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Chlamydia trachomatis CT229 Subverts Rab GTPase-Dependent CCV Trafficking Pathways to Promote Chlamydial Infection.

Faris R, Merling M, Andersen SE, Dooley CA, Hackstadt T, Weber MM.

Cell Rep. 2019 Mar 19;26(12):3380-3390.e5. doi: 10.1016/j.celrep.2019.02.079.


The Rickettsial Ankyrin Repeat Protein 2 Is a Type IV Secreted Effector That Associates with the Endoplasmic Reticulum.

Lehman SS, Noriea NF, Aistleitner K, Clark TR, Dooley CA, Nair V, Kaur SJ, Rahman MS, Gillespie JJ, Azad AF, Hackstadt T.

mBio. 2018 Jun 26;9(3). pii: e00975-18. doi: 10.1128/mBio.00975-18.


Impact of Active Metabolism on Chlamydia trachomatis Elementary Body Transcript Profile and Infectivity.

Grieshaber S, Grieshaber N, Yang H, Baxter B, Hackstadt T, Omsland A.

J Bacteriol. 2018 Jun 25;200(14). pii: e00065-18. doi: 10.1128/JB.00065-18. Print 2018 Jul 15.


Chlamydia trachomatis inclusion membrane protein MrcA interacts with the inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) to regulate extrusion formation.

Nguyen PH, Lutter EI, Hackstadt T.

PLoS Pathog. 2018 Mar 15;14(3):e1006911. doi: 10.1371/journal.ppat.1006911. eCollection 2018 Mar.


The intrinsically disordered Tarp protein from chlamydia binds actin with a partially preformed helix.

Tolchard J, Walpole SJ, Miles AJ, Maytum R, Eaglen LA, Hackstadt T, Wallace BA, Blumenschein TMA.

Sci Rep. 2018 Jan 31;8(1):1960. doi: 10.1038/s41598-018-20290-8.


Absence of Specific Chlamydia trachomatis Inclusion Membrane Proteins Triggers Premature Inclusion Membrane Lysis and Host Cell Death.

Weber MM, Lam JL, Dooley CA, Noriea NF, Hansen BT, Hoyt FH, Carmody AB, Sturdevant GL, Hackstadt T.

Cell Rep. 2017 May 16;19(7):1406-1417. doi: 10.1016/j.celrep.2017.04.058.


Chlamydia Hijacks ARF GTPases To Coordinate Microtubule Posttranslational Modifications and Golgi Complex Positioning.

Wesolowski J, Weber MM, Nawrotek A, Dooley CA, Calderon M, St Croix CM, Hackstadt T, Cherfils J, Paumet F.

mBio. 2017 May 2;8(3). pii: e02280-16. doi: 10.1128/mBio.02280-16.


Proteolytic Cleavage of the Immunodominant Outer Membrane Protein rOmpA in Rickettsia rickettsii.

Noriea NF, Clark TR, Mead D, Hackstadt T.

J Bacteriol. 2017 Feb 28;199(6). pii: e00826-16. doi: 10.1128/JB.00826-16. Print 2017 Mar 15.


A Functional Core of IncA Is Required for Chlamydia trachomatis Inclusion Fusion.

Weber MM, Noriea NF, Bauler LD, Lam JL, Sager J, Wesolowski J, Paumet F, Hackstadt T.

J Bacteriol. 2016 Mar 31;198(8):1347-55. doi: 10.1128/JB.00933-15. Print 2016 Apr.


Expression and localization of predicted inclusion membrane proteins in Chlamydia trachomatis.

Weber MM, Bauler LD, Lam J, Hackstadt T.

Infect Immun. 2015 Dec;83(12):4710-8. doi: 10.1128/IAI.01075-15. Epub 2015 Sep 28.


Chlamydia trachomatis inclusion membrane protein CT850 interacts with the dynein light chain DYNLT1 (Tctex1).

Mital J, Lutter EI, Barger AC, Dooley CA, Hackstadt T.

Biochem Biophys Res Commun. 2015 Jun 26;462(2):165-70. doi: 10.1016/j.bbrc.2015.04.116. Epub 2015 May 2.


Targeted knockout of the Rickettsia rickettsii OmpA surface antigen does not diminish virulence in a mammalian model system.

Noriea NF, Clark TR, Hackstadt T.

mBio. 2015 Mar 31;6(2). pii: e00323-15. doi: 10.1128/mBio.00323-15.


Comparative genome sequencing of Rickettsia rickettsii strains that differ in virulence.

Clark TR, Noriea NF, Bublitz DC, Ellison DW, Martens C, Lutter EI, Hackstadt T.

Infect Immun. 2015 Apr;83(4):1568-76. doi: 10.1128/IAI.03140-14. Epub 2015 Feb 2.


An α-helical core encodes the dual functions of the chlamydial protein IncA.

Ronzone E, Wesolowski J, Bauler LD, Bhardwaj A, Hackstadt T, Paumet F.

J Biol Chem. 2014 Nov 28;289(48):33469-80. doi: 10.1074/jbc.M114.592063. Epub 2014 Oct 16.


Chlamydial metabolism revisited: interspecies metabolic variability and developmental stage-specific physiologic activities.

Omsland A, Sixt BS, Horn M, Hackstadt T.

FEMS Microbiol Rev. 2014 Jul;38(4):779-801. doi: 10.1111/1574-6976.12059. Epub 2014 Feb 24. Review.


Expression and targeting of secreted proteins from Chlamydia trachomatis.

Bauler LD, Hackstadt T.

J Bacteriol. 2014 Apr;196(7):1325-34. doi: 10.1128/JB.01290-13. Epub 2014 Jan 17.


Bringing culture to the uncultured: Coxiella burnetii and lessons for obligate intracellular bacterial pathogens.

Omsland A, Hackstadt T, Heinzen RA.

PLoS Pathog. 2013;9(9):e1003540. doi: 10.1371/journal.ppat.1003540. Epub 2013 Sep 5. Review. No abstract available.


Vesicle-associated membrane protein 4 and syntaxin 6 interactions at the chlamydial inclusion.

Kabeiseman EJ, Cichos K, Hackstadt T, Lucas A, Moore ER.

Infect Immun. 2013 Sep;81(9):3326-37. doi: 10.1128/IAI.00584-13. Epub 2013 Jun 24.


Chlamydia trachomatis inclusion membrane protein CT228 recruits elements of the myosin phosphatase pathway to regulate release mechanisms.

Lutter EI, Barger AC, Nair V, Hackstadt T.

Cell Rep. 2013 Jun 27;3(6):1921-31. doi: 10.1016/j.celrep.2013.04.027. Epub 2013 May 30.


Role for chlamydial inclusion membrane proteins in inclusion membrane structure and biogenesis.

Mital J, Miller NJ, Dorward DW, Dooley CA, Hackstadt T.

PLoS One. 2013 May 17;8(5):e63426. doi: 10.1371/journal.pone.0063426. Print 2013.


Developmental stage-specific metabolic and transcriptional activity of Chlamydia trachomatis in an axenic medium.

Omsland A, Sager J, Nair V, Sturdevant DE, Hackstadt T.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19781-5. doi: 10.1073/pnas.1212831109. Epub 2012 Nov 5. Erratum in: Proc Natl Acad Sci U S A. 2013 Jan 20;110(5):1970.


Translation inhibition of the developmental cycle protein HctA by the small RNA IhtA is conserved across Chlamydia.

Tattersall J, Rao GV, Runac J, Hackstadt T, Grieshaber SS, Grieshaber NA.

PLoS One. 2012;7(10):e47439. doi: 10.1371/journal.pone.0047439. Epub 2012 Oct 11.


Chlamydia trachomatis Tarp cooperates with the Arp2/3 complex to increase the rate of actin polymerization.

Jiwani S, Ohr RJ, Fischer ER, Hackstadt T, Alvarado S, Romero A, Jewett TJ.

Biochem Biophys Res Commun. 2012 Apr 20;420(4):816-21. doi: 10.1016/j.bbrc.2012.03.080. Epub 2012 Mar 23.


Evolution and conservation of predicted inclusion membrane proteins in chlamydiae.

Lutter EI, Martens C, Hackstadt T.

Comp Funct Genomics. 2012;2012:362104. doi: 10.1155/2012/362104. Epub 2012 Feb 21.


Role for the SRC family kinase Fyn in sphingolipid acquisition by chlamydiae.

Mital J, Hackstadt T.

Infect Immun. 2011 Nov;79(11):4559-68. doi: 10.1128/IAI.05692-11. Epub 2011 Sep 6.


Transformation frequency of a mariner-based transposon in Rickettsia rickettsii.

Clark TR, Lackey AM, Kleba B, Driskell LO, Lutter EI, Martens C, Wood DO, Hackstadt T.

J Bacteriol. 2011 Sep;193(18):4993-5. doi: 10.1128/JB.05279-11. Epub 2011 Jul 15.


Biochemical and localization analyses of putative type III secretion translocator proteins CopB and CopB2 of Chlamydia trachomatis reveal significant distinctions.

Chellas-Géry B, Wolf K, Tisoncik J, Hackstadt T, Fields KA.

Infect Immun. 2011 Aug;79(8):3036-45. doi: 10.1128/IAI.00159-11. Epub 2011 May 23.


Diverse requirements for SRC-family tyrosine kinases distinguish chlamydial species.

Mital J, Hackstadt T.

mBio. 2011 Mar 22;2(2). pii: e00031-11. doi: 10.1128/mBio.00031-11. Print 2011.


Complementation of Rickettsia rickettsii RelA/SpoT restores a nonlytic plaque phenotype.

Clark TR, Ellison DW, Kleba B, Hackstadt T.

Infect Immun. 2011 Apr;79(4):1631-7. doi: 10.1128/IAI.00048-11. Epub 2011 Feb 7.


The trans-Golgi SNARE syntaxin 6 is recruited to the chlamydial inclusion membrane.

Moore ER, Mead DJ, Dooley CA, Sager J, Hackstadt T.

Microbiology. 2011 Mar;157(Pt 3):830-8. doi: 10.1099/mic.0.045856-0. Epub 2010 Nov 25.


The conserved Tarp actin binding domain is important for chlamydial invasion.

Jewett TJ, Miller NJ, Dooley CA, Hackstadt T.

PLoS Pathog. 2010 Jul 15;6(7):e1000997. doi: 10.1371/journal.ppat.1000997.


Phylogenetic analysis of Chlamydia trachomatis Tarp and correlation with clinical phenotype.

Lutter EI, Bonner C, Holland MJ, Suchland RJ, Stamm WE, Jewett TJ, McClarty G, Hackstadt T.

Infect Immun. 2010 Sep;78(9):3678-88. doi: 10.1128/IAI.00515-10. Epub 2010 Jul 6.


Specific chlamydial inclusion membrane proteins associate with active Src family kinases in microdomains that interact with the host microtubule network.

Mital J, Miller NJ, Fischer ER, Hackstadt T.

Cell Microbiol. 2010 Sep 1;12(9):1235-49. doi: 10.1111/j.1462-5822.2010.01465.x. Epub 2010 Mar 19.


Disruption of the Rickettsia rickettsii Sca2 autotransporter inhibits actin-based motility.

Kleba B, Clark TR, Lutter EI, Ellison DW, Hackstadt T.

Infect Immun. 2010 May;78(5):2240-7. doi: 10.1128/IAI.00100-10. Epub 2010 Mar 1.


Limited transcriptional responses of Rickettsia rickettsii exposed to environmental stimuli.

Ellison DW, Clark TR, Sturdevant DE, Virtaneva K, Hackstadt T.

PLoS One. 2009;4(5):e5612. doi: 10.1371/journal.pone.0005612. Epub 2009 May 19.


Induction of type III secretion by cell-free Chlamydia trachomatis elementary bodies.

Jamison WP, Hackstadt T.

Microb Pathog. 2008 Nov-Dec;45(5-6):435-40. doi: 10.1016/j.micpath.2008.10.002. Epub 2008 Oct 17.


The chlamydial inclusion preferentially intercepts basolaterally directed sphingomyelin-containing exocytic vacuoles.

Moore ER, Fischer ER, Mead DJ, Hackstadt T.

Traffic. 2008 Dec;9(12):2130-40. doi: 10.1111/j.1600-0854.2008.00828.x. Epub 2008 Oct 8.


Cytoplasmic lipid droplets are translocated into the lumen of the Chlamydia trachomatis parasitophorous vacuole.

Cocchiaro JL, Kumar Y, Fischer ER, Hackstadt T, Valdivia RH.

Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9379-84. doi: 10.1073/pnas.0712241105. Epub 2008 Jun 30.


Chlamydia trachomatis tarp is phosphorylated by src family tyrosine kinases.

Jewett TJ, Dooley CA, Mead DJ, Hackstadt T.

Biochem Biophys Res Commun. 2008 Jun 27;371(2):339-44. doi: 10.1016/j.bbrc.2008.04.089. Epub 2008 Apr 28.


Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa.

Ellison DW, Clark TR, Sturdevant DE, Virtaneva K, Porcella SF, Hackstadt T.

Infect Immun. 2008 Feb;76(2):542-50. Epub 2007 Nov 19.


Rac interacts with Abi-1 and WAVE2 to promote an Arp2/3-dependent actin recruitment during chlamydial invasion.

Carabeo RA, Dooley CA, Grieshaber SS, Hackstadt T.

Cell Microbiol. 2007 Sep;9(9):2278-88. Epub 2007 May 15.


Chlamydial TARP is a bacterial nucleator of actin.

Jewett TJ, Fischer ER, Mead DJ, Hackstadt T.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15599-604. Epub 2006 Oct 6.


Chlamydia trachomatis causes centrosomal defects resulting in chromosomal segregation abnormalities.

Grieshaber SS, Grieshaber NA, Miller N, Hackstadt T.

Traffic. 2006 Aug;7(8):940-9.


Regulation of the Chlamydia trachomatis histone H1-like protein Hc2 is IspE dependent and IhtA independent.

Grieshaber NA, Sager JB, Dooley CA, Hayes SF, Hackstadt T.

J Bacteriol. 2006 Jul;188(14):5289-92.


Maturation of human neutrophil phagosomes includes incorporation of molecular chaperones and endoplasmic reticulum quality control machinery.

Burlak C, Whitney AR, Mead DJ, Hackstadt T, Deleo FR.

Mol Cell Proteomics. 2006 Apr;5(4):620-34. Epub 2006 Jan 14.


A small RNA inhibits translation of the histone-like protein Hc1 in Chlamydia trachomatis.

Grieshaber NA, Grieshaber SS, Fischer ER, Hackstadt T.

Mol Microbiol. 2006 Jan;59(2):541-50.


Recent insights into the mechanisms of Chlamydia entry.

Dautry-Varsat A, Subtil A, Hackstadt T.

Cell Microbiol. 2005 Dec;7(12):1714-22. Review.


Degradation of Chlamydia pneumoniae by peripheral blood monocytic cells.

Wolf K, Fischer E, Hackstadt T.

Infect Immun. 2005 Aug;73(8):4560-70.


Tyrosine phosphorylation of the chlamydial effector protein Tarp is species specific and not required for recruitment of actin.

Clifton DR, Dooley CA, Grieshaber SS, Carabeo RA, Fields KA, Hackstadt T.

Infect Immun. 2005 Jul;73(7):3860-8.

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