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Items: 14

1.

How Phenotypic Screening Influenced Drug Discovery: Lessons from Five Years of Practice.

Haasen D, Schopfer U, Antczak C, Guy C, Fuchs F, Selzer P.

Assay Drug Dev Technol. 2017 Aug/Sep;15(6):239-246. doi: 10.1089/adt.2017.796. Epub 2017 Aug 11. Review.

PMID:
28800248
2.

Discovery of novel pyrrolidineoxy-substituted heteroaromatics as potent and selective PI3K delta inhibitors with improved physicochemical properties.

Hoegenauer K, Soldermann N, Hebach C, Hollingworth GJ, Lewis I, von Matt A, Smith AB, Wolf RM, Wilcken R, Haasen D, Burkhart C, Zécri F.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5657-5662. doi: 10.1016/j.bmcl.2016.10.069. Epub 2016 Oct 27.

PMID:
27816514
3.

Identification and optimisation of a 4',5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors.

Fairhurst RA, Imbach-Weese P, Gerspacher M, Caravatti G, Furet P, Zoller T, Fritsch C, Haasen D, Trappe J, Guthy DA, Arz D, Wirth J.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3569-74. doi: 10.1016/j.bmcl.2015.06.078. Epub 2015 Jun 27.

PMID:
26206504
4.

Targeting Plasmodium PI(4)K to eliminate malaria.

McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TS, Henrich PP, Gagaring K, Ibanez M, Kato N, Kuhen KL, Fischli C, Nagle A, Rottmann M, Plouffe DM, Bursulaya B, Meister S, Rameh L, Trappe J, Haasen D, Timmerman M, Sauerwein RW, Suwanarusk R, Russell B, Renia L, Nosten F, Tully DC, Kocken CH, Glynne RJ, Bodenreider C, Fidock DA, Diagana TT, Winzeler EA.

Nature. 2013 Dec 12;504(7479):248-253. doi: 10.1038/nature12782. Epub 2013 Nov 27.

5.

Characterization of kinase inhibitors using reverse phase protein arrays.

Martiny-Baron G, Haasen D, D'Dorazio D, Voshol J, Fabbro D.

Methods Mol Biol. 2011;785:79-107. doi: 10.1007/978-1-61779-286-1_7.

PMID:
21901595
6.

A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients.

Tiedt R, Degenkolbe E, Furet P, Appleton BA, Wagner S, Schoepfer J, Buck E, Ruddy DA, Monahan JE, Jones MD, Blank J, Haasen D, Drueckes P, Wartmann M, McCarthy C, Sellers WR, Hofmann F.

Cancer Res. 2011 Aug 1;71(15):5255-64. doi: 10.1158/0008-5472.CAN-10-4433. Epub 2011 Jun 22.

7.

High content screening of CXCR2-dependent signalling pathways.

Wolff M, Kredel S, Haasen D, Wiedenmann J, Nienhaus GU, Kistler B, Oswald F, Heilker R.

Comb Chem High Throughput Screen. 2010 Jan;13(1):3-15.

PMID:
20214572
8.

Pharmacological profiling of chemokine receptor-directed compounds using high-content screening.

Haasen D, Merk S, Seither P, Martyres D, Hobbie S, Heilker R.

J Biomol Screen. 2008 Jan;13(1):40-53. doi: 10.1177/1087057107312128.

PMID:
18227225
9.

Different species of alpha-synuclein oligomers induce calcium influx and seeding.

Danzer KM, Haasen D, Karow AR, Moussaud S, Habeck M, Giese A, Kretzschmar H, Hengerer B, Kostka M.

J Neurosci. 2007 Aug 22;27(34):9220-32.

10.

G protein-coupled receptor internalization assays in the high-content screening format.

Haasen D, Schnapp A, Valler MJ, Heilker R.

Methods Enzymol. 2006;414:121-39.

PMID:
17110190
11.

Automated high content screening for phosphoinositide 3 kinase inhibition using an AKT 1 redistribution assay.

Wolff M, Haasen D, Merk S, Kroner M, Maier U, Bordel S, Wiedenmann J, Nienhaus GU, Valler M, Heilker R.

Comb Chem High Throughput Screen. 2006 Jun;9(5):339-50.

PMID:
16787147
12.

Comparison of G-protein coupled receptor desensitization-related beta-arrestin redistribution using confocal and non-confocal imaging.

Haasen D, Wolff M, Valler MJ, Heilker R.

Comb Chem High Throughput Screen. 2006 Jan;9(1):37-47.

PMID:
16454685
13.

Arabidopsis transportin1 is the nuclear import receptor for the circadian clock-regulated RNA-binding protein AtGRP7.

Ziemienowicz A, Haasen D, Staiger D, Merkle T.

Plant Mol Biol. 2003 Sep;53(1-2):201-12.

PMID:
14756317
14.

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