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Lester Reed: A "complex" man who loved science.
Hackert ML, Appling DR, Lambowitz AM.
Proc Natl Acad Sci U S A. 2015 May 19;112(20):6247. doi: 10.1073/pnas.1505119112. Epub 2015 Apr 21. No abstract available.
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Kinetic, mutational, and structural analysis of malonate semialdehyde decarboxylase from Coryneform bacterium strain FG41: mechanistic implications for the decarboxylase and hydratase activities.
Guo Y, Serrano H, Poelarends GJ, Johnson WH Jr, Hackert ML, Whitman CP.
Biochemistry. 2013 Jul 16;52(28):4830-41. doi: 10.1021/bi400567a. Epub 2013 Jul 2.
Crystal structures of native and inactivated cis-3-chloroacrylic acid dehalogenase: Implications for the catalytic and inactivation mechanisms.
Guo Y, Serrano H, Johnson WH Jr, Ernst S, Hackert ML, Whitman CP.
Bioorg Chem. 2011 Feb;39(1):1-9. doi: 10.1016/j.bioorg.2010.10.001. Epub 2010 Oct 20.
Kinetic and structural characterization of DmpI from Helicobacter pylori and Archaeoglobus fulgidus, two 4-oxalocrotonate tautomerase family members.
Almrud JJ, Dasgupta R, Czerwinski RM, Kern AD, Hackert ML, Whitman CP.
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When size matters.
Hackert ML, Riggs AF.
Structure. 2006 Jul;14(7):1094-6. No abstract available.
Evolution of enzymatic activity in the tautomerase superfamily: mechanistic and structural consequences of the L8R mutation in 4-oxalocrotonate tautomerase.
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Biochemistry. 2006 Jun 27;45(25):7700-8.
Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate.
Golubkov PA, Johnson WH Jr, Czerwinski RM, Person MD, Wang SC, Whitman CP, Hackert ML.
Bioorg Chem. 2006 Aug;34(4):183-99. Epub 2006 Jun 14.
Crystal structures of the wild-type, P1A mutant, and inactivated malonate semialdehyde decarboxylase: a structural basis for the decarboxylase and hydratase activities.
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Biochemistry. 2005 Nov 15;44(45):14818-27.
Solution structure of a conserved domain of antizyme: a protein regulator of polyamines.
Hoffman DW, Carroll D, Martinez N, Hackert ML.
Biochemistry. 2005 Sep 6;44(35):11777-85.
The crystal structure of YdcE, a 4-oxalocrotonate tautomerase homologue from Escherichia coli, confirms the structural basis for oligomer diversity.
Almrud JJ, Kern AD, Wang SC, Czerwinski RM, Johnson WH Jr, Murzin AG, Hackert ML, Whitman CP.
Biochemistry. 2002 Oct 8;41(40):12010-24.
Mechanism of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor: properties of the P1G, P1A, Y95F, and N97A mutants.
Stamps SL, Taylor AB, Wang SC, Hackert ML, Whitman CP.
Biochemistry. 2000 Aug 15;39(32):9671-8.
Expression, purification, and structural analysis of the trimeric form of the catalytic domain of the Escherichia coli dihydrolipoamide succinyltransferase.
Knapp JE, Carroll D, Lawson JE, Ernst SR, Reed LJ, Hackert ML.
Protein Sci. 2000 Jan;9(1):37-48.
Three-dimensional structure of the Gly121Tyr dimeric form of ornithine decarboxylase from Lactobacillus 30a.
Vitali J, Carroll D, Chaudhry RG, Hackert ML.
Acta Crystallogr D Biol Crystallogr. 1999 Dec;55(Pt 12):1978-85.
Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding.
Almrud JJ, Oliveira MA, Kern AD, Grishin NV, Phillips MA, Hackert ML.
J Mol Biol. 2000 Jan 7;295(1):7-16.
Structure of mammalian ornithine decarboxylase at 1.6 A resolution: stereochemical implications of PLP-dependent amino acid decarboxylases.
Kern AD, Oliveira MA, Coffino P, Hackert ML.
Structure. 1999 May;7(5):567-81.
Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition.
Taylor AB, Johnson WH Jr, Czerwinski RM, Li HS, Hackert ML, Whitman CP.
Biochemistry. 1999 Jun 8;38(23):7444-52.
The structural and functional analysis of the hemoglobin D component from chicken.
Knapp JE, Oliveira MA, Xie Q, Ernst SR, Riggs AF, Hackert ML.
J Biol Chem. 1999 Mar 5;274(10):6411-20.
Crystal structure of 4-oxalocrotonate tautomerase inactivated by 2-oxo-3-pentynoate at 2.4 A resolution: analysis and implications for the mechanism of inactivation and catalysis.
Taylor AB, Czerwinski RM, Johnson WH Jr, Whitman CP, Hackert ML.
Biochemistry. 1998 Oct 20;37(42):14692-700.
Evolution of cooperativity in hemoglobins: what can invertebrate hemoglobins tell us?
Kitto GB, Thomas PW, Hackert ML.
J Exp Zool. 1998 Sep-Oct 1;282(1-2):120-6.
Crystal structure of the truncated cubic core component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex.
Knapp JE, Mitchell DT, Yazdi MA, Ernst SR, Reed LJ, Hackert ML.
J Mol Biol. 1998 Jul 24;280(4):655-68.
The GTP effector site of ornithine decarboxylase from Lactobacillus 30a: kinetic and structural characterization.
Oliveira MA, Carroll D, Davidson L, Momany C, Hackert ML.
Biochemistry. 1997 Dec 23;36(51):16147-54.
Crystallization of a mammalian ornithine decarboxylase.
Kern A, Oliveira MA, Chang NL, Ernst SR, Carroll DW, Momany C, Minard K, Coffino P, Hackert ML.
Proteins. 1996 Feb;24(2):266-8.
Crystallographic structure of a PLP-dependent ornithine decarboxylase from Lactobacillus 30a to 3.0 A resolution.
Momany C, Ernst S, Ghosh R, Chang NL, Hackert ML.
J Mol Biol. 1995 Oct 6;252(5):643-55.
X-ray structure determination of a dimeric hemoglobin from Caudina arenicola.
Mitchell DT, Ernst SR, Hackert ML.
Acta Crystallogr D Biol Crystallogr. 1995 Sep 1;51(Pt 5):760-6.
Three-dimensional structure of a hemichrome hemoglobin from Caudina arenicola.
Mitchell DT, Ernst SR, Wu WX, Hackert ML.
Acta Crystallogr D Biol Crystallogr. 1995 Sep 1;51(Pt 5):647-53.
Structural analysis of monomeric hemichrome and dimeric cyanomet hemoglobins from Caudina arenicola.
Mitchell DT, Kitto GB, Hackert ML.
J Mol Biol. 1995 Aug 18;251(3):421-31.
Structural motifs for pyridoxal-5'-phosphate binding in decarboxylases: an analysis based on the crystal structure of the Lactobacillus 30a ornithine decarboxylase.
Momany C, Ghosh R, Hackert ML.
Protein Sci. 1995 May;4(5):849-54.
Sequence of ornithine decarboxylase from Lactobacillus sp. strain 30a.
Hackert ML, Carroll DW, Davidson L, Kim SO, Momany C, Vaaler GL, Zhang L.
J Bacteriol. 1994 Dec;176(23):7391-4.
Structural analysis of Urechis caupo hemoglobin.
Kolatkar PR, Hackert ML, Riggs AF.
J Mol Biol. 1994 Mar 18;237(1):87-97.
Crystallization of biosynthetic arginine decarboxylase from Escherichia coli.
Rodrigez BR, Carroll DW, Mitchell D, Momany C, Hackert ML.
Acta Crystallogr D Biol Crystallogr. 1994 Mar 1;50(Pt 2):175-7.
Refined structure of the pyruvoyl-dependent histidine decarboxylase from Lactobacillus 30a.
Gallagher T, Rozwarski DA, Ernst SR, Hackert ML.
J Mol Biol. 1993 Mar 20;230(2):516-28.
Structure determination and refinement of homotetrameric hemoglobin from Urechis caupo at 2.5 A resolution.
Kolatkar PR, Ernst SR, Hackert ML, Ogata CM, Hendrickson WA, Merritt EA, Phizackerley RP.
Acta Crystallogr B. 1992 Apr 1;48 ( Pt 2):191-9.
Dipotassium and sodium/potassium crystalline picrate complexes with the crown ether 6,7,9,10,12,13,20,21,23,24,26,27-dodecahydrodibenzo[b,n]-[1,4, 7,10,13,16,19,22]octaoxacyclotetracosin (dibenzo-24-crown-8).
Gallagher T, Taylor MJ, Ernst SR, Hackert ML, Poonia NS.
Acta Crystallogr B. 1991 Jun 1;47 ( Pt 3):362-8.
Comparisons of the low-resolution structures of ornithine decarboxylase by electron microscopy and X-ray crystallography: the utility of methylamine tungstate stain and Butvar support film in the study of macromolecules by transmission electron microscopy.
Stoops JK, Momany C, Ernst SR, Oliver RM, Schroeter JP, Bretaudiere JP, Hackert ML.
J Electron Microsc Tech. 1991 Jun;18(2):157-66.
Structure-function relationships in dihydrolipoamide acyltransferases.
Reed LJ, Hackert ML.
J Biol Chem. 1990 Jun 5;265(16):8971-4. Review. No abstract available.
Branched-chain alpha-keto acid dehydrogenase complex from bovine kidney: radial distribution of mass determined from dark-field electron micrographs.
Hackert ML, Xu WX, Oliver RM, Wall JS, Hainfeld JF, Mullinax TR, Reed LJ.
Biochemistry. 1989 Aug 22;28(17):6816-21.
Pyruvoyl-dependent histidine decarboxylase. Active site structure and mechanistic analysis.
Gallagher T, Snell EE, Hackert ML.
J Biol Chem. 1989 Jul 25;264(21):12737-43.
Crystallization and molecular symmetry of ornithine decarboxylase from Lactobacillus 30a.
Momany C, Hackert ML.
J Biol Chem. 1989 Mar 15;264(8):4722-4.
Novel subunit structure observed for noncooperative hemoglobin from Urechis caupo.
Kolatkar PR, Meador WE, Stanfield RL, Hackert ML.
J Biol Chem. 1988 Mar 5;263(7):3462-5.
Crystal structure analysis and refinement at 2.5 A of hexameric C-phycocyanin from the cyanobacterium Agmenellum quadruplicatum. The molecular model and its implications for light-harvesting.
Schirmer T, Huber R, Schneider M, Bode W, Miller M, Hackert ML.
J Mol Biol. 1986 Apr 20;188(4):651-76.
Structure determination of histidine decarboxylase from Lactobacillus 30a at 3.0 A resolution.
Parks EH, Ernst SR, Hamlin R, Xuong NH, Hackert ML.
J Mol Biol. 1985 Apr 5;182(3):455-65.
A computer model analysis of the active-site coupling mechanism in the pyruvate dehydrogenase multienzyme complex of Escherichia coli.
Hackert ML, Oliver RM, Reed LJ.
Proc Natl Acad Sci U S A. 1983 May;80(10):2907-11.
Evidence for a multiple random coupling mechanism in the alpha-ketoglutarate dehydrogenase multienzyme complex of Escherichia coli: a computer model analysis.
Proc Natl Acad Sci U S A. 1983 Apr;80(8):2226-30.
Crystallization and subunit structure of histidine decarboxylase from Lactobacillus 30a.
Hackert ML, Meador WE, Oliver RM, Salmon JB, Recsei PA, Snell EE.
J Biol Chem. 1981 Jan 25;256(2):687-90.
Subunit structure of dihydrolipoyl transacetylase component of pyruvate dehydrogenase complex from bovine heart.
Bleile DM, Hackert ML, Pettit FH, Reed LJ.
J Biol Chem. 1981 Jan 10;256(1):514-9. No abstract available.
Crystallization of a dihydrolipoyl transacetylase--dihydrolipoyl dehydrogenase subcomplex and its implications regarding the subunit structure of the pyruvate dehydrogenase complex from Escherichia coli.
Fuller CC, Reed LJ, Oliver RM, Hackert ML.
Biochem Biophys Res Commun. 1979 Sep 27;90(2):431-8. No abstract available.
Preliminary crystallographic data on monomeric and dimeric hemoglobins from the sea cucumber, Molpadia arenicola.
Carson WM, Bowers TR, Kitto GB, Hackert ML.
J Biol Chem. 1979 Aug 10;254(15):7400-2.
The quaternary structure of a unique phycobiliprotein: B-phycoerythrin from Porphyridium cruentum.
Abad-Zapatero C, Fox JL, Hackert ML.
Biochem Biophys Res Commun. 1977 Sep 9;78(1):266-72. No abstract available.
Crystallization of C-phycocyanin from the marine blue-green alga Agmenellum quadruplicatum.
Hackert ML, Abad-Zapatero C, Stevens SE Jr, Fox JL.
J Mol Biol. 1977 Apr 15;111(3):365-9. No abstract available.
Purification and crystallization of NADP+-specific isocitrate dehydrogenase from Escherichia coli using polyethylene glycol.
Hackert ML, Harris BA, Poulsen LL.
Biochim Biophys Acta. 1977 Apr 12;481(2):340-7.
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