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Items: 9


Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β Induced Synaptic Dysfunction and Loss.

Salazar SV, Cox TO, Lee S, Brody AH, Chyung AS, Haas LT, Strittmatter SM.

J Neurosci. 2018 Dec 5. pii: 1873-18. doi: 10.1523/JNEUROSCI.1873-18.2018. [Epub ahead of print]


Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease.

Salazar SV, Gallardo C, Kaufman AC, Herber CS, Haas LT, Robinson S, Manson JC, Lee MK, Strittmatter SM.

J Neurosci. 2017 Sep 20;37(38):9207-9221. doi: 10.1523/JNEUROSCI.0722-17.2017. Epub 2017 Aug 21.


Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes.

Haas LT, Salazar SV, Smith LM, Zhao HR, Cox TO, Herber CS, Degnan AP, Balakrishnan A, Macor JE, Albright CF, Strittmatter SM.

Cell Rep. 2017 Jul 5;20(1):76-88. doi: 10.1016/j.celrep.2017.06.023.


Early Activation of Experience-Independent Dendritic Spine Turnover in a Mouse Model of Alzheimer's Disease.

Heiss JK, Barrett J, Yu Z, Haas LT, Kostylev MA, Strittmatter SM.

Cereb Cortex. 2017 Jul 1;27(7):3660-3674. doi: 10.1093/cercor/bhw188.


Oligomers of Amyloid β Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer Disease.

Haas LT, Strittmatter SM.

J Biol Chem. 2016 Aug 12;291(33):17112-21. doi: 10.1074/jbc.M116.720664. Epub 2016 Jun 20.


Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease.

Haas LT, Salazar SV, Kostylev MA, Um JW, Kaufman AC, Strittmatter SM.

Brain. 2016 Feb;139(Pt 2):526-46. doi: 10.1093/brain/awv356. Epub 2015 Dec 14.


Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.

Kostylev MA, Kaufman AC, Nygaard HB, Patel P, Haas LT, Gunther EC, Vortmeyer A, Strittmatter SM.

J Biol Chem. 2015 Jul 10;290(28):17415-38. doi: 10.1074/jbc.M115.643577. Epub 2015 May 27.


Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.

Kaufman AC, Salazar SV, Haas LT, Yang J, Kostylev MA, Jeng AT, Robinson SA, Gunther EC, van Dyck CH, Nygaard HB, Strittmatter SM.

Ann Neurol. 2015 Jun;77(6):953-71. doi: 10.1002/ana.24394. Epub 2015 Mar 21.


Therapeutic molecules and endogenous ligands regulate the interaction between brain cellular prion protein (PrPC) and metabotropic glutamate receptor 5 (mGluR5).

Haas LT, Kostylev MA, Strittmatter SM.

J Biol Chem. 2014 Oct 10;289(41):28460-77. doi: 10.1074/jbc.M114.584342. Epub 2014 Aug 22.

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