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Items: 16

1.

Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.

Reynolds DS, Rosahl TW, Cirone J, O'Meara GF, Haythornthwaite A, Newman RJ, Myers J, Sur C, Howell O, Rutter AR, Atack J, Macaulay AJ, Hadingham KL, Hutson PH, Belelli D, Lambert JJ, Dawson GR, McKernan R, Whiting PJ, Wafford KA.

J Neurosci. 2003 Sep 17;23(24):8608-17.

2.

Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice.

Sur C, Wafford KA, Reynolds DS, Hadingham KL, Bromidge F, Macaulay A, Collinson N, O'Meara G, Howell O, Newman R, Myers J, Atack JR, Dawson GR, McKernan RM, Whiting PJ, Rosahl TW.

J Neurosci. 2001 May 15;21(10):3409-18.

3.

Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.

Casula MA, Bromidge FA, Pillai GV, Wingrove PB, Martin K, Maubach K, Seabrook GR, Whiting PJ, Hadingham KL.

J Neurochem. 2001 Apr;77(2):445-51.

4.

Pharmacology of recombinant human GABA(A) receptor subtypes measured using a novel pH-based high-throughput functional efficacy assay.

Simpson PB, Woollacott AJ, Pillai GV, Maubach KA, Hadingham KL, Martin K, Choudhury HI, Seabrook GR.

J Neurosci Methods. 2000 Jun 30;99(1-2):91-100.

PMID:
10936648
5.

Alpha subunit isoform influences GABA(A) receptor modulation by propofol.

Krasowski MD, O'Shea SM, Rick CE, Whiting PJ, Hadingham KL, Czajkowski C, Harrison NL.

Neuropharmacology. 1997 Jul;36(7):941-9.

6.

Microtubule depolymerization inhibits ethanol-induced enhancement of GABAA responses in stably transfected cells.

Whatley VJ, Brozowski SJ, Hadingham KL, Whiting PJ, Harris RA.

J Neurochem. 1996 Mar;66(3):1318-21.

PMID:
8769900
7.

Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors.

Hadingham KL, Garrett EM, Wafford KA, Bain C, Heavens RP, Sirinathsinghji DJ, Whiting PJ.

Mol Pharmacol. 1996 Feb;49(2):253-9.

PMID:
8632757
8.

Identification of domains in human recombinant GABAA receptors that are photoaffinity labelled by [3H]flunitrazepam and [3H]Ro15-4513.

Davies M, Martin IL, Bateson AN, Hadingham KL, Whiting PJ, Dunn SM.

Neuropharmacology. 1996;35(9-10):1199-208.

PMID:
9014135
9.

Expression and pharmacology of human GABAA receptors containing gamma 3 subunits.

Hadingham KL, Wafford KA, Thompson SA, Palmer KJ, Whiting PJ.

Eur J Pharmacol. 1995 Nov 30;291(3):301-9.

PMID:
8719414
10.

Regulation of allosteric coupling and function of stably expressed gamma-aminobutyric acid (GABA)A receptors by chronic treatment with GABAA and benzodiazepine agonists.

Klein RL, Mascia MP, Harkness PC, Hadingham KL, Whiting PJ, Harris RA.

J Pharmacol Exp Ther. 1995 Sep;274(3):1484-92.

PMID:
7562525
11.

The pharmacology of the benzodiazepine site of the GABA-A receptor is dependent on the type of gamma-subunit present.

McKernan RM, Wafford K, Quirk K, Hadingham KL, Harley EA, Ragan CI, Whiting PJ.

J Recept Signal Transduct Res. 1995 Jan-Mar;15(1-4):173-83.

PMID:
8903939
12.

Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors.

Hadingham KL, Wingrove PB, Wafford KA, Bain C, Kemp JA, Palmer KJ, Wilson AW, Wilcox AS, Sikela JM, Ragan CI, et al.

Mol Pharmacol. 1993 Dec;44(6):1211-8. Erratum in: Mol Pharmacol 1994 Jul;46(1):211.

PMID:
8264558
14.

The influence of the gamma 2L subunit on the modulation of responses to GABAA receptor activation.

Horne AL, Harkness PC, Hadingham KL, Whiting P, Kemp JA.

Br J Pharmacol. 1993 Mar;108(3):711-6.

15.
16.

Stable expression of mammalian type A gamma-aminobutyric acid receptors in mouse cells: demonstration of functional assembly of benzodiazepine-responsive sites.

Hadingham KL, Harkness PC, McKernan RM, Quirk K, Le Bourdell├Ęs B, Horne AL, Kemp JA, Barnard EA, Ragan CI, Whiting PJ.

Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6378-82.

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