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Items: 39

1.

Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression.

Nason SR, Kim T, Antipenko JP, Finan B, DiMarchi R, Hunter CS, Habegger KM.

Endocrinology. 2020 Jan 1;161(1). pii: bqz013. doi: 10.1210/endocr/bqz013.

PMID:
31673703
2.

Glucagon Regulation of Energy Expenditure.

Kleinert M, Sachs S, Habegger KM, Hofmann SM, Müller TD.

Int J Mol Sci. 2019 Oct 30;20(21). pii: E5407. doi: 10.3390/ijms20215407. Review.

3.

The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis.

Bethea M, Liu Y, Wade AK, Mullen R, Gupta R, Gelfanov V, DiMarchi R, Bhatnagar S, Behringer R, Habegger KM, Hunter CS.

Am J Physiol Endocrinol Metab. 2019 Mar 1;316(3):E397-E409. doi: 10.1152/ajpendo.00235.2018. Epub 2019 Jan 8.

PMID:
30620636
4.

Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents.

Kim T, Holleman CL, Nason S, Arble DM, Ottaway N, Chabenne J, Loyd C, Kim JA, Sandoval D, Drucker DJ, DiMarchi R, Perez-Tilve D, Habegger KM.

Diabetes. 2018 Nov;67(11):2157-2166. doi: 10.2337/db18-0068. Epub 2018 Aug 27.

5.

Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21.

Kim T, Nason S, Holleman C, Pepin M, Wilson L, Berryhill TF, Wende AR, Steele C, Young ME, Barnes S, Drucker DJ, Finan B, DiMarchi R, Perez-Tilve D, Tschöp M, Habegger KM.

Diabetes. 2018 Sep;67(9):1773-1782. doi: 10.2337/db17-1502. Epub 2018 Jun 20.

6.

Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance.

Pepin ME, Padgett LE, McDowell RE, Burg AR, Brahma MK, Holleman C, Kim T, Crossman D, Kutsch O, Tse HM, Wende AR, Habegger KM.

Mol Metab. 2018 Jun;12:48-61. doi: 10.1016/j.molmet.2018.04.006. Epub 2018 Apr 20.

7.

Dietary Manipulations That Induce Ketosis Activate the HPA Axis in Male Rats and Mice: A Potential Role for Fibroblast Growth Factor-21.

Ryan KK, Packard AEB, Larson KR, Stout J, Fourman SM, Thompson AMK, Ludwick K, Habegger KM, Stemmer K, Itoh N, Perez-Tilve D, Tschöp MH, Seeley RJ, Ulrich-Lai YM.

Endocrinology. 2018 Jan 1;159(1):400-413. doi: 10.1210/en.2017-00486.

8.

LDB1 Regulates Energy Homeostasis During Diet-Induced Obesity.

Loyd C, Liu Y, Kim T, Holleman C, Galloway J, Bethea M, Ediger BN, Swain TA, Tang Y, Stoffers DA, Rowe GC, Young M, Steele C, Habegger KM, Hunter CS.

Endocrinology. 2017 May 1;158(5):1289-1297. doi: 10.1210/en.2016-1791.

9.

Duodenal endoluminal barrier sleeve alters gut microbiota of ZDF rats.

Kim T, Holleman CL, Ptacek T, Morrow CD, Habegger KM.

Int J Obes (Lond). 2017 Mar;41(3):381-389. doi: 10.1038/ijo.2016.224. Epub 2016 Dec 7.

10.

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.

Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Müller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sánchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Döring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Köhrle J, Rozman J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Hofmann SM, Yang B, Tschöp MH, DiMarchi R, Müller TD.

Cell. 2016 Oct 20;167(3):843-857.e14. doi: 10.1016/j.cell.2016.09.014. Epub 2016 Oct 6.

11.

Fibroblast activation protein (FAP) as a novel metabolic target.

Sánchez-Garrido MA, Habegger KM, Clemmensen C, Holleman C, Müller TD, Perez-Tilve D, Li P, Agrawal AS, Finan B, Drucker DJ, Tschöp MH, DiMarchi RD, Kharitonenkov A.

Mol Metab. 2016 Jul 16;5(10):1015-1024. doi: 10.1016/j.molmet.2016.07.003. eCollection 2016 Oct.

12.

Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding.

Loyd C, Magrisso IJ, Haas M, Balusu S, Krishna R, Itoh N, Sandoval DA, Perez-Tilve D, Obici S, Habegger KM.

J Appl Physiol (1985). 2016 Sep 1;121(3):687-98. doi: 10.1152/japplphysiol.00456.2016. Epub 2016 Jul 21.

13.

FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice.

Stemmer K, Zani F, Habegger KM, Neff C, Kotzbeck P, Bauer M, Yalamanchilli S, Azad A, Lehti M, Martins PJ, Müller TD, Pfluger PT, Seeley RJ.

Diabetologia. 2015 Oct;58(10):2414-23. doi: 10.1007/s00125-015-3668-7. Epub 2015 Jun 23.

14.

Ghrelin.

Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, van der Lely AJ, van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH.

Mol Metab. 2015 Mar 21;4(6):437-60. doi: 10.1016/j.molmet.2015.03.005. eCollection 2015 Jun. Review.

15.

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.

Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH.

Nat Med. 2015 Jan;21(1):27-36. doi: 10.1038/nm.3761. Epub 2014 Dec 8.

PMID:
25485909
16.

Chromium enhances insulin responsiveness via AMPK.

Hoffman NJ, Penque BA, Habegger KM, Sealls W, Tackett L, Elmendorf JS.

J Nutr Biochem. 2014 May;25(5):565-72. doi: 10.1016/j.jnutbio.2014.01.007. Epub 2014 Feb 20.

17.

GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats.

Habegger KM, Heppner KM, Amburgy SE, Ottaway N, Holland J, Raver C, Bartley E, Müller TD, Pfluger PT, Berger J, Toure M, Benoit SC, Dimarchi RD, Perez-Tilve D, D'Alessio DA, Seeley RJ, Tschöp MH.

Diabetes. 2014 Feb;63(2):505-13. doi: 10.2337/db13-0511. Epub 2013 Nov 1.

18.

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.

Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH.

Sci Transl Med. 2013 Oct 30;5(209):209ra151. doi: 10.1126/scitranslmed.3007218.

19.

High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice.

Lehti M, Donelan E, Abplanalp W, Al-Massadi O, Habegger KM, Weber J, Ress C, Mansfeld J, Somvanshi S, Trivedi C, Keuper M, Ograjsek T, Striese C, Cucuruz S, Pfluger PT, Krishna R, Gordon SM, Silva RA, Luquet S, Castel J, Martinez S, D'Alessio D, Davidson WS, Hofmann SM.

Circulation. 2013 Nov 26;128(22):2364-71. doi: 10.1161/CIRCULATIONAHA.113.001551. Epub 2013 Oct 29.

20.

Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia.

Habegger KM, Al-Massadi O, Heppner KM, Myronovych A, Holland J, Berger J, Yi CX, Gao Y, Lehti M, Ottaway N, Amburgy S, Raver C, Müller TD, Pfluger PT, Kohli R, Perez-Tilve D, Seeley RJ, Tschöp MH.

Gut. 2014 Aug;63(8):1238-46. doi: 10.1136/gutjnl-2013-304583. Epub 2013 Oct 9.

21.

Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors.

Heppner KM, Piechowski CL, Müller A, Ottaway N, Sisley S, Smiley DL, Habegger KM, Pfluger PT, Dimarchi R, Biebermann H, Tschöp MH, Sandoval DA, Perez-Tilve D.

Diabetes. 2014 Jan;63(1):122-31. doi: 10.2337/db13-0414. Epub 2013 Sep 23.

22.

GLP-1R agonism enhances adjustable gastric banding in diet-induced obese rats.

Habegger KM, Kirchner H, Yi CX, Heppner KM, Sweeney D, Ottaway N, Holland J, Amburgy S, Raver C, Krishna R, Müller TD, Perez-Tilve D, Pfluger PT, Obici S, DiMarchi RD, D'Alessio DA, Seeley RJ, Tschöp MH.

Diabetes. 2013 Sep;62(9):3261-7. doi: 10.2337/db13-0117. Epub 2013 Jun 17.

23.

The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.

Müller TD, Müller A, Yi CX, Habegger KM, Meyer CW, Gaylinn BD, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski CL, Pratzka J, Stemmer K, Holland J, Hembree J, Bhardwaj N, Raver C, Ottaway N, Krishna R, Sah R, Sallee FR, Woods SC, Perez-Tilve D, Bidlingmaier M, Thorner MO, Krude H, Smiley D, DiMarchi R, Hofmann S, Pfluger PT, Kleinau G, Biebermann H, Tschöp MH.

Nat Commun. 2013;4:1968. doi: 10.1038/ncomms2968.

24.

Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance.

Habegger KM, Matzke D, Ottaway N, Hembree J, Holland J, Raver C, Mansfeld J, Müller TD, Perez-Tilve D, Pfluger PT, Lee SJ, Diaz-Meco M, Moscat J, Leitges M, Tschöp MH, Hofmann SM.

Adipocyte. 2012 Oct 1;1(4):203-214.

25.

Fibroblast growth factor 21 mediates specific glucagon actions.

Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, Itoh N, Kharitonenkov A, Spranger J, DiMarchi RD, Tschöp MH.

Diabetes. 2013 May;62(5):1453-63. doi: 10.2337/db12-1116. Epub 2013 Jan 10.

26.

p62 links β-adrenergic input to mitochondrial function and thermogenesis.

Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Küchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH.

J Clin Invest. 2013 Jan;123(1):469-78. doi: 10.1172/JCI64209. Epub 2012 Dec 21.

27.

Acylation type determines ghrelin's effects on energy homeostasis in rodents.

Heppner KM, Chaudhary N, Müller TD, Kirchner H, Habegger KM, Ottaway N, Smiley DL, Dimarchi R, Hofmann SM, Woods SC, Sivertsen B, Holst B, Pfluger PT, Perez-Tilve D, Tschöp MH.

Endocrinology. 2012 Oct;153(10):4687-95. Epub 2012 Aug 3.

28.

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism.

Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschöp MH.

Physiol Rev. 2012 Jul;92(3):1479-514. doi: 10.1152/physrev.00022.2011. Review.

29.

Caloric restriction chronically impairs metabolic programming in mice.

Kirchner H, Hofmann SM, Fischer-Rosinský A, Hembree J, Abplanalp W, Ottaway N, Donelan E, Krishna R, Woods SC, Müller TD, Spranger J, Perez-Tilve D, Pfluger PT, Tschöp MH, Habegger KM.

Diabetes. 2012 Nov;61(11):2734-42. doi: 10.2337/db11-1621. Epub 2012 Jul 10.

30.

AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol.

Habegger KM, Hoffman NJ, Ridenour CM, Brozinick JT, Elmendorf JS.

Endocrinology. 2012 May;153(5):2130-41. doi: 10.1210/en.2011-2099. Epub 2012 Mar 20.

31.

The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction.

Yi CX, Heppner KM, Kirchner H, Tong J, Bielohuby M, Gaylinn BD, Müller TD, Bartley E, Davis HW, Zhao Y, Joseph A, Kruthaupt T, Ottaway N, Kabra D, Habegger KM, Benoit SC, Bidlingmaier M, Thorner MO, Perez-Tilve D, Tschöp MH, Pfluger PT.

PLoS One. 2012;7(2):e32100. doi: 10.1371/journal.pone.0032100. Epub 2012 Feb 21.

32.

Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle.

Habegger KM, Penque BA, Sealls W, Tackett L, Bell LN, Blue EK, Gallagher PJ, Sturek M, Alloosh MA, Steinberg HO, Considine RV, Elmendorf JS.

Diabetologia. 2012 Feb;55(2):457-67. doi: 10.1007/s00125-011-2334-y. Epub 2011 Oct 15.

33.

Carbohydrate content of post-operative diet influences the effect of vertical sleeve gastrectomy on body weight reduction in obese rats.

Bielohuby M, Stemmer K, Berger J, Ramisch J, Smith K, Holland J, Parks K, Pfluger PT, Habegger KM, Tschöp MH, Seeley RJ, Bidlingmaier M.

Obes Surg. 2012 Jan;22(1):140-51. doi: 10.1007/s11695-011-0528-5.

PMID:
21971629
34.

Evidence coupling increased hexosamine biosynthesis pathway activity to membrane cholesterol toxicity and cortical filamentous actin derangement contributing to cellular insulin resistance.

Bhonagiri P, Pattar GR, Habegger KM, McCarthy AM, Tackett L, Elmendorf JS.

Endocrinology. 2011 Sep;152(9):3373-84. doi: 10.1210/en.2011-1295. Epub 2011 Jun 28.

35.

A role for astrocytes in the central control of metabolism.

Yi CX, Habegger KM, Chowen JA, Stern J, Tschöp MH.

Neuroendocrinology. 2011;93(3):143-9. doi: 10.1159/000324888. Epub 2011 Mar 4. Review.

PMID:
21372559
36.

Ghrelin Receptor Deficiency does not Affect Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice.

Habegger KM, Grant E, Pfluger PT, Perez-Tilve D, Daugherty A, Bruemmer D, Tschöp MH, Hofmann SM.

Front Endocrinol (Lausanne). 2011 Nov 2;2:67. doi: 10.3389/fendo.2011.00067. eCollection 2011.

37.

The metabolic actions of glucagon revisited.

Habegger KM, Heppner KM, Geary N, Bartness TJ, DiMarchi R, Tschöp MH.

Nat Rev Endocrinol. 2010 Dec;6(12):689-97. doi: 10.1038/nrendo.2010.187. Epub 2010 Oct 19. Review.

38.

Glucagon regulation of energy metabolism.

Heppner KM, Habegger KM, Day J, Pfluger PT, Perez-Tilve D, Ward B, Gelfanov V, Woods SC, DiMarchi R, Tschöp M.

Physiol Behav. 2010 Jul 14;100(5):545-8. doi: 10.1016/j.physbeh.2010.03.019. Epub 2010 Apr 8. Review.

PMID:
20381509
39.

Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actin.

Bhonagiri P, Pattar GR, Horvath EM, Habegger KM, McCarthy AM, Elmendorf JS.

Endocrinology. 2009 Apr;150(4):1636-45. doi: 10.1210/en.2008-1102. Epub 2008 Nov 26. Retraction in: Endocrinology. 2010 Jun;151(6):2967. Corrected and republished in: Endocrinology. 2011 Sep;152(9):3373-84.

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