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Anaplastic lymphoma kinase 5A4 immunohistochemistry as a diagnostic assay in lung cancer: A Canadian reference testing center's results in population-based reflex testing.

Fiset PO, Labbé C, Young K, Craddock KJ, Smith AC, Tanguay J, Pintilie M, Wang R, Torlakovic E, Cheung C, da Cunha Santos G, Ko HM, Boerner SL, Hwang DM, Leighl NB, Tsao MS.

Cancer. 2019 Aug 7. doi: 10.1002/cncr.32422. [Epub ahead of print]


A B Cell-Dependent Pathway Drives Chronic Lung Allograft Rejection After Ischemia-Reperfusion Injury in Mice.

Watanabe T, Martinu T, Chruscinski A, Boonstra K, Joe B, Horie M, Guan Z, Bei KF, Hwang DM, Liu M, Keshavjee S, Juvet SC.

Am J Transplant. 2019 Jul 31. doi: 10.1111/ajt.15550. [Epub ahead of print]


Histogram-based models on non-thin section chest CT predict invasiveness of primary lung adenocarcinoma subsolid nodules.

Oikonomou A, Salazar P, Zhang Y, Hwang DM, Petersen A, Dmytriw AA, Paul NS, Nguyen ET.

Sci Rep. 2019 Apr 12;9(1):6009. doi: 10.1038/s41598-019-42340-5.


Effect of Coexisting KRAS and TP53 Mutations in Patients Treated With Chemotherapy for Non-small-cell Lung Cancer.

Tomasini P, Mascaux C, Jao K, Labbe C, Kamel-Reid S, Stockley T, Hwang DM, Leighl NB, Liu G, Bradbury PA, Pintilie M, Tsao MS, Shepherd FA.

Clin Lung Cancer. 2019 May;20(3):e338-e345. doi: 10.1016/j.cllc.2018.12.009. Epub 2018 Dec 19.


Microbiome networks and change-point analysis reveal key community changes associated with cystic fibrosis pulmonary exacerbations.

Layeghifard M, Li H, Wang PW, Donaldson SL, Coburn B, Clark ST, Caballero JD, Zhang Y, Tullis DE, Yau YCW, Waters V, Hwang DM, Guttman DS.

NPJ Biofilms Microbiomes. 2019 Jan 21;5:4. doi: 10.1038/s41522-018-0077-y. eCollection 2019.


Penicillin-binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with β-lactams.

Clark ST, Sinha U, Zhang Y, Wang PW, Donaldson SL, Coburn B, Waters VJ, Yau YCW, Tullis DE, Guttman DS, Hwang DM.

Int J Antimicrob Agents. 2019 May;53(5):620-628. doi: 10.1016/j.ijantimicag.2019.01.009. Epub 2019 Jan 19.


A genome-wide association analysis reveals a potential role for recombination in the evolution of antimicrobial resistance in Burkholderia multivorans.

Diaz Caballero J, Clark ST, Wang PW, Donaldson SL, Coburn B, Tullis DE, Yau YCW, Waters VJ, Hwang DM, Guttman DS.

PLoS Pathog. 2018 Dec 7;14(12):e1007453. doi: 10.1371/journal.ppat.1007453. eCollection 2018 Dec.


Spectrum of chronic lung allograft pathology in a mouse minor-mismatched orthotopic lung transplant model.

Martinu T, Oishi H, Juvet SC, Cypel M, Liu M, Berry GJ, Hwang DM, Keshavjee S.

Am J Transplant. 2019 Jan;19(1):247-258. doi: 10.1111/ajt.15167. Epub 2018 Nov 29.


Constructing and Analyzing Microbiome Networks in R.

Layeghifard M, Hwang DM, Guttman DS.

Methods Mol Biol. 2018;1849:243-266. doi: 10.1007/978-1-4939-8728-3_16.


The prognostic effect of single and multiple cancer-related somatic mutations in resected non-small-cell lung cancer.

Jao K, Tomasini P, Kamel-Reid S, Korpanty GJ, Mascaux C, Sakashita S, Labbé C, Leighl NB, Liu G, Feld R, Bradbury PA, Hwang DM, Pintilie M, Tsao MS, Shepherd FA.

Lung Cancer. 2018 Sep;123:22-29. doi: 10.1016/j.lungcan.2018.06.023. Epub 2018 Jun 19.


Banff Lung Report: Current knowledge and future research perspectives for diagnosis and treatment of pulmonary antibody-mediated rejection (AMR).

Roux A, Levine DJ, Zeevi A, Hachem R, Halloran K, Halloran PF, Gibault L, Taupin JL, Neil DAH, Loupy A, Adam BA, Mengel M, Hwang DM, Calabrese F, Berry G, Pavlisko EN.

Am J Transplant. 2019 Jan;19(1):21-31. doi: 10.1111/ajt.14990. Epub 2018 Aug 1.


Lung cancer in never smokers from the Princess Margaret Cancer Centre.

Korpanty GJ, Kamel-Reid S, Pintilie M, Hwang DM, Zer A, Liu G, Leighl NB, Feld R, Siu LL, Bedard PL, Tsao MS, Shepherd FA.

Oncotarget. 2018 Apr 27;9(32):22559-22570. doi: 10.18632/oncotarget.25176. eCollection 2018 Apr 27.


Translation of Knowledge to Practice-Improving Awareness in NSCLC Molecular Testing.

Zer A, Cutz JC, Sekhon H, Hwang DM, Sit C, Maganti M, Sung M, Binnie M, Brade A, Chung TB, Kamel-Reid S, Paul N, Tsao MS, Waddell T, da Cunha Santos G, Patel M, Carter RF, Leighl NB.

J Thorac Oncol. 2018 Jul;13(7):1004-1011. doi: 10.1016/j.jtho.2018.03.005. Epub 2018 Mar 11.


Pentraxin 3 deficiency enhances features of chronic rejection in a mouse orthotopic lung transplantation model.

Yoshida M, Oishi H, Martinu T, Hwang DM, Takizawa H, Sugihara J, McKee TD, Bai X, Guana Z, Lua C, Cho HR, Juvet S, Cypel M, Keshavjee S, Liu M.

Oncotarget. 2018 Jan 3;9(9):8489-8501. doi: 10.18632/oncotarget.23902. eCollection 2018 Feb 2.


Diversification of Pseudomonas aeruginosa within the cystic fibrosis lung and its effects on antibiotic resistance.

Clark ST, Guttman DS, Hwang DM.

FEMS Microbiol Lett. 2018 Mar 1;365(6). doi: 10.1093/femsle/fny026.


Evaluations of the tongue and hyoid bone positions and pharyngeal airway dimensions after maxillary protraction treatment.

Hwang DM, Lee JY, Choi YJ, Hwang CJ.

Cranio. 2019 Jul;37(4):214-222. doi: 10.1080/08869634.2017.1418644. Epub 2018 Jan 12.


Participant selection for lung cancer screening by risk modelling (the Pan-Canadian Early Detection of Lung Cancer [PanCan] study): a single-arm, prospective study.

Tammemagi MC, Schmidt H, Martel S, McWilliams A, Goffin JR, Johnston MR, Nicholas G, Tremblay A, Bhatia R, Liu G, Soghrati K, Yasufuku K, Hwang DM, Laberge F, Gingras M, Pasian S, Couture C, Mayo JR, Nasute Fauerbach PV, Atkar-Khattra S, Peacock SJ, Cressman S, Ionescu D, English JC, Finley RJ, Yee J, Puksa S, Stewart L, Tsai S, Haider E, Boylan C, Cutz JC, Manos D, Xu Z, Goss GD, Seely JM, Amjadi K, Sekhon HS, Burrowes P, MacEachern P, Urbanski S, Sin DD, Tan WC, Leighl NB, Shepherd FA, Evans WK, Tsao MS, Lam S; PanCan Study Team.

Lancet Oncol. 2017 Nov;18(11):1523-1531. doi: 10.1016/S1470-2045(17)30597-1. Epub 2017 Oct 18.


The Cost-Effectiveness of High-Risk Lung Cancer Screening and Drivers of Program Efficiency.

Cressman S, Peacock SJ, Tammemägi MC, Evans WK, Leighl NB, Goffin JR, Tremblay A, Liu G, Manos D, MacEachern P, Bhatia R, Puksa S, Nicholas G, McWilliams A, Mayo JR, Yee J, English JC, Pataky R, McPherson E, Atkar-Khattra S, Johnston MR, Schmidt H, Shepherd FA, Soghrati K, Amjadi K, Burrowes P, Couture C, Sekhon HS, Yasufuku K, Goss G, Ionescu DN, Hwang DM, Martel S, Sin DD, Tan WC, Urbanski S, Xu Z, Tsao MS, Lam S.

J Thorac Oncol. 2017 Aug;12(8):1210-1222. doi: 10.1016/j.jtho.2017.04.021. Epub 2017 May 10.


Improving molecular testing and personalized medicine in non-small-cell lung cancer in Ontario.

Lim C, Sekhon HS, Cutz JC, Hwang DM, Kamel-Reid S, Carter RF, Santos GDC, Waddell T, Binnie M, Patel M, Paul N, Chung T, Brade A, El-Maraghi R, Sit C, Tsao MS, Leighl NB.

Curr Oncol. 2017 Apr;24(2):103-110. doi: 10.3747/co.24.3495. Epub 2017 Apr 27.


Sevoflurane Attenuates Ischemia-Reperfusion Injury in a Rat Lung Transplantation Model.

Ohsumi A, Marseu K, Slinger P, McRae K, Kim H, Guan Z, Hwang DM, Liu M, Keshavjee S, Cypel M.

Ann Thorac Surg. 2017 May;103(5):1578-1586. doi: 10.1016/j.athoracsur.2016.10.062. Epub 2017 Feb 9.


Navigating social and ethical challenges of biobanking for human microbiome research.

Chuong KH, Hwang DM, Tullis DE, Waters VJ, Yau YC, Guttman DS, O'Doherty KC.

BMC Med Ethics. 2017 Jan 11;18(1):1. doi: 10.1186/s12910-016-0160-y.


Efficacy and safety of adding evogliptin versus sitagliptin for metformin-treated patients with type 2 diabetes: A 24-week randomized, controlled trial with open label extension.

Hong SM, Park CY, Hwang DM, Han KA, Lee CB, Chung CH, Yoon KH, Mok JO, Park KS, Park SW.

Diabetes Obes Metab. 2017 May;19(5):654-663. doi: 10.1111/dom.12870. Epub 2017 Feb 22.


Safety and Efficacy of Ex Vivo Donor Lung Adenoviral IL-10 Gene Therapy in a Large Animal Lung Transplant Survival Model.

Machuca TN, Cypel M, Bonato R, Yeung JC, Chun YM, Juvet S, Guan Z, Hwang DM, Chen M, Saito T, Harmantas C, Davidson BL, Waddell TK, Liu M, Keshavjee S.

Hum Gene Ther. 2017 Sep;28(9):757-765. doi: 10.1089/hum.2016.070. Epub 2017 Jan 4.


Disentangling Interactions in the Microbiome: A Network Perspective.

Layeghifard M, Hwang DM, Guttman DS.

Trends Microbiol. 2017 Mar;25(3):217-228. doi: 10.1016/j.tim.2016.11.008. Epub 2016 Dec 2. Review.


ALK-Rearranged Non-Small-Cell Lung Cancer Is Associated With a High Rate of Venous Thromboembolism.

Zer A, Moskovitz M, Hwang DM, Hershko-Klement A, Fridel L, Korpanty GJ, Dudnik E, Peled N, Shochat T, Leighl NB, Liu G, Feld R, Burkes R, Wollner M, Tsao MS, Shepherd FA.

Clin Lung Cancer. 2017 Mar;18(2):156-161. doi: 10.1016/j.cllc.2016.10.007. Epub 2016 Oct 26.


Evaluation of a New Ultrasound Thoracoscope for Localization of Lung Nodules in Ex Vivo Human Lungs.

Ujiie H, Kato T, Hu HP, Hasan S, Patel P, Wada H, Lee D, Fujino K, Hwang DM, Cypel M, de Perrot M, Pierre A, Darling G, Waddell TK, Keshavjee S, Yasufuku K.

Ann Thorac Surg. 2017 Mar;103(3):926-934. doi: 10.1016/j.athoracsur.2016.08.031. Epub 2016 Oct 17.


Porphysome nanoparticles for enhanced photothermal therapy in a patient-derived orthotopic pancreas xenograft cancer model: a pilot study.

MacLaughlin CM, Ding L, Jin C, Cao P, Siddiqui I, Hwang DM, Chen J, Wilson BC, Zheng G, Hedley DW.

J Biomed Opt. 2016 Aug 1;21(8):84002. doi: 10.1117/1.JBO.21.8.084002.


Pharmacological profiles of gemigliptin (LC15-0444), a novel dipeptidyl peptidase-4 inhibitor, in vitro and in vivo.

Kim SH, Jung E, Yoon MK, Kwon OH, Hwang DM, Kim DW, Kim J, Lee SM, Yim HJ.

Eur J Pharmacol. 2016 Oct 5;788:54-64. doi: 10.1016/j.ejphar.2016.06.016. Epub 2016 Jun 11.


Tailoring nanoparticle designs to target cancer based on tumor pathophysiology.

Sykes EA, Dai Q, Sarsons CD, Chen J, Rocheleau JV, Hwang DM, Zheng G, Cramb DT, Rinker KD, Chan WC.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1142-51. doi: 10.1073/pnas.1521265113. Epub 2016 Feb 16.


Halofuginone treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model.

Oishi H, Martinu T, Sato M, Matsuda Y, Hirayama S, Juvet SC, Guan Z, Saito T, Cypel M, Hwang DM, Keller TL, Whitman MR, Liu M, Keshavjee S.

J Heart Lung Transplant. 2016 Apr;35(4):518-27. doi: 10.1016/j.healun.2015.12.003. Epub 2015 Dec 10.


Ex Vivo Perfusion Treatment of Infection in Human Donor Lungs.

Nakajima D, Cypel M, Bonato R, Machuca TN, Iskender I, Hashimoto K, Linacre V, Chen M, Coutinho R, Azad S, Martinu T, Waddell TK, Hwang DM, Husain S, Liu M, Keshavjee S.

Am J Transplant. 2016 Apr;16(4):1229-37. doi: 10.1111/ajt.13562. Epub 2016 Jan 5.


Global Analysis of the Fungal Microbiome in Cystic Fibrosis Patients Reveals Loss of Function of the Transcriptional Repressor Nrg1 as a Mechanism of Pathogen Adaptation.

Kim SH, Clark ST, Surendra A, Copeland JK, Wang PW, Ammar R, Collins C, Tullis DE, Nislow C, Hwang DM, Guttman DS, Cowen LE.

PLoS Pathog. 2015 Nov 20;11(11):e1005308. doi: 10.1371/journal.ppat.1005308. eCollection 2015 Nov.


Chronic infection phenotypes of Pseudomonas aeruginosa are associated with failure of eradication in children with cystic fibrosis.

Vidya P, Smith L, Beaudoin T, Yau YC, Clark S, Coburn B, Guttman DS, Hwang DM, Waters V.

Eur J Clin Microbiol Infect Dis. 2016 Jan;35(1):67-74.


Low-dose computed tomography volumetry for subtyping chronic lung allograft dysfunction.

Saito T, Horie M, Sato M, Nakajima D, Shoushtarizadeh H, Binnie M, Azad S, Hwang DM, Machuca TN, Waddell TK, Singer LG, Cypel M, Liu M, Paul NS, Keshavjee S.

J Heart Lung Transplant. 2016 Jan;35(1):59-66. doi: 10.1016/j.healun.2015.07.005. Epub 2015 Aug 13.


Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung.

Diaz Caballero J, Clark ST, Coburn B, Zhang Y, Wang PW, Donaldson SL, Tullis DE, Yau YC, Waters VJ, Hwang DM, Guttman DS.

MBio. 2015 Sep 1;6(5):e00981-15. doi: 10.1128/mBio.00981-15.


Phenotypic diversity within a Pseudomonas aeruginosa population infecting an adult with cystic fibrosis.

Clark ST, Diaz Caballero J, Cheang M, Coburn B, Wang PW, Donaldson SL, Zhang Y, Liu M, Keshavjee S, Yau YC, Waters VJ, Elizabeth Tullis D, Guttman DS, Hwang DM.

Sci Rep. 2015 Jun 5;5:10932. doi: 10.1038/srep10932.


Lung microbiota across age and disease stage in cystic fibrosis.

Coburn B, Wang PW, Diaz Caballero J, Clark ST, Brahma V, Donaldson S, Zhang Y, Surendra A, Gong Y, Elizabeth Tullis D, Yau YC, Waters VJ, Hwang DM, Guttman DS.

Sci Rep. 2015 May 14;5:10241. doi: 10.1038/srep10241.


Canadian anaplastic lymphoma kinase study: a model for multicenter standardization and optimization of ALK testing in lung cancer.

Cutz JC, Craddock KJ, Torlakovic E, Brandao G, Carter RF, Bigras G, Deschenes J, Izevbaye I, Xu Z, Greer W, Yatabe Y, Ionescu D, Karsan A, Jung S, Fraser RS, Blumenkrantz M, Lavoie J, Fortin F, Bojarski A, Côté GB, van den Berghe JA, Rashid-Kolvear F, Trotter M, Sekhon HS, Albadine R, Tran-Thanh D, Gorska I, Knoll JH, Xu J, Blencowe B, Iafrate AJ, Hwang DM, Pintilie M, Gaspo R, Couture C, Tsao MS.

J Thorac Oncol. 2014 Sep;9(9):1255-63. doi: 10.1097/JTO.0000000000000239.


Resource utilization and costs during the initial years of lung cancer screening with computed tomography in Canada.

Cressman S, Lam S, Tammemagi MC, Evans WK, Leighl NB, Regier DA, Bolbocean C, Shepherd FA, Tsao MS, Manos D, Liu G, Atkar-Khattra S, Cromwell I, Johnston MR, Mayo JR, McWilliams A, Couture C, English JC, Goffin J, Hwang DM, Puksa S, Roberts H, Tremblay A, MacEachern P, Burrowes P, Bhatia R, Finley RJ, Goss GD, Nicholas G, Seely JM, Sekhon HS, Yee J, Amjadi K, Cutz JC, Ionescu DN, Yasufuku K, Martel S, Soghrati K, Sin DD, Tan WC, Urbanski S, Xu Z, Peacock SJ; Pan-Canadian Early Detection of Lung Cancer Study Team.

J Thorac Oncol. 2014 Oct;9(10):1449-58. doi: 10.1097/JTO.0000000000000283.


Sample features associated with success rates in population-based EGFR mutation testing.

Shiau CJ, Babwah JP, da Cunha Santos G, Sykes JR, Boerner SL, Geddie WR, Leighl NB, Wei C, Kamel-Reid S, Hwang DM, Tsao MS.

J Thorac Oncol. 2014 Jul;9(7):947-56. doi: 10.1097/JTO.0000000000000196.


Nanoparticle exposure in animals can be visualized in the skin and analysed via skin biopsy.

Sykes EA, Dai Q, Tsoi KM, Hwang DM, Chan WC.

Nat Commun. 2014 May 13;5:3796. doi: 10.1038/ncomms4796.


Orthotopic lung cancer murine model by nonoperative transbronchial approach.

Nakajima T, Anayama T, Matsuda Y, Hwang DM, McVeigh PZ, Wilson BC, Zheng G, Keshavjee S, Yasufuku K.

Ann Thorac Surg. 2014 May;97(5):1771-5. doi: 10.1016/j.athoracsur.2014.01.048.


A feasibility study evaluating Surgery for Mesothelioma After Radiation Therapy: the "SMART" approach for resectable malignant pleural mesothelioma.

Cho BC, Feld R, Leighl N, Opitz I, Anraku M, Tsao MS, Hwang DM, Hope A, de Perrot M.

J Thorac Oncol. 2014 Mar;9(3):397-402. doi: 10.1097/JTO.0000000000000078.


In compressed lung tissue microscopic sections of adenocarcinoma in situ may mimic papillary adenocarcinoma.

Thunnissen E, Beliën JA, Kerr KM, Chung JH, Flieder DB, Noguchi M, Yatabe Y, Hwang DM, Lely RJ, Hartemink KJ, Meijer-Jorna LB, Tsao MS.

Arch Pathol Lab Med. 2013 Dec;137(12):1792-7. doi: 10.5858/arpa.2012-0613-SA.


Injury-specific ex vivo treatment of the donor lung: pulmonary thrombolysis followed by successful lung transplantation.

Machuca TN, Hsin MK, Ott HC, Chen M, Hwang DM, Cypel M, Waddell TK, Keshavjee S.

Am J Respir Crit Care Med. 2013 Oct 1;188(7):878-80. doi: 10.1164/rccm.201302-0368LE. No abstract available.


Data set for reporting of lung carcinomas: recommendations from International Collaboration on Cancer Reporting.

Jones KD, Churg A, Henderson DW, Hwang DM, Ma Wyatt J, Nicholson AG, Rice AJ, Washington MK, Butnor KJ.

Arch Pathol Lab Med. 2013 Aug;137(8):1054-62. doi: 10.5858/arpa.2012-0511-OA. Review.


Lentivirus IL-10 gene therapy down-regulates IL-17 and attenuates mouse orthotopic lung allograft rejection.

Hirayama S, Sato M, Loisel-Meyer S, Matsuda Y, Oishi H, Guan Z, Saito T, Yeung J, Cypel M, Hwang DM, Medin JA, Liu M, Keshavjee S.

Am J Transplant. 2013 Jun;13(6):1586-93. doi: 10.1111/ajt.12230. Epub 2013 Apr 19.


Time-dependent changes in the risk of death in pure bronchiolitis obliterans syndrome (BOS).

Sato M, Ohmori-Matsuda K, Saito T, Matsuda Y, Hwang DM, Waddell TK, Singer LG, Keshavjee S.

J Heart Lung Transplant. 2013 May;32(5):484-91. doi: 10.1016/j.healun.2013.01.1054. Epub 2013 Feb 22.


Progression pattern of restrictive allograft syndrome after lung transplantation.

Sato M, Hwang DM, Waddell TK, Singer LG, Keshavjee S.

J Heart Lung Transplant. 2013 Jan;32(1):23-30. doi: 10.1016/j.healun.2012.09.026. Erratum in: J Heart Lung Transplant. 2013 Jun;32(6):664-6.


Analysis of the cystic fibrosis lung microbiota via serial Illumina sequencing of bacterial 16S rRNA hypervariable regions.

Maughan H, Wang PW, Diaz Caballero J, Fung P, Gong Y, Donaldson SL, Yuan L, Keshavjee S, Zhang Y, Yau YC, Waters VJ, Tullis DE, Hwang DM, Guttman DS.

PLoS One. 2012;7(10):e45791. doi: 10.1371/journal.pone.0045791. Epub 2012 Oct 2.

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