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Neutrophil Extracellular Traps in the Pathogenesis of Equine Recurrent Uveitis (ERU).

Fingerhut L, Ohnesorge B, von Borstel M, Schumski A, Strutzberg-Minder K, Mörgelin M, Deeg CA, Haagsman HP, Beineke A, von Köckritz-Blickwede M, de Buhr N.

Cells. 2019 Nov 27;8(12). pii: E1528. doi: 10.3390/cells8121528.


Enhanced Antiviral Activity of Human Surfactant Protein D by Site-Specific Engineering of the Carbohydrate Recognition Domain.

van Eijk M, Hillaire MLB, Rimmelzwaan GF, Rynkiewicz MJ, White MR, Hartshorn KL, Hessing M, Koolmees PA, Tersteeg MH, van Es MH, Meijerhof T, Huckriede A, Haagsman HP.

Front Immunol. 2019 Oct 22;10:2476. doi: 10.3389/fimmu.2019.02476. eCollection 2019.


Chicken CATH-2 Increases Antigen Presentation Markers on Chicken Monocytes and Macrophages.

Kraaij MD, van Dijk A, Scheenstra MR, van Harten RM, Haagsman HP, Veldhuizen EJA.

Protein Pept Lett. 2020;27(1):60-66. doi: 10.2174/0929866526666190730125525.


Avian pathogenic Escherichia coli infection of a chicken lung epithelial cell line.

Mol N, Peng L, Esnault E, Quéré P, Haagsman HP, Veldhuizen EJA.

Vet Immunol Immunopathol. 2019 Apr;210:55-59. doi: 10.1016/j.vetimm.2019.03.007. Epub 2019 Mar 19.


Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action.

Scheenstra MR, van den Belt M, Tjeerdsma-van Bokhoven JLM, Schneider VAF, Ordonez SR, van Dijk A, Veldhuizen EJA, Haagsman HP.

Sci Rep. 2019 Mar 18;9(1):4780. doi: 10.1038/s41598-019-41246-6.


Involvement of Surfactant Protein D in Ebola Virus Infection Enhancement via Glycoprotein Interaction.

Favier AL, Reynard O, Gout E, van Eijk M, Haagsman HP, Crouch E, Volchkov V, Peyrefitte C, Thielens NM.

Viruses. 2018 Dec 26;11(1). pii: E15. doi: 10.3390/v11010015.


Antifungal activities of surfactant protein D in an environment closely mimicking the lung lining.

Ordonez SR, van Eijk M, Escobar Salazar N, de Cock H, Veldhuizen EJA, Haagsman HP.

Mol Immunol. 2019 Jan;105:260-269. doi: 10.1016/j.molimm.2018.12.003. Epub 2018 Dec 15.


Cathelicidins: Immunomodulatory Antimicrobials.

van Harten RM, van Woudenbergh E, van Dijk A, Haagsman HP.

Vaccines (Basel). 2018 Sep 14;6(3). pii: E63. doi: 10.3390/vaccines6030063. Review.


The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production.

van Dijk A, Hedegaard CJ, Haagsman HP, Heegaard PMH.

Vet Res. 2018 Jul 31;49(1):68. doi: 10.1186/s13567-018-0558-2. Review.


Inhibition and Eradication of Pseudomonas aeruginosa Biofilms by Host Defence Peptides.

Chen H, Wubbolts RW, Haagsman HP, Veldhuizen EJA.

Sci Rep. 2018 Jul 11;8(1):10446. doi: 10.1038/s41598-018-28842-8.


Avian pathogenic Escherichia coli-induced activation of chicken macrophage HD11 cells.

Peng L, Matthijs MGR, Haagsman HP, Veldhuizen EJA.

Dev Comp Immunol. 2018 Oct;87:75-83. doi: 10.1016/j.dci.2018.05.019. Epub 2018 May 23.


Immunomodulation and effects on microbiota after in ovo administration of chicken cathelicidin-2.

Cuperus T, Kraaij MD, Zomer AL, van Dijk A, Haagsman HP.

PLoS One. 2018 Jun 5;13(6):e0198188. doi: 10.1371/journal.pone.0198188. eCollection 2018.


A new and efficient culture method for porcine bone marrow-derived M1- and M2-polarized macrophages.

Gao J, Scheenstra MR, van Dijk A, Veldhuizen EJA, Haagsman HP.

Vet Immunol Immunopathol. 2018 Jun;200:7-15. doi: 10.1016/j.vetimm.2018.04.002. Epub 2018 Apr 14.


Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus.

van Eijk M, Rynkiewicz MJ, Khatri K, Leymarie N, Zaia J, White MR, Hartshorn KL, Cafarella TR, van Die I, Hessing M, Seaton BA, Haagsman HP.

J Biol Chem. 2018 Jul 6;293(27):10646-10662. doi: 10.1074/jbc.RA117.001430. Epub 2018 May 16.


Role of Soluble Innate Effector Molecules in Pulmonary Defense against Fungal Pathogens.

Ordonez SR, Veldhuizen EJA, van Eijk M, Haagsman HP.

Front Microbiol. 2017 Oct 31;8:2098. doi: 10.3389/fmicb.2017.02098. eCollection 2017. Review.


The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens.

Banaschewski BJH, Baer B, Arsenault C, Jazey T, Veldhuizen EJA, Delport J, Gooyers T, Lewis JF, Haagsman HP, Veldhuizen RAW, Yamashita C.

Sci Rep. 2017 Nov 14;7(1):15545. doi: 10.1038/s41598-017-15558-4.


Imaging the Antistaphylococcal Activity of CATH-2: Mechanism of Attack and Regulation of Inflammatory Response.

Schneider VAF, Coorens M, Tjeerdsma-van Bokhoven JLM, Posthuma G, van Dijk A, Veldhuizen EJA, Haagsman HP.

mSphere. 2017 Nov 1;2(6). pii: e00370-17. doi: 10.1128/mSphere.00370-17. eCollection 2017 Nov-Dec.


Killing of Pseudomonas aeruginosa by Chicken Cathelicidin-2 Is Immunogenically Silent, Preventing Lung Inflammation In Vivo.

Coorens M, Banaschewski BJH, Baer BJ, Yamashita C, van Dijk A, Haagsman HP, Veldhuizen RAW, Veldhuizen EJA.

Infect Immun. 2017 Nov 17;85(12). pii: e00546-17. doi: 10.1128/IAI.00546-17. Print 2017 Dec.


CATH-2 and LL-37 increase mannose receptor expression, antigen presentation and the endocytic capacity of chicken mononuclear phagocytes.

Kraaij MD, van Dijk A, Haagsman HP.

Mol Immunol. 2017 Oct;90:118-125. doi: 10.1016/j.molimm.2017.07.005. Epub 2017 Jul 14.


Cathelicidins Inhibit Escherichia coli-Induced TLR2 and TLR4 Activation in a Viability-Dependent Manner.

Coorens M, Schneider VAF, de Groot AM, van Dijk A, Meijerink M, Wells JM, Scheenstra MR, Veldhuizen EJA, Haagsman HP.

J Immunol. 2017 Aug 15;199(4):1418-1428. doi: 10.4049/jimmunol.1602164. Epub 2017 Jul 14.


Chicken mannose binding lectin has antiviral activity towards infectious bronchitis virus.

Zhang W, Bouwman KM, van Beurden SJ, Ordonez SR, van Eijk M, Haagsman HP, Verheije MH, Veldhuizen EJA.

Virology. 2017 Sep;509:252-259. doi: 10.1016/j.virol.2017.06.028. Epub 2017 Jul 4.


Antimicrobial and Immunomodulatory Activity of PMAP-23 Derived Peptides.

Veldhuizen EJA, Scheenstra MR, Tjeerdsma-van Bokhoven JLM, Coorens M, Schneider VAF, Bikker FJ, van Dijk A, Haagsman HP.

Protein Pept Lett. 2017;24(7):609-616. doi: 10.2174/0929866524666170428150925.


A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 β-like: from in silico identification to experimental evidence.

Bosso A, Pirone L, Gaglione R, Pane K, Del Gatto A, Zaccaro L, Di Gaetano S, Diana D, Fattorusso R, Pedone E, Cafaro V, Haagsman HP, van Dijk A, Scheenstra MR, Zanfardino A, Crescenzi O, Arciello A, Varcamonti M, Veldhuizen EJA, Di Donato A, Notomista E, Pizzo E.

Biochim Biophys Acta Gen Subj. 2017 Sep;1861(9):2342-2353. doi: 10.1016/j.bbagen.2017.04.009. Epub 2017 Apr 26.


Characterization of bovine embryos cultured under conditions appropriate for sustaining human naïve pluripotency.

Brinkhof B, van Tol HT, Groot Koerkamp MJ, Wubbolts RW, Haagsman HP, Roelen BA.

PLoS One. 2017 Feb 27;12(2):e0172920. doi: 10.1371/journal.pone.0172920. eCollection 2017.


Proinflammatory Cytokines Impair Vitamin D-Induced Host Defense in Cultured Airway Epithelial Cells.

Schrumpf JA, Amatngalim GD, Veldkamp JB, Verhoosel RM, Ninaber DK, Ordonez SR, van der Does AM, Haagsman HP, Hiemstra PS.

Am J Respir Cell Mol Biol. 2017 Jun;56(6):749-761. doi: 10.1165/rcmb.2016-0289OC.


Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke.

Amatngalim GD, Schrumpf JA, Henic A, Dronkers E, Verhoosel RM, Ordonez SR, Haagsman HP, Fuentes ME, Sridhar S, Aarbiou J, Janssen RAJ, Lekkerkerker AN, Hiemstra PS.

J Innate Immun. 2017;9(4):359-374. doi: 10.1159/000455193. Epub 2017 Feb 8.


Novel human bioactive peptides identified in Apolipoprotein B: Evaluation of their therapeutic potential.

Gaglione R, Dell'Olmo E, Bosso A, Chino M, Pane K, Ascione F, Itri F, Caserta S, Amoresano A, Lombardi A, Haagsman HP, Piccoli R, Pizzo E, Veldhuizen EJA, Notomista E, Arciello A.

Biochem Pharmacol. 2017 Apr 15;130:34-50. doi: 10.1016/j.bcp.2017.01.009. Epub 2017 Jan 25.


Interspecies cathelicidin comparison reveals divergence in antimicrobial activity, TLR modulation, chemokine induction and regulation of phagocytosis.

Coorens M, Scheenstra MR, Veldhuizen EJ, Haagsman HP.

Sci Rep. 2017 Jan 19;7:40874. doi: 10.1038/srep40874.


Expression and characterization of recombinant chicken mannose binding lectin.

Zhang W, van Eijk M, Guo H, van Dijk A, Bleijerveld OB, Verheije MH, Wang G, Haagsman HP, Veldhuizen EJ.

Immunobiology. 2017 Mar;222(3):518-528. doi: 10.1016/j.imbio.2016.10.019. Epub 2016 Oct 29.


Imaging the antimicrobial mechanism(s) of cathelicidin-2.

Schneider VA, Coorens M, Ordonez SR, Tjeerdsma-van Bokhoven JL, Posthuma G, van Dijk A, Haagsman HP, Veldhuizen EJ.

Sci Rep. 2016 Sep 14;6:32948. doi: 10.1038/srep32948.


Protective effect of in ovo treatment with the chicken cathelicidin analog D-CATH-2 against avian pathogenic E. coli.

Cuperus T, van Dijk A, Matthijs MG, Veldhuizen EJ, Haagsman HP.

Sci Rep. 2016 May 27;6:26622. doi: 10.1038/srep26622.


Hide, Keep Quiet, and Keep Low: Properties That Make Aspergillus fumigatus a Successful Lung Pathogen.

Escobar N, Ordonez SR, Wösten HA, Haas PJ, de Cock H, Haagsman HP.

Front Microbiol. 2016 Apr 6;7:438. doi: 10.3389/fmicb.2016.00438. eCollection 2016.


Developmental regulation of chicken surfactant protein A and its localization in lung.

Zhang W, Cuperus T, van Dijk A, Skjødt K, Hansen S, Haagsman HP, Veldhuizen EJ.

Dev Comp Immunol. 2016 Aug;61:80-7. doi: 10.1016/j.dci.2016.03.010. Epub 2016 Mar 11.


Localization and developmental expression of two chicken host defense peptides: cathelicidin-2 and avian β-defensin 9.

Cuperus T, van Dijk A, Dwars RM, Haagsman HP.

Dev Comp Immunol. 2016 Aug;61:48-59. doi: 10.1016/j.dci.2016.03.008. Epub 2016 Mar 10.


Histones as mediators of host defense, inflammation and thrombosis.

Hoeksema M, van Eijk M, Haagsman HP, Hartshorn KL.

Future Microbiol. 2016;11(3):441-53. doi: 10.2217/fmb.15.151. Epub 2016 Mar 4. Review.


Prophylactic administration of chicken cathelicidin-2 boosts zebrafish embryonic innate immunity.

Schneider VA, van Dijk A, van der Sar AM, Kraaij MD, Veldhuizen EJ, Haagsman HP.

Dev Comp Immunol. 2016 Jul;60:108-14. doi: 10.1016/j.dci.2016.02.023. Epub 2016 Feb 23.


Immunomodulatory and Anti-Inflammatory Activities of Chicken Cathelicidin-2 Derived Peptides.

van Dijk A, van Eldik M, Veldhuizen EJ, Tjeerdsma-van Bokhoven HL, de Zoete MR, Bikker FJ, Haagsman HP.

PLoS One. 2016 Feb 5;11(2):e0147919. doi: 10.1371/journal.pone.0147919. eCollection 2016.


Importance of Endosomal Cathelicidin Degradation To Enhance DNA-Induced Chicken Macrophage Activation.

Coorens M, van Dijk A, Bikker F, Veldhuizen EJ, Haagsman HP.

J Immunol. 2015 Oct 15;195(8):3970-7. doi: 10.4049/jimmunol.1501242. Epub 2015 Sep 16.


A mRNA landscape of bovine embryos after standard and MAPK-inhibited culture conditions: a comparative analysis.

Brinkhof B, van Tol HT, Groot Koerkamp MJ, Riemers FM, IJzer SG, Mashayekhi K, Haagsman HP, Roelen BA.

BMC Genomics. 2015 Apr 10;16:277. doi: 10.1186/s12864-015-1448-x.


Antimicrobial and biophysical properties of surfactant supplemented with an antimicrobial peptide for treatment of bacterial pneumonia.

Banaschewski BJ, Veldhuizen EJ, Keating E, Haagsman HP, Zuo YY, Yamashita CM, Veldhuizen RA.

Antimicrob Agents Chemother. 2015;59(6):3075-83. doi: 10.1128/AAC.04937-14. Epub 2015 Mar 9.


Assessment of the antiviral properties of recombinant surfactant protein D against influenza B virus in vitro.

Hillaire ML, van Eijk M, Vogelzang-van Trierum SE, Nieuwkoop NJ, van Riel D, Fouchier RA, Kuiken T, Osterhaus AD, Haagsman HP, Rimmelzwaan GF.

Virus Res. 2015 Jan 2;195:43-6. doi: 10.1016/j.virusres.2014.08.019. Epub 2014 Sep 6.


Antimicrobial and immunomodulatory activities of PR-39 derived peptides.

Veldhuizen EJ, Schneider VA, Agustiandari H, van Dijk A, Tjeerdsma-van Bokhoven JL, Bikker FJ, Haagsman HP.

PLoS One. 2014 Apr 22;9(4):e95939. doi: 10.1371/journal.pone.0095939. eCollection 2014.


Leukocyte-associated Ig-like receptor-1 is a novel inhibitory receptor for surfactant protein D.

Olde Nordkamp MJ, van Eijk M, Urbanus RT, Bont L, Haagsman HP, Meyaard L.

J Leukoc Biol. 2014 Jul;96(1):105-11. doi: 10.1189/jlb.3AB0213-092RR. Epub 2014 Feb 28.


Fungicidal mechanisms of cathelicidins LL-37 and CATH-2 revealed by live-cell imaging.

Ordonez SR, Amarullah IH, Wubbolts RW, Veldhuizen EJ, Haagsman HP.

Antimicrob Agents Chemother. 2014;58(4):2240-8. doi: 10.1128/AAC.01670-13. Epub 2014 Feb 3.


Recombinant porcine surfactant protein D inhibits influenza A virus replication ex vivo.

Hillaire ML, van Eijk M, Vogelzang-van Trierum SE, Fouchier RA, Osterhaus AD, Haagsman HP, Rimmelzwaan GF.

Virus Res. 2014 Mar 6;181:22-6. doi: 10.1016/j.virusres.2013.12.032. Epub 2014 Jan 1.


Avian host defense peptides.

Cuperus T, Coorens M, van Dijk A, Haagsman HP.

Dev Comp Immunol. 2013 Nov;41(3):352-69. doi: 10.1016/j.dci.2013.04.019. Epub 2013 May 3. Review.


Pulmonary surfactant protein D in first-line innate defence against influenza A virus infections.

Hillaire ML, Haagsman HP, Osterhaus AD, Rimmelzwaan GF, van Eijk M.

J Innate Immun. 2013;5(3):197-208. doi: 10.1159/000346374. Epub 2013 Feb 5. Review.


Microfabricated devices for biomolecule encapsulation.

Desmarais SM, Haagsman HP, Barron AE.

Electrophoresis. 2012 Sep;33(17):2639-49. doi: 10.1002/elps.201200189. Review.


The number and position of N-linked glycosylation sites in the hemagglutinin determine differential recognition of seasonal and 2009 pandemic H1N1 influenza virus by porcine surfactant protein D.

Hillaire ML, van Eijk M, Nieuwkoop NJ, Vogelzang-van Trierum SE, Fouchier RA, Osterhaus AD, Haagsman HP, Rimmelzwaan GF.

Virus Res. 2012 Oct;169(1):301-5. doi: 10.1016/j.virusres.2012.08.003. Epub 2012 Aug 15.


Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung.

Pezzulo AA, Tang XX, Hoegger MJ, Abou Alaiwa MH, Ramachandran S, Moninger TO, Karp PH, Wohlford-Lenane CL, Haagsman HP, van Eijk M, Bánfi B, Horswill AR, Stoltz DA, McCray PB Jr, Welsh MJ, Zabner J.

Nature. 2012 Jul 4;487(7405):109-13. doi: 10.1038/nature11130.

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