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Intermittent Hypoxia and Hypercapnia Induces Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta-dependent Atherosclerosis in Pulmonary Arteries.

Imamura T, Xue J, Poulsen O, Zhou D, Karin M, Haddad GG.

Am J Physiol Regul Integr Comp Physiol. 2019 Oct 16. doi: 10.1152/ajpregu.00056.2019. [Epub ahead of print]


Increased hypoxic proliferative response and gene expression in erythroid progenitor cells of Andean highlanders with Chronic Mountain Sickness.

Bermudez D, Azad P, Figueroa-Mujíca R, Vizcardo-Galindo G, Corante N, Guerra-Giraldez C, Haddad GG, Villafuerte FC.

Am J Physiol Regul Integr Comp Physiol. 2019 Oct 16. doi: 10.1152/ajpregu.00250.2019. [Epub ahead of print]


Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.

Trujillo CA, Gao R, Negraes PD, Gu J, Buchanan J, Preissl S, Wang A, Wu W, Haddad GG, Chaim IA, Domissy A, Vandenberghe M, Devor A, Yeo GW, Voytek B, Muotri AR.

Cell Stem Cell. 2019 Oct 3;25(4):558-569.e7. doi: 10.1016/j.stem.2019.08.002. Epub 2019 Aug 29.


Commentary: Novel Insight into the Genetic Basis of High Altitude Pulmonary Hypertension in Kyrgyz Highlanders.

Stobdan T, Haddad GG.

J Lung Health Dis. 2019;3(2):29-30. Epub 2019 Mar 19. No abstract available.


Intermittent Hypoxia and Hypercapnia Reproducibly Change the Gut Microbiome and Metabolome across Rodent Model Systems.

Tripathi A, Xu ZZ, Xue J, Poulsen O, Gonzalez A, Humphrey G, Meehan MJ, Melnik AV, Ackermann G, Zhou D, Malhotra A, Haddad GG, Dorrestein PC, Knight R.

mSystems. 2019 Apr 30;4(2). pii: e00058-19. doi: 10.1128/mSystems.00058-19. eCollection 2019 Mar-Apr.


Frontal-subcortical behaviors during Alzheimer's disease in individuals with Down syndrome.

Fonseca LM, Mattar GP, Haddad GG, Gonçalves AS, Miguel AQC, Guilhoto LM, Zaman S, Holland AJ, Bottino CMC, Hoexter MQ.

Neurobiol Aging. 2019 Jun;78:186-194. doi: 10.1016/j.neurobiolaging.2019.02.028. Epub 2019 Mar 11.


High fat diet induces sex-specific differential gene expression in Drosophila melanogaster.

Stobdan T, Sahoo D, Azad P, Hartley I, Heinrichsen E, Zhou D, Haddad GG.

PLoS One. 2019 Mar 12;14(3):e0213474. doi: 10.1371/journal.pone.0213474. eCollection 2019.


The validity and reliability of the CAMDEX-DS for assessing dementia in adults with Down syndrome in Brazil.

Fonseca LM, Haddad GG, Mattar GP, Oliveira MC, Simon SS, Guilhoto LM, Busatto GF, Zaman S, Holland AJ, Hoexter MQ, Bottino CM.

Braz J Psychiatry. 2019 May-Jun;41(3):225-233. doi: 10.1590/1516-4446-2018-0033. Epub 2018 Oct 22.


Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders.

Iranmehr A, Stobdan T, Zhou D, Poulsen O, Strohl KP, Aldashev A, Telenti A, Wong EHM, Kirkness EF, Venter JC, Bafna V, Haddad GG.

Eur J Hum Genet. 2019 Jan;27(1):150-159. doi: 10.1038/s41431-018-0270-8. Epub 2018 Sep 25.


Cardiac-specific knockout and pharmacological inhibition of Endothelin receptor type B lead to cardiac resistance to extreme hypoxia.

Stobdan T, Zhou D, Williams AT, Cabrales P, Haddad GG.

J Mol Med (Berl). 2018 Sep;96(9):975-982. doi: 10.1007/s00109-018-1673-2. Epub 2018 Aug 1.


Exploring miRNA-mRNA regulatory network in cardiac pathology in Na+/H+ exchanger isoform 1 transgenic mice.

Xue J, Zhou D, Poulsen O, Hartley I, Imamura T, Xie EX, Haddad GG.

Physiol Genomics. 2018 Oct 1;50(10):846-861. doi: 10.1152/physiolgenomics.00048.2018. Epub 2018 Jul 20.


Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome.

Tripathi A, Melnik AV, Xue J, Poulsen O, Meehan MJ, Humphrey G, Jiang L, Ackermann G, McDonald D, Zhou D, Knight R, Dorrestein PC, Haddad GG.

mSystems. 2018 Jun 5;3(3). pii: e00020-18. doi: 10.1128/mSystems.00020-18. eCollection 2018 May-Jun.


Intracellular pH Regulation in iPSCs-derived Astrocytes from Subjects with Chronic Mountain Sickness.

Yao H, Zhao H, Wang J, Haddad GG.

Neuroscience. 2018 Apr 1;375:25-33. doi: 10.1016/j.neuroscience.2018.02.008. Epub 2018 Feb 10.


Mitochondrial dysfunction in iPSC-derived neurons of subjects with chronic mountain sickness.

Zhao H, Perkins G, Yao H, Callacondo D, Appenzeller O, Ellisman M, La Spada AR, Haddad GG.

J Appl Physiol (1985). 2018 Sep 1;125(3):832-840. doi: 10.1152/japplphysiol.00689.2017. Epub 2017 Dec 21.


Down-regulation of Inwardly Rectifying K+ Currents in Astrocytes Derived from Patients with Monge's Disease.

Wu W, Yao H, Zhao HW, Wang J, Haddad GG.

Neuroscience. 2018 Mar 15;374:70-79. doi: 10.1016/j.neuroscience.2018.01.016. Epub 2018 Feb 2.


New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude.

Stobdan T, Akbari A, Azad P, Zhou D, Poulsen O, Appenzeller O, Gonzales GF, Telenti A, Wong EHM, Saini S, Kirkness EF, Venter JC, Bafna V, Haddad GG.

Mol Biol Evol. 2017 Dec 1;34(12):3154-3168. doi: 10.1093/molbev/msx239.


High-altitude adaptation in humans: from genomics to integrative physiology.

Azad P, Stobdan T, Zhou D, Hartley I, Akbari A, Bafna V, Haddad GG.

J Mol Med (Berl). 2017 Dec;95(12):1269-1282. doi: 10.1007/s00109-017-1584-7. Epub 2017 Sep 26. Review.


Transcriptomic analysis identifies a role of PI3K-Akt signalling in the responses of skeletal muscle to acute hypoxia in vivo.

Gan Z, Powell FL, Zambon AC, Buchholz KS, Fu Z, Ocorr K, Bodmer R, Moya EA, Stowe JC, Haddad GG, McCulloch AD.

J Physiol. 2017 Sep 1;595(17):5797-5813. doi: 10.1113/JP274556. Epub 2017 Jul 27.


Intermittent Hypoxia and Hypercapnia Accelerate Atherosclerosis, Partially via Trimethylamine-Oxide.

Xue J, Zhou D, Poulsen O, Imamura T, Hsiao YH, Smith TH, Malhotra A, Dorrestein P, Knight R, Haddad GG.

Am J Respir Cell Mol Biol. 2017 Nov;57(5):581-588. doi: 10.1165/rcmb.2017-0086OC.


Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease.

Azad P, Zhao HW, Cabrales PJ, Ronen R, Zhou D, Poulsen O, Appenzeller O, Hsiao YH, Bafna V, Haddad GG.

J Exp Med. 2016 Nov 14;213(12):2729-2744. Epub 2016 Nov 7.


The Na+/HCO3- co-transporter is protective during ischemia in astrocytes.

Yao H, Azad P, Zhao HW, Wang J, Poulsen O, Freitas BC, Muotri AR, Haddad GG.

Neuroscience. 2016 Dec 17;339:329-337. doi: 10.1016/j.neuroscience.2016.09.050. Epub 2016 Oct 4.


Intermittent hypoxia induces murine macrophage foam cell formation by IKK-β-dependent NF-κB pathway activation.

Imamura T, Poulsen O, Haddad GG.

J Appl Physiol (1985). 2016 Sep 1;121(3):670-7. doi: 10.1152/japplphysiol.00307.2016. Epub 2016 Jul 28.


Experimental evolution of recombination and crossover interference in Drosophila caused by directional selection for stress-related traits.

Aggarwal DD, Rashkovetsky E, Michalak P, Cohen I, Ronin Y, Zhou D, Haddad GG, Korol AB.

BMC Biol. 2015 Nov 27;13:101. doi: 10.1186/s12915-015-0206-5.


Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations.

Jha AR, Zhou D, Brown CD, Kreitman M, Haddad GG, White KP.

Mol Biol Evol. 2016 Feb;33(2):501-17. doi: 10.1093/molbev/msv248. Epub 2015 Nov 17.


Cardiac responses to hypoxia and reoxygenation in Drosophila.

Zarndt R, Piloto S, Powell FL, Haddad GG, Bodmer R, Ocorr K.

Am J Physiol Regul Integr Comp Physiol. 2015 Dec 1;309(11):R1347-57. doi: 10.1152/ajpregu.00164.2015. Epub 2015 Sep 16.


Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice.

Stobdan T, Zhou D, Ao-Ieong E, Ortiz D, Ronen R, Hartley I, Gan Z, McCulloch AD, Bafna V, Cabrales P, Haddad GG.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10425-30. doi: 10.1073/pnas.1507486112. Epub 2015 Aug 3.


Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism.

Manchenkov T, Pasillas MP, Haddad GG, Imam FB.

G3 (Bethesda). 2015 Apr 3;5(6):1107-16. doi: 10.1534/g3.115.018010.


Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension.

Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad GG, Powell FL, Makino A, Mehta D, Yuan JX.

Am J Respir Cell Mol Biol. 2015 Sep;53(3):355-67. doi: 10.1165/rcmb.2014-0235OC.


Altered iPSC-derived neurons' sodium channel properties in subjects with Monge's disease.

Zhao HW, Gu XQ, Chailangkarn T, Perkins G, Callacondo D, Appenzeller O, Poulsen O, Zhou D, Muotri AR, Haddad GG.

Neuroscience. 2015 Mar 12;288:187-99. doi: 10.1016/j.neuroscience.2014.12.039. Epub 2015 Jan 3.


A Drosophila ABC transporter regulates lifespan.

Huang H, Lu-Bo Y, Haddad GG.

PLoS Genet. 2014 Dec 4;10(12):e1004844. doi: 10.1371/journal.pgen.1004844. eCollection 2014 Dec.


High-throughput cell death assays.

Pamenter ME, Haddad GG.

Methods Mol Biol. 2015;1254:153-63. doi: 10.1007/978-1-4939-2152-2_12.


The genetic basis of chronic mountain sickness.

Ronen R, Zhou D, Bafna V, Haddad GG.

Physiology (Bethesda). 2014 Nov;29(6):403-12. doi: 10.1152/physiol.00008.2014. Review.


Hematopoietic stem cells: potential new applications for translational medicine.

Felfly H, Haddad GG.

J Stem Cells. 2014;9(3):163-97. doi: jsc.2014.9.3.163. Review.


Wnt pathway activation increases hypoxia tolerance during development.

Gersten M, Zhou D, Azad P, Haddad GG, Subramaniam S.

PLoS One. 2014 Aug 5;9(8):e103292. doi: 10.1371/journal.pone.0103292. eCollection 2014.


Do BK channels mediate glioma hypoxia-tolerance?

Pamenter ME, Haddad GG.

Channels (Austin). 2014;8(3):176-7. No abstract available.


MAAMD: a workflow to standardize meta-analyses and comparison of affymetrix microarray data.

Gan Z, Wang J, Salomonis N, Stowe JC, Haddad GG, McCulloch AD, Altintas I, Zambon AC.

BMC Bioinformatics. 2014 Mar 12;15:69. doi: 10.1186/1471-2105-15-69.


Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster.

Heinrichsen ET, Zhang H, Robinson JE, Ngo J, Diop S, Bodmer R, Joiner WJ, Metallo CM, Haddad GG.

Mol Metab. 2013 Oct 23;3(1):42-54. doi: 10.1016/j.molmet.2013.10.003. eCollection 2014 Feb.


Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes.

Udpa N, Ronen R, Zhou D, Liang J, Stobdan T, Appenzeller O, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Claydon VE, Hainsworth R, Gamboa JL, Zibenigus M, Zenebe G, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad GG.

Genome Biol. 2014 Feb 20;15(2):R36. doi: 10.1186/gb-2014-15-2-r36.


Mitochondrial but not plasmalemmal BK channels are hypoxia-sensitive in human glioma.

Gu XQ, Pamenter ME, Siemen D, Sun X, Haddad GG.

Glia. 2014 Apr;62(4):504-13. doi: 10.1002/glia.22620. Epub 2014 Jan 20.


Long-lasting changes in DNA methylation following short-term hypoxic exposure in primary hippocampal neuronal cultures.

Hartley I, Elkhoury FF, Heon Shin J, Xie B, Gu X, Gao Y, Zhou D, Haddad GG.

PLoS One. 2013 Oct 25;8(10):e77859. doi: 10.1371/journal.pone.0077859. eCollection 2013.


Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions.

Yin S, Xue J, Sun H, Wen B, Wang Q, Perkins G, Zhao HW, Ellisman MH, Hsiao YH, Yin L, Xie Y, Hou G, Zi J, Lin L, Haddad GG, Zhou D, Liu S.

PLoS One. 2013 Sep 12;8(9):e74011. doi: 10.1371/journal.pone.0074011. eCollection 2013.


Intermittent hypoxia and hypercapnia induce pulmonary artery atherosclerosis and ventricular dysfunction in low density lipoprotein receptor deficient mice.

Douglas RM, Bowden K, Pattison J, Peterson AB, Juliano J, Dalton ND, Gu Y, Alvarez E, Imamura T, Peterson KL, Witztum JL, Haddad GG, Li AC.

J Appl Physiol (1985). 2013 Dec;115(11):1694-704. doi: 10.1152/japplphysiol.00442.2013. Epub 2013 Aug 29.


Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders.

Zhou D, Udpa N, Ronen R, Stobdan T, Liang J, Appenzeller O, Zhao HW, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Gamboa JL, Villafuerte F, Callacondo D, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad GG.

Am J Hum Genet. 2013 Sep 5;93(3):452-62. doi: 10.1016/j.ajhg.2013.07.011. Epub 2013 Aug 15.


Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia.

Xie L, Ng C, Ali T, Valencia R, Ferreira BL, Xue V, Tanweer M, Zhou D, Haddad GG, Bourne PE, Xie L.

BMC Genomics. 2013;14 Suppl 3:S9. doi: 10.1186/1471-2164-14-S3-S9. Epub 2013 May 28.


Chemokine receptor-like 2 is involved in ischemic brain injury.

Douglas RM, Chen AH, Iniguez A, Wang J, Fu Z, Powell FL Jr, Haddad GG, Yao H.

J Exp Stroke Transl Med. 2013 Feb 17;6:1-6.


Genetic analysis of hypoxia tolerance and susceptibility in Drosophila and humans.

Zhou D, Haddad GG.

Annu Rev Genomics Hum Genet. 2013;14:25-43. doi: 10.1146/annurev-genom-091212-153439. Epub 2013 Jun 26. Review.


DIDS (4,4-diisothiocyanatostilbenedisulphonic acid) induces apoptotic cell death in a hippocampal neuronal cell line and is not neuroprotective against ischemic stress.

Pamenter ME, Perkins GA, Gu XQ, Ellisman MH, Haddad GG.

PLoS One. 2013;8(4):e60804. doi: 10.1371/journal.pone.0060804. Epub 2013 Apr 5.


Genetic animal models of preconditioning.

Azad P, Haddad GG.

Transl Stroke Res. 2013 Feb;4(1):51-5. doi: 10.1007/s12975-012-0218-1. Epub 2012 Nov 22. Review.


Physiology's impact: discovering life.

Sieck GC, Haddad GG, Lucchesi P.

Physiology (Bethesda). 2013 Mar;28(2):62-3. doi: 10.1152/physiol.00003.2013. No abstract available.


Autophagy and apoptosis are differentially induced in neurons and astrocytes treated with an in vitro mimic of the ischemic penumbra.

Pamenter ME, Perkins GA, McGinness AK, Gu XQ, Ellisman MH, Haddad GG.

PLoS One. 2012;7(12):e51469. doi: 10.1371/journal.pone.0051469. Epub 2012 Dec 12.

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