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Items: 37

1.

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.

Limbocker R, Chia S, Ruggeri FS, Perni M, Cascella R, Heller GT, Meisl G, Mannini B, Habchi J, Michaels TCT, Challa PK, Ahn M, Casford ST, Fernando N, Xu CK, Kloss ND, Cohen SIA, Kumita JR, Cecchi C, Zasloff M, Linse S, Knowles TPJ, Chiti F, Vendruscolo M, Dobson CM.

Nat Commun. 2019 Jan 15;10(1):225. doi: 10.1038/s41467-018-07699-5.

2.

Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation.

Ahn M, Lee BI, Chia S, Habchi J, Kumita JR, Vendruscolo M, Dobson CM, Park CB.

Chem Commun (Camb). 2019 Jan 25;55(8):1152-1155. doi: 10.1039/c8cc09288e. Epub 2019 Jan 11.

PMID:
30632567
3.

SAR by kinetics for drug discovery in protein misfolding diseases.

Chia S, Habchi J, Michaels TCT, Cohen SIA, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10245-10250. doi: 10.1073/pnas.1807884115. Epub 2018 Sep 26.

4.

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity.

Ruggeri FS, Charmet J, Kartanas T, Peter Q, Chia S, Habchi J, Dobson CM, Vendruscolo M, Knowles TPJ.

Nat Commun. 2018 Sep 24;9(1):3890. doi: 10.1038/s41467-018-06345-4.

5.

Structure-based design of allosteric calpain-1 inhibitors populating a novel bioactivity space.

Kalash L, Cresser-Brown J, Habchi J, Morgan C, Miller DJ, Glen RC, Allemann RK, Bender A.

Eur J Med Chem. 2018 Sep 5;157:1264-1275. doi: 10.1016/j.ejmech.2018.08.049. Epub 2018 Aug 23.

6.

Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.

Mannini B, Habchi J, Chia S, Ruggeri FS, Perni M, Knowles TPJ, Dobson CM, Vendruscolo M.

ACS Chem Neurosci. 2018 Dec 19;9(12):2959-2971. doi: 10.1021/acschemneuro.8b00141. Epub 2018 Aug 10.

PMID:
29986583
7.

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.

Habchi J, Chia S, Galvagnion C, Michaels TCT, Bellaiche MMJ, Ruggeri FS, Sanguanini M, Idini I, Kumita JR, Sparr E, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Nat Chem. 2018 Jun;10(6):673-683. doi: 10.1038/s41557-018-0031-x. Epub 2018 May 7.

PMID:
29736006
8.

Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.

Michaels TCT, Šarić A, Habchi J, Chia S, Meisl G, Vendruscolo M, Dobson CM, Knowles TPJ.

Annu Rev Phys Chem. 2018 Apr 20;69:273-298. doi: 10.1146/annurev-physchem-050317-021322. Epub 2018 Feb 28. Review.

PMID:
29490200
9.

Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.

Perni M, Challa PK, Kirkegaard JB, Limbocker R, Koopman M, Hardenberg MC, Sormanni P, Müller T, Saar KL, Roode LWY, Habchi J, Vecchi G, Fernando N, Casford S, Nollen EAA, Vendruscolo M, Dobson CM, Knowles TPJ.

J Neurosci Methods. 2018 Aug 1;306:57-67. doi: 10.1016/j.jneumeth.2018.02.005. Epub 2018 Feb 13.

PMID:
29452179
10.

Interfacial Properties of NTAIL, an Intrinsically Disordered Protein.

Bénarouche A, Habchi J, Cagna A, Maniti O, Girard-Egrot A, Cavalier JF, Longhi S, Carrière F.

Biophys J. 2017 Dec 19;113(12):2723-2735. doi: 10.1016/j.bpj.2017.10.010.

11.

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates.

Chia S, Flagmeier P, Habchi J, Lattanzi V, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8005-8010. doi: 10.1073/pnas.1700239114. Epub 2017 Jul 11.

12.

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease.

Habchi J, Chia S, Limbocker R, Mannini B, Ahn M, Perni M, Hansson O, Arosio P, Kumita JR, Challa PK, Cohen SI, Linse S, Dobson CM, Knowles TP, Vendruscolo M.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E200-E208. doi: 10.1073/pnas.1615613114. Epub 2016 Dec 23.

13.

AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species.

Ruggeri FS, Habchi J, Cerreta A, Dietler G.

Curr Pharm Des. 2016;22(26):3950-70. Review.

14.

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease.

Habchi J, Arosio P, Perni M, Costa AR, Yagi-Utsumi M, Joshi P, Chia S, Cohen SI, Müller MB, Linse S, Nollen EA, Dobson CM, Knowles TP, Vendruscolo M.

Sci Adv. 2016 Feb 12;2(2):e1501244. doi: 10.1126/sciadv.1501244. eCollection 2016 Feb.

15.

A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.

Joshi P, Chia S, Habchi J, Knowles TP, Dobson CM, Vendruscolo M.

ACS Comb Sci. 2016 Mar 14;18(3):144-53. doi: 10.1021/acscombsci.5b00129. Epub 2016 Feb 29.

PMID:
26923286
16.

The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments.

Granata D, Baftizadeh F, Habchi J, Galvagnion C, De Simone A, Camilloni C, Laio A, Vendruscolo M.

Sci Rep. 2015 Oct 26;5:15449. doi: 10.1038/srep15449.

17.

Order and Disorder in the Replicative Complex of Paramyxoviruses.

Erales J, Blocquel D, Habchi J, Beltrandi M, Gruet A, Dosnon M, Bignon C, Longhi S.

Adv Exp Med Biol. 2015;870:351-81. doi: 10.1007/978-3-319-20164-1_12. Review.

PMID:
26387109
18.
19.

Neuronal Cx3cr1 Deficiency Protects against Amyloid β-Induced Neurotoxicity.

Dworzak J, Renvoisé B, Habchi J, Yates EV, Combadière C, Knowles TP, Dobson CM, Blackstone C, Paulsen O, Murphy PM.

PLoS One. 2015 Jun 3;10(6):e0127730. doi: 10.1371/journal.pone.0127730. eCollection 2015.

20.

Molecular basis for structural heterogeneity of an intrinsically disordered protein bound to a partner by combined ESI-IM-MS and modeling.

D'Urzo A, Konijnenberg A, Rossetti G, Habchi J, Li J, Carloni P, Sobott F, Longhi S, Grandori R.

J Am Soc Mass Spectrom. 2015 Mar;26(3):472-81. doi: 10.1007/s13361-014-1048-z. Epub 2014 Dec 16.

PMID:
25510932
21.

Dynamics of the intrinsically disordered C-terminal domain of the nipah virus nucleoprotein and interaction with the x domain of the phosphoprotein as unveiled by NMR spectroscopy.

Baronti L, Erales J, Habchi J, Felli IC, Pierattelli R, Longhi S.

Chembiochem. 2015 Jan 19;16(2):268-76. doi: 10.1002/cbic.201402534. Epub 2014 Dec 9.

PMID:
25492314
22.

Coiled-coil deformations in crystal structures: the measles virus phosphoprotein multimerization domain as an illustrative example.

Blocquel D, Habchi J, Durand E, Sevajol M, Ferron F, Erales J, Papageorgiou N, Longhi S.

Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1589-603. doi: 10.1107/S139900471400234X. Epub 2014 May 24.

PMID:
24914970
23.

Structural disorder in viral proteins.

Xue B, Blocquel D, Habchi J, Uversky AV, Kurgan L, Uversky VN, Longhi S.

Chem Rev. 2014 Jul 9;114(13):6880-911. doi: 10.1021/cr4005692. Epub 2014 May 13. Review. No abstract available.

PMID:
24823319
24.

Introducing protein intrinsic disorder.

Habchi J, Tompa P, Longhi S, Uversky VN.

Chem Rev. 2014 Jul 9;114(13):6561-88. doi: 10.1021/cr400514h. Epub 2014 Apr 17. Review. No abstract available.

PMID:
24739139
25.

Diversification of EPR signatures in Site Directed Spin Labeling using a β-phosphorylated nitroxide.

Le Breton N, Martinho M, Kabytaev K, Topin J, Mileo E, Blocquel D, Habchi J, Longhi S, Rockenbauer A, Golebiowski J, Guigliarelli B, Marque SR, Belle V.

Phys Chem Chem Phys. 2014 Mar 7;16(9):4202-9. doi: 10.1039/c3cp54816c.

PMID:
24452480
26.

Atomic resolution description of the interaction between the nucleoprotein and phosphoprotein of Hendra virus.

Communie G, Habchi J, Yabukarski F, Blocquel D, Schneider R, Tarbouriech N, Papageorgiou N, Ruigrok RW, Jamin M, Jensen MR, Longhi S, Blackledge M.

PLoS Pathog. 2013;9(9):e1003631. doi: 10.1371/journal.ppat.1003631. Epub 2013 Sep 26.

27.

Extracting structural information from charge-state distributions of intrinsically disordered proteins by non-denaturing electrospray-ionization mass spectrometry.

Testa L, Brocca S, Santambrogio C, D'Urzo A, Habchi J, Longhi S, Uversky VN, Grandori R.

Intrinsically Disord Proteins. 2013 Apr 1;1(1):e25068. doi: 10.4161/idp.25068. eCollection 2013 Jan-Dec. Review.

28.

Interaction between the C-terminal domains of measles virus nucleoprotein and phosphoprotein: a tight complex implying one binding site.

Blocquel D, Habchi J, Costanzo S, Doizy A, Oglesbee M, Longhi S.

Protein Sci. 2012 Oct;21(10):1577-85. doi: 10.1002/pro.2138. Epub 2012 Sep 17.

29.

Assessing induced folding within the intrinsically disordered C-terminal domain of the Henipavirus nucleoproteins by site-directed spin labeling EPR spectroscopy.

Martinho M, Habchi J, El Habre Z, Nesme L, Guigliarelli B, Belle V, Longhi S.

J Biomol Struct Dyn. 2013;31(5):453-71. doi: 10.1080/07391102.2012.706068. Epub 2012 Aug 13.

PMID:
22881220
30.

Monitoring structural transitions in IDPs by site-directed spin labeling EPR spectroscopy.

Habchi J, Martinho M, Gruet A, Guigliarelli B, Longhi S, Belle V.

Methods Mol Biol. 2012;895:361-86. doi: 10.1007/978-1-61779-927-3_21.

PMID:
22760328
31.

Monitoring structural transitions in IDPs by vibrational spectroscopy of cyanylated cysteine.

Yang H, Habchi J, Longhi S, Londergan CH.

Methods Mol Biol. 2012;895:245-70. doi: 10.1007/978-1-61779-927-3_17.

PMID:
22760324
32.

Plasticity in structural and functional interactions between the phosphoprotein and nucleoprotein of measles virus.

Shu Y, Habchi J, Costanzo S, Padilla A, Brunel J, Gerlier D, Oglesbee M, Longhi S.

J Biol Chem. 2012 Apr 6;287(15):11951-67. doi: 10.1074/jbc.M111.333088. Epub 2012 Feb 8.

33.

Compaction and binding properties of the intrinsically disordered C-terminal domain of Henipavirus nucleoprotein as unveiled by deletion studies.

Blocquel D, Habchi J, Gruet A, Blangy S, Longhi S.

Mol Biosyst. 2012 Jan;8(1):392-410. doi: 10.1039/c1mb05401e. Epub 2011 Nov 23.

PMID:
22108848
34.

Structural disorder within paramyxovirus nucleoproteins and phosphoproteins.

Habchi J, Longhi S.

Mol Biosyst. 2012 Jan;8(1):69-81. doi: 10.1039/c1mb05204g. Epub 2011 Aug 1. Review.

PMID:
21805002
35.

Dividing to unveil protein microheterogeneities: traveling wave ion mobility study.

Halgand F, Habchi J, Cravello L, Martinho M, Guigliarelli B, Longhi S.

Anal Chem. 2011 Oct 1;83(19):7306-15. doi: 10.1021/ac200994c. Epub 2011 Aug 29.

36.

Characterization of the interactions between the nucleoprotein and the phosphoprotein of Henipavirus.

Habchi J, Blangy S, Mamelli L, Jensen MR, Blackledge M, Darbon H, Oglesbee M, Shu Y, Longhi S.

J Biol Chem. 2011 Apr 15;286(15):13583-602. doi: 10.1074/jbc.M111.219857. Epub 2011 Feb 11.

37.

Structural disorder within Henipavirus nucleoprotein and phosphoprotein: from predictions to experimental assessment.

Habchi J, Mamelli L, Darbon H, Longhi S.

PLoS One. 2010 Jul 21;5(7):e11684. doi: 10.1371/journal.pone.0011684.

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