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Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3.

Haag F, Ahmed L, Reiss K, Block E, Batista VS, Krautwurst D.

Cell Mol Life Sci. 2019 Aug 21. doi: 10.1007/s00018-019-03279-y. [Epub ahead of print]


Generation and Function of Non-cell-bound CD73 in Inflammation.

Schneider E, Rissiek A, Winzer R, Puig B, Rissiek B, Haag F, Mittrücker HW, Magnus T, Tolosa E.

Front Immunol. 2019 Jul 26;10:1729. doi: 10.3389/fimmu.2019.01729. eCollection 2019. Review.


P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP.

Johnsen B, Kaschubowski KE, Nader S, Schneider E, Nicola JA, Fliegert R, Wolf IMA, Guse AH, Nikolaev VO, Koch-Nolte F, Haag F.

Purinergic Signal. 2019 Jun;15(2):155-166. doi: 10.1007/s11302-019-09654-5. Epub 2019 Apr 23.


Novel biologics targeting the P2X7 ion channel.

Koch-Nolte F, Eichhoff A, Pinto-Espinoza C, Schwarz N, Schäfer T, Menzel S, Haag F, Demeules M, Gondé H, Adriouch S.

Curr Opin Pharmacol. 2019 Aug;47:110-118. doi: 10.1016/j.coph.2019.03.001. Epub 2019 Apr 12. Review.


Synthesizing Highly Regular Single-Layer Alkynyl-Silver Networks at the Micrometer Scale via Gas-Mediated Surface Reaction.

Zhang YQ, Paintner T, Hellwig R, Haag F, Allegretti F, Feulner P, Klyatskaya S, Ruben M, Seitsonen AP, Barth JV, Klappenberger F.

J Am Chem Soc. 2019 Apr 3;141(13):5087-5091. doi: 10.1021/jacs.8b13547. Epub 2019 Mar 22.


Modification of Pb quantum well states by the adsorption of organic molecules.

Stadtmüller B, Grad L, Seidel J, Haag F, Haag N, Cinchetti M, Aeschlimann M.

J Phys Condens Matter. 2019 Apr 3;31(13):134005. doi: 10.1088/1361-648X/aafcf5. Epub 2019 Jan 9.


CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells.

Schütze K, Petry K, Hambach J, Schuster N, Fumey W, Schriewer L, Röckendorf J, Menzel S, Albrecht B, Haag F, Stortelers C, Bannas P, Koch-Nolte F.

Front Immunol. 2018 Nov 19;9:2553. doi: 10.3389/fimmu.2018.02553. eCollection 2018.


Monitoring the Sensitivity of T Cell Populations Towards NAD+ Released During Cell Preparation.

Rissiek B, Lukowiak M, Haag F, Magnus T, Koch-Nolte F.

Methods Mol Biol. 2018;1813:317-326. doi: 10.1007/978-1-4939-8588-3_22.


Monitoring Expression and Enzyme Activity of Ecto-ARTCs.

Menzel S, Adriouch S, Bannas P, Haag F, Koch-Nolte F.

Methods Mol Biol. 2018;1813:167-186. doi: 10.1007/978-1-4939-8588-3_11.


CD39 is upregulated during activation of mouse and human T cells and attenuates the immune response to Listeria monocytogenes.

Raczkowski F, Rissiek A, Ricklefs I, Heiss K, Schumacher V, Wundenberg K, Haag F, Koch-Nolte F, Tolosa E, Mittrücker HW.

PLoS One. 2018 May 9;13(5):e0197151. doi: 10.1371/journal.pone.0197151. eCollection 2018.


Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity.

Menzel S, Schwarz N, Haag F, Koch-Nolte F.

Front Pharmacol. 2018 Mar 27;9:266. doi: 10.3389/fphar.2018.00266. eCollection 2018. Review.


N-Heterocyclic carbenes on close-packed coinage metal surfaces: bis-carbene metal adatom bonding scheme of monolayer films on Au, Ag and Cu.

Jiang L, Zhang B, Médard G, Seitsonen AP, Haag F, Allegretti F, Reichert J, Kuster B, Barth JV, Papageorgiou AC.

Chem Sci. 2017 Dec 1;8(12):8301-8308. doi: 10.1039/c7sc03777e. Epub 2017 Sep 28.


Selective Prostacyclin Receptor Agonist Selexipag, in Contrast to Prostacyclin Analogs, Does Not Evoke Paradoxical Vasoconstriction of the Rat Femoral Artery.

Morrison K, Haag F, Ernst R, Iglarz M, Clozel M.

J Pharmacol Exp Ther. 2018 Jun;365(3):727-733. doi: 10.1124/jpet.117.246058. Epub 2018 Mar 27.


A cDNA Immunization Strategy to Generate Nanobodies against Membrane Proteins in Native Conformation.

Eden T, Menzel S, Wesolowski J, Bergmann P, Nissen M, Dubberke G, Seyfried F, Albrecht B, Haag F, Koch-Nolte F.

Front Immunol. 2018 Jan 23;8:1989. doi: 10.3389/fimmu.2017.01989. eCollection 2017.


Ecto-ADP-ribosyltransferase ARTC2.1 functionally modulates FcγR1 and FcγR2B on murine microglia.

Rissiek B, Menzel S, Leutert M, Cordes M, Behr S, Jank L, Ludewig P, Gelderblom M, Rissiek A, Adriouch S, Haag F, Hottiger MO, Koch-Nolte F, Magnus T.

Sci Rep. 2017 Nov 28;7(1):16477. doi: 10.1038/s41598-017-16613-w.


Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo.

Fumey W, Koenigsdorf J, Kunick V, Menzel S, Schütze K, Unger M, Schriewer L, Haag F, Adam G, Oberle A, Binder M, Fliegert R, Guse A, Zhao YJ, Cheung Lee H, Malavasi F, Goldbaum F, van Hegelsom R, Stortelers C, Bannas P, Koch-Nolte F.

Sci Rep. 2017 Oct 30;7(1):14289. doi: 10.1038/s41598-017-14112-6.


The reversible P2Y12 antagonist ACT-246475 causes significantly less blood loss than ticagrelor at equivalent antithrombotic efficacy in rat.

Rey M, Kramberg M, Hess P, Morrison K, Ernst R, Haag F, Weber E, Clozel M, Baumann M, Caroff E, Hubler F, Riederer MA, Steiner B.

Pharmacol Res Perspect. 2017 Oct;5(5). doi: 10.1002/prp2.338.


Neutrophil Extracellular Traps Contain Selected Antigens of Anti-Neutrophil Cytoplasmic Antibodies.

Panda R, Krieger T, Hopf L, Renné T, Haag F, Röber N, Conrad K, Csernok E, Fuchs TA.

Front Immunol. 2017 Apr 13;8:439. doi: 10.3389/fimmu.2017.00439. eCollection 2017.


Down-regulation of CD73 on B cells of patients with viremic HIV correlates with B cell activation and disease progression.

Kim ES, Ackermann C, Tóth I, Dierks P, Eberhard JM, Wroblewski R, Scherg F, Geyer M, Schmidt RE, Beisel C, Bockhorn M, Haag F, van Lunzen J, Schulze Zur Wiesch J.

J Leukoc Biol. 2017 May;101(5):1263-1271. doi: 10.1189/jlb.5A0816-346R. Epub 2017 Feb 13.


Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation.

Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte F.

Sci Transl Med. 2016 Nov 23;8(366):366ra162.


Postoperative Changes in the Distal Residual Aorta after Surgery for Acute Type A Aortic Dissection: Impact of False Lumen Patency and Size of Descending Aorta.

Leontyev S, Haag F, Davierwala PM, Lehmkuhl L, Borger MA, Etz CD, Misfeld M, Gutberlet M, Mohr FW.

Thorac Cardiovasc Surg. 2017 Mar;65(2):90-98. doi: 10.1055/s-0036-1571813. Epub 2016 Apr 25.


A transplant "immunome" screening platform defines a targetable epitope fingerprint of multiple myeloma.

Schieferdecker A, Oberle A, Thiele B, Hofmann F, Göthel M, Miethe S, Hust M, Braig F, Voigt M, von Pein UM, Koch-Nolte F, Haag F, Alawi M, Indenbirken D, Grundhoff A, Bokemeyer C, Bacher U, Kröger N, Binder M.

Blood. 2016 Jun 23;127(25):3202-14. doi: 10.1182/blood-2015-10-676536. Epub 2016 Mar 31.


Nucleotide-Induced Membrane-Proximal Proteolysis Controls the Substrate Specificity of T Cell Ecto-ADP-Ribosyltransferase ARTC2.2.

Menzel S, Rissiek B, Bannas P, Jakoby T, Miksiewicz M, Schwarz N, Nissen M, Haag F, Tholey A, Koch-Nolte F.

J Immunol. 2015 Sep 1;195(5):2057-66. doi: 10.4049/jimmunol.1401677. Epub 2015 Jul 24.


Amino acids as possible alternative nitrogen source for growth of Euglena gracilis Z in life support systems.

Richter PR, Liu Y, An Y, Li X, Nasir A, Strauch SM, Becker I, Krüger J, Schuster M, Ntefidou M, Daiker V, Haag FW, Aiach A, Lebert M.

Life Sci Space Res (Amst). 2015 Jan;4:1-5. doi: 10.1016/j.lssr.2014.11.001. Epub 2014 Dec 3.


P2X7 on Mouse T Cells: One Channel, Many Functions.

Rissiek B, Haag F, Boyer O, Koch-Nolte F, Adriouch S.

Front Immunol. 2015 May 19;6:204. doi: 10.3389/fimmu.2015.00204. eCollection 2015. Review.


Association of hepatitis E virus and essential cryoglobulinemia?

Pischke S, Polywka S, Haag F, Iking-Konert C, Sterneck M, Lütgehetmann M, Dammermann W, Lüth S, Schirmer JH.

J Clin Virol. 2015 Jun;67:23-4. doi: 10.1016/j.jcv.2015.03.020. Epub 2015 Mar 28. No abstract available.


Molecular imaging of tumors with nanobodies and antibodies: Timing and dosage are crucial factors for improved in vivo detection.

Bannas P, Lenz A, Kunick V, Well L, Fumey W, Rissiek B, Haag F, Schmid J, Schütze K, Eichhoff A, Trepel M, Adam G, Ittrich H, Koch-Nolte F.

Contrast Media Mol Imaging. 2015 Sep-Oct;10(5):367-78. doi: 10.1002/cmmi.1637. Epub 2015 Apr 27.


Validation of nanobody and antibody based in vivo tumor xenograft NIRF-imaging experiments in mice using ex vivo flow cytometry and microscopy.

Bannas P, Lenz A, Kunick V, Fumey W, Rissiek B, Schmid J, Haag F, Leingärtner A, Trepel M, Adam G, Koch-Nolte F.

J Vis Exp. 2015 Apr 6;(98):e52462. doi: 10.3791/52462.


Tuning IL-2 signaling by ADP-ribosylation of CD25.

Teege S, Hann A, Miksiewicz M, MacMillan C, Rissiek B, Buck F, Menzel S, Nissen M, Bannas P, Haag F, Boyer O, Seman M, Adriouch S, Koch-Nolte F.

Sci Rep. 2015 Mar 10;5:8959. doi: 10.1038/srep08959.


The expression of CD39 on regulatory T cells is genetically driven and further upregulated at sites of inflammation.

Rissiek A, Baumann I, Cuapio A, Mautner A, Kolster M, Arck PC, Dodge-Khatami A, Mittrücker HW, Koch-Nolte F, Haag F, Tolosa E.

J Autoimmun. 2015 Apr;58:12-20. doi: 10.1016/j.jaut.2014.12.007. Epub 2015 Jan 29.


Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin CDT.

Unger M, Eichhoff AM, Schumacher L, Strysio M, Menzel S, Schwan C, Alzogaray V, Zylberman V, Seman M, Brandner J, Rohde H, Zhu K, Haag F, Mittrücker HW, Goldbaum F, Aktories K, Koch-Nolte F.

Sci Rep. 2015 Jan 19;5:7850. doi: 10.1038/srep07850.


Function of the Th17/interleukin-17A immune response in murine lupus nephritis.

Schmidt T, Paust HJ, Krebs CF, Turner JE, Kaffke A, Bennstein SB, Koyro T, Peters A, Velden J, Hünemörder S, Haag F, Steinmetz OM, Mittrücker HW, Stahl RA, Panzer U.

Arthritis Rheumatol. 2015 Feb;67(2):475-87. doi: 10.1002/art.38955.


Nonlinear stiffness characteristics of the annular ligament.

Lauxmann M, Eiber A, Haag F, Ihrle S.

J Acoust Soc Am. 2014 Oct;136(4):1756-67. doi: 10.1121/1.4895696.


Influence of different light-dark cycles on motility and photosynthesis of Euglena gracilis in closed bioreactors.

Richter PR, Strauch SM, Ntefidou M, Schuster M, Daiker V, Nasir A, Haag FW, Lebert M.

Astrobiology. 2014 Oct;14(10):848-58. doi: 10.1089/ast.2014.1176. Epub 2014 Oct 3.


Identification and analysis of ADP-ribosylated proteins.

Haag F, Buck F.

Curr Top Microbiol Immunol. 2015;384:33-50. doi: 10.1007/82_2014_424. Review.


Functional autoantibodies against SSX-2 and NY-ESO-1 in multiple myeloma patients after allogeneic stem cell transplantation.

Luetkens T, Kobold S, Cao Y, Ristic M, Schilling G, Tams S, Bartels BM, Templin J, Bartels K, Hildebrandt Y, Yousef S, Marx A, Haag F, Bokemeyer C, Kröger N, Atanackovic D.

Cancer Immunol Immunother. 2014 Nov;63(11):1151-62. doi: 10.1007/s00262-014-1588-x. Epub 2014 Jul 31.


ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells.

Rissiek B, Haag F, Boyer O, Koch-Nolte F, Adriouch S.

Curr Top Microbiol Immunol. 2015;384:107-26. doi: 10.1007/82_2014_420. Review.


Multidimensional scaling analysis identifies pathological and prognostically relevant profiles of circulating T-cells in chronic lymphocytic leukemia.

Rissiek A, Schulze C, Bacher U, Schieferdecker A, Thiele B, Jacholkowski A, Flammiger A, Horn C, Haag F, Tiegs G, Zirlik K, Trepel M, Tolosa E, Binder M.

Int J Cancer. 2014 Nov 15;135(10):2370-9. doi: 10.1002/ijc.28884. Epub 2014 Apr 18.


In vivo near-infrared fluorescence targeting of T cells: comparison of nanobodies and conventional monoclonal antibodies.

Bannas P, Well L, Lenz A, Rissiek B, Haag F, Schmid J, Hochgräfe K, Trepel M, Adam G, Ittrich H, Koch-Nolte F.

Contrast Media Mol Imaging. 2014 Mar-Apr;9(2):135-42. doi: 10.1002/cmmi.1548.


Mucolipidosis II-related mutations inhibit the exit from the endoplasmic reticulum and proteolytic cleavage of GlcNAc-1-phosphotransferase precursor protein (GNPTAB).

De Pace R, Coutinho MF, Koch-Nolte F, Haag F, Prata MJ, Alves S, Braulke T, Pohl S.

Hum Mutat. 2014 Mar;35(3):368-76. doi: 10.1002/humu.22502. Epub 2014 Jan 15.


Technical Advance: a new cell preparation strategy that greatly improves the yield of vital and functional Tregs and NKT cells.

Rissiek B, Danquah W, Haag F, Koch-Nolte F.

J Leukoc Biol. 2014 Mar;95(3):543-9. doi: 10.1189/jlb.0713407. Epub 2013 Nov 8.


Peripheral blood biomarkers for the characterization of alloimmune reactivity after pediatric liver transplantation.

Briem-Richter A, Leuschner A, Krieger T, Grabhorn E, Fischer L, Nashan B, Haag F, Ganschow R.

Pediatr Transplant. 2013 Dec;17(8):757-64. doi: 10.1111/petr.12161. Epub 2013 Oct 6.


Immune activation in amyloid-β-related angiitis correlates with decreased parenchymal amyloid-β plaque load.

Bogner S, Bernreuther C, Matschke J, Barrera-Ocampo A, Sepulveda-Falla D, Leypoldt F, Magnus T, Haag F, Bergmann M, Brück W, Vogelgesang S, Glatzel M.

Neurodegener Dis. 2014;13(1):38-44. doi: 10.1159/000352020. Epub 2013 Sep 6.


CD38 controls the innate immune response against Listeria monocytogenes.

Lischke T, Heesch K, Schumacher V, Schneider M, Haag F, Koch-Nolte F, Mittrücker HW.

Infect Immun. 2013 Nov;81(11):4091-9. doi: 10.1128/IAI.00340-13. Epub 2013 Aug 26.


The art of blocking ADP-ribosyltransferases (ARTs): nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs.

Menzel S, Rissiek B, Haag F, Goldbaum FA, Koch-Nolte F.

FEBS J. 2013 Aug;280(15):3543-50. doi: 10.1111/febs.12313. Epub 2013 Jun 14. Review.


CD8-β ADP-ribosylation affects CD8(+) T-cell function.

Lischke T, Schumacher V, Wesolowski J, Hurwitz R, Haag F, Koch-Nolte F, Mittrücker HW.

Eur J Immunol. 2013 Jul;43(7):1828-38. doi: 10.1002/eji.201243231. Epub 2013 May 17.


Cytokine concentrations and regulatory T cells in living donor and deceased donor liver transplant recipients.

Briem-Richter A, Leuschner A, Haag F, Grabhorn E, Ganschow R.

Pediatr Transplant. 2013 Mar;17(2):185-90. doi: 10.1111/petr.12044. Epub 2013 Jan 17.


Expansion of HIV-specific T follicular helper cells in chronic HIV infection.

Lindqvist M, van Lunzen J, Soghoian DZ, Kuhl BD, Ranasinghe S, Kranias G, Flanders MD, Cutler S, Yudanin N, Muller MI, Davis I, Farber D, Hartjen P, Haag F, Alter G, Schulze zur Wiesch J, Streeck H.

J Clin Invest. 2012 Sep;122(9):3271-80. doi: 10.1172/JCI64314. Epub 2012 Aug 27.


Differential effects of Selexipag [corrected] and prostacyclin analogs in rat pulmonary artery.

Morrison K, Studer R, Ernst R, Haag F, Kauser K, Clozel M.

J Pharmacol Exp Ther. 2012 Dec;343(3):547-55. doi: 10.1124/jpet.112.197152. Epub 2012 Aug 23. Erratum in: J Pharmacol Exp Ther. 2013 Jan;344(1):317.


Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.

Schwarz N, Drouot L, Nicke A, Fliegert R, Boyer O, Guse AH, Haag F, Adriouch S, Koch-Nolte F.

PLoS One. 2012;7(7):e41269. doi: 10.1371/journal.pone.0041269. Epub 2012 Jul 27.

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