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Items: 1 to 50 of 268

1.

Improved Detection of Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasms.

Franses JW, Basar O, Kadayifci A, Yuksel O, Choz M, Kulkarni AS, Tai E, Vo KD, Arora KS, Desai N, Licausi JA, Toner M, Maheswaran S, Haber DA, Ryan DP, Brugge WR, Ting DT.

Oncologist. 2018 Oct;23(10):1260. doi: 10.1634/theoncologist.2017-0234erratum. No abstract available.

PMID:
30315083
2.

Detection and Analysis of Circulating Epithelial Cells in Liquid Biopsies From Patients With Liver Disease.

Bhan I, Mosesso K, Goyal L, Philipp J, Kalinich M, Franses JW, Choz M, Oklu R, Toner M, Maheswaran S, Haber DA, Zhu AX, Chung RT, Aryee M, Ting DT.

Gastroenterology. 2018 Sep 12. pii: S0016-5085(18)34975-8. doi: 10.1053/j.gastro.2018.09.020. [Epub ahead of print]

PMID:
30218669
3.

A Digital RNA Signature of Circulating Tumor Cells Predicting Early Therapeutic Response in Localized and Metastatic Breast Cancer.

Kwan TT, Bardia A, Spring LM, Giobbie-Hurder A, Kalinich M, Dubash T, Sundaresan T, Hong X, LiCausi JA, Ho U, Silva EJ, Wittner BS, Sequist LV, Kapur R, Miyamoto DT, Toner M, Haber DA, Maheswaran S.

Cancer Discov. 2018 Oct;8(10):1286-1299. doi: 10.1158/2159-8290.CD-18-0432. Epub 2018 Aug 13.

PMID:
30104333
4.

Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts.

Drapkin BJ, George J, Christensen CL, Mino-Kenudson M, Dries R, Sundaresan T, Phat S, Myers DT, Zhong J, Igo P, Hazar-Rethinam MH, Licausi JA, Gomez-Caraballo M, Kem M, Jani KN, Azimi R, Abedpour N, Menon R, Lakis S, Heist RS, Büttner R, Haas S, Sequist LV, Shaw AT, Wong KK, Hata AN, Toner M, Maheswaran S, Haber DA, Peifer M, Dyson N, Thomas RK, Farago AF.

Cancer Discov. 2018 May;8(5):600-615. doi: 10.1158/2159-8290.CD-17-0935. Epub 2018 Feb 26.

PMID:
29483136
5.

Ultra-fast vitrification of patient-derived circulating tumor cell lines.

Sandlin RD, Wong KHK, Tessier SN, Swei A, Bookstaver LD, Ahearn BE, Maheswaran S, Haber DA, Stott SL, Toner M.

PLoS One. 2018 Feb 23;13(2):e0192734. doi: 10.1371/journal.pone.0192734. eCollection 2018.

6.

Cancer detection: Seeking signals in blood.

Kalinich M, Haber DA.

Science. 2018 Feb 23;359(6378):866-867. doi: 10.1126/science.aas9102. No abstract available.

PMID:
29472467
7.

AR Expression in Breast Cancer CTCs Associates with Bone Metastases.

Aceto N, Bardia A, Wittner BS, Donaldson MC, O'Keefe R, Engstrom A, Bersani F, Zheng Y, Comaills V, Niederhoffer K, Zhu H, Mackenzie O, Shioda T, Sgroi D, Kapur R, Ting DT, Moy B, Ramaswamy S, Toner M, Haber DA, Maheswaran S.

Mol Cancer Res. 2018 Apr;16(4):720-727. doi: 10.1158/1541-7786.MCR-17-0480. Epub 2018 Feb 16.

PMID:
29453314
8.

Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy.

Hong X, Sullivan RJ, Kalinich M, Kwan TT, Giobbie-Hurder A, Pan S, LiCausi JA, Milner JD, Nieman LT, Wittner BS, Ho U, Chen T, Kapur R, Lawrence DP, Flaherty KT, Sequist LV, Ramaswamy S, Miyamoto DT, Lawrence M, Toner M, Isselbacher KJ, Maheswaran S, Haber DA.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2467-2472. doi: 10.1073/pnas.1719264115. Epub 2018 Feb 16.

9.

An RNA-Based Digital Circulating Tumor Cell Signature Is Predictive of Drug Response and Early Dissemination in Prostate Cancer.

Miyamoto DT, Lee RJ, Kalinich M, LiCausi JA, Zheng Y, Chen T, Milner JD, Emmons E, Ho U, Broderick K, Silva E, Javaid S, Kwan TT, Hong X, Dahl DM, McGovern FJ, Efstathiou JA, Smith MR, Sequist LV, Kapur R, Wu CL, Stott SL, Ting DT, Giobbie-Hurder A, Toner M, Maheswaran S, Haber DA.

Cancer Discov. 2018 Mar;8(3):288-303. doi: 10.1158/2159-8290.CD-16-1406. Epub 2018 Jan 4.

PMID:
29301747
10.

Clusters of Circulating Tumor Cells: a Biophysical and Technological Perspective.

Au SH, Edd J, Haber DA, Maheswaran S, Stott SL, Toner M.

Curr Opin Biomed Eng. 2017 Sep;3:13-19. doi: 10.1016/j.cobme.2017.08.001. Epub 2017 Aug 10.

11.

Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells.

Wong KHK, Tessier SN, Miyamoto DT, Miller KL, Bookstaver LD, Carey TR, Stannard CJ, Thapar V, Tai EC, Vo KD, Emmons ES, Pleskow HM, Sandlin RD, Sequist LV, Ting DT, Haber DA, Maheswaran S, Stott SL, Toner M.

Nat Commun. 2017 Nov 23;8(1):1733. doi: 10.1038/s41467-017-01705-y.

12.

A conduit to metastasis: circulating tumor cell biology.

Micalizzi DS, Maheswaran S, Haber DA.

Genes Dev. 2017 Sep 15;31(18):1827-1840. doi: 10.1101/gad.305805.117. Review.

13.

Microfluidic isolation of platelet-covered circulating tumor cells.

Jiang X, Wong KHK, Khankhel AH, Zeinali M, Reategui E, Phillips MJ, Luo X, Aceto N, Fachin F, Hoang AN, Kim W, Jensen AE, Sequist LV, Maheswaran S, Haber DA, Stott SL, Toner M.

Lab Chip. 2017 Oct 11;17(20):3498-3503. doi: 10.1039/c7lc00654c.

14.

Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells.

Fachin F, Spuhler P, Martel-Foley JM, Edd JF, Barber TA, Walsh J, Karabacak M, Pai V, Yu M, Smith K, Hwang H, Yang J, Shah S, Yarmush R, Sequist LV, Stott SL, Maheswaran S, Haber DA, Kapur R, Toner M.

Sci Rep. 2017 Sep 7;7(1):10936. doi: 10.1038/s41598-017-11119-x.

15.

Improved Detection of Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasms.

Franses JW, Basar O, Kadayifci A, Yuksel O, Choz M, Kulkarni AS, Tai E, Vo KD, Arora KS, Desai N, Licausi JA, Toner M, Maheswaran S, Haber DA, Ryan DP, Brugge WR, Ting DT.

Oncologist. 2018 Jan;23(1):121-127. doi: 10.1634/theoncologist.2017-0234. Epub 2017 Aug 31. Erratum in: Oncologist. 2018 Oct;23(10):1260.

16.

A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer.

Polak P, Kim J, Braunstein LZ, Karlic R, Haradhavala NJ, Tiao G, Rosebrock D, Livitz D, Kübler K, Mouw KW, Kamburov A, Maruvka YE, Leshchiner I, Lander ES, Golub TR, Zick A, Orthwein A, Lawrence MS, Batra RN, Caldas C, Haber DA, Laird PW, Shen H, Ellisen LW, D'Andrea AD, Chanock SJ, Foulkes WD, Getz G.

Nat Genet. 2017 Oct;49(10):1476-1486. doi: 10.1038/ng.3934. Epub 2017 Aug 21.

PMID:
28825726
17.

Preservative solution that stabilizes erythrocyte morphology and leukocyte viability under ambient conditions.

Sandlin RD, Wong KHK, Boneschansker L, Carey TR, Miller KL, Rose G, Haber DA, Maheswaran S, Irimia D, Stott SL, Toner M.

Sci Rep. 2017 Jul 18;7(1):5658. doi: 10.1038/s41598-017-05978-7.

18.

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.

Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, Chen S, Boskovic ZV, Javaid S, Huang C, Wu X, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR, Schreiber SL.

Nature. 2017 Jul 27;547(7664):453-457. doi: 10.1038/nature23007. Epub 2017 Jul 5.

19.

Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry.

Au SH, Edd J, Stoddard AE, Wong KHK, Fachin F, Maheswaran S, Haber DA, Stott SL, Kapur R, Toner M.

Sci Rep. 2017 May 26;7(1):2433. doi: 10.1038/s41598-017-01150-3.

20.

Cancer metastasis through the prism of epithelial-to-mesenchymal transition in circulating tumor cells.

Micalizzi DS, Haber DA, Maheswaran S.

Mol Oncol. 2017 Jul;11(7):770-780. doi: 10.1002/1878-0261.12081. Epub 2017 Jun 9. Review.

21.

Single-Cell Analysis of Circulating Tumor Cells as a Window into Tumor Heterogeneity.

Miyamoto DT, Ting DT, Toner M, Maheswaran S, Haber DA.

Cold Spring Harb Symp Quant Biol. 2016;81:269-274. doi: 10.1101/sqb.2016.81.031120. Epub 2017 Apr 7. Review.

22.

ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells.

Yazinski SA, Comaills V, Buisson R, Genois MM, Nguyen HD, Ho CK, Todorova Kwan T, Morris R, Lauffer S, Nussenzweig A, Ramaswamy S, Benes CH, Haber DA, Maheswaran S, Birrer MJ, Zou L.

Genes Dev. 2017 Feb 1;31(3):318-332. doi: 10.1101/gad.290957.116. Epub 2017 Feb 27.

23.

Modeling background radiation in Southern Nevada.

Haber DA, Burnley PC, Adcock CT, Malchow RL, Marsac KE, Hausrath EM.

J Environ Radioact. 2017 May;171:41-64. doi: 10.1016/j.jenvrad.2017.01.020. Epub 2017 Feb 6.

24.

Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination.

Zheng Y, Miyamoto DT, Wittner BS, Sullivan JP, Aceto N, Jordan NV, Yu M, Karabacak NM, Comaills V, Morris R, Desai R, Desai N, Emmons E, Milner JD, Lee RJ, Wu CL, Sequist LV, Haas W, Ting DT, Toner M, Ramaswamy S, Maheswaran S, Haber DA.

Nat Commun. 2017 Feb 9;8:14344. doi: 10.1038/ncomms14344.

25.

An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma.

Kalinich M, Bhan I, Kwan TT, Miyamoto DT, Javaid S, LiCausi JA, Milner JD, Hong X, Goyal L, Sil S, Choz M, Ho U, Kapur R, Muzikansky A, Zhang H, Weitz DA, Sequist LV, Ryan DP, Chung RT, Zhu AX, Isselbacher KJ, Ting DT, Toner M, Maheswaran S, Haber DA.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1123-1128. doi: 10.1073/pnas.1617032114. Epub 2017 Jan 17.

26.

Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition.

Comaills V, Kabeche L, Morris R, Buisson R, Yu M, Madden MW, LiCausi JA, Boukhali M, Tajima K, Pan S, Aceto N, Sil S, Zheng Y, Sundaresan T, Yae T, Jordan NV, Miyamoto DT, Ting DT, Ramaswamy S, Haas W, Zou L, Haber DA, Maheswaran S.

Cell Rep. 2016 Dec 6;17(10):2632-2647. doi: 10.1016/j.celrep.2016.11.022.

27.

Monte Carlo simulations of the gamma-ray exposure rates of common rocks.

Haber DA, Malchow RL, Burnley PC.

J Environ Radioact. 2017 Feb;167:20-25. doi: 10.1016/j.jenvrad.2016.11.013. Epub 2016 Nov 24.

28.

Modeling background radiation using geochemical data: A case study in and around Cameron, Arizona.

Marsac KE, Burnley PC, Adcock CT, Haber DA, Malchow RL, Hausrath EM.

J Environ Radioact. 2016 Dec;165:68-85. doi: 10.1016/j.jenvrad.2016.07.012. Epub 2016 Sep 16.

29.

HER2 expression identifies dynamic functional states within circulating breast cancer cells.

Jordan NV, Bardia A, Wittner BS, Benes C, Ligorio M, Zheng Y, Yu M, Sundaresan TK, Licausi JA, Desai R, O'Keefe RM, Ebright RY, Boukhali M, Sil S, Onozato ML, Iafrate AJ, Kapur R, Sgroi D, Ting DT, Toner M, Ramaswamy S, Haas W, Maheswaran S, Haber DA.

Nature. 2016 Sep 1;537(7618):102-106. doi: 10.1038/nature19328. Epub 2016 Aug 24.

30.

A Landscape of Pharmacogenomic Interactions in Cancer.

Iorio F, Knijnenburg TA, Vis DJ, Bignell GR, Menden MP, Schubert M, Aben N, Gonçalves E, Barthorpe S, Lightfoot H, Cokelaer T, Greninger P, van Dyk E, Chang H, de Silva H, Heyn H, Deng X, Egan RK, Liu Q, Mironenko T, Mitropoulos X, Richardson L, Wang J, Zhang T, Moran S, Sayols S, Soleimani M, Tamborero D, Lopez-Bigas N, Ross-Macdonald P, Esteller M, Gray NS, Haber DA, Stratton MR, Benes CH, Wessels LFA, Saez-Rodriguez J, McDermott U, Garnett MJ.

Cell. 2016 Jul 28;166(3):740-754. doi: 10.1016/j.cell.2016.06.017. Epub 2016 Jul 7.

31.

Clusters of circulating tumor cells traverse capillary-sized vessels.

Au SH, Storey BD, Moore JC, Tang Q, Chen YL, Javaid S, Sarioglu AF, Sullivan R, Madden MW, O'Keefe R, Haber DA, Maheswaran S, Langenau DM, Stott SL, Toner M.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):4947-52. doi: 10.1073/pnas.1524448113. Epub 2016 Apr 18.

32.

A tunable delivery platform to provide local chemotherapy for pancreatic ductal adenocarcinoma.

Indolfi L, Ligorio M, Ting DT, Xega K, Tzafriri AR, Bersani F, Aceto N, Thapar V, Fuchs BC, Deshpande V, Baker AB, Ferrone CR, Haber DA, Langer R, Clark JW, Edelman ER.

Biomaterials. 2016 Jul;93:71-82. doi: 10.1016/j.biomaterials.2016.03.044. Epub 2016 Mar 31.

33.

The Role of Physical Stabilization in Whole Blood Preservation.

Wong KH, Sandlin RD, Carey TR, Miller KL, Shank AT, Oklu R, Maheswaran S, Haber DA, Irimia D, Stott SL, Toner M.

Sci Rep. 2016 Feb 15;6:21023. doi: 10.1038/srep21023.

34.

Fantastic voyage: the future of cancer diagnostics.

Sundaresan TK, Haber DA.

Lancet Oncol. 2015 Dec;16(16):1596-8. doi: 10.1016/S1470-2045(15)00469-6. No abstract available.

PMID:
26678190
35.

Correlating chemical sensitivity and basal gene expression reveals mechanism of action.

Rees MG, Seashore-Ludlow B, Cheah JH, Adams DJ, Price EV, Gill S, Javaid S, Coletti ME, Jones VL, Bodycombe NE, Soule CK, Alexander B, Li A, Montgomery P, Kotz JD, Hon CS, Munoz B, Liefeld T, Dančík V, Haber DA, Clish CB, Bittker JA, Palmer M, Wagner BK, Clemons PA, Shamji AF, Schreiber SL.

Nat Chem Biol. 2016 Feb;12(2):109-16. doi: 10.1038/nchembio.1986. Epub 2015 Dec 14.

36.

Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer.

Bersani F, Lee E, Kharchenko PV, Xu AW, Liu M, Xega K, MacKenzie OC, Brannigan BW, Wittner BS, Jung H, Ramaswamy S, Park PJ, Maheswaran S, Ting DT, Haber DA.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15148-53. doi: 10.1073/pnas.1518008112. Epub 2015 Nov 2.

37.

Cell fate: Transition loses its invasive edge.

Maheswaran S, Haber DA.

Nature. 2015 Nov 26;527(7579):452-3. doi: 10.1038/nature16313. Epub 2015 Nov 11. No abstract available.

PMID:
26560026
38.

Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment.

Friedman AA, Amzallag A, Pruteanu-Malinici I, Baniya S, Cooper ZA, Piris A, Hargreaves L, Igras V, Frederick DT, Lawrence DP, Haber DA, Flaherty KT, Wargo JA, Ramaswamy S, Benes CH, Fisher DE.

PLoS One. 2015 Oct 13;10(10):e0140310. doi: 10.1371/journal.pone.0140310. eCollection 2015.

39.

Detection of T790M, the Acquired Resistance EGFR Mutation, by Tumor Biopsy versus Noninvasive Blood-Based Analyses.

Sundaresan TK, Sequist LV, Heymach JV, Riely GJ, Jänne PA, Koch WH, Sullivan JP, Fox DB, Maher R, Muzikansky A, Webb A, Tran HT, Giri U, Fleisher M, Yu HA, Wei W, Johnson BE, Barber TA, Walsh JR, Engelman JA, Stott SL, Kapur R, Maheswaran S, Toner M, Haber DA.

Clin Cancer Res. 2016 Mar 1;22(5):1103-10. doi: 10.1158/1078-0432.CCR-15-1031. Epub 2015 Oct 7.

40.

SETD1A modulates cell cycle progression through a miRNA network that regulates p53 target genes.

Tajima K, Yae T, Javaid S, Tam O, Comaills V, Morris R, Wittner BS, Liu M, Engstrom A, Takahashi F, Black JC, Ramaswamy S, Shioda T, Hammell M, Haber DA, Whetstine JR, Maheswaran S.

Nat Commun. 2015 Sep 23;6:8257. doi: 10.1038/ncomms9257.

41.

RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.

Miyamoto DT, Zheng Y, Wittner BS, Lee RJ, Zhu H, Broderick KT, Desai R, Fox DB, Brannigan BW, Trautwein J, Arora KS, Desai N, Dahl DM, Sequist LV, Smith MR, Kapur R, Wu CL, Shioda T, Ramaswamy S, Ting DT, Toner M, Maheswaran S, Haber DA.

Science. 2015 Sep 18;349(6254):1351-6. doi: 10.1126/science.aab0917.

42.

En Route to Metastasis: Circulating Tumor Cell Clusters and Epithelial-to-Mesenchymal Transition.

Aceto N, Toner M, Maheswaran S, Haber DA.

Trends Cancer. 2015 Sep;1(1):44-52. doi: 10.1016/j.trecan.2015.07.006. Epub 2015 Sep 28. Review.

PMID:
28741562
43.

Does molecular monitoring matter in early-stage breast cancer?

Sundaresan TK, Haber DA.

Sci Transl Med. 2015 Aug 26;7(302):302fs35. doi: 10.1126/scitranslmed.aac9445.

PMID:
26311727
44.

Biodegradable nano-films for capture and non-invasive release of circulating tumor cells.

Li W, Reátegui E, Park MH, Castleberry S, Deng JZ, Hsu B, Mayner S, Jensen AE, Sequist LV, Maheswaran S, Haber DA, Toner M, Stott SL, Hammond PT.

Biomaterials. 2015 Oct;65:93-102. doi: 10.1016/j.biomaterials.2015.06.036. Epub 2015 Jun 20.

45.

A computational study of circulating large tumor cells traversing microvessels.

Kojić N, Milošević M, Petrović D, Isailović V, Sarioglu AF, Haber DA, Kojić M, Toner M.

Comput Biol Med. 2015 Aug;63:187-95. doi: 10.1016/j.compbiomed.2015.05.024. Epub 2015 Jun 10.

46.

Continuous Flow Microfluidic Bioparticle Concentrator.

Martel JM, Smith KC, Dlamini M, Pletcher K, Yang J, Karabacak M, Haber DA, Kapur R, Toner M.

Sci Rep. 2015 Jun 10;5:11300. doi: 10.1038/srep11300.

47.

Ex Vivo Culture of CTCs: An Emerging Resource to Guide Cancer Therapy.

Maheswaran S, Haber DA.

Cancer Res. 2015 Jun 15;75(12):2411-5. doi: 10.1158/0008-5472.CAN-15-0145. Epub 2015 May 21. Review.

48.

A microfluidic device for label-free, physical capture of circulating tumor cell clusters.

Sarioglu AF, Aceto N, Kojic N, Donaldson MC, Zeinali M, Hamza B, Engstrom A, Zhu H, Sundaresan TK, Miyamoto DT, Luo X, Bardia A, Wittner BS, Ramaswamy S, Shioda T, Ting DT, Stott SL, Kapur R, Maheswaran S, Haber DA, Toner M.

Nat Methods. 2015 Jul;12(7):685-91. doi: 10.1038/nmeth.3404. Epub 2015 May 18.

49.

The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28.

Kim WJ, Wittner BS, Amzallag A, Brannigan BW, Ting DT, Ramaswamy S, Maheswaran S, Haber DA.

J Biol Chem. 2015 Jun 5;290(23):14381-90. doi: 10.1074/jbc.M114.631945. Epub 2015 Apr 16.

50.

Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways.

Rothenberg SM, Concannon K, Cullen S, Boulay G, Turke AB, Faber AC, Lockerman EL, Rivera MN, Engelman JA, Maheswaran S, Haber DA.

Elife. 2015 Feb 16;4. doi: 10.7554/eLife.06132.

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