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Items: 38

1.

Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans.

Wagner A, Hofmeister O, Rolland SG, Maiser A, Aasumets K, Schmitt S, Schorpp K, Feuchtinger A, Hadian K, Schneider S, Zischka H, Leonhardt H, Conradt B, Gerhold JM, Wolf A.

J Cell Sci. 2019 Oct 1;132(19). pii: jcs223891. doi: 10.1242/jcs.223891.

PMID:
31434717
2.

Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.

Mariappan A, Soni K, Schorpp K, Zhao F, Minakar A, Zheng X, Mandad S, Macheleidt I, Ramani A, Kubelka T, Dawidowski M, Golfmann K, Wason A, Yang C, Simons J, Schmalz HG, Hyman AA, Aneja R, Ullrich R, Urlaub H, Odenthal M, Büttner R, Li H, Sattler M, Hadian K, Gopalakrishnan J.

EMBO J. 2019 Jan 15;38(2). pii: e99876. doi: 10.15252/embj.201899876. Epub 2018 Dec 10.

3.

Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity.

Brenke JK, Popowicz GM, Schorpp K, Rothenaigner I, Roesner M, Meininger I, Kalinski C, Ringelstetter L, R'kyek O, Jürjens G, Vincendeau M, Plettenburg O, Sattler M, Krappmann D, Hadian K.

J Biol Chem. 2018 Aug 24;293(34):13191-13203. doi: 10.1074/jbc.RA118.002649. Epub 2018 Jun 27.

4.

A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor.

Tretter JY, Schorpp K, Luxenburger E, Trambauer J, Steiner H, Hadian K, Gires O, Niessing D.

J Biol Chem. 2018 Jun 8;293(23):8994-9005. doi: 10.1074/jbc.RA118.002776. Epub 2018 Apr 26.

5.

E1B-55K-Mediated Regulation of RNF4 SUMO-Targeted Ubiquitin Ligase Promotes Human Adenovirus Gene Expression.

Müncheberg S, Hay RT, Ip WH, Meyer T, Weiß C, Brenke J, Masser S, Hadian K, Dobner T, Schreiner S.

J Virol. 2018 Jun 13;92(13). pii: e00164-18. doi: 10.1128/JVI.00164-18. Print 2018 Jul 1.

6.

Luciferase Advisor: High-Accuracy Model To Flag False Positive Hits in Luciferase HTS Assays.

Ghosh D, Koch U, Hadian K, Sattler M, Tetko IV.

J Chem Inf Model. 2018 May 29;58(5):933-942. doi: 10.1021/acs.jcim.7b00574. Epub 2018 Apr 18.

PMID:
29667823
7.

Reducing Mutant Huntingtin Protein Expression in Living Cells by a Newly Identified RNA CAG Binder.

Matthes F, Massari S, Bochicchio A, Schorpp K, Schilling J, Weber S, Offermann N, Desantis J, Wanker E, Carloni P, Hadian K, Tabarrini O, Rossetti G, Krauss S.

ACS Chem Neurosci. 2018 Jun 20;9(6):1399-1408. doi: 10.1021/acschemneuro.8b00027. Epub 2018 Mar 14.

8.

An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system.

Kirchner M, Schorpp K, Hadian K, Schneider S.

Sci Rep. 2017 Aug 10;7(1):7732. doi: 10.1038/s41598-017-07870-w.

9.

A high-content small molecule screen identifies novel inducers of definitive endoderm.

Korostylev A, Mahaddalkar PU, Keminer O, Hadian K, Schorpp K, Gribbon P, Lickert H.

Mol Metab. 2017 May 4;6(7):640-650. doi: 10.1016/j.molmet.2017.04.009. eCollection 2017 Jul.

10.

Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.

Dawidowski M, Emmanouilidis L, Kalel VC, Tripsianes K, Schorpp K, Hadian K, Kaiser M, Mäser P, Kolonko M, Tanghe S, Rodriguez A, Schliebs W, Erdmann R, Sattler M, Popowicz GM.

Science. 2017 Mar 31;355(6332):1416-1420. doi: 10.1126/science.aal1807.

PMID:
28360328
11.

YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB.

Schimmack G, Schorpp K, Kutzner K, Gehring T, Brenke JK, Hadian K, Krappmann D.

Elife. 2017 Feb 28;6. pii: e22416. doi: 10.7554/eLife.22416.

12.

A High-Throughput Screening Strategy for Development of RNF8-Ubc13 Protein-Protein Interaction Inhibitors.

Weber E, Rothenaigner I, Brandner S, Hadian K, Schorpp K.

SLAS Discov. 2017 Mar;22(3):316-323. doi: 10.1177/1087057116681408. Epub 2016 Dec 13.

PMID:
27909234
13.

A Multiplexed High-Content Screening Approach Using the Chromobody Technology to Identify Cell Cycle Modulators in Living Cells.

Schorpp K, Rothenaigner I, Maier J, Traenkle B, Rothbauer U, Hadian K.

J Biomol Screen. 2016 Oct;21(9):965-77. doi: 10.1177/1087057116641935. Epub 2016 Apr 4.

PMID:
27044685
14.

Identification of Small-Molecule Frequent Hitters of Glutathione S-Transferase-Glutathione Interaction.

Brenke JK, Salmina ES, Ringelstetter L, Dornauer S, Kuzikov M, Rothenaigner I, Schorpp K, Giehler F, Gopalakrishnan J, Kieser A, Gul S, Tetko IV, Hadian K.

J Biomol Screen. 2016 Jul;21(6):596-607. doi: 10.1177/1087057116639992. Epub 2016 Apr 4.

PMID:
27044684
15.

Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.

Jung B, Messias AC, Schorpp K, Geerlof A, Schneider G, Saur D, Hadian K, Sattler M, Wanker EE, Hasenöder S, Lickert H.

Sci Rep. 2016 Mar 2;6:22540. doi: 10.1038/srep22540.

16.

Three-dimensional microtissues essentially contribute to preclinical validations of therapeutic targets in breast cancer.

Falkenberg N, Höfig I, Rosemann M, Szumielewski J, Richter S, Schorpp K, Hadian K, Aubele M, Atkinson MJ, Anastasov N.

Cancer Med. 2016 Apr;5(4):703-10. doi: 10.1002/cam4.630. Epub 2016 Jan 14.

17.

Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction.

Vincendeau M, Hadian K, Messias AC, Brenke JK, Halander J, Griesbach R, Greczmiel U, Bertossi A, Stehle R, Nagel D, Demski K, Velvarska H, Niessing D, Geerlof A, Sattler M, Krappmann D.

Sci Rep. 2016 Jan 7;6:18934. doi: 10.1038/srep18934.

18.

Development of A Cell-Based Assay to Identify Small Molecule Inhibitors of FGF23 Signaling.

Diener S, Schorpp K, Strom TM, Hadian K, Lorenz-Depiereux B.

Assay Drug Dev Technol. 2015 Oct;13(8):476-87. doi: 10.1089/adt.2015.653.

PMID:
26461432
19.

A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment.

Anastasov N, Höfig I, Radulović V, Ströbel S, Salomon M, Lichtenberg J, Rothenaigner I, Hadian K, Kelm JM, Thirion C, Atkinson MJ.

BMC Cancer. 2015 Jun 10;15:466. doi: 10.1186/s12885-015-1481-9.

20.

New small molecules targeting apoptosis and cell viability in osteosarcoma.

Maugg D, Rothenaigner I, Schorpp K, Potukuchi HK, Korsching E, Baumhoer D, Hadian K, Smida J, Nathrath M.

PLoS One. 2015 Jun 3;10(6):e0129058. doi: 10.1371/journal.pone.0129058. eCollection 2015.

21.

Modulation of human endogenous retrovirus (HERV) transcription during persistent and de novo HIV-1 infection.

Vincendeau M, Göttesdorfer I, Schreml JM, Wetie AG, Mayer J, Greenwood AD, Helfer M, Kramer S, Seifarth W, Hadian K, Brack-Werner R, Leib-Mösch C.

Retrovirology. 2015 Mar 24;12:27. doi: 10.1186/s12977-015-0156-6.

22.

In vitro detection of NEMO-ubiquitin binding using DELFIA and microscale thermophoresis assays.

Vincendeau M, Krappmann D, Hadian K.

Methods Mol Biol. 2015;1280:311-20. doi: 10.1007/978-1-4939-2422-6_18.

PMID:
25736757
23.

Protein-protein interaction modulator drug discovery: past efforts and future opportunities using a rich source of low- and high-throughput screening assays.

Gul S, Hadian K.

Expert Opin Drug Discov. 2014 Dec;9(12):1393-404. doi: 10.1517/17460441.2014.954544. Epub 2014 Nov 6. Review.

PMID:
25374163
24.

Small molecule screening at Helmholtz Zentrum München - from biology to molecules.

Schorpp K, Hadian K.

Comb Chem High Throughput Screen. 2014 Mar;17(3):266-71.

PMID:
24409952
25.

Identification of Small-Molecule Frequent Hitters from AlphaScreen High-Throughput Screens.

Schorpp K, Rothenaigner I, Salmina E, Reinshagen J, Low T, Brenke JK, Gopalakrishnan J, Tetko IV, Gul S, Hadian K.

J Biomol Screen. 2014 Jun;19(5):715-26. doi: 10.1177/1087057113516861. Epub 2013 Dec 26.

26.

Heterogenous nuclear ribonucleoprotein Q increases protein expression from HIV-1 Rev-dependent transcripts.

Vincendeau M, Nagel D, Brenke JK, Brack-Werner R, Hadian K.

Virol J. 2013 May 16;10:151. doi: 10.1186/1743-422X-10-151.

27.

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.

Müller-Rischart AK, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Peis R, Deinlein A, Schweimer C, Kuhn PH, Lichtenthaler SF, Motori E, Hrelia S, Wurst W, Trümbach D, Langer T, Krappmann D, Dittmar G, Tatzelt J, Winklhofer KF.

Mol Cell. 2013 Mar 7;49(5):908-21. doi: 10.1016/j.molcel.2013.01.036. Epub 2013 Feb 28.

28.

Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.

Nagel D, Spranger S, Vincendeau M, Grau M, Raffegerst S, Kloo B, Hlahla D, Neuenschwander M, Peter von Kries J, Hadian K, Dörken B, Lenz P, Lenz G, Schendel DJ, Krappmann D.

Cancer Cell. 2012 Dec 11;22(6):825-37. doi: 10.1016/j.ccr.2012.11.002.

29.

NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation.

Hadian K, Griesbach RA, Dornauer S, Wanger TM, Nagel D, Metlitzky M, Beisker W, Schmidt-Supprian M, Krappmann D.

J Biol Chem. 2011 Jul 22;286(29):26107-17. doi: 10.1074/jbc.M111.233163. Epub 2011 May 26.

30.

Signals from the nucleus: activation of NF-kappaB by cytosolic ATM in the DNA damage response.

Hadian K, Krappmann D.

Sci Signal. 2011 Jan 18;4(156):pe2. doi: 10.1126/scisignal.2001712.

PMID:
21245467
31.

Ubiquitin Conjugation and Deconjugation in NF-κB Signaling.

Düwel M, Hadian K, Krappmann D.

Subcell Biochem. 2010;54:88-99. doi: 10.1007/978-1-4419-6676-6_7. Review.

PMID:
21222275
32.

Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation.

Eitelhuber AC, Warth S, Schimmack G, Düwel M, Hadian K, Demski K, Beisker W, Shinohara H, Kurosaki T, Heissmeyer V, Krappmann D.

EMBO J. 2011 Feb 2;30(3):594-605. doi: 10.1038/emboj.2010.331. Epub 2010 Dec 14.

33.

Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).

Vincendeau M, Kramer S, Hadian K, Rothenaigner I, Bell J, Hauck SM, Bickel C, Nagel D, Kremmer E, Werner T, Leib-Mösch C, Brack-Werner R.

AIDS. 2010 Oct 23;24(16):2433-42. doi: 10.1097/QAD.0b013e32833e8758.

PMID:
20827171
34.

The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2.

Rybak A, Fuchs H, Hadian K, Smirnova L, Wulczyn EA, Michel G, Nitsch R, Krappmann D, Wulczyn FG.

Nat Cell Biol. 2009 Dec;11(12):1411-20. doi: 10.1038/ncb1987. Epub 2009 Nov 8.

PMID:
19898466
35.

Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein.

Hadian K, Vincendeau M, Mäusbacher N, Nagel D, Hauck SM, Ueffing M, Loyter A, Werner T, Wolff H, Brack-Werner R.

J Biol Chem. 2009 Nov 27;284(48):33384-91. doi: 10.1074/jbc.M109.021659. Epub 2009 Oct 5.

36.

Live-cell assay for simultaneous monitoring of expression and interaction of proteins.

Wolff H, Hartl A, Eilken HM, Hadian K, Ziegler M, Brack-Werner R.

Biotechniques. 2006 Dec;41(6):688, 690, 692. No abstract available.

37.

Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging.

Wolff H, Hadian K, Ziegler M, Weierich C, Kramer-Hammerle S, Kleinschmidt A, Erfle V, Brack-Werner R.

Exp Cell Res. 2006 Feb 15;312(4):443-56.

PMID:
16368434
38.

The periplasmic E. coli chaperone Skp is a trimer in solution: biophysical and preliminary crystallographic characterization.

Schlapschy M, Dommel MK, Hadian K, Fogarasi M, Korndörfer IP, Skerra A.

Biol Chem. 2004 Feb;385(2):137-43.

PMID:
15101556

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