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Items: 1 to 50 of 107

1.

A Reverse Transfection Method for Screening of Nuclear Receptor Activators.

Küblbeck J, Honkakoski P.

Methods Mol Biol. 2019;1966:163-173. doi: 10.1007/978-1-4939-9195-2_13.

PMID:
31041746
2.

DNA elements for constitutive androstane receptor- and pregnane X receptor-mediated regulation of bovine CYP3A28 gene.

Giantin M, Küblbeck J, Zancanella V, Prantner V, Sansonetti F, Schoeniger A, Tolosi R, Guerra G, Da Ros S, Dacasto M, Honkakoski P.

PLoS One. 2019 Mar 25;14(3):e0214338. doi: 10.1371/journal.pone.0214338. eCollection 2019.

3.

Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells.

Malinen MM, Ito K, Kang HE, Honkakoski P, Brouwer KLR.

Eur J Pharm Sci. 2019 Mar 15;130:186-195. doi: 10.1016/j.ejps.2019.01.022. Epub 2019 Jan 24.

PMID:
30685239
4.

Novel in Vitro Method Reveals Drugs That Inhibit Organic Solute Transporter Alpha/Beta (OSTα/β).

Malinen MM, Kauttonen A, Beaudoin JJ, Sjöstedt N, Honkakoski P, Brouwer KLR.

Mol Pharm. 2019 Jan 7;16(1):238-246. doi: 10.1021/acs.molpharmaceut.8b00966. Epub 2018 Dec 14.

PMID:
30481467
5.

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.

Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M.

J Neuroinflammation. 2017 Nov 7;14(1):215. doi: 10.1186/s12974-017-0991-6.

6.

Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells.

Hytti M, Szabó D, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Petrovski G, Kauppinen A.

J Nutr Biochem. 2017 Apr;42:37-42. doi: 10.1016/j.jnutbio.2016.12.014. Epub 2017 Jan 9.

PMID:
28113103
7.

A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine.

Puris E, Pasanen M, Gynther M, Häkkinen MR, Pihlajamäki J, Keränen T, Honkakoski P, Raunio H, Petsalo A.

Anal Bioanal Chem. 2017 Jan;409(1):251-268. doi: 10.1007/s00216-016-9994-x. Epub 2016 Oct 12.

PMID:
27734142
8.

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models.

Toivonen S, Malinen MM, Küblbeck J, Petsalo A, Urtti A, Honkakoski P, Otonkoski T.

Tissue Eng Part A. 2016 Jul;22(13-14):971-84. doi: 10.1089/ten.TEA.2016.0127. Epub 2016 Jul 7.

PMID:
27329070
9.

Inhibition of BET bromodomains alleviates inflammation in human RPE cells.

Hytti M, Tokarz P, Määttä E, Piippo N, Korhonen E, Suuronen T, Honkakoski P, Kaarniranta K, Lahtela-Kakkonen M, Kauppinen A.

Biochem Pharmacol. 2016 Jun 15;110-111:71-9. doi: 10.1016/j.bcp.2016.04.009. Epub 2016 Apr 19.

PMID:
27106081
10.

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity.

Küblbeck J, Hakkarainen JJ, Petsalo A, Vellonen KS, Tolonen A, Reponen P, Forsberg MM, Honkakoski P.

J Pharm Sci. 2016 Feb;105(2):941-949. doi: 10.1016/S0022-3549(15)00187-2.

PMID:
26869438
11.

Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation.

Hytti M, Piippo N, Korhonen E, Honkakoski P, Kaarniranta K, Kauppinen A.

Sci Rep. 2015 Dec 1;5:17645. doi: 10.1038/srep17645.

12.

Improved assays for xenosensor activation based on reverse transfection.

Küblbeck J, Anttila T, Pulkkinen JT, Honkakoski P.

Toxicol In Vitro. 2015 Oct;29(7):1759-65. doi: 10.1016/j.tiv.2015.07.011. Epub 2015 Jul 14.

PMID:
26187274
13.

Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons.

Küblbeck J, Zancanella V, Prantner V, Molnár F, Squires EJ, Dacasto M, Honkakoski P, Giantin M.

Xenobiotica. 2016;46(3):200-10. doi: 10.3109/00498254.2015.1060374. Epub 2015 Jul 7.

PMID:
26153444
14.

Regulation of gene expression by CAR: an update.

Kobayashi K, Hashimoto M, Honkakoski P, Negishi M.

Arch Toxicol. 2015 Jul;89(7):1045-55. doi: 10.1007/s00204-015-1522-9. Epub 2015 May 16. Review.

PMID:
25975989
15.

Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells.

Hytti M, Piippo N, Salminen A, Honkakoski P, Kaarniranta K, Kauppinen A.

Exp Eye Res. 2015 Mar;132:208-15. doi: 10.1016/j.exer.2015.02.001. Epub 2015 Feb 4.

PMID:
25662315
16.

Evaluating collaborative planning methods supporting programme-based planning in natural resource management.

Vacik H, Kurttila M, Hujala T, Khadka C, Haara A, Pykäläinen J, Honkakoski P, Wolfslehner B, Tikkanen J.

J Environ Manage. 2014 Nov 1;144:304-15. doi: 10.1016/j.jenvman.2014.05.029. Epub 2014 Jun 28. Review.

PMID:
24981159
17.

Direct and rapid transcript analysis assay for CYP mRNA expression and inducibility in human primary hepatocytes.

Mattinen L, Kublbeck J, Rechardt O, Honkakoski P, Rautio J.

Drug Metab Lett. 2014;8(2):77-87.

PMID:
24910238
18.

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator.

Poutiainen PK, Huhtala T, Jääskeläinen T, Petsalo A, Küblbeck J, Kaikkonen S, Palvimo JJ, Raunio H, Närvänen A, Peräkylä M, Juvonen RO, Honkakoski P, Laatikainen R, Pulkkinen JT.

Mol Cell Endocrinol. 2014 Apr 25;387(1-2):8-18. doi: 10.1016/j.mce.2014.02.008. Epub 2014 Feb 22.

PMID:
24565895
19.

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.

Pimkaew P, Küblbeck J, Petsalo A, Jukka J, Suksamrarn A, Juvonen R, Auriola S, Piyachaturawat P, Honkakoski P.

Toxicol In Vitro. 2013 Sep;27(6):2005-12. doi: 10.1016/j.tiv.2013.07.004. Epub 2013 Jul 12.

PMID:
23850985
20.

An update on the constitutive androstane receptor (CAR).

Molnár F, Küblbeck J, Jyrkkärinne J, Prantner V, Honkakoski P.

Drug Metabol Drug Interact. 2013;28(2):79-93. doi: 10.1515/dmdi-2013-0009. Review.

PMID:
23729557
21.

Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system.

Ma L, Barker J, Zhou C, Li W, Zhang J, Lin B, Foltz G, Küblbeck J, Honkakoski P.

Biomaterials. 2012 Jun;33(17):4353-61. doi: 10.1016/j.biomaterials.2012.02.054. Epub 2012 Mar 18.

22.

Characterization of human cytochrome P450 induction by pesticides.

Abass K, Lämsä V, Reponen P, Küblbeck J, Honkakoski P, Mattila S, Pelkonen O, Hakkola J.

Toxicology. 2012 Mar 29;294(1):17-26. doi: 10.1016/j.tox.2012.01.010. Epub 2012 Jan 28.

PMID:
22310298
24.

Molecular dynamics simulations for human CAR inverse agonists.

Jyrkkärinne J, Küblbeck J, Pulkkinen J, Honkakoski P, Laatikainen R, Poso A, Laitinen T.

J Chem Inf Model. 2012 Feb 27;52(2):457-64. doi: 10.1021/ci200432k. Epub 2012 Jan 25.

PMID:
22233089
25.

New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists.

Küblbeck J, Jyrkkärinne J, Molnár F, Kuningas T, Patel J, Windshügel B, Nevalainen T, Laitinen T, Sippl W, Poso A, Honkakoski P.

Mol Pharm. 2011 Dec 5;8(6):2424-33. doi: 10.1021/mp2003658. Epub 2011 Nov 1.

PMID:
22044162
26.

Use of comprehensive screening methods to detect selective human CAR activators.

Küblbeck J, Laitinen T, Jyrkkärinne J, Rousu T, Tolonen A, Abel T, Kortelainen T, Uusitalo J, Korjamo T, Honkakoski P, Molnár F.

Biochem Pharmacol. 2011 Dec 15;82(12):1994-2007. doi: 10.1016/j.bcp.2011.08.027. Epub 2011 Sep 8.

PMID:
21924250
27.

Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor alpha and beta agonists.

Poutiainen PK, Venäläinen TA, Peräkylä M, Matilainen JM, Väisänen S, Honkakoski P, Laatikainen R, Pulkkinen JT.

Bioorg Med Chem. 2010 May 15;18(10):3437-47. doi: 10.1016/j.bmc.2010.04.007. Epub 2010 Apr 7.

PMID:
20430632
28.

Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors.

Küblbeck J, Reinisalo M, Mustonen R, Honkakoski P.

Eur J Pharm Sci. 2010 Jul 11;40(4):263-72. doi: 10.1016/j.ejps.2010.03.022. Epub 2010 Apr 8.

PMID:
20381613
29.

Monocarboxylate transport in human corneal epithelium and cell lines.

Vellonen KS, Häkli M, Merezhinskaya N, Tervo T, Honkakoski P, Urtti A.

Eur J Pharm Sci. 2010 Feb 19;39(4):241-7. doi: 10.1016/j.ejps.2009.12.006. Epub 2009 Dec 24.

PMID:
20035863
30.

Effluxing ABC transporters in human corneal epithelium.

Vellonen KS, Mannermaa E, Turner H, Häkli M, Wolosin JM, Tervo T, Honkakoski P, Urtti A.

J Pharm Sci. 2010 Feb;99(2):1087-98. doi: 10.1002/jps.21878.

31.

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship.

Jyrkkärinne J, Windshügel B, Rönkkö T, Tervo AJ, Küblbeck J, Lahtela-Kakkonen M, Sippl W, Poso A, Honkakoski P.

J Med Chem. 2008 Nov 27;51(22):7181-92. doi: 10.1021/jm800731b.

PMID:
18983136
32.

Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.

Repo S, Jyrkkärinne J, Pulkkinen JT, Laatikainen R, Honkakoski P, Johnson MS.

J Med Chem. 2008 Nov 27;51(22):7119-31. doi: 10.1021/jm800337r.

PMID:
18973326
33.

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor.

Küblbeck J, Jyrkkärinne J, Poso A, Turpeinen M, Sippl W, Honkakoski P, Windshügel B.

Biochem Pharmacol. 2008 Nov 15;76(10):1288-97. doi: 10.1016/j.bcp.2008.08.014. Epub 2008 Aug 22.

PMID:
18786510
34.

Inhibition and induction of human cytochrome P450 enzymes: current status.

Pelkonen O, Turpeinen M, Hakkola J, Honkakoski P, Hukkanen J, Raunio H.

Arch Toxicol. 2008 Oct;82(10):667-715. doi: 10.1007/s00204-008-0332-8. Epub 2008 Jul 11. Review.

PMID:
18618097
35.

Synthesis and evaluation of estrogen agonism of diaryl 4,5-dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1,3-diketones: a compound set forming a 4D molecular library.

Pulkkinen JT, Honkakoski P, Peräkylä M, Berczi I, Laatikainen R.

J Med Chem. 2008 Jun 26;51(12):3562-71. doi: 10.1021/jm8001795. Epub 2008 Jun 3.

PMID:
18517258
36.

Alginate-based microencapsulation of retinal pigment epithelial cell line for cell therapy.

Wikström J, Elomaa M, Syväjärvi H, Kuokkanen J, Yliperttula M, Honkakoski P, Urtti A.

Biomaterials. 2008 Mar;29(7):869-76. Epub 2007 Nov 28.

PMID:
18045685
37.

Microarray analysis of the global alterations in the gene expression in the placentas from cigarette-smoking mothers.

Huuskonen P, Storvik M, Reinisalo M, Honkakoski P, Rysä J, Hakkola J, Pasanen M.

Clin Pharmacol Ther. 2008 Apr;83(4):542-50. Epub 2007 Oct 27.

PMID:
17928820
38.

Polyplex-mediated gene transfer and cell cycle: effect of carrier on cellular uptake and intracellular kinetics, and significance of glycosaminoglycans.

Männistö M, Reinisalo M, Ruponen M, Honkakoski P, Tammi M, Urtti A.

J Gene Med. 2007 Jun;9(6):479-87.

PMID:
17410614
39.

Metabolic and efflux properties of Caco-2 cells stably transfected with nuclear receptors.

Korjamo T, Mönkkönen J, Uusitalo J, Turpeinen M, Pelkonen O, Honkakoski P.

Pharm Res. 2006 Sep;23(9):1991-2001. Epub 2006 Aug 9.

PMID:
16951996
40.

In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin.

Simonsson US, Lindell M, Raffalli-Mathieu F, Lannerbro A, Honkakoski P, Lang MA.

Eur J Clin Invest. 2006 Sep;36(9):647-53.

PMID:
16919048
41.
42.

Comparison of homology models and X-ray structures of the nuclear receptor CAR: assessing the structural basis of constitutive activity.

Windshügel B, Jyrkkärinne J, Vanamo J, Poso A, Honkakoski P, Sippl W.

J Mol Graph Model. 2007 Jan;25(5):644-57. Epub 2006 May 10.

PMID:
16831563
43.

Freeze-drying of cationic polymer DNA complexes enables their long-term storage and reverse transfection of post-mitotic cells.

Reinisalo M, Urtti A, Honkakoski P.

J Control Release. 2006 Jan 10;110(2):437-443. doi: 10.1016/j.jconrel.2005.10.003. Epub 2005 Nov 16.

PMID:
16297485
44.

Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines.

Korjamo T, Honkakoski P, Toppinen MR, Niva S, Reinisalo M, Palmgrén JJ, Mönkkönen J.

Eur J Pharm Sci. 2005 Nov;26(3-4):266-79.

PMID:
16111871
45.

In vitro methods in the prediction of kinetics of drugs: focus on drug metabolism.

Raunio H, Taavitsainen P, Honkakoski P, Juvonen R, Pelkonen O.

Altern Lab Anim. 2004 Oct;32(4):425-30. Review.

PMID:
15651928
46.

The role of cell cycle on polyplex-mediated gene transfer into a retinal pigment epithelial cell line.

Männistö M, Rönkkö S, Mättö M, Honkakoski P, Hyttinen M, Pelkonen J, Urtti A.

J Gene Med. 2005 Apr;7(4):466-76.

PMID:
15619286
47.

Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity.

Windshügel B, Jyrkkärinne J, Poso A, Honkakoski P, Sippl W.

J Mol Model. 2005 Feb;11(1):69-79. Epub 2004 Dec 23.

PMID:
15616833
48.

Amino acids important for ligand specificity of the human constitutive androstane receptor.

Jyrkkärinne J, Windshügel B, Mäkinen J, Ylisirniö M, Peräkylä M, Poso A, Sippl W, Honkakoski P.

J Biol Chem. 2005 Feb 18;280(7):5960-71. Epub 2004 Nov 29.

49.
50.

Requirements for delivery of active antisense oligonucleotides into cells with lipid carriers.

Jääskeläinen I, Lappalainen K, Honkakoski P, Urtti A.

Methods Enzymol. 2004;387:210-30. No abstract available.

PMID:
15172166

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