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Essentiality of Plasmodium falciparum plasmepsin V.

Boonyalai N, Collins CR, Hackett F, Withers-Martinez C, Blackman MJ.

PLoS One. 2018 Dec 5;13(12):e0207621. doi: 10.1371/journal.pone.0207621. eCollection 2018.


Lymphoma survivors' experiences at the end of treatment.

Hackett F, Dowling M.

J Clin Nurs. 2019 Feb;28(3-4):400-409. doi: 10.1111/jocn.14658. Epub 2018 Sep 19. Review.


Publisher Correction: A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells.

Thomas JA, Tan MSY, Bisson C, Borg A, Umrekar TR, Hackett F, Hale VL, Vizcay-Barrena G, Fleck RA, Snijders AP, Saibil HR, Blackman MJ.

Nat Microbiol. 2018 Apr;3(4):523. doi: 10.1038/s41564-018-0134-6.


A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells.

Thomas JA, Tan MSY, Bisson C, Borg A, Umrekar TR, Hackett F, Hale VL, Vizcay-Barrena G, Fleck RA, Snijders AP, Saibil HR, Blackman MJ.

Nat Microbiol. 2018 Apr;3(4):447-455. doi: 10.1038/s41564-018-0111-0. Epub 2018 Feb 19. Erratum in: Nat Microbiol. 2018 Mar 6;:.


The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes.

Collins CR, Hackett F, Atid J, Tan MSY, Blackman MJ.

PLoS Pathog. 2017 Jul 6;13(7):e1006453. doi: 10.1371/journal.ppat.1006453. eCollection 2017 Jul.


Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress.

Hale VL, Watermeyer JM, Hackett F, Vizcay-Barrena G, van Ooij C, Thomas JA, Spink MC, Harkiolaki M, Duke E, Fleck RA, Blackman MJ, Saibil HR.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3439-3444. doi: 10.1073/pnas.1619441114. Epub 2017 Mar 14.


Anthropometric indices of First Nations children and youth on first entry to Manitoba/Saskatchewan residential schools-1919 to 1953.

Hackett FJ, Abonyi S, Dyck RF.

Int J Circumpolar Health. 2016 Jun 27;75:30734. doi: 10.3402/ijch.v75.30734. eCollection 2016.


Development and Application of a Simple Plaque Assay for the Human Malaria Parasite Plasmodium falciparum.

Thomas JA, Collins CR, Das S, Hackett F, Graindorge A, Bell D, Deu E, Blackman MJ.

PLoS One. 2016 Jun 22;11(6):e0157873. doi: 10.1371/journal.pone.0157873. eCollection 2016.


A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum-infected erythrocytes.

Watermeyer JM, Hale VL, Hackett F, Clare DK, Cutts EE, Vakonakis I, Fleck RA, Blackman MJ, Saibil HR.

Blood. 2016 Jan 21;127(3):343-51. doi: 10.1182/blood-2015-10-674002. Epub 2015 Dec 4.


Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle.

Stallmach R, Kavishwar M, Withers-Martinez C, Hackett F, Collins CR, Howell SA, Yeoh S, Knuepfer E, Atid AJ, Holder AA, Blackman MJ.

Mol Microbiol. 2015 Apr;96(2):368-87. doi: 10.1111/mmi.12941. Epub 2015 Feb 11.


The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.

Withers-Martinez C, Strath M, Hackett F, Haire LF, Howell SA, Walker PA, Christodoulou E, Dodson GG, Blackman MJ.

Nat Commun. 2014 May 2;5:3726. doi: 10.1038/ncomms4726. Erratum in: Nat Commun. 2014;5:4031. Evangelos, Christodoulou [corrected to Christodoulou, Evangelos].


Cyclic Nucleotide (cAMP and cGMP) Assays and Capture ELISA for Quantitative Analysis of Plasmodium falciparum Blood-stage Egress.

Hackett F, Collins CR, Strath M, Blackman MJ.

Bio Protoc. 2014 Mar 5;4(5). pii: e1055. doi: 10.21769/BioProtoc.1055.


Incorporating scale dependence in disease burden estimates: the case of human African trypanosomiasis in Uganda.

Hackett F, Berrang Ford L, Fèvre E, Simarro P.

PLoS Negl Trop Dis. 2014 Feb 13;8(2):e2704. doi: 10.1371/journal.pntd.0002704. eCollection 2014 Feb.


Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress.

Collins CR, Hackett F, Strath M, Penzo M, Withers-Martinez C, Baker DA, Blackman MJ.

PLoS Pathog. 2013 May;9(5):e1003344. doi: 10.1371/journal.ppat.1003344. Epub 2013 May 9.


Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle.

Collins CR, Das S, Wong EH, Andenmatten N, Stallmach R, Hackett F, Herman JP, Müller S, Meissner M, Blackman MJ.

Mol Microbiol. 2013 May;88(4):687-701. doi: 10.1111/mmi.12206. Epub 2013 Mar 26.


Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte.

Ruecker A, Shea M, Hackett F, Suarez C, Hirst EM, Milutinovic K, Withers-Martinez C, Blackman MJ.

J Biol Chem. 2012 Nov 2;287(45):37949-63. doi: 10.1074/jbc.M112.400820. Epub 2012 Sep 14.


Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.

Withers-Martinez C, Suarez C, Fulle S, Kher S, Penzo M, Ebejer JP, Koussis K, Hackett F, Jirgensons A, Finn P, Blackman MJ.

Int J Parasitol. 2012 May 15;42(6):597-612. doi: 10.1016/j.ijpara.2012.04.005. Epub 2012 Apr 27.


Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies.

Olivieri A, Collins CR, Hackett F, Withers-Martinez C, Marshall J, Flynn HR, Skehel JM, Blackman MJ.

PLoS Pathog. 2011 Dec;7(12):e1002448. doi: 10.1371/journal.ppat.1002448. Epub 2011 Dec 15. Erratum in: PLoS Pathog. 2012 Feb;8(2). doi:10.1371/annotation/72b02b2e-460a-44f4-bc87-067cfe76bfdb.


Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease.

Silmon de Monerri NC, Flynn HR, Campos MG, Hackett F, Koussis K, Withers-Martinez C, Skehel JM, Blackman MJ.

Infect Immun. 2011 Mar;79(3):1086-97. doi: 10.1128/IAI.00902-10. Epub 2011 Jan 10.


Implantation success and infection in cardiovascular implantable electronic device procedures utilizing an antibacterial envelope.

Bloom HL, Constantin L, Dan D, De Lurgio DB, El-Chami M, Ganz LI, Gleed KJ, Hackett FK, Kanuru NK, Lerner DJ, Rasekh A, Simons GR, Sogade FO, Sohail MR; COoperative Multicenter study Monitoring a CIED ANtimicrobial Device Investigators.

Pacing Clin Electrophysiol. 2011 Feb;34(2):133-42. doi: 10.1111/j.1540-8159.2010.02931.x. Epub 2010 Oct 13.


A multifunctional serine protease primes the malaria parasite for red blood cell invasion.

Koussis K, Withers-Martinez C, Yeoh S, Child M, Hackett F, Knuepfer E, Juliano L, Woehlbier U, Bujard H, Blackman MJ.

EMBO J. 2009 Mar 18;28(6):725-35. doi: 10.1038/emboj.2009.22. Epub 2009 Feb 12.


An inhibitory antibody blocks interactions between components of the malarial invasion machinery.

Collins CR, Withers-Martinez C, Hackett F, Blackman MJ.

PLoS Pathog. 2009 Jan;5(1):e1000273. doi: 10.1371/journal.ppat.1000273. Epub 2009 Jan 23.


Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes.

Yeoh S, O'Donnell RA, Koussis K, Dluzewski AR, Ansell KH, Osborne SA, Hackett F, Withers-Martinez C, Mitchell GH, Bannister LH, Bryans JS, Kettleborough CA, Blackman MJ.

Cell. 2007 Dec 14;131(6):1072-83.


Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface.

Withers-Martinez C, Haire LF, Hackett F, Walker PA, Howell SA, Smerdon SJ, Dodson GG, Blackman MJ.

J Mol Biol. 2008 Jan 18;375(3):773-81. Epub 2007 Nov 1.


Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite.

O'Donnell RA, Hackett F, Howell SA, Treeck M, Struck N, Krnajski Z, Withers-Martinez C, Gilberger TW, Blackman MJ.

J Cell Biol. 2006 Sep 25;174(7):1023-33.


Molecular identification of a malaria merozoite surface sheddase.

Harris PK, Yeoh S, Dluzewski AR, O'Donnell RA, Withers-Martinez C, Hackett F, Bannister LH, Mitchell GH, Blackman MJ.

PLoS Pathog. 2005 Nov;1(3):241-51. Epub 2005 Nov 25.


Unique insertions within Plasmodium falciparum subtilisin-like protease-1 are crucial for enzyme maturation and activity.

Jean L, Withers-Martinez C, Hackett F, Blackman MJ.

Mol Biochem Parasitol. 2005 Dec;144(2):187-97. Epub 2005 Sep 8.


Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens.

Howell SA, Hackett F, Jongco AM, Withers-Martinez C, Kim K, Carruthers VB, Blackman MJ.

Mol Microbiol. 2005 Sep;57(5):1342-56.


Crystal structure of the malaria vaccine candidate apical membrane antigen 1.

Pizarro JC, Vulliez-Le Normand B, Chesne-Seck ML, Collins CR, Withers-Martinez C, Hackett F, Blackman MJ, Faber BW, Remarque EJ, Kocken CH, Thomas AW, Bentley GA.

Science. 2005 Apr 15;308(5720):408-11. Epub 2005 Feb 24.


Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity.

Ersmark K, Feierberg I, Bjelic S, Hamelink E, Hackett F, Blackman MJ, Hultén J, Samuelsson B, Aqvist J, Hallberg A.

J Med Chem. 2004 Jan 1;47(1):110-22.


Functional characterization of the propeptide of Plasmodium falciparum subtilisin-like protease-1.

Jean L, Hackett F, Martin SR, Blackman MJ.

J Biol Chem. 2003 Aug 1;278(31):28572-9. Epub 2003 May 22.


High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion.

Kocken CH, Withers-Martinez C, Dubbeld MA, van der Wel A, Hackett F, Valderrama A, Blackman MJ, Thomas AW.

Infect Immun. 2002 Aug;70(8):4471-6. Erratum in: Infect Immun 2002 Oct;70(10):5901.


Expression of recombinant Plasmodium falciparum subtilisin-like protease-1 in insect cells. Characterization, comparison with the parasite protease, and homology modeling.

Withers-Martinez C, Saldanha JW, Ely B, Hackett F, O'Connor T, Blackman MJ.

J Biol Chem. 2002 Aug 16;277(33):29698-709. Epub 2002 Jun 6.


PCR-based gene synthesis as an efficient approach for expression of the A+T-rich malaria genome.

Withers-Martinez C, Carpenter EP, Hackett F, Ely B, Sajid M, Grainger M, Blackman MJ.

Protein Eng. 1999 Dec;12(12):1113-20.


PfSUB-2: a second subtilisin-like protein in Plasmodium falciparum merozoites.

Hackett F, Sajid M, Withers-Martinez C, Grainger M, Blackman MJ.

Mol Biochem Parasitol. 1999 Oct 15;103(2):183-95.


A subtilisin-like protein in secretory organelles of Plasmodium falciparum merozoites.

Blackman MJ, Fujioka H, Stafford WH, Sajid M, Clough B, Fleck SL, Aikawa M, Grainger M, Hackett F.

J Biol Chem. 1998 Sep 4;273(36):23398-409.


Neutralizing monoclonal antibodies to glycosylphosphatidylinositol, the dominant TNF-alpha-inducing toxin of Plasmodium falciparum: prospects for the immunotherapy of severe malaria.

Schofield L, Vivas L, Hackett F, Gerold P, Schwarz RT, Tachado S.

Ann Trop Med Parasitol. 1993 Dec;87(6):617-26. Review.


Regional cardiac sympathetic denervation in patients with ventricular tachycardia in the absence of coronary artery disease.

Mitrani RD, Klein LS, Miles WM, Hackett FK, Burt RW, Wellman HN, Zipes DP.

J Am Coll Cardiol. 1993 Nov 1;22(5):1344-53.


Radiofrequency catheter ablation of Mahaim fibers at the tricuspid annulus.

Klein LS, Hackett FK, Zipes DP, Miles WM.

Circulation. 1993 Mar;87(3):738-47.


Catheter ablation for cardiac arrhythmias.

Miles WM, Klein LS, Hackett FK.

Curr Opin Cardiol. 1993 Jan;8(1):75-87. Review.


The culture of Schistosoma mansoni and production of life cycle stages.

Hackett F.

Methods Mol Biol. 1993;21:89-99. No abstract available.


Radiofrequency catheter ablation of ventricular tachycardia in patients without structural heart disease.

Klein LS, Shih HT, Hackett FK, Zipes DP, Miles WM.

Circulation. 1992 May;85(5):1666-74.


Structure of Sm25, an antigenic integral membrane glycoprotein of adult Schistosoma mansoni.

Ali PO, Jeffs SA, Meadows HM, Hollyer T, Owen CA, Abath FG, Allen R, Hackett F, Smithers SR, Simpson AJ.

Mol Biochem Parasitol. 1991 Apr;45(2):215-22.


Epitopes expressed on very low Mr Schistosoma mansoni adult tegumental antigens conform to a general pattern of life-cycle cross-reactivity.

Simpson AJ, Hagan P, Hackett F, Omer Ali P, Smithers SR.

Parasitology. 1990 Feb;100 Pt 1:73-81.


Immunoblotting identifies additional antigens recognised by mice protectively vaccinated with adult Schistosoma mansoni tegumental membranes.

Smithers SR, Hackett F, Braga V, Simpson AJ.

Parasitol Res. 1990;76(5):454-6. No abstract available.


Protective immunization of mice against Schistosoma mansoni with purified adult worm surface membranes.

Smithers SR, Hackett F, Ali PO, Simpson AJ.

Parasite Immunol. 1989 Jul;11(4):301-18.


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