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Items: 1 to 50 of 93

1.

Consolidative mediastinal irradiation of malignant lymphoma using active scanning proton beams: clinical outcome and dosimetric comparison.

König L, Bougatf N, Hörner-Rieber J, Chaudhri N, Mielke T, Klüter S, Haefner MF, Rieken S, Haberer T, Debus J, Herfarth K.

Strahlenther Onkol. 2019 Jul;195(7):677-687. doi: 10.1007/s00066-019-01460-7. Epub 2019 Apr 10.

PMID:
30972453
2.

Fast robust dose calculation on GPU for high-precision 1H, 4He, 12C and 16O ion therapy: the FRoG platform.

Mein S, Choi K, Kopp B, Tessonnier T, Bauer J, Ferrari A, Haberer T, Debus J, Abdollahi A, Mairani A.

Sci Rep. 2018 Oct 4;8(1):14829. doi: 10.1038/s41598-018-33194-4.

3.

Dosimetric comparison of advanced radiotherapy approaches using photon techniques and particle therapy in the postoperative management of thymoma.

Haefner MF, Verma V, Bougatf N, Mielke T, Tonndorf-Martini E, König L, Rwigema JM, Simone CB 2nd, Uhlmann L, Eichhorn F, Winter H, Grosch H, Haberer T, Herfarth K, Debus J, Rieken S.

Acta Oncol. 2018 Dec;57(12):1713-1720. doi: 10.1080/0284186X.2018.1502467. Epub 2018 Sep 28.

PMID:
30264630
4.

High control rates of proton- and carbon-ion-beam treatment with intensity-modulated active raster scanning in 101 patients with skull base chondrosarcoma at the Heidelberg Ion Beam Therapy Center.

Mattke M, Vogt K, Bougatf N, Welzel T, Oelmann-Avendano J, Hauswald H, Jensen A, Ellerbrock M, Jäkel O, Haberer T, Herfarth K, Debus J, Uhl M.

Cancer. 2018 May 1;124(9):2036-2044. doi: 10.1002/cncr.31298. Epub 2018 Feb 22.

5.

Proton and helium ion radiotherapy for meningioma tumors: a Monte Carlo-based treatment planning comparison.

Tessonnier T, Mairani A, Chen W, Sala P, Cerutti F, Ferrari A, Haberer T, Debus J, Parodi K.

Radiat Oncol. 2018 Jan 9;13(1):2. doi: 10.1186/s13014-017-0944-3.

6.

Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation.

Klein C, Dokic I, Mairani A, Mein S, Brons S, Häring P, Haberer T, Jäkel O, Zimmermann A, Zenke F, Blaukat A, Debus J, Abdollahi A.

Radiat Oncol. 2017 Dec 29;12(1):208. doi: 10.1186/s13014-017-0939-0.

7.

Sequential proton boost after standard chemoradiation for high-grade glioma.

Adeberg S, Bernhardt D, Harrabi SB, Uhl M, Paul A, Bougatf N, Verma V, Unterberg A, Wick W, Haberer T, Combs SE, Herfarth K, Debus J, Rieken S.

Radiother Oncol. 2017 Nov;125(2):266-272. doi: 10.1016/j.radonc.2017.09.040. Epub 2017 Oct 16.

PMID:
29050959
8.

Helium ions at the heidelberg ion beam therapy center: comparisons between FLUKA Monte Carlo code predictions and dosimetric measurements.

Tessonnier T, Mairani A, Brons S, Sala P, Cerutti F, Ferrari A, Haberer T, Debus J, Parodi K.

Phys Med Biol. 2017 Aug 1;62(16):6784-6803. doi: 10.1088/1361-6560/aa7b12.

PMID:
28762335
9.

Dosimetric verification in water of a Monte Carlo treatment planning tool for proton, helium, carbon and oxygen ion beams at the Heidelberg Ion Beam Therapy Center.

Tessonnier T, Böhlen TT, Ceruti F, Ferrari A, Sala P, Brons S, Haberer T, Debus J, Parodi K, Mairani A.

Phys Med Biol. 2017 Jul 31;62(16):6579-6594. doi: 10.1088/1361-6560/aa7be4.

PMID:
28650846
10.

Experimental dosimetric comparison of 1H, 4He, 12C and 16O scanned ion beams.

Tessonnier T, Mairani A, Brons S, Haberer T, Debus J, Parodi K.

Phys Med Biol. 2017 May 21;62(10):3958-3982. doi: 10.1088/1361-6560/aa6516. Epub 2017 Apr 13.

PMID:
28406796
11.

Optimizing the modified microdosimetric kinetic model input parameters for proton and 4He ion beam therapy application.

Mairani A, Magro G, Tessonnier T, Böhlen TT, Molinelli S, Ferrari A, Parodi K, Debus J, Haberer T.

Phys Med Biol. 2017 Jun 7;62(11):N244-N256. doi: 10.1088/1361-6560/aa6be9. Epub 2017 Apr 6.

PMID:
28384125
12.

Combination of Photon and Carbon Ion Irradiation with Targeted Therapy Substances Temsirolimus and Gemcitabine in Hepatocellular Carcinoma Cell Lines.

Dehne S, Fritz C, Rieken S, Baris D, Brons S, Haberer T, Debus J, Weber KJ, Schmid TE, Combs SE, Habermehl D.

Front Oncol. 2017 Mar 13;7:35. doi: 10.3389/fonc.2017.00035. eCollection 2017.

13.

A phenomenological relative biological effectiveness approach for proton therapy based on an improved description of the mixed radiation field.

Mairani A, Dokic I, Magro G, Tessonnier T, Bauer J, Böhlen TT, Ciocca M, Ferrari A, Sala PR, Jäkel O, Debus J, Haberer T, Abdollahi A, Parodi K.

Phys Med Biol. 2017 Feb 21;62(4):1378-1395. doi: 10.1088/1361-6560/aa51f7. Epub 2017 Jan 23.

PMID:
28114106
14.

Dosimetric advantages of proton therapy over conventional radiotherapy with photons in young patients and adults with low-grade glioma.

Harrabi SB, Bougatf N, Mohr A, Haberer T, Herfarth K, Combs SE, Debus J, Adeberg S.

Strahlenther Onkol. 2016 Nov;192(11):759-769. Epub 2016 Jun 30.

15.

Intensity-modulated proton therapy, volumetric-modulated arc therapy, and 3D conformal radiotherapy in anaplastic astrocytoma and glioblastoma : A dosimetric comparison.

Adeberg S, Harrabi SB, Bougatf N, Bernhardt D, Rieber J, Koerber SA, Syed M, Sprave T, Mohr A, Abdollahi A, Haberer T, Combs SE, Herfarth K, Debus J, Rieken S.

Strahlenther Onkol. 2016 Nov;192(11):770-779. Epub 2016 Jun 22.

PMID:
27334276
16.

Next generation multi-scale biophysical characterization of high precision cancer particle radiotherapy using clinical proton, helium-, carbon- and oxygen ion beams.

Dokic I, Mairani A, Niklas M, Zimmermann F, Chaudhri N, Krunic D, Tessonnier T, Ferrari A, Parodi K, Jäkel O, Debus J, Haberer T, Abdollahi A.

Oncotarget. 2016 Aug 30;7(35):56676-56689. doi: 10.18632/oncotarget.10996.

17.

Biologically optimized helium ion plans: calculation approach and its in vitro validation.

Mairani A, Dokic I, Magro G, Tessonnier T, Kamp F, Carlson DJ, Ciocca M, Cerutti F, Sala PR, Ferrari A, Böhlen TT, Jäkel O, Parodi K, Debus J, Abdollahi A, Haberer T.

Phys Med Biol. 2016 Jun 7;61(11):4283-99. doi: 10.1088/0031-9155/61/11/4283. Epub 2016 May 20.

PMID:
27203864
18.

Acute Toxicity and Quality of Life in Patients With Prostate Cancer Treated With Protons or Carbon Ions in a Prospective Randomized Phase II Study--The IPI Trial.

Habl G, Uhl M, Katayama S, Kessel KA, Hatiboglu G, Hadaschik B, Edler L, Tichy D, Ellerbrock M, Haberer T, Wolf MB, Schlemmer HP, Debus J, Herfarth K.

Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):435-43. doi: 10.1016/j.ijrobp.2016.02.025. Epub 2016 Feb 12.

PMID:
27084659
19.

S-phase-specific radiosensitization by gemcitabine for therapeutic carbon ion exposure in vitro.

Harrabi SB, Adeberg S, Winter M, Haberer T, Debus J, Weber KJ.

J Radiat Res. 2016 Mar;57(2):110-4. doi: 10.1093/jrr/rrv097. Epub 2016 Jan 7.

20.

Data-driven RBE parameterization for helium ion beams.

Mairani A, Magro G, Dokic I, Valle SM, Tessonnier T, Galm R, Ciocca M, Parodi K, Ferrari A, Jäkel O, Haberer T, Pedroni P, Böhlen TT.

Phys Med Biol. 2016 Jan 21;61(2):888-905. doi: 10.1088/0031-9155/61/2/888. Epub 2016 Jan 7.

PMID:
26740518
21.

COSMIC: A Regimen of Intensity Modulated Radiation Therapy Plus Dose-Escalated, Raster-Scanned Carbon Ion Boost for Malignant Salivary Gland Tumors: Results of the Prospective Phase 2 Trial.

Jensen AD, Nikoghosyan AV, Lossner K, Haberer T, Jäkel O, Münter MW, Debus J.

Int J Radiat Oncol Biol Phys. 2015 Sep 1;93(1):37-46. doi: 10.1016/j.ijrobp.2015.05.013. Epub 2015 May 19.

PMID:
26279022
22.

High-LET radiotherapy for adenoid cystic carcinoma of the head and neck: 15 years' experience with raster-scanned carbon ion therapy.

Jensen AD, Poulakis M, Nikoghosyan AV, Welzel T, Uhl M, Federspil PA, Freier K, Krauss J, Höss A, Haberer T, Jäkel O, Münter MW, Schulz-Ertner D, Huber PE, Debus J.

Radiother Oncol. 2016 Feb;118(2):272-80. doi: 10.1016/j.radonc.2015.05.010. Epub 2015 Jul 8.

PMID:
26164774
23.

Combined intensity-modulated radiotherapy plus raster-scanned carbon ion boost for advanced adenoid cystic carcinoma of the head and neck results in superior locoregional control and overall survival.

Jensen AD, Nikoghosyan AV, Poulakis M, Höss A, Haberer T, Jäkel O, Münter MW, Schulz-Ertner D, Huber PE, Debus J.

Cancer. 2015 Sep 1;121(17):3001-9. doi: 10.1002/cncr.29443. Epub 2015 Jun 4.

24.

Ion therapy of prostate cancer: daily rectal dose reduction by application of spacer gel.

Rucinski A, Brons S, Richter D, Habl G, Debus J, Bert C, Haberer T, Jäkel O.

Radiat Oncol. 2015 Feb 27;10:56. doi: 10.1186/s13014-015-0348-1.

25.

Clinical implementation and range evaluation of in vivo PET dosimetry for particle irradiation in patients with primary glioma.

Nischwitz SP, Bauer J, Welzel T, Rief H, Jäkel O, Haberer T, Frey K, Debus J, Parodi K, Combs SE, Rieken S.

Radiother Oncol. 2015 May;115(2):179-85. doi: 10.1016/j.radonc.2015.03.022. Epub 2015 Apr 2.

PMID:
25842968
26.

Carbon ion beam treatment in patients with primary and recurrent sacrococcygeal chordoma.

Uhl M, Welzel T, Jensen A, Ellerbrock M, Haberer T, Jäkel O, Herfarth K, Debus J.

Strahlenther Onkol. 2015 Jul;191(7):597-603. doi: 10.1007/s00066-015-0825-3. Epub 2015 Mar 4.

PMID:
25737378
27.

Treatment of arrhythmias by external charged particle beams: a Langendorff feasibility study.

Prall M, Lehmann HI, Prokesch H, Richter D, Graeff C, Kaderka R, Sonnenberg K, Hauswald H, Weymann A, Bauer J, Constantinescu A, Haberer T, Debus J, Szabó G, Korkmaz S, Durante M, Packer DL, Bert C.

Biomed Tech (Berl). 2015 Apr;60(2):147-56. doi: 10.1515/bmt-2014-0101.

PMID:
25719279
28.

Atrioventricular node ablation in Langendorff-perfused porcine hearts using carbon ion particle therapy: methods and an in vivo feasibility investigation for catheter-free ablation of cardiac arrhythmias.

Lehmann HI, Richter D, Prokesch H, Graeff C, Prall M, Simoniello P, Fournier C, Bauer J, Kaderka R, Weymann A, Szabó G, Sonnenberg K, Constantinescu AM, Johnson SB, Misiri J, Takami M, Miller RC, Herman MG, Asirvatham SJ, Brons S, Jäkel O, Haberer T, Debus J, Durante M, Bert C, Packer DL.

Circ Arrhythm Electrophysiol. 2015 Apr;8(2):429-38. doi: 10.1161/CIRCEP.114.002436. Epub 2015 Jan 21.

PMID:
25609687
29.

The relative biological effectiveness for carbon and oxygen ion beams using the raster-scanning technique in hepatocellular carcinoma cell lines.

Habermehl D, Ilicic K, Dehne S, Rieken S, Orschiedt L, Brons S, Haberer T, Weber KJ, Debus J, Combs SE.

PLoS One. 2014 Dec 2;9(12):e113591. doi: 10.1371/journal.pone.0113591. eCollection 2014. Erratum in: PLoS One. 2015;10(2):e0117960.

30.

In response to the comments to the paper 'Modelling of cell killing due to sparsely ionizing radiation in normoxic and hypoxic conditions and an extension to high LET radiation' by T. Friedrich et al.

Mairani A, Böhlen TT, Dokic I, Cabal G, Brons S, Haberer T.

Int J Radiat Biol. 2015 Jan;91(1):129-31. doi: 10.3109/09553002.2015.985115. No abstract available.

PMID:
25380346
31.

Highly effective treatment of skull base chordoma with carbon ion irradiation using a raster scan technique in 155 patients: first long-term results.

Uhl M, Mattke M, Welzel T, Roeder F, Oelmann J, Habl G, Jensen A, Ellerbrock M, Jäkel O, Haberer T, Herfarth K, Debus J.

Cancer. 2014 Nov 1;120(21):3410-7. doi: 10.1002/cncr.28877. Epub 2014 Jun 19.

32.

Improvements for extending the time between maintenance periods for the Heidelberg ion beam therapy center (HIT) ion sources.

Winkelmann T, Cee R, Haberer T, Naas B, Peters A, Schreiner J.

Rev Sci Instrum. 2014 Feb;85(2):02A951. doi: 10.1063/1.4860651.

PMID:
24593530
33.

High control rate in patients with chondrosarcoma of the skull base after carbon ion therapy: first report of long-term results.

Uhl M, Mattke M, Welzel T, Oelmann J, Habl G, Jensen AD, Ellerbrock M, Haberer T, Herfarth KK, Debus J.

Cancer. 2014 May 15;120(10):1579-85. doi: 10.1002/cncr.28606. Epub 2014 Feb 5.

34.

Comparison of the effects of photon versus carbon ion irradiation when combined with chemotherapy in vitro.

Schlaich F, Brons S, Haberer T, Debus J, Combs SE, Weber KJ.

Radiat Oncol. 2013 Nov 6;8:260. doi: 10.1186/1748-717X-8-260.

35.

Gating delays for two respiratory motion sensors in scanned particle radiation therapy.

Steidl P, Haberer T, Durante M, Bert C.

Phys Med Biol. 2013 Nov 7;58(21):N295-302. doi: 10.1088/0031-9155/58/21/N295. Epub 2013 Oct 18.

PMID:
24141025
36.

Proton and carbon ion radiotherapy for primary brain tumors and tumors of the skull base.

Combs SE, Kessel K, Habermehl D, Haberer T, Jäkel O, Debus J.

Acta Oncol. 2013 Oct;52(7):1504-9. doi: 10.3109/0284186X.2013.818255. Epub 2013 Aug 21.

PMID:
23962241
37.

A Monte Carlo-based treatment-planning tool for ion beam therapy.

Böhlen TT, Bauer J, Dosanjh M, Ferrari A, Haberer T, Parodi K, Patera V, Mairani A.

J Radiat Res. 2013 Jul;54 Suppl 1:i77-81. doi: 10.1093/jrr/rrt050.

38.

In vitro evaluation of photon and raster-scanned carbon ion radiotherapy in combination with gemcitabine in pancreatic cancer cell lines.

El Shafie RA, Habermehl D, Rieken S, Mairani A, Orschiedt L, Brons S, Haberer T, Weber KJ, Debus J, Combs SE.

J Radiat Res. 2013 Jul;54 Suppl 1:i113-9. doi: 10.1093/jrr/rrt052.

39.

Towards clinical evidence in particle therapy: ENLIGHT, PARTNER, ULICE and beyond.

Combs SE, Djosanjh M, Pötter R, Orrechia R, Haberer T, Durante M, Fossati P, Parodi K, Balosso J, Amaldi U, Baumann M, Debus J.

J Radiat Res. 2013 Jul;54 Suppl 1:i6-12. doi: 10.1093/jrr/rrt039. No abstract available.

40.

Preclinical investigations towards the first spacer gel application in prostate cancer treatment during particle therapy at HIT.

Ruciński A, Bauer J, Campbell P, Brons S, Unholtz D, Habl G, Herfarth K, Debus J, Bert C, Parodi K, Jäkel O, Haberer T.

Radiat Oncol. 2013 Jun 6;8:134. doi: 10.1186/1748-717X-8-134.

41.

Implementation and initial clinical experience of offline PET/CT-based verification of scanned carbon ion treatment.

Bauer J, Unholtz D, Sommerer F, Kurz C, Haberer T, Herfarth K, Welzel T, Combs SE, Debus J, Parodi K.

Radiother Oncol. 2013 May;107(2):218-26. doi: 10.1016/j.radonc.2013.02.018. Epub 2013 May 4.

PMID:
23647759
42.

Modelling of cell killing due to sparsely ionizing radiation in normoxic and hypoxic conditions and an extension to high LET radiation.

Mairani A, Böhlen TT, Dokic I, Cabal G, Brons S, Haberer T.

Int J Radiat Biol. 2013 Oct;89(10):782-93. doi: 10.3109/09553002.2013.800247. Epub 2013 Jun 26.

PMID:
23627742
43.

Temozolomide in combination with carbon ion or photon irradiation in glioblastoma multiforme cell lines - does scheduling matter?

Harrabi S, Combs SE, Brons S, Haberer T, Debus J, Weber KJ.

Int J Radiat Biol. 2013 Sep;89(9):692-7. doi: 10.3109/09553002.2013.791406. Epub 2013 May 13.

PMID:
23577964
44.

Hypofractionated carbon ion therapy delivered with scanned ion beams for patients with hepatocellular carcinoma - feasibility and clinical response.

Habermehl D, Debus J, Ganten T, Ganten MK, Bauer J, Brecht IC, Brons S, Haberer T, Haertig M, Jäkel O, Parodi K, Welzel T, Combs SE.

Radiat Oncol. 2013 Mar 13;8:59. doi: 10.1186/1748-717X-8-59.

45.

Investigating the robustness of ion beam therapy treatment plans to uncertainties in biological treatment parameters.

Böhlen TT, Brons S, Dosanjh M, Ferrari A, Fossati P, Haberer T, Patera V, Mairani A.

Phys Med Biol. 2012 Dec 7;57(23):7983-8004. doi: 10.1088/0031-9155/57/23/7983. Epub 2012 Nov 15.

PMID:
23154750
46.

Monte Carlo simulations to support start-up and treatment planning of scanned proton and carbon ion therapy at a synchrotron-based facility.

Parodi K, Mairani A, Brons S, Hasch BG, Sommerer F, Naumann J, Jäkel O, Haberer T, Debus J.

Phys Med Biol. 2012 Jun 21;57(12):3759-84. doi: 10.1088/0031-9155/57/12/3759. Epub 2012 May 23.

PMID:
22617050
47.

Identification of stable endogenous control genes for transcriptional profiling of photon, proton and carbon-ion irradiated cells.

Sharungbam GD, Schwager C, Chiblak S, Brons S, Hlatky L, Haberer T, Debus J, Abdollahi A.

Radiat Oncol. 2012 May 17;7:70. doi: 10.1186/1748-717X-7-70.

48.

Monitoring of patients treated with particle therapy using positron-emission-tomography (PET): the MIRANDA study.

Combs SE, Bauer J, Unholtz D, Kurz C, Welzel T, Habermehl D, Haberer T, Debus J, Parodi K.

BMC Cancer. 2012 Apr 3;12:133. doi: 10.1186/1471-2407-12-133.

49.

A breathing thorax phantom with independently programmable 6D tumour motion for dosimetric measurements in radiation therapy.

Steidl P, Richter D, Schuy C, Schubert E, Haberer T, Durante M, Bert C.

Phys Med Biol. 2012 Apr 21;57(8):2235-50. doi: 10.1088/0031-9155/57/8/2235. Epub 2012 Mar 29.

PMID:
22455990
50.

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