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Unraveling the identity of FoxP3+ regulatory T cells in Granulomatosis with Polyangiitis patients.

Reijnders TDY, Stegeman CA, Huitema MG, Rutgers A, Heeringa P, Abdulahad WH.

Sci Rep. 2019 Jun 4;9(1):8273. doi: 10.1038/s41598-019-44636-y.


Clinical outcome in anti-neutrophil cytoplasmic antibody-associated vasculitis and gene variants of 11β-hydroxysteroid dehydrogenase type 1 and the glucocorticoid receptor.

Hessels AC, Tuin J, Sanders JSF, Huitema MG, van Rossum EFC, Koper JW, van Beek AP, Stegeman CA, Rutgers A.

Rheumatology (Oxford). 2018 Nov 14. doi: 10.1093/rheumatology/key319. [Epub ahead of print]


B Cell Depletion Therapy Normalizes Circulating Follicular Th Cells in Primary Sjögren Syndrome.

Verstappen GM, Kroese FG, Meiners PM, Corneth OB, Huitema MG, Haacke EA, van der Vegt B, Arends S, Vissink A, Bootsma H, Abdulahad WH.

J Rheumatol. 2017 Jan;44(1):49-58. doi: 10.3899/jrheum.160313. Epub 2016 Nov 15.


Intermediate monocytes in ANCA vasculitis: increased surface expression of ANCA autoantigens and IL-1β secretion in response to anti-MPO antibodies.

O'Brien EC, Abdulahad WH, Rutgers A, Huitema MG, O'Reilly VP, Coughlan AM, Harrington M, Heeringa P, Little MA, Hickey FB.

Sci Rep. 2015 Jul 7;5:11888. doi: 10.1038/srep11888.


Expression of Lectin-Like Transcript 1, the Ligand for CD161, in Rheumatoid Arthritis.

Chalan P, Bijzet J, Huitema MG, Kroesen BJ, Brouwer E, Boots AM.

PLoS One. 2015 Jul 6;10(7):e0132436. doi: 10.1371/journal.pone.0132436. eCollection 2015.


Differential expression of granulopoiesis related genes in neutrophil subsets distinguished by membrane expression of CD177.

Hu N, Mora-Jensen H, Theilgaard-Mönch K, Doornbos-van der Meer B, Huitema MG, Stegeman CA, Heeringa P, Kallenberg CG, Westra J.

PLoS One. 2014 Jun 13;9(6):e99671. doi: 10.1371/journal.pone.0099671. eCollection 2014.


Disturbed B cell homeostasis in newly diagnosed giant cell arteritis and polymyalgia rheumatica.

van der Geest KS, Abdulahad WH, Chalan P, Rutgers A, Horst G, Huitema MG, Roffel MP, Roozendaal C, Kluin PM, Bos NA, Boots AM, Brouwer E.

Arthritis Rheumatol. 2014 Jul;66(7):1927-38. doi: 10.1002/art.38625.


Circulating CD4+CD161+ T lymphocytes are increased in seropositive arthralgia patients but decreased in patients with newly diagnosed rheumatoid arthritis.

Chalan P, Kroesen BJ, van der Geest KS, Huitema MG, Abdulahad WH, Bijzet J, Brouwer E, Boots AM.

PLoS One. 2013 Nov 1;8(11):e79370. doi: 10.1371/journal.pone.0079370. eCollection 2013.


Predominantly proinflammatory cytokines decrease after B cell depletion therapy in patients with primary Sjogren's syndrome.

Pollard RP, Abdulahad WH, Bootsma H, Meiners PM, Spijkervet FK, Huitema MG, Burgerhof JG, Vissink A, Kroese FG.

Ann Rheum Dis. 2013 Dec;72(12):2048-50. doi: 10.1136/annrheumdis-2013-203447. Epub 2013 Jul 17. No abstract available.


Increased frequency of circulating IL-21 producing Th-cells in patients with granulomatosis with polyangiitis (GPA).

Abdulahad WH, Lepse N, Stegeman CA, Huitema MG, Doornbos-van der Meer B, Tadema H, Rutgers A, Limburg PC, Kallenberg CG, Heeringa P.

Arthritis Res Ther. 2013;15(3):R70.


Serum levels of BAFF, but not APRIL, are increased after rituximab treatment in patients with primary Sjogren's syndrome: data from a placebo-controlled clinical trial.

Pollard RP, Abdulahad WH, Vissink A, Hamza N, Burgerhof JG, Meijer JM, Visser A, Huitema MG, Spijkervet FK, Kallenberg CG, Bootsma H, Kroese FG.

Ann Rheum Dis. 2013 Jan;72(1):146-8. doi: 10.1136/annrheumdis-2012-202071. Epub 2012 Jul 31. No abstract available.


CCR5Δ32 genotype leads to a Th2 type directed immune response in ESRD patients.

Muntinghe FL, Abdulahad WH, Huitema MG, Damman J, Seelen MA, Lems SP, Hepkema BG, Navis G, Westra J.

PLoS One. 2012;7(2):e31257. doi: 10.1371/journal.pone.0031257. Epub 2012 Feb 13.


Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration.

Hu N, Westra J, Rutgers A, Doornbos-Van der Meer B, Huitema MG, Stegeman CA, Abdulahad WH, Satchell SC, Mathieson PW, Heeringa P, Kallenberg CG.

Arthritis Res Ther. 2011;13(6):R201. doi: 10.1186/ar3534. Epub 2011 Dec 8.


Fluorescent cell barcoding as a tool to assess the age-related development of intracellular cytokine production in small amounts of blood from infants.

Stam J, Abdulahad W, Huitema MG, Roozendaal C, Limburg PC, van Stuijvenberg M, Schölvinck EH.

PLoS One. 2011;6(10):e25690. doi: 10.1371/journal.pone.0025690. Epub 2011 Oct 17.


Disturbed Th1, Th2, Th17 and T(reg) balance in patients with systemic lupus erythematosus.

Dolff S, Bijl M, Huitema MG, Limburg PC, Kallenberg CG, Abdulahad WH.

Clin Immunol. 2011 Nov;141(2):197-204. doi: 10.1016/j.clim.2011.08.005. Epub 2011 Aug 16.


Cell-mediated immune responses to influenza vaccination in Wegener's granulomatosis.

Holvast A, de Haan A, van Assen S, Stegeman CA, Huitema MG, Huckriede A, Benne CA, Westra J, Palache A, Wilschut J, Kallenberg CG, Bijl M.

Ann Rheum Dis. 2010 May;69(5):924-7. doi: 10.1136/ard.2009.112813. Epub 2009 Jul 12.


Autoantibodies against glomerular endothelial cells in anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis.

Hu N, Westra J, Huitema MG, Stegeman CA, Limburg PC, Kallenberg CG.

Nephrology (Carlton). 2009 Feb;14(1):11-5. doi: 10.1111/j.1440-1797.2008.01068.x. Epub 2008 Feb 2.


Systemic and local interferon-gamma production following Mycobacterium ulcerans infection.

Schipper HS, Rutgers B, Huitema MG, Etuaful SN, Westenbrink BD, Limburg PC, Timens W, van der Werf TS.

Clin Exp Immunol. 2007 Dec;150(3):451-9. Epub 2007 Sep 27.


Urinary matrix metalloproteinases reflect renal damage in anti-neutrophil cytoplasm autoantibody-associated vasculitis.

Sanders JS, Huitema MG, Hanemaaijer R, van Goor H, Kallenberg CG, Stegeman CA.

Am J Physiol Renal Physiol. 2007 Dec;293(6):F1927-34. Epub 2007 Sep 26.


Rats and mice immunised with chimeric human/mouse proteinase 3 produce autoantibodies to mouse Pr3 and rat granulocytes.

van der Geld YM, Hellmark T, Selga D, Heeringa P, Huitema MG, Limburg PC, Kallenberg CG.

Ann Rheum Dis. 2007 Dec;66(12):1679-82. Epub 2007 Jul 20.


Standardised assessment of membrane proteinase 3 expression. Analysis in ANCA-associated vasculitis and controls.

van Rossum AP, Huitema MG, Stegeman CA, Bijl M, de Leeuw K, Van Leeuwen MA, Limburg PC, Kallenberg CG.

Ann Rheum Dis. 2007 Oct;66(10):1350-5. Epub 2007 Apr 19. Erratum in: Ann Rheum Dis. 2007 Dec;66(12):1688. Ann Rheum Dis. 2007 Nov;66(11):1548.


Abundance of the long pentraxin PTX3 at sites of leukocytoclastic lesions in patients with small-vessel vasculitis.

van Rossum AP, Pas HH, Fazzini F, Huitema MG, Limburg PC, Jonkman MF, Kallenberg CG.

Arthritis Rheum. 2006 Mar;54(3):986-91.


Cytokine responses to stimulation of whole blood from patients with Buruli ulcer disease in Ghana.

Westenbrink BD, Stienstra Y, Huitema MG, Thompson WA, Klutse EO, Ampadu EO, Boezen HM, Limburg PC, van der Werf TS.

Clin Diagn Lab Immunol. 2005 Jan;12(1):125-9.


Constitutive membrane expression of proteinase 3 (PR3) and neutrophil activation by anti-PR3 antibodies.

van Rossum AP, Rarok AA, Huitema MG, Fassina G, Limburg PC, Kallenberg CG.

J Leukoc Biol. 2004 Dec;76(6):1162-70. Epub 2004 Aug 26.


Recombinant protein to analyze autoantibodies to proteinase 3 in systemic vasculitis.

Rarok AA, Huitema MG, van der Leij MJ, van der Geld YM, Berthold H, Schmitt J, Stegeman CA, Limburg PC, Kallenberg CG.

Am J Clin Pathol. 2003 Oct;120(4):586-95.


Expression of recombinant proteinase 3, the autoantigen in Wegener's granulomatosis, in insect cells.

Van der Geld YM, Smook ML, Huitema MG, Harmsen MC, Limburg PC, Kallenberg CG.

J Immunol Methods. 2002 Jun 1;264(1-2):195-205.


In vitro T lymphocyte responses to proteinase 3 (PR3) and linear peptides of PR3 in patients with Wegener's granulomatosis (WG).

van der Geld YM, Huitema MG, Franssen CF, van der Zee R, Limburg PC, Kallenberg CG.

Clin Exp Immunol. 2000 Dec;122(3):504-13.


Antimyeloperoxidase-associated lung disease. An experimental model.

Foucher P, Heeringa P, Petersen AH, Huitema MG, Brouwer E, Tervaert JW, Prop J, Camus P, Weening JJ, Kallenberg CG.

Am J Respir Crit Care Med. 1999 Sep;160(3):987-94.


In vitro neutrophil activation by antibodies to proteinase 3 and myeloperoxidase from patients with crescentic glomerulonephritis.

Franssen CF, Huitema MG, Muller Kobold AC, Oost-Kort WW, Limburg PC, Tiebosch A, Stegeman CA, Kallenberg CG, Tervaert JW.

J Am Soc Nephrol. 1999 Jul;10(7):1506-15.


Expression of iNOS, eNOS, and peroxynitrite-modified proteins in experimental anti-myeloperoxidase associated crescentic glomerulonephritis.

Heeringa P, van Goor H, Moshage H, Klok PA, Huitema MG, de Jager A, Schep AJ, Kallenberg CG.

Kidney Int. 1998 Feb;53(2):382-93.


Recombinant proteinase 3 (Wegener's antigen) expressed in Pichia pastoris is functionally active and is recognized by patient sera.

Harmsen MC, Heeringa P, van der Geld YM, Huitema MG, Klimp A, Tiran A, Kallenberg CG.

Clin Exp Immunol. 1997 Nov;110(2):257-64.


Systemic injection of products of activated neutrophils and H2O2 in myeloperoxidase-immunized rats leads to necrotizing vasculitis in the lungs and gut.

Heeringa P, Foucher P, Klok PA, Huitema MG, Tervaert JW, Weening JJ, Kallenberg CG.

Am J Pathol. 1997 Jul;151(1):131-40.


Autoantibodies to myeloperoxidase aggravate mild anti-glomerular-basement-membrane-mediated glomerular injury in the rat.

Heeringa P, Brouwer E, Klok PA, Huitema MG, van den Born J, Weening JJ, Kallenberg CG.

Am J Pathol. 1996 Nov;149(5):1695-706.


Elastase, but not proteinase 3 (PR3), induces proteinuria associated with loss of glomerular basement membrane heparan sulphate after in vivo renal perfusion in rats.

Heeringa P, Van den Born J, Brouwer E, Dolman KM, Klok PA, Huitema MG, Limburg PC, Bakker MA, Berden JH, Daha MR, Kallenberg CG.

Clin Exp Immunol. 1996 Aug;105(2):321-9.


Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus.

Spronk PE, Bootsma H, Horst G, Huitema MG, Limburg PC, Tervaert JW, Kallenberg CG.

Br J Rheumatol. 1996 Jul;35(7):625-31.


T cell reactivity to proteinase 3 and myeloperoxidase in patients with Wegener's granulomatosis (WG).

Brouwer E, Stegeman CA, Huitema MG, Limburg PC, Kallenberg CG.

Clin Exp Immunol. 1994 Dec;98(3):448-53.


Relationship between antineutrophil cytoplasmic antibody levels and disease activity in Wegener's granulomatosis: comment on the article by Kerr et al.

Tervaert JW, Stegeman CA, Huitema MG, Kallenberg CG.

Arthritis Rheum. 1994 Apr;37(4):596-7. No abstract available.


Neutrophil activation in vitro and in vivo in Wegener's granulomatosis.

Brouwer E, Huitema MG, Mulder AH, Heeringa P, van Goor H, Tervaert JW, Weening JJ, Kallenberg CG.

Kidney Int. 1994 Apr;45(4):1120-31.


Antimyeloperoxidase-associated proliferative glomerulonephritis: an animal model.

Brouwer E, Huitema MG, Klok PA, de Weerd H, Tervaert JW, Weening JJ, Kallenberg CG.

J Exp Med. 1993 Apr 1;177(4):905-14.


Serum markers of T cell activation in relapses of Wegener's granulomatosis.

Stegeman CA, Tervaert JW, Huitema MG, Kallenberg CG.

Clin Exp Immunol. 1993 Mar;91(3):415-20.


Serum markers of T-cell activation in relapses of Wegener's granulomatosis.

Stegeman CA, Tervaert JW, Huitema MG, Kallenberg CG.

Adv Exp Med Biol. 1993;336:389-92.


Induction of an humoral and cellular (auto) immune response to human and rat myeloperoxidase(MPO) in Brown-Norway(BN), Lewis and Wistar Kyoto(WKY) rat strains.

Brouwer E, Weening JJ, Klok PA, Huitema MG, Tervaert JW, Kallenberg CG.

Adv Exp Med Biol. 1993;336:139-42.


Detection of autoantibodies against myeloid lysosomal enzymes: a useful adjunct to classification of patients with biopsy-proven necrotizing arteritis.

Tervaert JW, Limburg PC, Elema JD, Huitema MG, Horst G, The TH, Kallenberg CG.

Am J Med. 1991 Jul;91(1):59-66.


Predominance of IgG1 and IgG4 subclasses of anti-neutrophil cytoplasmic autoantibodies (ANCA) in patients with Wegener's granulomatosis and clinically related disorders.

Brouwer E, Tervaert JW, Horst G, Huitema MG, van der Giessen M, Limburg PC, Kallenberg CG.

Clin Exp Immunol. 1991 Mar;83(3):379-86.

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