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Items: 1 to 50 of 86

1.

Vinylphosphonites for Staudinger-induced chemoselective peptide cyclization and functionalization.

Kasper MA, Glanz M, Oder A, Schmieder P, von Kries JP, Hackenberger CPR.

Chem Sci. 2019 May 16;10(25):6322-6329. doi: 10.1039/c9sc01345h. eCollection 2019 Jul 7.

2.

One-Step Fluorescent Protein Labeling by Tubulin Tyrosine Ligase.

Schumacher D, Leonhardt H, Hackenberger CPR, Helma J.

Methods Mol Biol. 2019;2033:167-189. doi: 10.1007/978-1-4939-9654-4_12.

PMID:
31332754
3.

Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates.

Kasper MA, Stengl A, Ochtrop P, Gerlach M, Stoschek T, Schumacher D, Helma J, Penkert M, Krause E, Leonhardt H, Hackenberger CPR.

Angew Chem Int Ed Engl. 2019 Aug 19;58(34):11631-11636. doi: 10.1002/anie.201904193. Epub 2019 Jul 18.

PMID:
31250955
4.

Tubulin Tyrosine Ligase-Mediated Modification of Proteins.

Gerlach M, Stoschek T, Leonhardt H, Hackenberger CPR, Schumacher D, Helma J.

Methods Mol Biol. 2019;2012:327-355. doi: 10.1007/978-1-4939-9546-2_17.

PMID:
31161516
5.

Tag and release: strategies for the intracellular cleavage of protein conjugates.

Baumann AL, Hackenberger CPR.

Curr Opin Chem Biol. 2019 May 31;52:39-46. doi: 10.1016/j.cbpa.2019.04.019. [Epub ahead of print] Review.

PMID:
31158654
6.

Electron Transfer/Higher Energy Collisional Dissociation of Doubly Charged Peptide Ions: Identification of Labile Protein Phosphorylations.

Penkert M, Hauser A, Harmel R, Fiedler D, Hackenberger CPR, Krause E.

J Am Soc Mass Spectrom. 2019 Sep;30(9):1578-1585. doi: 10.1007/s13361-019-02240-4. Epub 2019 May 20.

PMID:
31111417
7.

In-Cell Synthesis of Bioorthogonal Alkene Tag S-Allyl-Homocysteine and Its Coupling with Reprogrammed Translation.

Nojoumi S, Ma Y, Schwagerus S, Hackenberger CPR, Budisa N.

Int J Mol Sci. 2019 May 9;20(9). pii: E2299. doi: 10.3390/ijms20092299.

8.

TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles.

Stengl A, Gerlach M, Kasper MA, Hackenberger CPR, Leonhardt H, Schumacher D, Helma J.

Org Biomol Chem. 2019 May 28;17(20):4964-4969. doi: 10.1039/c9ob00508k. Epub 2019 Apr 1.

PMID:
30932115
9.

Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations.

Kasper MA, Glanz M, Stengl A, Penkert M, Klenk S, Sauer T, Schumacher D, Helma J, Krause E, Cardoso MC, Leonhardt H, Hackenberger CPR.

Angew Chem Int Ed Engl. 2019 Aug 19;58(34):11625-11630. doi: 10.1002/anie.201814715. Epub 2019 Apr 29.

PMID:
30828930
10.

Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptides.

Schneider AFL, Wallabregue ALD, Franz L, Hackenberger CPR.

Bioconjug Chem. 2019 Feb 20;30(2):400-404. doi: 10.1021/acs.bioconjchem.8b00855. Epub 2019 Jan 14.

PMID:
30616339
11.

Modern Ligation Methods to Access Natural and Modified Proteins.

Baumann AL, Hackenberger CPR.

Chimia (Aarau). 2018 Nov 30;72(11):802-808. doi: 10.2533/chimia.2018.802. Review.

PMID:
30514423
12.

Tub-Tag Labeling; Chemoenzymatic Incorporation of Unnatural Amino Acids.

Helma J, Leonhardt H, Hackenberger CPR, Schumacher D.

Methods Mol Biol. 2018;1728:67-93. doi: 10.1007/978-1-4939-7574-7_4.

PMID:
29404991
13.

Chemoselective triazole-phosphonamidate conjugates suitable for photorelease.

Siebertz KD, Hackenberger CPR.

Chem Commun (Camb). 2018 Jan 18;54(7):763-766. doi: 10.1039/c7cc08605a.

PMID:
29308492
14.

Nanobodies: Chemical Functionalization Strategies and Intracellular Applications.

Schumacher D, Helma J, Schneider AFL, Leonhardt H, Hackenberger CPR.

Angew Chem Int Ed Engl. 2018 Feb 23;57(9):2314-2333. doi: 10.1002/anie.201708459. Epub 2018 Jan 26. Review.

15.

Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells.

Herce HD, Schumacher D, Schneider AFL, Ludwig AK, Mann FA, Fillies M, Kasper MA, Reinke S, Krause E, Leonhardt H, Cardoso MC, Hackenberger CPR.

Nat Chem. 2017 Aug;9(8):762-771. doi: 10.1038/nchem.2811. Epub 2017 Jul 17.

PMID:
28754949
16.

Chemical Approaches to Investigate Labile Peptide and Protein Phosphorylation.

Hauser A, Penkert M, Hackenberger CPR.

Acc Chem Res. 2017 Aug 15;50(8):1883-1893. doi: 10.1021/acs.accounts.7b00170. Epub 2017 Jul 19.

PMID:
28723107
17.

Werner Reutter: A Visionary Pioneer in Molecular Glycobiology.

Hinderlich S, Tauber R, Bertozzi CR, Hackenberger CPR.

Chembiochem. 2017 Jul 4;18(13):1141-1145. doi: 10.1002/cbic.201700277. Epub 2017 Jun 16.

PMID:
28621497
18.

Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling.

Schumacher D, Lemke O, Helma J, Gerszonowicz L, Waller V, Stoschek T, Durkin PM, Budisa N, Leonhardt H, Keller BG, Hackenberger CPR.

Chem Sci. 2017 May 1;8(5):3471-3478. doi: 10.1039/c7sc00574a. Epub 2017 Mar 20.

19.

Multivalent Peptide-Nanoparticle Conjugates for Influenza-Virus Inhibition.

Lauster D, Glanz M, Bardua M, Ludwig K, Hellmund M, Hoffmann U, Hamann A, Böttcher C, Haag R, Hackenberger CPR, Herrmann A.

Angew Chem Int Ed Engl. 2017 May 15;56(21):5931-5936. doi: 10.1002/anie.201702005. Epub 2017 Apr 26.

20.

Fluorescent labelling in living cells.

Schneider AFL, Hackenberger CPR.

Curr Opin Biotechnol. 2017 Dec;48:61-68. doi: 10.1016/j.copbio.2017.03.012. Epub 2017 Apr 7. Review.

PMID:
28395178
21.

Small Molecules Targeting Human N-Acetylmannosamine Kinase.

Hinderlich S, Neuenschwander M, Wratil PR, Oder A, Lisurek M, Nguyen LD, von Kries JP, Hackenberger CPR.

Chembiochem. 2017 Jul 4;18(13):1279-1285. doi: 10.1002/cbic.201700066. Epub 2017 Apr 27.

PMID:
28346741
22.

Tag-Free Semi-Synthesis of the Tau Protein.

Reimann O, Smet-Nocca C, Hackenberger CP.

Methods Mol Biol. 2017;1523:215-235.

PMID:
27975252
23.

Design of S-Allylcysteine in Situ Production and Incorporation Based on a Novel Pyrrolysyl-tRNA Synthetase Variant.

Exner MP, Kuenzl T, To TM, Ouyang Z, Schwagerus S, Hoesl MG, Hackenberger CP, Lensen MC, Panke S, Budisa N.

Chembiochem. 2017 Jan 3;18(1):85-90. doi: 10.1002/cbic.201600537. Epub 2016 Nov 30.

PMID:
27862817
24.

Chemoselective synthesis and analysis of naturally occurring phosphorylated cysteine peptides.

Bertran-Vicente J, Penkert M, Nieto-Garcia O, Jeckelmann JM, Schmieder P, Krause E, Hackenberger CP.

Nat Commun. 2016 Sep 2;7:12703. doi: 10.1038/ncomms12703.

25.

Bis(arylmethyl)-substituted unsymmetrical phosphites for the synthesis of lipidated peptides via Staudinger-phosphite reactions.

Nischan N, Kasper MA, Mathew T, Hackenberger CP.

Org Biomol Chem. 2016 Aug 21;14(31):7500-8. doi: 10.1039/c6ob00843g. Epub 2016 Jul 18.

PMID:
27424660
26.

Inhibition of the key enzyme of sialic acid biosynthesis by C6-Se modified N-acetylmannosamine analogs.

Nieto-Garcia O, Wratil PR, Nguyen LD, Böhrsch V, Hinderlich S, Reutter W, Hackenberger CPR.

Chem Sci. 2016 Jun 1;7(6):3928-3933. doi: 10.1039/c5sc04082e. Epub 2016 Feb 19.

27.

Semi-synthesis of a tag-free O-GlcNAcylated tau protein by sequential chemoselective ligation.

Schwagerus S, Reimann O, Despres C, Smet-Nocca C, Hackenberger CP.

J Pept Sci. 2016 May;22(5):327-33. doi: 10.1002/psc.2870. Epub 2016 Apr 12.

PMID:
27071766
28.

Current Status: Site-Specific Antibody Drug Conjugates.

Schumacher D, Hackenberger CP, Leonhardt H, Helma J.

J Clin Immunol. 2016 May;36 Suppl 1:100-7. doi: 10.1007/s10875-016-0265-6. Epub 2016 Mar 22. Review.

29.

Stabilization of bacterially expressed erythropoietin by single site-specific introduction of short branched PEG chains at naturally occurring glycosylation sites.

Hoffmann E, Streichert K, Nischan N, Seitz C, Brunner T, Schwagerus S, Hackenberger CP, Rubini M.

Mol Biosyst. 2016 May 24;12(6):1750-5. doi: 10.1039/c5mb00857c.

PMID:
26776361
30.

Applying Acylated Fucose Analogues to Metabolic Glycoengineering.

Rosenlöcher J, Böhrsch V, Sacharjat M, Blanchard V, Giese C, Sandig V, Hackenberger CPR, Hinderlich S.

Bioengineering (Basel). 2015 Nov 30;2(4):213-234. doi: 10.3390/bioengineering2040213.

31.

Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase.

Schumacher D, Helma J, Mann FA, Pichler G, Natale F, Krause E, Cardoso MC, Hackenberger CP, Leonhardt H.

Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13787-91. doi: 10.1002/anie.201505456. Epub 2015 Sep 25.

PMID:
26404067
32.

Editorial overview: Synthetic biomolecules: Synthetic protein modifications-a giant leap towards understanding and generating biological functions.

Hackenberger CP, Chen PR.

Curr Opin Chem Biol. 2015 Oct;28:vii-ix. doi: 10.1016/j.cbpa.2015.09.005. Epub 2015 Sep 21. No abstract available.

PMID:
26403808
33.

Multicolor Caged dSTORM Resolves the Ultrastructure of Synaptic Vesicles in the Brain.

Lehmann M, Gottschalk B, Puchkov D, Schmieder P, Schwagerus S, Hackenberger CP, Haucke V, Schmoranzer J.

Angew Chem Int Ed Engl. 2015 Nov 2;54(45):13230-5. doi: 10.1002/anie.201505138. Epub 2015 Sep 8.

PMID:
26346505
34.

Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration.

Kuropka B, Witte A, Sticht J, Waldt N, Majkut P, Hackenberger CP, Schraven B, Krause E, Kliche S, Freund C.

Mol Cell Proteomics. 2015 Nov;14(11):2961-72. doi: 10.1074/mcp.M115.048249. Epub 2015 Aug 5.

35.

Orthogonal dual-modification of proteins for the engineering of multivalent protein scaffolds.

Mühlberg M, Hoesl MG, Kuehne C, Dernedde J, Budisa N, Hackenberger CPR.

Beilstein J Org Chem. 2015 May 13;11:784-791. doi: 10.3762/bjoc.11.88. eCollection 2015.

36.

Gas-Phase Rearrangement in Lysine Phosphorylated Peptides During Electron-Transfer Dissociation Tandem Mass Spectrometry.

Bertran-Vicente J, Schümann M, Hackenberger CP, Krause E.

Anal Chem. 2015 Jul 21;87(14):6990-4. doi: 10.1021/acs.analchem.5b01389. Epub 2015 Jun 29.

PMID:
26110354
37.

Direct access to site-specifically phosphorylated-lysine peptides from a solid-support.

Bertran-Vicente J, Schümann M, Schmieder P, Krause E, Hackenberger CP.

Org Biomol Chem. 2015 Jun 28;13(24):6839-43. doi: 10.1039/c5ob00734h.

PMID:
26018866
38.

Native chemical ligation between asparagine and valine: application and limitations for the synthesis of tri-phosphorylated C-terminal tau.

Reimann O, Glanz M, Hackenberger CP.

Bioorg Med Chem. 2015 Jun 15;23(12):2890-4. doi: 10.1016/j.bmc.2015.03.028. Epub 2015 Mar 17.

PMID:
25882528
39.

Side-chain cysteine-functionalized poly(2-oxazoline)s for multiple peptide conjugation by native chemical ligation.

Schmitz M, Kuhlmann M, Reimann O, Hackenberger CP, Groll J.

Biomacromolecules. 2015 Apr 13;16(4):1088-94. doi: 10.1021/bm501697t. Epub 2015 Mar 20.

40.

Live-cell MRI with xenon hyper-CEST biosensors targeted to metabolically labeled cell-surface glycans.

Witte C, Martos V, Rose HM, Reinke S, Klippel S, Schröder L, Hackenberger CP.

Angew Chem Int Ed Engl. 2015 Feb 23;54(9):2806-10. doi: 10.1002/anie.201410573. Epub 2015 Feb 9.

PMID:
25676513
41.

Cysteine-functional polymers via thiol-ene conjugation.

Kuhlmann M, Reimann O, Hackenberger CP, Groll J.

Macromol Rapid Commun. 2015 Mar;36(5):472-6. doi: 10.1002/marc.201400703. Epub 2015 Jan 21.

PMID:
25645319
42.

Covalent attachment of cyclic TAT peptides to GFP results in protein delivery into live cells with immediate bioavailability.

Nischan N, Herce HD, Natale F, Bohlke N, Budisa N, Cardoso MC, Hackenberger CP.

Angew Chem Int Ed Engl. 2015 Feb 2;54(6):1950-3. doi: 10.1002/anie.201410006. Epub 2014 Dec 17.

PMID:
25521313
43.

Chemoselective bioconjugation of triazole phosphonites in aqueous media.

Vallée MR, Majkut P, Krause D, Gerrits M, Hackenberger CP.

Chemistry. 2015 Jan 12;21(3):970-4. doi: 10.1002/chem.201404690. Epub 2014 Nov 21.

PMID:
25418325
44.

Traceless purification and desulfurization of tau protein ligation products.

Reimann O, Smet-Nocca C, Hackenberger CP.

Angew Chem Int Ed Engl. 2015 Jan 2;54(1):306-10. doi: 10.1002/anie.201408674. Epub 2014 Nov 17.

PMID:
25404175
45.

Site-specific PEGylation of proteins: recent developments.

Nischan N, Hackenberger CP.

J Org Chem. 2014 Nov 21;79(22):10727-33. doi: 10.1021/jo502136n. Epub 2014 Nov 3.

PMID:
25333794
46.

More than add-on: chemoselective reactions for the synthesis of functional peptides and proteins.

Schumacher D, Hackenberger CP.

Curr Opin Chem Biol. 2014 Oct;22:62-9. doi: 10.1016/j.cbpa.2014.09.018. Epub 2014 Oct 3. Review.

PMID:
25285752
47.

Site-specifically phosphorylated lysine peptides.

Bertran-Vicente J, Serwa RA, Schümann M, Schmieder P, Krause E, Hackenberger CP.

J Am Chem Soc. 2014 Oct 1;136(39):13622-8. doi: 10.1021/ja507886s. Epub 2014 Sep 22.

PMID:
25196693
48.

Controlled thioamide vs. amide formation in the thioacid-azide reaction under acidic aqueous conditions.

Mühlberg M, Siebertz KD, Schlegel B, Schmieder P, Hackenberger CP.

Chem Commun (Camb). 2014 May 7;50(35):4603-6. doi: 10.1039/c4cc00774c.

PMID:
24667922
49.

Chemical protein synthesis.

Becker CF, Brik A, Dawson P, Hackenberger CP.

J Pept Sci. 2014 Feb;20(2):63. doi: 10.1002/psc.2607. No abstract available.

PMID:
25975419
50.

Completion of proteomic data sets by Kd measurement using cell-free synthesis of site-specifically labeled proteins.

Majkut P, Claußnitzer I, Merk H, Freund C, Hackenberger CP, Gerrits M.

PLoS One. 2013 Dec 10;8(12):e82352. doi: 10.1371/journal.pone.0082352. eCollection 2013.

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