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A comparison of sterilization techniques for production of decellularized intestine in mice.

Gosztyla C, Ladd MR, Werts A, Fulton W, Johnson B, Sodhi C, Hackam DJ.

Tissue Eng Part C Methods. 2019 Dec 5. doi: 10.1089/ten.TEC.2019.0219. [Epub ahead of print]


A Novel Role for Necroptosis in the Pathogenesis of Necrotizing Enterocolitis.

Werts AD, Fulton WB, Ladd MR, Saad-Eldin A, Chen YX, Kovler ML, Jia H, Banfield EC, Buck R, Goerhing K, Prindle T Jr, Wang S, Zhou Q, Lu P, Yamaguchi Y, Sodhi CP, Hackam DJ.

Cell Mol Gastroenterol Hepatol. 2019 Nov 19. pii: S2352-345X(19)30157-2. doi: 10.1016/j.jcmgh.2019.11.002. [Epub ahead of print]


Generating an Artificial Intestine for the Treatment of Short Bowel Syndrome.

Kovler ML, Hackam DJ.

Gastroenterol Clin North Am. 2019 Dec;48(4):585-605. doi: 10.1016/j.gtc.2019.08.011. Epub 2019 Oct 4. Review.


A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice.

Sodhi CP, Nguyen J, Yamaguchi Y, Werts AD, Lu P, Ladd MR, Fulton WB, Kovler ML, Wang S, Prindle T Jr, Zhang Y, Lazartigues ED, Holtzman MJ, Alcorn JF, Hackam DJ, Jia H.

J Immunol. 2019 Dec 1;203(11):3000-3012. doi: 10.4049/jimmunol.1900579. Epub 2019 Oct 23.


Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23.

Chen L, Strohmeier V, He Z, Deshpande M, Catalan-Dibene J, Durum SK, Moran TM, Kraus T, Xiong H, Faith JJ, Sodhi CP, Hackam DJ, Lira SA, Furtado GC.

Nat Commun. 2019 Oct 4;10(1):4517. doi: 10.1038/s41467-019-12540-8.


The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis.

Hou X, Chen G, Bracamonte-Baran W, Choi HS, Diny NL, Sung J, Hughes D, Won T, Wood MK, Talor MV, Hackam DJ, Klingel K, Davogustto G, Taegtmeyer H, Coppens I, Barin JG, Čiháková D.

Cell Rep. 2019 Jul 2;28(1):172-189.e7. doi: 10.1016/j.celrep.2019.06.007.


Non-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population.

Bracamonte-Baran W, Chen G, Hou X, Talor MV, Choi HS, Davogustto G, Taegtmeyer H, Sung J, Hackam DJ, Nauen D, Čiháková D.

Front Immunol. 2019 Mar 29;10:634. doi: 10.3389/fimmu.2019.00634. eCollection 2019.


Development of Intestinal Scaffolds that Mimic Native Mammalian Intestinal Tissue.

Ladd MR, Costello CM, Gosztyla C, Werts AD, Johnson B, Fulton WB, Martin LY, Redfield EJ, Crawford B, Panaparambil R, Sodhi CP, March JC, Hackam DJ.

Tissue Eng Part A. 2019 Sep;25(17-18):1225-1241. doi: 10.1089/ten.TEA.2018.0239. Epub 2019 Sep 3.


Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis.

Koliaraki V, Chalkidi N, Henriques A, Tzaferis C, Polykratis A, Waisman A, Muller W, Hackam DJ, Pasparakis M, Kollias G.

Cell Rep. 2019 Jan 15;26(3):536-545.e4. doi: 10.1016/j.celrep.2018.12.072.


The recruitment of extra-intestinal cells to the injured mucosa promotes healing in radiation enteritis and chemical colitis in a mouse parabiosis model.

Sung J, Sodhi CP, Voltaggio L, Hou X, Jia H, Zhou Q, Čiháková D, Hackam DJ.

Mucosal Immunol. 2019 Mar;12(2):503-517. doi: 10.1038/s41385-018-0123-3. Epub 2019 Jan 7.


Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain.

Niño DF, Zhou Q, Yamaguchi Y, Martin LY, Wang S, Fulton WB, Jia H, Lu P, Prindle T Jr, Zhang F, Crawford J, Hou Z, Mori S, Chen LL, Guajardo A, Fatemi A, Pletnikov M, Kannan RM, Kannan S, Sodhi CP, Hackam DJ.

Sci Transl Med. 2018 Dec 12;10(471). pii: eaan0237. doi: 10.1126/scitranslmed.aan0237.


Solid Pseudopapillary Neoplasm of the Pancreas in a Young Pediatric Patient: A Case Report and Systematic Review of the Literature.

Bender AM, Thompson ED, Hackam DJ, Cameron JL, Rhee DS.

Pancreas. 2018 Nov/Dec;47(10):1364-1368. doi: 10.1097/MPA.0000000000001183.


Fat composition in infant formula contributes to the severity of necrotising enterocolitis.

Sodhi CP, Fulton WB, Good M, Vurma M, Das T, Lai CS, Jia H, Yamaguchi Y, Lu P, Prindle T, Ozolek JA, Hackam DJ.

Br J Nutr. 2018 Sep;120(6):665-680. doi: 10.1017/S0007114518001836.


Toll Like Receptor 4 Mediated Lymphocyte Imbalance Induces Nec-Induced Lung Injury.

Jia H, Sodhi CP, Yamaguchi Y, Lu P, Ladd MR, Werts A, Fulton WB, Wang S, Prindle T Jr, Hackam DJ.

Shock. 2019 Aug;52(2):215-223. doi: 10.1097/SHK.0000000000001255.


Toll-Like Receptor-Mediated Intestinal Inflammatory Imbalance in the Pathogenesis of Necrotizing Enterocolitis.

Hackam DJ, Sodhi CP.

Cell Mol Gastroenterol Hepatol. 2018 Apr 6;6(2):229-238.e1. doi: 10.1016/j.jcmgh.2018.04.001. eCollection 2018. Review.


New insights into necrotizing enterocolitis: From laboratory observation to personalized prevention and treatment.

Hackam DJ, Sodhi CP, Good M.

J Pediatr Surg. 2019 Mar;54(3):398-404. doi: 10.1016/j.jpedsurg.2018.06.012. Epub 2018 Jun 18. Review.


A Roadmap for Aspiring Surgeon-Scientists in Today's Healthcare Environment.

Goldstein AM, Blair AB, Keswani SG, Gosain A, Morowitz M, Kuo JS, Levine M, Ahuja N, Hackam DJ; Basic Science Committee of the Society of University Surgeons.

Ann Surg. 2019 Jan;269(1):66-72. doi: 10.1097/SLA.0000000000002840. Review.


Scholarly Research Projects Benefit Medical Students' Research Productivity and Residency Choice: Outcomes From the University of Pittsburgh School of Medicine.

Conroy MB, Shaffiey S, Jones S, Hackam DJ, Sowa G, Winger DG, Wang L, Boninger ML, Wagner AK, Levine AS.

Acad Med. 2018 Nov;93(11):1727-1731. doi: 10.1097/ACM.0000000000002328.


Contrast-Enhanced Ultrasound and Near-Infrared Spectroscopy of the Neonatal Bowel: Novel, Bedside, Noninvasive, and Radiation-Free Imaging for Early Detection of Necrotizing Enterocolitis.

Al-Hamad S, Hackam DJ, Goldstein SD, Huisman TAGM, Darge K, Hwang M.

Am J Perinatol. 2018 Dec;35(14):1358-1365. doi: 10.1055/s-0038-1655768. Epub 2018 May 31. Review.


Human Fetal Enterospheres: New Tools for the Study of Necrotizing Enterocolitis.

Hackam DJ.

Cell Mol Gastroenterol Hepatol. 2018 Mar 8;5(4):651. doi: 10.1016/j.jcmgh.2018.02.004. eCollection 2018. No abstract available.


The Development of Newborn Porcine Models for Evaluation of Tissue-Engineered Small Intestine.

Ladd MR, Martin LY, Werts A, Costello C, Sodhi CP, Fulton WB, March JC, Hackam DJ.

Tissue Eng Part C Methods. 2018 Jun;24(6):331-345. doi: 10.1089/ten.TEC.2018.0040. Epub 2018 May 7.


Early detection of necrotizing enterocolitis using broadband optical spectroscopy.

Goldstein SD, Beaulieu RJ, Niño DF, Chun Y, Banerjee A, Sodhi CP, Hackam DJ.

J Pediatr Surg. 2018 Jun;53(6):1192-1196. doi: 10.1016/j.jpedsurg.2018.02.083. Epub 2018 Mar 7.


Abdominal near-infrared spectroscopy in a piglet model of gastrointestinal hypoxia produced by graded hypoxia or superior mesenteric artery ligation.

Chen MW, Reyes M, Kulikowicz E, Martin L, Hackam DJ, Koehler RC, Lee JK.

Pediatr Res. 2018 Jun;83(6):1172-1181. doi: 10.1038/pr.2018.37. Epub 2018 May 2.


Intestinal epithelial Toll-like receptor 4 prevents metabolic syndrome by regulating interactions between microbes and intestinal epithelial cells in mice.

Lu P, Sodhi CP, Yamaguchi Y, Jia H, Prindle T Jr, Fulton WB, Vikram A, Bibby KJ, Morowitz MJ, Hackam DJ.

Mucosal Immunol. 2018 May;11(3):727-740. doi: 10.1038/mi.2017.114. Epub 2018 Jan 24.


The neonatal window of opportunity-early priming for life.

Renz H, Adkins BD, Bartfeld S, Blumberg RS, Farber DL, Garssen J, Ghazal P, Hackam DJ, Marsland BJ, McCoy KD, Penders J, Prinz I, Verhasselt V, von Mutius E, Weiser JN, Wesemann DR, Hornef MW.

J Allergy Clin Immunol. 2018 Apr;141(4):1212-1214. doi: 10.1016/j.jaci.2017.11.019. Epub 2017 Dec 14. No abstract available.


Tissue engineering for the treatment of short bowel syndrome in children.

Martin LY, Ladd MR, Werts A, Sodhi CP, March JC, Hackam DJ.

Pediatr Res. 2018 Jan;83(1-2):249-257. doi: 10.1038/pr.2017.234. Epub 2017 Nov 1. Review.


Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration.

Sodhi CP, Wohlford-Lenane C, Yamaguchi Y, Prindle T, Fulton WB, Wang S, McCray PB Jr, Chappell M, Hackam DJ, Jia H.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L17-L31. doi: 10.1152/ajplung.00498.2016. Epub 2017 Sep 21.


TLR4 Inactivation in Myeloid Cells Accelerates Bone Healing of a Calvarial Defect Model in Mice.

Wang D, Gilbert JR, Taylor GM, Sodhi CP, Hackam DJ, Losee JE, Billiar TR, Cooper GM.

Plast Reconstr Surg. 2017 Aug;140(2):296e-306e. doi: 10.1097/PRS.0000000000003541.


Pediatric choledochal cysts: diagnosis and current management.

Soares KC, Goldstein SD, Ghaseb MA, Kamel I, Hackam DJ, Pawlik TM.

Pediatr Surg Int. 2017 Jun;33(6):637-650. doi: 10.1007/s00383-017-4083-6. Epub 2017 Mar 31. Review.


Enhanced Calvarial Bone Healing in CD11c-TLR4-/- and MyD88-/- Mice.

Wang D, Taylor GM, Gilbert JR, Losee JE, Sodhi CP, Hackam DJ, Billiar TR, Cooper GM.

Plast Reconstr Surg. 2017 Apr;139(4):933e-940e. doi: 10.1097/PRS.0000000000003206.


Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents.

Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE.

J Neurosci. 2017 Feb 1;37(5):1139-1155. doi: 10.1523/JNEUROSCI.2002-16.2016. Epub 2016 Dec 16.


The Future of Basic Science in Academic Surgery: Identifying Barriers to Success for Surgeon-scientists.

Keswani SG, Moles CM, Morowitz M, Zeh H, Kuo JS, Levine MH, Cheng LS, Hackam DJ, Ahuja N, Goldstein AM; Basic Science Committee of the Society of University Surgeons.

Ann Surg. 2017 Jun;265(6):1053-1059. doi: 10.1097/SLA.0000000000002009.


The human milk oligosaccharide 2'-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine.

Good M, Sodhi CP, Yamaguchi Y, Jia H, Lu P, Fulton WB, Martin LY, Prindle T, Nino DF, Zhou Q, Ma C, Ozolek JA, Buck RH, Goehring KC, Hackam DJ.

Br J Nutr. 2016 Oct;116(7):1175-1187. Epub 2016 Sep 9.


Necrotizing enterocolitis: new insights into pathogenesis and mechanisms.

Niño DF, Sodhi CP, Hackam DJ.

Nat Rev Gastroenterol Hepatol. 2016 Oct;13(10):590-600. doi: 10.1038/nrgastro.2016.119. Epub 2016 Aug 18. Review.


Retinoic Acid Improves Incidence and Severity of Necrotizing Enterocolitis by Lymphocyte Balance Restitution and Repopulation of LGR5+ Intestinal Stem Cells.

Niño DF, Sodhi CP, Egan CE, Zhou Q, Lin J, Lu P, Yamaguchi Y, Jia H, Martin LY, Good M, Fulton WB, Prindle T Jr, Ozolek JA, Hackam DJ.

Shock. 2017 Jan;47(1):22-32.


Pancreatic surgery for tumors in children and adolescents.

Sacco Casamassima MG, Gause CD, Goldstein SD, Abdullah F, Meoded A, Lukish JR, Wolfgang CL, Cameron J, Hackam DJ, Hruban RH, Colombani PM.

Pediatr Surg Int. 2016 Aug;32(8):779-88. doi: 10.1007/s00383-016-3925-y. Epub 2016 Jun 30.


Pulmonary Epithelial TLR4 Activation Leads to Lung Injury in Neonatal Necrotizing Enterocolitis.

Jia H, Sodhi CP, Yamaguchi Y, Lu P, Martin LY, Good M, Zhou Q, Sung J, Fulton WB, Nino DF, Prindle T Jr, Ozolek JA, Hackam DJ.

J Immunol. 2016 Aug 1;197(3):859-71. doi: 10.4049/jimmunol.1600618. Epub 2016 Jun 15.


Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects against Experimental Murine Colitis.

Cunningham KE, Vincent G, Sodhi CP, Novak EA, Ranganathan S, Egan CE, Stolz DB, Rogers MB, Firek B, Morowitz MJ, Gittes GK, Zuckerbraun BS, Hackam DJ, Mollen KP.

J Biol Chem. 2016 May 6;291(19):10184-200. doi: 10.1074/jbc.M115.688812. Epub 2016 Mar 11.


Generation of an artificial intestine for the management of short bowel syndrome.

Ladd MR, Niño DF, March JC, Sodhi CP, Hackam DJ.

Curr Opin Organ Transplant. 2016 Apr;21(2):178-85. doi: 10.1097/MOT.0000000000000284. Review.


Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis.

Egan CE, Sodhi CP, Good M, Lin J, Jia H, Yamaguchi Y, Lu P, Ma C, Branca MF, Weyandt S, Fulton WB, Niño DF, Prindle T Jr, Ozolek JA, Hackam DJ.

J Clin Invest. 2016 Feb;126(2):495-508.


Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.

Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Wilhelms DB, Lazarus M, Löfberg A, Jaarola M, Kugelberg UÖ, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schütz G, Parkitna JR, Saper CB, Blomqvist A, Engblom D.

J Clin Invest. 2016 Feb;126(2):695-705.


Toll-like Receptor 4 Signaling on Dendritic Cells Suppresses Polymorphonuclear Leukocyte CXCR2 Expression and Trafficking via Interleukin 10 During Intra-abdominal Sepsis.

Deng M, Ma T, Yan Z, Zettel KR, Scott MJ, Liao H, Frank A, Morelli AE, Sodhi CP, Hackam DJ, Billiar TR.

J Infect Dis. 2016 Apr 15;213(8):1280-8. doi: 10.1093/infdis/jiv562. Epub 2015 Nov 24.


HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4.

Cai J, Yuan H, Wang Q, Yang H, Al-Abed Y, Hua Z, Wang J, Chen D, Wu J, Lu B, Pribis JP, Jiang W, Yang K, Hackam DJ, Tracey KJ, Billiar TR, Chen AF.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2579-93. doi: 10.1161/ATVBAHA.115.305789. Epub 2015 Oct 29.


Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals.

Shaffiey SA, Jia H, Keane T, Costello C, Wasserman D, Quidgley M, Dziki J, Badylak S, Sodhi CP, March JC, Hackam DJ.

Regen Med. 2016 Jan;11(1):45-61. doi: 10.2217/rme.15.70. Epub 2015 Sep 23.


Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4).

Wipf P, Eyer BR, Yamaguchi Y, Zhang F, Neal MD, Sodhi CP, Good M, Branca M, Prindle T Jr, Lu P, Brodsky JL, Hackam DJ.

Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100.


The dawn of the third renaissance in surgery.

Hackam DJ.

Surgery. 2015 Aug;158(2):317-22. doi: 10.1016/j.surg.2015.05.001. Epub 2015 Jun 16.


What's New in Shock? JUNE 2015.

Hackam DJ.

Shock. 2015 Jun;43(6):519-21. doi: 10.1097/SHK.0000000000000374. No abstract available.


Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor.

Good M, Sodhi CP, Egan CE, Afrazi A, Jia H, Yamaguchi Y, Lu P, Branca MF, Ma C, Prindle T Jr, Mielo S, Pompa A, Hodzic Z, Ozolek JA, Hackam DJ.

Mucosal Immunol. 2015 Sep;8(5):1166-79. doi: 10.1038/mi.2015.30. Epub 2015 Apr 22.


Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut.

Sodhi CP, Jia H, Yamaguchi Y, Lu P, Good M, Egan C, Ozolek J, Zhu X, Billiar TR, Hackam DJ.

J Immunol. 2015 May 15;194(10):4931-9. doi: 10.4049/jimmunol.1402490. Epub 2015 Apr 10.


Myocyte TLR4 enhances enteric and systemic inflammation driving late murine endotoxic ileus.

Buchholz BM, Shapiro RA, Vodovotz Y, Billiar TR, Sodhi CP, Hackam DJ, Bauer AJ.

Am J Physiol Gastrointest Liver Physiol. 2015 May 15;308(10):G852-62. doi: 10.1152/ajpgi.00211.2014. Epub 2015 Mar 6.

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