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A novel model of persistent retinal neovascularization for the development of sustained anti-VEGF therapies.

Li Y, Busoy JM, Zaman BAA, Tan QSW, Tan GSW, Barathi VA, Cheung N, Wei JJ, Hunziker W, Hong W, Wong TY, Cheung CMG.

Exp Eye Res. 2018 Sep;174:98-106. doi: 10.1016/j.exer.2018.05.027. Epub 2018 May 28.


Effects of the differential expression of ZO-1 and ZO-2 on podocyte structure and function.

Itoh M, Nakadate K, Matsusaka T, Hunziker W, Sugimoto H.

Genes Cells. 2018 Jul;23(7):546-556. doi: 10.1111/gtc.12598. Epub 2018 May 29.


Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function.

Lee MC, Shei W, Chan AS, Chua BT, Goh SR, Chong YF, Hilmy MH, Nongpiur ME, Baskaran M, Khor CC, Aung T, Hunziker W, Vithana EN.

Hum Mol Genet. 2017 Oct 15;26(20):4011-4027. doi: 10.1093/hmg/ddx292.


Juxtanodin in retinal pigment epithelial cells: Expression and biological activities in regulating cell morphology and actin cytoskeleton organization.

Liang F, Hwang JH, Tang NW, Hunziker W.

J Comp Neurol. 2018 Feb 1;526(2):205-215. doi: 10.1002/cne.24301. Epub 2017 Aug 30.


Directed Differentiation of Human Embryonic Stem Cells to Neural Crest Stem Cells, Functional Peripheral Neurons, and Corneal Keratocytes.

Zhu Q, Li M, Yan C, Lu Q, Wei S, Gao R, Yu M, Zou Y, Sriram G, Tong HJ, Hunziker W, Seneviratne CJ, Gong Z, Olsen BR, Cao T.

Biotechnol J. 2017 Dec;12(12). doi: 10.1002/biot.201700067. Epub 2017 Aug 22.


Immobilization Strategies for Functional Complement Convertase Assembly at Lipid Membrane Interfaces.

Yorulmaz Avsar S, Jackman JA, Kim MC, Yoon BK, Hunziker W, Cho NJ.

Langmuir. 2017 Jul 25;33(29):7332-7342. doi: 10.1021/acs.langmuir.7b01465. Epub 2017 Jul 17.


Immature Midbrain Dopaminergic Neurons Derived from Floor-Plate Method Improve Cell Transplantation Therapy Efficacy for Parkinson's Disease.

Qiu L, Liao MC, Chen AK, Wei S, Xie S, Reuveny S, Zhou ZD, Hunziker W, Tan EK, Oh SKW, Zeng L.

Stem Cells Transl Med. 2017 Sep;6(9):1803-1814. doi: 10.1002/sctm.16-0470. Epub 2017 Jun 26.


Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.

Lu H, Galeano MCR, Ott E, Kaeslin G, Kausalya PJ, Kramer C, Ortiz-Brüchle N, Hilger N, Metzis V, Hiersche M, Tay SY, Tunningley R, Vij S, Courtney AD, Whittle B, Wühl E, Vester U, Hartleben B, Neuber S, Frank V, Little MH, Epting D, Papathanasiou P, Perkins AC, Wright GD, Hunziker W, Gee HY, Otto EA, Zerres K, Hildebrandt F, Roy S, Wicking C, Bergmann C.

Nat Genet. 2017 Jul;49(7):1025-1034. doi: 10.1038/ng.3871. Epub 2017 May 22.


Zonula occludens-1/NF-κB/CXCL8: a new regulatory axis for tumor angiogenesis.

Lesage J, Suarez-Carmona M, Neyrinck-Leglantier D, Grelet S, Blacher S, Hunziker W, Birembaut P, Noël A, Nawrocki-Raby B, Gilles C, Polette M.

FASEB J. 2017 Apr;31(4):1678-1688. doi: 10.1096/fj.201600890R. Epub 2017 Jan 5.


Influence of membrane surface charge on adsorption of complement proteins onto supported lipid bilayers.

Yorulmaz S, Jackman JA, Hunziker W, Cho NJ.

Colloids Surf B Biointerfaces. 2016 Dec 1;148:270-277. doi: 10.1016/j.colsurfb.2016.08.036. Epub 2016 Aug 22.


Characterization of Fatty Acid Binding Protein 7 (FABP7) in the Murine Retina.

Su X, Tan QS, Parikh BH, Tan A, Mehta MN, Sia Wey Y, Tun SB, Li LJ, Han XY, Wong TY, Hunziker W, Luu CD, Owada Y, Barathi VA, Zhang SS, Chaurasia SS.

Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3397-408. doi: 10.1167/iovs.15-18542.


Tight Junction Protein 1 Modulates Proteasome Capacity and Proteasome Inhibitor Sensitivity in Multiple Myeloma via EGFR/JAK1/STAT3 Signaling.

Zhang XD, Baladandayuthapani V, Lin H, Mulligan G, Li B, Esseltine DW, Qi L, Xu J, Hunziker W, Barlogie B, Usmani SZ, Zhang Q, Crowley J, Hoering A, Shah JJ, Weber DM, Manasanch EE, Thomas SK, Li BZ, Wang HH, Zhang J, Kuiatse I, Tang JL, Wang H, He J, Yang J, Milan E, Cenci S, Ma WC, Wang ZQ, Davis RE, Yang L, Orlowski RZ.

Cancer Cell. 2016 May 9;29(5):639-652. doi: 10.1016/j.ccell.2016.03.026. Epub 2016 Apr 28.


Supported Lipid Bilayer Platform To Test Inhibitors of the Membrane Attack Complex: Insights into Biomacromolecular Assembly and Regulation.

Yorulmaz S, Jackman JA, Hunziker W, Cho NJ.

Biomacromolecules. 2015 Nov 9;16(11):3594-602. doi: 10.1021/acs.biomac.5b01060. Epub 2015 Oct 15.


Nanoscopic leg irons: harvesting of polymer-stabilized membrane proteins with antibody-functionalized silica nanoparticles.

Zapf T, Zafiu C, Zaba C, Tan CW, Hunziker W, Sinner EK.

Biomater Sci. 2015 Sep;3(9):1279-83. doi: 10.1039/c5bm00133a.


Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity.

Yao F, Kausalya JP, Sia YY, Teo AS, Lee WH, Ong AG, Zhang Z, Tan JH, Li G, Bertrand D, Liu X, Poh HM, Guan P, Zhu F, Pathiraja TN, Ariyaratne PN, Rao J, Woo XY, Cai S, Mulawadi FH, Poh WT, Veeravalli L, Chan CS, Lim SS, Leong ST, Neo SC, Choi PS, Chew EG, Nagarajan N, Jacques PÉ, So JB, Ruan X, Yeoh KG, Tan P, Sung WK, Hunziker W, Ruan Y, Hillmer AM.

Cell Rep. 2015 Jul 14;12(2):272-85. doi: 10.1016/j.celrep.2015.06.020. Epub 2015 Jul 2.


Familial hypomagnesemia with hypercalciuria and nephrocalcinosis: variable phenotypic expression in three affected sisters from Mexican ancestry.

Arteaga ME, Hunziker W, Teo AS, Hillmer AM, Mutchinick OM.

Ren Fail. 2015 Feb;37(1):180-3. doi: 10.3109/0886022X.2014.977141. Epub 2014 Nov 4.


The structural and functional organization of the podocyte filtration slits is regulated by Tjp1/ZO-1.

Itoh M, Nakadate K, Horibata Y, Matsusaka T, Xu J, Hunziker W, Sugimoto H.

PLoS One. 2014 Sep 3;9(9):e106621. doi: 10.1371/journal.pone.0106621. eCollection 2014.


Myotonia congenita-associated mutations in chloride channel-1 affect zebrafish body wave swimming kinematics.

Cheng W, Tian J, Burgunder JM, Hunziker W, Eng HL.

PLoS One. 2014 Aug 1;9(8):e103445. doi: 10.1371/journal.pone.0103445. eCollection 2014.


ZO-1 and ZO-2 are required for extra-embryonic endoderm integrity, primitive ectoderm survival and normal cavitation in embryoid bodies derived from mouse embryonic stem cells.

Phua DC, Xu J, Ali SM, Boey A, Gounko NV, Hunziker W.

PLoS One. 2014 Jun 6;9(6):e99532. doi: 10.1371/journal.pone.0099532. eCollection 2014.


Expression of the primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 in endothelial and epithelial cell junctions in the eye.

Lee MC, Chan AS, Goh SR, Hilmy MH, Nongpiur ME, Hong W, Aung T, Hunziker W, Vithana EN.

Invest Ophthalmol Vis Sci. 2014 May 6;55(6):3833-41. doi: 10.1167/iovs.14-14145.


BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis.

Béguin P, Nagashima K, Mahalakshmi RN, Vigot R, Matsunaga A, Miki T, Ng MY, Ng YJ, Lim CH, Tay HS, Hwang LA, Firsov D, Tang BL, Inagaki N, Mori Y, Seino S, Launey T, Hunziker W.

J Cell Biol. 2014 Apr 28;205(2):233-49. doi: 10.1083/jcb.201304101. Epub 2014 Apr 21.


Regulation of membrane-type 1 matrix metalloproteinase expression by zonula occludens-2 in human lung cancer cells.

Luczka E, Syne L, Nawrocki-Raby B, Kileztky C, Hunziker W, Birembaut P, Gilles C, Polette M.

Clin Exp Metastasis. 2013 Oct;30(7):833-43. doi: 10.1007/s10585-013-9583-8. Epub 2013 Apr 21.


ZO-1 regulates Erk, Smad1/5/8, Smad2, and RhoA activities to modulate self-renewal and differentiation of mouse embryonic stem cells.

Xu J, Lim SB, Ng MY, Ali SM, Kausalya JP, Limviphuvadh V, Maurer-Stroh S, Hunziker W.

Stem Cells. 2012 Sep;30(9):1885-900. doi: 10.1002/stem.1172.


A novel microfluidics-based method for probing weak protein-protein interactions.

Tan DC, Wijaya IP, Andreasson-Ochsner M, Vasina EN, Nallani M, Hunziker W, Sinner EK.

Lab Chip. 2012 Aug 7;12(15):2726-35. doi: 10.1039/c2lc40228a. Epub 2012 May 29.


Identification of new interacting partners of the shuttling protein ubinuclein (Ubn-1).

Lupo J, Conti A, Sueur C, Coly PA, Couté Y, Hunziker W, Burmeister WP, Germi R, Manet E, Gruffat H, Morand P, Boyer V.

Exp Cell Res. 2012 Mar 10;318(5):509-20. doi: 10.1016/j.yexcr.2011.12.020. Epub 2012 Jan 4.


Proteopolymersomes: in vitro production of a membrane protein in polymersome membranes.

Nallani M, Andreasson-Ochsner M, Tan CW, Sinner EK, Wisantoso Y, Geifman-Shochat S, Hunziker W.

Biointerphases. 2011 Dec;6(4):153-7. doi: 10.1116/1.3644384.


Regulation of CXCL8/IL-8 expression by zonula occludens-1 in human breast cancer cells.

Brysse A, Mestdagt M, Polette M, Luczka E, Hunziker W, Noël A, Birembaut P, Foidart JM, Gilles C.

Mol Cancer Res. 2012 Jan;10(1):121-32. doi: 10.1158/1541-7786.MCR-11-0180. Epub 2011 Nov 7.


Methods to analyze subcellular localization and intracellular trafficking of Claudin-16.

Kausalya PJ, Hunziker W.

Methods Mol Biol. 2011;762:129-46. doi: 10.1007/978-1-61779-185-7_10.


Biophysical methods to probe claudin-mediated adhesion at the cellular and molecular level.

Vedula SR, Lim TS, Hunziker W, Lim CT.

Methods Mol Biol. 2011;762:77-89. doi: 10.1007/978-1-61779-185-7_6.


The Hippo pathway regulates Wnt/beta-catenin signaling.

Varelas X, Miller BW, Sopko R, Song S, Gregorieff A, Fellouse FA, Sakuma R, Pawson T, Hunziker W, McNeill H, Wrana JL, Attisano L.

Dev Cell. 2010 Apr 20;18(4):579-91. doi: 10.1016/j.devcel.2010.03.007.


Zona occludens-2 is critical for blood-testis barrier integrity and male fertility.

Xu J, Anuar F, Ali SM, Ng MY, Phua DC, Hunziker W.

Mol Biol Cell. 2009 Oct;20(20):4268-77. doi: 10.1091/mbc.E08-12-1236. Epub 2009 Aug 19.


Claudin function in the thick ascending limb of Henle's loop.

Günzel D, Haisch L, Pfaffenbach S, Krug SM, Milatz S, Amasheh S, Hunziker W, Müller D.

Ann N Y Acad Sci. 2009 May;1165:152-62. doi: 10.1111/j.1749-6632.2009.04051.x.


Vertebrate animal models unravel physiological roles for zonula occludens tight junction adaptor proteins.

Hunziker W, Kiener TK, Xu J.

Ann N Y Acad Sci. 2009 May;1165:28-33. doi: 10.1111/j.1749-6632.2009.04033.x.


Claudin-16 affects transcellular Cl- secretion in MDCK cells.

Günzel D, Amasheh S, Pfaffenbach S, Richter JF, Kausalya PJ, Hunziker W, Fromm M.

J Physiol. 2009 Aug 1;587(Pt 15):3777-93. doi: 10.1113/jphysiol.2009.173401. Epub 2009 Jun 15.


Vimentin regulates scribble activity by protecting it from proteasomal degradation.

Phua DC, Humbert PO, Hunziker W.

Mol Biol Cell. 2009 Jun;20(12):2841-55. doi: 10.1091/mbc.E08-02-0199. Epub 2009 Apr 22.


Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function.

Günzel D, Stuiver M, Kausalya PJ, Haisch L, Krug SM, Rosenthal R, Meij IC, Hunziker W, Fromm M, Müller D.

J Cell Sci. 2009 May 15;122(Pt 10):1507-17. doi: 10.1242/jcs.040113. Epub 2009 Apr 21.


Mechanistic insights into the physiological functions of cell adhesion proteins using single molecule force spectroscopy.

Vedula SR, Lim TS, Hunziker W, Lim CT.

Mol Cell Biomech. 2008 Sep;5(3):169-82. Review.


Kinetics of adhesion mediated by extracellular loops of claudin-2 as revealed by single-molecule force spectroscopy.

Lim TS, Vedula SR, Hunziker W, Lim CT.

J Mol Biol. 2008 Sep 5;381(3):681-91. doi: 10.1016/j.jmb.2008.06.009. Epub 2008 Jun 10.


Probing effects of pH change on dynamic response of Claudin-2 mediated adhesion using single molecule force spectroscopy.

Lim TS, Vedula SR, Hui S, Kausalya PJ, Hunziker W, Lim CT.

Exp Cell Res. 2008 Aug 15;314(14):2643-51. doi: 10.1016/j.yexcr.2008.05.015. Epub 2008 Jun 3.


Novel chloride channel mutations leading to mild myotonia among Chinese.

Burgunder JM, Huifang S, Beguin P, Baur R, Eng CS, Seet RC, Lim EC, Ong BK, Hunziker W, Sigel E.

Neuromuscul Disord. 2008 Aug;18(8):633-40. doi: 10.1016/j.nmd.2008.05.007. Epub 2008 Jun 24.


A comparative molecular force spectroscopy study of homophilic JAM-A interactions and JAM-A interactions with reovirus attachment protein sigma1.

Vedula SR, Lim TS, Kirchner E, Guglielmi KM, Dermody TS, Stehle T, Hunziker W, Lim CT.

J Mol Recognit. 2008 Jul-Aug;21(4):210-6. doi: 10.1002/jmr.886.


A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells.

Chan SW, Lim CJ, Guo K, Ng CP, Lee I, Hunziker W, Zeng Q, Hong W.

Cancer Res. 2008 Apr 15;68(8):2592-8. doi: 10.1158/0008-5472.CAN-07-2696.


Tjp3/zo-3 is critical for epidermal barrier function in zebrafish embryos.

Kiener TK, Selptsova-Friedrich I, Hunziker W.

Dev Biol. 2008 Apr 1;316(1):36-49. doi: 10.1016/j.ydbio.2007.12.047. Epub 2008 Jan 26.


Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development.

Xu J, Kausalya PJ, Phua DC, Ali SM, Hossain Z, Hunziker W.

Mol Cell Biol. 2008 Mar;28(5):1669-78. doi: 10.1128/MCB.00891-07. Epub 2008 Jan 2.


Single-molecular-level study of claudin-1-mediated adhesion.

Lim TS, Vedula SR, Kausalya PJ, Hunziker W, Lim CT.

Langmuir. 2008 Jan 15;24(2):490-5. Epub 2007 Dec 21.


All-optical sampling with a monolithically integrated Mach-Zehnder interferometer gate.

Fischer S, Bitter M, Caraccia M, Dülk M, Gamper E, Vogt W, Gini E, Melchior H, Hunziker W.

Opt Lett. 2001 May 1;26(9):626-8.


Snapin interacts with the Exo70 subunit of the exocyst and modulates GLUT4 trafficking.

Bao Y, Lopez JA, James DE, Hunziker W.

J Biol Chem. 2008 Jan 4;283(1):324-31. Epub 2007 Oct 18.


CMO1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice.

Hessel S, Eichinger A, Isken A, Amengual J, Hunzelmann S, Hoeller U, Elste V, Hunziker W, Goralczyk R, Oberhauser V, von Lintig J, Wyss A.

J Biol Chem. 2007 Nov 16;282(46):33553-61. Epub 2007 Sep 12.


Molecular force spectroscopy of homophilic nectin-1 interactions.

Vedula SR, Lim TS, Hui S, Kausalya PJ, Lane EB, Rajagopal G, Hunziker W, Lim CT.

Biochem Biophys Res Commun. 2007 Nov 3;362(4):886-92. Epub 2007 Aug 28.


Transcriptomics does not show adverse effects of beta-carotene in A/J mice exposed to smoke for 2 weeks.

Kuntz E, Borlak J, Riss G, Aebischer CP, Bachmann H, Seifert N, Hunziker PB, Sölle D, Hunziker W, Goralczyk R, Wertz K.

Arch Biochem Biophys. 2007 Sep 15;465(2):336-46. Epub 2007 Jul 18.


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