Jan 14. Review.

PMID:
21238488
43.

An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation.

Rauch A, Gossye V, Bracke D, Gevaert E, Jacques P, Van Beneden K, Vandooren B, Rauner M, Hofbauer LC, Haegeman G, Elewaut D, Tuckermann JP, De Bosscher K.

FASEB J. 2011 Apr;25(4):1323-32. doi: 10.1096/fj.10-173393. Epub 2011 Jan 13.

PMID:
21233489
44.

Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions.

Borroto-Escuela DO, Van Craenenbroeck K, Romero-Fernandez W, Guidolin D, Woods AS, Rivera A, Haegeman G, Agnati LF, Tarakanov AO, Fuxe K.

Biochem Biophys Res Commun. 2011 Jan 28;404(4):928-34. doi: 10.1016/j.bbrc.2010.12.083. Epub 2010 Dec 22.

PMID:
21184734
45.

Dissociation of osteogenic and immunological effects by the selective glucocorticoid receptor agonist, compound A, in human bone marrow stromal cells.

Rauner M, Goettsch C, Stein N, Thiele S, Bornhaeuser M, De Bosscher K, Haegeman G, Tuckermann J, Hofbauer LC.

Endocrinology. 2011 Jan;152(1):103-12. doi: 10.1210/en.2010-0456. Epub 2010 Nov 17.

PMID:
21084452
46.

Nature or nurture: let food be your epigenetic medicine in chronic inflammatory disorders.

Szarc vel Szic K, Ndlovu MN, Haegeman G, Vanden Berghe W.

Biochem Pharmacol. 2010 Dec 15;80(12):1816-32. doi: 10.1016/j.bcp.2010.07.029. Epub 2010 Aug 3. Review.

PMID:
20688047
47.

Classic glucocorticoids versus non-steroidal glucocorticoid receptor modulators: survival of the fittest regulator of the immune system?

De Bosscher K, Beck IM, Haegeman G.

Brain Behav Immun. 2010 Oct;24(7):1035-42. doi: 10.1016/j.bbi.2010.06.010. Epub 2010 Jun 25. Review.

PMID:
20600811
48.

Epigenetic remedies by dietary phytochemicals against inflammatory skin disorders: myth or reality?

Vanden Berghe W, Haegeman G.

Curr Drug Metab. 2010 Jun 1;11(5):436-50. Review.

PMID:
20540697
49.

Targeting inflammation using selective glucocorticoid receptor modulators.

De Bosscher K, Haegeman G, Elewaut D.

Curr Opin Pharmacol. 2010 Aug;10(4):497-504. doi: 10.1016/j.coph.2010.04.007. Epub 2010 May 20. Review.

PMID:
20493772
50.

Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols.

Suttana W, Mankhetkorn S, Poompimon W, Palagani A, Zhokhov S, Gerlo S, Haegeman G, Berghe WV.

Mol Cancer. 2010 May 3;9:99. doi: 10.1186/1476-4598-9-99.

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