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Items: 1 to 50 of 1170

1.

Survey of Contemporary Cardiac Surgery ICU Models in the United States.

Arora RC, Chatterjee S, Shake JG, Hirose H, Engelman DT, Rabin J, Firstenberg M, Moosdorf RGH, Geller CM, Hiebert B, Whitman GJ; Society of Thoracic Surgery Workforce for Critical Care (STS WFCC).

Ann Thorac Surg. 2019 Aug 14. pii: S0003-4975(19)31179-8. doi: 10.1016/j.athoracsur.2019.06.077. [Epub ahead of print]

PMID:
31421102
2.

Periarticular injection of tranexamic acid promotes early recovery of the range of knee motion after total knee arthroplasty.

Hirose H, Ogawa H, Matsumoto K, Akiyama H.

J Orthop Surg (Hong Kong). 2019 Sep-Dec;27(3):2309499019864693. doi: 10.1177/2309499019864693.

PMID:
31359848
3.
4.

A Case Study on the Keap1 Interaction with Peptide Sequence Epitopes Selected by the Peptidomic mRNA Display.

Hirose H, Hideshima T, Katoh T, Suga H.

Chembiochem. 2019 Aug 16;20(16):2089-2100. doi: 10.1002/cbic.201900039. Epub 2019 Jun 6.

PMID:
31169361
5.

Discovery of Superconductivity in 2M WS2 with Possible Topological Surface States.

Fang Y, Pan J, Zhang D, Wang D, Hirose HT, Terashima T, Uji S, Yuan Y, Li W, Tian Z, Xue J, Ma Y, Zhao W, Xue Q, Mu G, Zhang H, Huang F.

Adv Mater. 2019 Jul;31(30):e1901942. doi: 10.1002/adma.201901942. Epub 2019 Jun 3.

PMID:
31157482
6.

Staged arthrodesis using the Masquelet technique for osteomyelitis of the finger with articular destruction: a report of two cases.

Ono R, Komura S, Hirakawa A, Hirose H, Tsugita M, Masuda T, Ito Y, Akiyama H.

Arch Orthop Trauma Surg. 2019 Jul;139(7):1025-1031. doi: 10.1007/s00402-019-03197-5. Epub 2019 May 15.

PMID:
31093754
7.

Pharmacokinetics of Ketamine at Dissociative Doses in an Adult Patient With Refractory Status Asthmaticus Receiving Extracorporeal Membrane Oxygenation Therapy.

Lam E, Rochani A, Kaushal G, Thoma BN, Tanjuakio J, West FM, Hirose H.

Clin Ther. 2019 May;41(5):994-999. doi: 10.1016/j.clinthera.2019.03.005. Epub 2019 Mar 28.

PMID:
30929859
8.

[A Case of Early Gastric Cancer That Coexisted with Multiple Submucosal Heterotopic Gastric Glands].

Nagai K, Tamura S, Matsuyama J, Imamura H, Yagi Y, Mokutani Y, Hashimoto Y, Hirose H, Ide Y, Kubota M, Fukushima Y, Sasaki Y.

Gan To Kagaku Ryoho. 2019 Mar;46(3):592-594. Japanese.

PMID:
30914624
9.

[A Case of Recurrence in the Lateral Pelvic Lymph Node after Local Excision of Lower Rectal pT1a Cancer].

Ide Y, Mokutani Y, Hirose H, Imamura H, Yoneda N, Shigetsu K, Kidogami S, Kishimoto T, Hashimoto Y, Matsuyama J, Tamura S, Takeda M, Sasaki Y.

Gan To Kagaku Ryoho. 2019 Feb;46(2):363-365. Japanese.

PMID:
30914561
10.

Features of and preventive measures against hypertension in the young.

Kawabe H, Azegami T, Takeda A, Kanda T, Saito I, Saruta T, Hirose H.

Hypertens Res. 2019 Jul;42(7):935-948. doi: 10.1038/s41440-019-0229-3. Epub 2019 Mar 20. Review.

PMID:
30894695
11.

Oligoarginine-Bearing Tandem Repeat Penetration-Accelerating Sequence Delivers Protein to Cytosol via Caveolae-Mediated Endocytosis.

Okuda A, Tahara S, Hirose H, Takeuchi T, Nakase I, Ono A, Takehashi M, Tanaka S, Futaki S.

Biomacromolecules. 2019 May 13;20(5):1849-1859. doi: 10.1021/acs.biomac.8b01299. Epub 2019 Apr 1.

PMID:
30893557
12.

Dysbiosis of the Gut Microbiota on the Inflammatory Background due to Lack of Suppressor of Cytokine Signalling-1 in Mice.

Gendo Y, Matsumoto T, Kamiyama N, Saechue B, Fukuda C, Dewayani A, Hidano S, Noguchi K, Sonoda A, Ozaki T, Sachi N, Hirose H, Ozaka S, Eshita Y, Mizukami K, Okimoto T, Kodama M, Yoshimatsu T, Nishida H, Daa T, Yamaoka Y, Murakami K, Kobayashi T.

Inflamm Intest Dis. 2019 Feb;3(3):145-154. doi: 10.1159/000495462. Epub 2019 Jan 10.

13.

Multiple physician visits after restricting the prescription of compresses/patches in a Japanese rural community: preliminary results.

Ban T, Hirose H, Teraura H, Kotani K, Gotoh T.

Rural Remote Health. 2019 Feb;19(1):5078. doi: 10.22605/RRH5078. Epub 2019 Feb 12. No abstract available.

14.

Skin advanced glycation end products as biomarkers of photosensitivity in schizophrenia.

Tani E, Ohnuma T, Hirose H, Nakayama K, Mao W, Nakadaira M, Orimo N, Yamashita H, Takebayashi Y, Miki Y, Katsuta N, Nishimon S, Hasegawa T, Komiyama E, Suga Y, Ikeda S, Arai H.

Int J Methods Psychiatr Res. 2019 Mar;28(1):e1769. doi: 10.1002/mpr.1769. Epub 2019 Jan 31.

PMID:
30701623
15.

[A Case of Anastomotic Recurrence of Rectal Cancer 22 Years after Surgery].

Hirose H, Ide Y, Mokutani Y, Takeda M, Imamura H, Hashimoto Y, Nagai K, Matsuyama J, Kubota M, Tamura S, Sasaki Y.

Gan To Kagaku Ryoho. 2018 Dec;45(13):1800-1802. Japanese.

PMID:
30692358
16.

Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice.

Takahashi A, Wakihata S, Ma L, Adachi T, Hirose H, Yoshida Y, Ohira Y.

Int J Mol Sci. 2018 Dec 9;19(12). pii: E3959. doi: 10.3390/ijms19123959.

17.

Sox2 is associated with cancer stem-like properties in colorectal cancer.

Takeda K, Mizushima T, Yokoyama Y, Hirose H, Wu X, Qian Y, Ikehata K, Miyoshi N, Takahashi H, Haraguchi N, Hata T, Matsuda C, Doki Y, Mori M, Yamamoto H.

Sci Rep. 2018 Dec 5;8(1):17639. doi: 10.1038/s41598-018-36251-0.

18.

Handoffs From the Operating Room to the Intensive Care Unit After Cardiothoracic Surgery: From The Society of Thoracic Surgeons Workforce on Critical Care.

Chatterjee S, Shake JG, Arora RC, Engelman DT, Firstenberg MS, Geller CM, Hirose H, Lonchyna VA, Lytle FT, Milewski RKC, Moosdorf RGH, Rabin J, Sanjanwala R, Galati M, Whitman GJ; Society of Thoracic Surgeons Workforce on Critical Care.

Ann Thorac Surg. 2019 Feb;107(2):619-630. doi: 10.1016/j.athoracsur.2018.11.010. Epub 2018 Nov 27. No abstract available.

PMID:
30500341
19.

In vitro expression of genetically encoded non-standard peptides consisting of exotic amino acid building blocks.

Hirose H, Tsiamantas C, Katoh T, Suga H.

Curr Opin Biotechnol. 2018 Nov 16;58:28-36. doi: 10.1016/j.copbio.2018.10.012. [Epub ahead of print] Review.

PMID:
30453154
20.

Oral administration of antibiotics results in fecal occult bleeding due to metabolic disorders and defective proliferation of the gut epithelial cell in mice.

Sonoda A, Kamiyama N, Ozaka S, Gendo Y, Ozaki T, Hirose H, Noguchi K, Saechue B, Sachi N, Sakai K, Mizukami K, Hidano S, Murakami K, Kobayashi T.

Genes Cells. 2018 Dec;23(12):1043-1055. doi: 10.1111/gtc.12649. Epub 2018 Nov 18.

21.

Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21.

Tanikawa C, Kamatani Y, Toyoshima O, Sakamoto H, Ito H, Takahashi A, Momozawa Y, Hirata M, Fuse N, Takai-Igarashi T, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Hishida A, Wakai K, Furusyo N, Murakami Y, Nakamura Y, Imoto I, Inazawa J, Oze I, Sato N, Tanioka F, Sugimura H, Hirose H, Yoshida T, Matsuo K, Kubo M, Matsuda K.

Cancer Sci. 2018 Dec;109(12):4015-4024. doi: 10.1111/cas.13815. Epub 2018 Oct 31.

22.

Autoimmune sialadenitis is associated with the upregulation of chemokine/chemokine receptor pairs in T cell-specific TRAF6-deficient mice.

Noguchi K, Kamiyama N, Hidano S, Gendo Y, Sonoda A, Ozaki T, Hirose H, Sachi N, Saechue B, Ozaka S, Eshita Y, Mizukami K, Kawano K, Kobayashi T.

Biochem Biophys Res Commun. 2018 Sep 26;504(1):245-250. doi: 10.1016/j.bbrc.2018.08.162. Epub 2018 Sep 3.

PMID:
30190125
23.

The Supercarbonate Apatite-MicroRNA Complex Inhibits Dextran Sodium Sulfate-Induced Colitis.

Fukata T, Mizushima T, Nishimura J, Okuzaki D, Wu X, Hirose H, Yokoyama Y, Kubota Y, Nagata K, Tsujimura N, Inoue A, Miyoshi N, Haraguchi N, Takahashi H, Hata T, Matsuda C, Kayama H, Takeda K, Doki Y, Mori M, Yamamoto H.

Mol Ther Nucleic Acids. 2018 Sep 7;12:658-671. doi: 10.1016/j.omtn.2018.07.007. Epub 2018 Aug 6.

24.

Mesothelial cells facilitate cancer stem‑like properties in spheroids of ovarian cancer cells.

Shishido A, Mori S, Yokoyama Y, Hamada Y, Minami K, Qian Y, Wang J, Hirose H, Wu X, Kawaguchi N, Nagumo S, Matsuura N, Yamamoto H.

Oncol Rep. 2018 Oct;40(4):2105-2114. doi: 10.3892/or.2018.6605. Epub 2018 Jul 27.

PMID:
30066911
25.

Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.

Ito Y, Nakamura S, Sugimoto N, Shigemori T, Kato Y, Ohno M, Sakuma S, Ito K, Kumon H, Hirose H, Okamoto H, Nogawa M, Iwasaki M, Kihara S, Fujio K, Matsumoto T, Higashi N, Hashimoto K, Sawaguchi A, Harimoto KI, Nakagawa M, Yamamoto T, Handa M, Watanabe N, Nishi E, Arai F, Nishimura S, Eto K.

Cell. 2018 Jul 26;174(3):636-648.e18. doi: 10.1016/j.cell.2018.06.011. Epub 2018 Jul 12.

26.

What Is the Optimal Blood Pressure on Veno-Arterial Extracorporeal Membrane Oxygenation? Impact of Mean Arterial Pressure on Survival.

Tanaka D, Shimada S, Mullin M, Kreitler K, Cavarocchi N, Hirose H.

ASAIO J. 2019 May/Jun;65(4):336-341. doi: 10.1097/MAT.0000000000000824.

PMID:
29762229
27.

Minor Electrocardiographic ST-T Change and Risk of Stroke in the General Japanese Population.

Ishikawa J, Hirose H, Schwartz JE, Ishikawa S.

Circ J. 2018 Jun 25;82(7):1797-1804. doi: 10.1253/circj.CJ-17-1084. Epub 2018 Apr 20.

28.

[Gallbladder Carcinoma That Occurred 50 Years after Cholecystojejunostomy].

Kubota M, Hashimoto Y, Imamura H, Yagi Y, Noma T, Mokutani Y, Nagai K, Hirose H, Ide Y, Matsuyama J, Fukushima Y, Nishioka Y, Takeda M, Tamura S, Sasaki Y.

Gan To Kagaku Ryoho. 2018 Mar;45(3):513-514. Japanese.

PMID:
29650922
29.

[Hepatocellular Carcinoma with Bile Duct Thrombosis - A Case Report].

Kubota M, Hashimoto Y, Imamura H, Yagi Y, Noma T, Mokutani Y, Nagai K, Hirose H, Ide Y, Matsuyama J, Fukushima Y, Nishioka Y, Takeda M, Tamura S, Sasaki Y.

Gan To Kagaku Ryoho. 2018 Mar;45(3):501-503. Japanese.

PMID:
29650918
30.

A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-κB Signaling in KRAS-Mutant Colon Cancer Cells.

Inoue A, Mizushima T, Wu X, Okuzaki D, Kambara N, Ishikawa S, Wang J, Qian Y, Hirose H, Yokoyama Y, Ikeshima R, Hiraki M, Miyoshi N, Takahashi H, Haraguchi N, Hata T, Matsuda C, Doki Y, Mori M, Yamamoto H.

Mol Cancer Ther. 2018 May;17(5):977-987. doi: 10.1158/1535-7163.MCT-17-0850. Epub 2018 Mar 15.

31.

[A Case of Malignant Transformation of Intraductal Papillary Mucinous Neoplasm of the Pancreas Accompanied by Metachronous Triple Primary Cancer].

Noma T, Hirose H, Ide Y, Imamura H, Yagi Y, Mokutani Y, Hashimoto Y, Nagai K, Matsuyama J, Kubota M, Fukushima Y, Tamura S, Sasaki Y.

Gan To Kagaku Ryoho. 2017 Nov;44(12):2026-2028. Review. Japanese.

PMID:
29394856
32.

Does acute kidney injury affect survival in adults with acute respiratory distress syndrome requiring extracorporeal membrane oxygenation?

Devasagayaraj R, Cavarocchi NC, Hirose H.

Perfusion. 2018 Jul;33(5):375-382. doi: 10.1177/0267659118755272. Epub 2018 Jan 23.

PMID:
29360002
33.

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Demenais F, Margaritte-Jeannin P, Barnes KC, Cookson WOC, Altmüller J, Ang W, Barr RG, Beaty TH, Becker AB, Beilby J, Bisgaard H, Bjornsdottir US, Bleecker E, Bønnelykke K, Boomsma DI, Bouzigon E, Brightling CE, Brossard M, Brusselle GG, Burchard E, Burkart KM, Bush A, Chan-Yeung M, Chung KF, Couto Alves A, Curtin JA, Custovic A, Daley D, de Jongste JC, Del-Rio-Navarro BE, Donohue KM, Duijts L, Eng C, Eriksson JG, Farrall M, Fedorova Y, Feenstra B, Ferreira MA; Australian Asthma Genetics Consortium (AAGC) collaborators, Freidin MB, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib SA, Gilliland F, Granell R, Graves PE, Gudbjartsson DF, Haahtela T, Heckbert SR, Heederik D, Heinrich J, Heliövaara M, Henderson J, Himes BE, Hirose H, Hirschhorn JN, Hofman A, Holt P, Hottenga J, Hudson TJ, Hui J, Imboden M, Ivanov V, Jaddoe VWV, James A, Janson C, Jarvelin MR, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kähönen M, Kantor DB, Karunas AS, Khusnutdinova E, Koppelman GH, Kozyrskyj AL, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Laprise C, Lathrop M, Lau S, Lee YA, Lehtimäki T, Letort S, Levin AM, Li G, Liang L, Loehr LR, London SJ, Loth DW, Manichaikul A, Marenholz I, Martinez FJ, Matheson MC, Mathias RA, Matsumoto K, Mbarek H, McArdle WL, Melbye M, Melén E, Meyers D, Michel S, Mohamdi H, Musk AW, Myers RA, Nieuwenhuis MAE, Noguchi E, O'Connor GT, Ogorodova LM, Palmer CD, Palotie A, Park JE, Pennell CE, Pershagen G, Polonikov A, Postma DS, Probst-Hensch N, Puzyrev VP, Raby BA, Raitakari OT, Ramasamy A, Rich SS, Robertson CF, Romieu I, Salam MT, Salomaa V, Schlünssen V, Scott R, Selivanova PA, Sigsgaard T, Simpson A, Siroux V, Smith LJ, Solodilova M, Standl M, Stefansson K, Strachan DP, Stricker BH, Takahashi A, Thompson PJ, Thorleifsson G, Thorsteinsdottir U, Tiesler CMT, Torgerson DG, Tsunoda T, Uitterlinden AG, van der Valk RJP, Vaysse A, Vedantam S, von Berg A, von Mutius E, Vonk JM, Waage J, Wareham NJ, Weiss ST, White WB, Wickman M, Widén E, Willemsen G, Williams LK, Wouters IM, Yang JJ, Zhao JH, Moffatt MF, Ober C, Nicolae DL.

Nat Genet. 2018 Jan;50(1):42-53. doi: 10.1038/s41588-017-0014-7. Epub 2017 Dec 22.

34.

Is hemodynamic transesophageal echocardiography needed for patients with left ventricular assist device?

Bahatyrevich N, Yang Q, Cavarocchi NC, Hirose H.

J Thorac Cardiovasc Surg. 2018 Mar;155(3):1071-1077. doi: 10.1016/j.jtcvs.2017.09.142. Epub 2017 Nov 8.

PMID:
29248289
35.

Reply.

Unai S, Hirose H, Cavarocchi NC.

Ann Thorac Surg. 2017 Nov;104(5):1758-1759. doi: 10.1016/j.athoracsur.2017.02.008. No abstract available.

PMID:
29054220
36.

Description of the Surgical Strategy Used for the Treatment of a Complex Disease: Report of a Case.

Kihara K, Tashiro M, Miyashita K, Yamamoto M, Hirose H, Fukutomi T, Nishimori H, Orihashi K.

Ann Vasc Dis. 2017 Jun 25;10(2):146-148. doi: 10.3400/avd.cr.16-00113.

37.

Issues in the Intensive Care Unit for Patients with Extracorporeal Membrane Oxygenation.

Hirose H, Pitcher HT, Baram M, Cavarocchi NC.

Crit Care Clin. 2017 Oct;33(4):855-862. doi: 10.1016/j.ccc.2017.06.007. Epub 2017 Jul 29. Review.

PMID:
28887932
38.

Vascular Complications in Extracoporeal Membrane Oxygenation.

Lamb KM, Hirose H.

Crit Care Clin. 2017 Oct;33(4):813-824. doi: 10.1016/j.ccc.2017.06.004. Epub 2017 Jul 28. Review.

PMID:
28887929
39.

Randomized Trial of Sternal Closure for Low Risk Patients: Rigid Fixation versus Wire Closure.

Peigh G, Kumar J, Unai S, James DT, Hirose H.

Heart Surg Forum. 2017 Aug 28;20(4):E164-E169. doi: 10.1532/hsf.1860.

PMID:
28846532
40.

Neurological complications during veno-venous extracorporeal membrane oxygenation.

Hirose H, Cavarocchi NC.

J Thorac Dis. 2017 Jul;9(7):1796-1797. doi: 10.21037/jtd.2017.06.75. No abstract available.

41.

P-REX1 amplification promotes progression of cutaneous melanoma via the PAK1/P38/MMP-2 pathway.

Wang J, Hirose H, Du G, Chong K, Kiyohara E, Witz IP, Hoon DSB.

Cancer Lett. 2017 Oct 28;407:66-75. doi: 10.1016/j.canlet.2017.08.001. Epub 2017 Aug 10.

PMID:
28803992
42.

Short-term outcomes following single-port laparoscopic surgery in elderly patients with colon cancer compared with younger patients.

Takeda M, Tokuoka M, Hirose H, Ide Y, Hashimoto Y, Matsuyama J, Yokoyama S, Morimoto T, Fukishima Y, Nomura T, Kodama K, Sasaki Y.

Oncol Lett. 2017 Aug;14(2):1595-1601. doi: 10.3892/ol.2017.6344. Epub 2017 Jun 8.

43.

Reply.

Unai S, Hirose H, Cavarocchi NC.

Ann Thorac Surg. 2017 Aug;104(2):725-726. doi: 10.1016/j.athoracsur.2016.12.006. No abstract available.

PMID:
28734424
44.

Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus.

Hirose H, Yamasaki T, Ogino M, Mizojiri R, Tamura-Okano Y, Yashiro H, Muraki Y, Nakano Y, Sugama J, Hata A, Iwasaki S, Watanabe M, Maekawa T, Kasai S.

Bioorg Med Chem. 2017 Aug 1;25(15):4175-4193. doi: 10.1016/j.bmc.2017.06.007. Epub 2017 Jun 9.

PMID:
28642028
45.

Use of Provider Debriefing to Improve Fast-Track Extubation Rates Following Cardiac Surgery at an Academic Medical Center.

Goldhammer JE, Dashiell JM, Davis S, Torjman MC, Hirose H.

Am J Med Qual. 2018 Mar/Apr;33(2):172-176. doi: 10.1177/1062860617712859. Epub 2017 Jun 19.

PMID:
28629228
46.

Discovery of novel somatostatin receptor subtype 5 (SSTR5) antagonists: Pharmacological studies and design to improve pharmacokinetic profiles and human Ether-a-go-go-related gene (hERG) inhibition.

Yamasaki T, Hirose H, Yamashita T, Takakura N, Morimoto S, Nakahata T, Kina A, Nakano Y, Okano Tamura Y, Sugama J, Odani T, Shimizu Y, Iwasaki S, Watanabe M, Maekawa T, Kasai S.

Bioorg Med Chem. 2017 Aug 1;25(15):4153-4162. doi: 10.1016/j.bmc.2017.06.003. Epub 2017 Jun 13.

PMID:
28622905
47.

Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese.

Fujii C, Kawai T, Azuma K, Oguma Y, Katsukawa F, Hirose H, Tanaka K, Meguro S, Matsumoto H, Itoh H.

J Diabetes Res. 2017;2017:1567467. doi: 10.1155/2017/1567467. Epub 2017 Apr 30.

48.

Arterial protocol including prophylactic distal perfusion catheter decreases limb ischemia complications in patients undergoing extracorporeal membrane oxygenation.

Lamb KM, DiMuzio PJ, Johnson A, Batista P, Moudgill N, McCullough M, Eisenberg JA, Hirose H, Cavarocchi NC.

J Vasc Surg. 2017 Apr;65(4):1074-1079. doi: 10.1016/j.jvs.2016.10.059.

49.

Temporal trends in renal function and birthweight in Japanese adolescent males (1998-2015).

Kanda T, Takeda A, Hirose H, Abe T, Urai H, Inokuchi M, Wakino S, Tokumura M, Itoh H, Kawabe H.

Nephrol Dial Transplant. 2018 Feb 1;33(2):304-310. doi: 10.1093/ndt/gfw428.

50.

Selective Inhibition of ADAM17 Efficiently Mediates Glycoprotein Ibα Retention During Ex Vivo Generation of Human Induced Pluripotent Stem Cell-Derived Platelets.

Hirata S, Murata T, Suzuki D, Nakamura S, Jono-Ohnishi R, Hirose H, Sawaguchi A, Nishimura S, Sugimoto N, Eto K.

Stem Cells Transl Med. 2017 Mar;6(3):720-730. doi: 10.5966/sctm.2016-0104. Epub 2016 Oct 5.

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