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Items: 44


A ligand-based system for receptor-specific delivery of proteins.

Maffei M, Morelli C, Graham E, Patriarca S, Donzelli L, Doleschall B, de Castro Reis F, Nocchi L, Chadick CH, Reymond L, Corrêa IR Jr, Johnsson K, Hackett JA, Heppenstall PA.

Sci Rep. 2019 Dec 16;9(1):19214. doi: 10.1038/s41598-019-55797-1.


Publisher Correction: Tracing the transitions from pluripotency to germ cell fate with CRISPR screening.

Hackett JA, Huang Y, Günesdogan U, Gretarsson KA, Kobayashi T, Surani MA.

Nat Commun. 2018 Dec 11;9(1):5328. doi: 10.1038/s41467-018-07765-y.


Tracing the transitions from pluripotency to germ cell fate with CRISPR screening.

Hackett JA, Huang Y, Günesdogan U, Gretarsson KA, Kobayashi T, Surani MA.

Nat Commun. 2018 Oct 16;9(1):4292. doi: 10.1038/s41467-018-06230-0. Erratum in: Nat Commun. 2018 Dec 11;9(1):5328.


Activation of Lineage Regulators and Transposable Elements across a Pluripotent Spectrum.

Hackett JA, Kobayashi T, Dietmann S, Surani MA.

Stem Cell Reports. 2017 Jun 6;8(6):1645-1658. doi: 10.1016/j.stemcr.2017.05.014.


Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition.

Huang Y, Kim JK, Do DV, Lee C, Penfold CA, Zylicz JJ, Marioni JC, Hackett JA, Surani MA.

Elife. 2017 Mar 21;6. pii: e22345. doi: 10.7554/eLife.22345.


Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development.

Zylicz JJ, Dietmann S, Günesdogan U, Hackett JA, Cougot D, Lee C, Surani MA.

Elife. 2015 Nov 9;4. pii: e09571. doi: 10.7554/eLife.09571.


A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development.

Tang WW, Dietmann S, Irie N, Leitch HG, Floros VI, Bradshaw CR, Hackett JA, Chinnery PF, Surani MA.

Cell. 2015 Jun 4;161(6):1453-67. doi: 10.1016/j.cell.2015.04.053.


PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos.

Kim S, Günesdogan U, Zylicz JJ, Hackett JA, Cougot D, Bao S, Lee C, Dietmann S, Allen GE, Sengupta R, Surani MA.

Mol Cell. 2014 Nov 20;56(4):564-79. doi: 10.1016/j.molcel.2014.10.003. Epub 2014 Nov 6.


Regulatory principles of pluripotency: from the ground state up.

Hackett JA, Surani MA.

Cell Stem Cell. 2014 Oct 2;15(4):416-430. doi: 10.1016/j.stem.2014.09.015. Review.


Dynamic heterogeneity and DNA methylation in embryonic stem cells.

Singer ZS, Yong J, Tischler J, Hackett JA, Altinok A, Surani MA, Cai L, Elowitz MB.

Mol Cell. 2014 Jul 17;55(2):319-31. doi: 10.1016/j.molcel.2014.06.029.


Synergistic mechanisms of DNA demethylation during transition to ground-state pluripotency.

Hackett JA, Dietmann S, Murakami K, Down TA, Leitch HG, Surani MA.

Stem Cell Reports. 2013 Dec 17;1(6):518-31. doi: 10.1016/j.stemcr.2013.11.010. eCollection 2013.


Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation.

Grabole N, Tischler J, Hackett JA, Kim S, Tang F, Leitch HG, Magnúsdóttir E, Surani MA.

EMBO Rep. 2013 Jul;14(7):629-37. doi: 10.1038/embor.2013.67. Epub 2013 May 14.


Beyond DNA: programming and inheritance of parental methylomes.

Hackett JA, Surani MA.

Cell. 2013 May 9;153(4):737-9. doi: 10.1016/j.cell.2013.04.044.


Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine.

Hackett JA, Sengupta R, Zylicz JJ, Murakami K, Lee C, Down TA, Surani MA.

Science. 2013 Jan 25;339(6118):448-52. doi: 10.1126/science.1229277. Epub 2012 Dec 6.


DNA methylation dynamics during the mammalian life cycle.

Hackett JA, Surani MA.

Philos Trans R Soc Lond B Biol Sci. 2013 Jan 5;368(1609):20110328. doi: 10.1098/rstb.2011.0328. Review.


Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome.

Thomson JP, Lempiäinen H, Hackett JA, Nestor CE, Müller A, Bolognani F, Oakeley EJ, Schübeler D, Terranova R, Reinhardt D, Moggs JG, Meehan RR.

Genome Biol. 2012 Oct 3;13(10):R93. doi: 10.1186/gb-2012-13-10-r93.


Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline.

Hackett JA, Reddington JP, Nestor CE, Dunican DS, Branco MR, Reichmann J, Reik W, Surani MA, Adams IR, Meehan RR.

Development. 2012 Oct;139(19):3623-32. doi: 10.1242/dev.081661.


Parallel mechanisms of epigenetic reprogramming in the germline.

Hackett JA, Zylicz JJ, Surani MA.

Trends Genet. 2012 Apr;28(4):164-74. doi: 10.1016/j.tig.2012.01.005. Epub 2012 Mar 3. Review.


The effects of an amino acid supplement on glucose homeostasis, inflammatory markers, and incretins after laparoscopic gastric bypass.

Breitman I, Saraf N, Kakade M, Yellumahanthi K, White M, Hackett JA, Clements RH.

J Am Coll Surg. 2011 Apr;212(4):617-25; discussion 625-7. doi: 10.1016/j.jamcollsurg.2010.12.040.


Apoptosis and DNA methylation.

Meng HX, Hackett JA, Nestor C, Dunican DS, Madej M, Reddington JP, Pennings S, Harrison DJ, Meehan RR.

Cancers (Basel). 2011 Apr 1;3(2):1798-820. doi: 10.3390/cancers3021798.


Nutritional effect of oral supplement enriched in beta-hydroxy-beta-methylbutyrate, glutamine and arginine on resting metabolic rate after laparoscopic gastric bypass.

Clements RH, Saraf N, Kakade M, Yellumahanthi K, White M, Hackett JA.

Surg Endosc. 2011 May;25(5):1376-82. doi: 10.1007/s00464-010-1371-9. Epub 2010 Oct 17.


The non-methylated DNA-binding function of Kaiso is not required in early Xenopus laevis development.

Ruzov A, Savitskaya E, Hackett JA, Reddington JP, Prokhortchouk A, Madej MJ, Chekanov N, Li M, Dunican DS, Prokhortchouk E, Pennings S, Meehan RR.

Development. 2009 Mar;136(5):729-38. doi: 10.1242/dev.025569. Epub 2009 Jan 21.


The interaction of xKaiso with xTcf3: a revised model for integration of epigenetic and Wnt signalling pathways.

Ruzov A, Hackett JA, Prokhortchouk A, Reddington JP, Madej MJ, Dunican DS, Prokhortchouk E, Pennings S, Meehan RR.

Development. 2009 Mar;136(5):723-7. doi: 10.1242/dev.025577. Epub 2009 Jan 21.


Identification of nuclear and cytoplasmic mRNA targets for the shuttling protein SF2/ASF.

Sanford JR, Coutinho P, Hackett JA, Wang X, Ranahan W, Caceres JF.

PLoS One. 2008 Oct 8;3(10):e3369. doi: 10.1371/journal.pone.0003369.


xDnmt1 regulates transcriptional silencing in pre-MBT Xenopus embryos independently of its catalytic function.

Dunican DS, Ruzov A, Hackett JA, Meehan RR.

Development. 2008 Apr;135(7):1295-302. doi: 10.1242/dev.016402. Epub 2008 Feb 27.


Cancer proliferation gene discovery through functional genomics.

Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJ.

Science. 2008 Feb 1;319(5863):620-4. doi: 10.1126/science.1149200. Erratum in: Science.2008 Apr 18;320(5874):316.


Prostaglandin production by human osteoclasts in culture.

Hackett JA, Allard-Chamard H, Sarrazin P, de Fatima Lucena M, Gallant MA, Fortier I, Nader M, Parent JL, Bkaily G, de Brum-Fernandes AJ.

J Rheumatol. 2006 Jul;33(7):1320-8. Epub 2006 Jun 1.


Production of prostaglandin D(2) by human osteoblasts and modulation of osteoprotegerin, RANKL, and cellular migration by DP and CRTH2 receptors.

Gallant MA, Samadfam R, Hackett JA, Antoniou J, Parent JL, de Brum-Fernandes AJ.

J Bone Miner Res. 2005 Apr;20(4):672-81. Epub 2004 Dec 6.


Role of EP3 and EP4 prostaglandin receptors in reorganization of the cytoskeleton in mature human osteoclasts.

Sarrazin P, Hackett JA, Fortier I, Gallant MA, de Brum-Fernandes A.

J Rheumatol. 2004 Aug;31(8):1598-606.


Immunolocalization of the prostaglandin E2 receptor subtypes in human bone tissue: differences in foetal, adult normal, osteoporotic and pagetic bone.

Fortier I, Gallant MA, Hackett JA, Patry C, de Brum-Fernandes AJ.

Prostaglandins Leukot Essent Fatty Acids. 2004 May;70(5):431-9.


End resection initiates genomic instability in the absence of telomerase.

Hackett JA, Greider CW.

Mol Cell Biol. 2003 Dec;23(23):8450-61.


Telomere dysfunction and the initiation of genome instability.

Feldser DM, Hackett JA, Greider CW.

Nat Rev Cancer. 2003 Aug;3(8):623-7. doi: 10.1038/nrc1142.


Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis.

Hackett JA, Greider CW.

Oncogene. 2002 Jan 21;21(4):619-26. Review.


Telomere dysfunction increases mutation rate and genomic instability.

Hackett JA, Feldser DM, Greider CW.

Cell. 2001 Aug 10;106(3):275-86.


Frequency of human leukocyte antigen-A 24 alleles in patients with melanoma determined by human leukocyte antigen-A sequence-based typing.

Bettinotti MP, Norris RD, Hackett JA, Thompson CO, Simonis TB, Stroncek D, Marincola FM.

J Immunother. 2000 Mar-Apr;23(2):282-7.


Natural variation of the expression of HLA and endogenous antigen modulates CTL recognition in an in vitro melanoma model.

Cormier JN, Panelli MC, Hackett JA, Bettinotti MP, Mixon A, Wunderlich J, Parker LL, Restifo NP, Ferrone S, Marincola FM.

Int J Cancer. 1999 Mar 1;80(5):781-90.


Sulpiride-induced increases in serum prolactin levels in female rats exposed prenatally to alcohol.

Hannigan JH, Hackett JA, Tilak J, Subramanian MG.

Alcohol. 1997 Nov-Dec;14(6):585-92.


Construction of K88- and K99-expressing clones of Salmonella typhimurium G30: immunogenicity following oral administration to pigs.

Morona R, Morona JK, Considine A, Hackett JA, van den Bosch L, Beyer L, Attridge SR.

Vaccine. 1994 May;12(6):513-7.


A physical map of the chromosomal region determining O-antigen biosynthesis in Vibrio cholerae O1.

Ward HM, Morelli G, Kamke M, Morona R, Yeadon J, Hackett JA, Manning PA.

Gene. 1987;55(2-3):197-204.


Molecular cloning using immune sera of a 22-kDal minor outer membrane protein of Vibrio cholerae.

Manning PA, Bartowsky EJ, Leavesly DI, Hackett JA, Heuzenroeder MW.

Gene. 1985;34(1):95-103.


Gene 8 of influenza virus: sequences of cDNA transcribed from the 3' ends of viral RNA of influenza A and B strains.

Air GM, Hackett JA.

Virology. 1980 Jun;103(2):291-8. No abstract available.


The isolation and biosynthesis of the ceramide-phosphoinositol of Aspergillus niger.

Hackett JA, Brennan PJ.

FEBS Lett. 1977 Mar 1;74(2):259-63. No abstract available.


Reaction of fungal ceramides containing alpha-hydroxy acids with the periodate-Schiff reagents.

Hackett JA, Brennan PJ.

J Chromatogr. 1976 Feb 18;117(2):436-8. No abstract available.


The mannophosphoinositides of Corynebacterium aquaticum.

Hackett JA, Brennan PJ.

Biochem J. 1975 May;148(2):253-8.

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