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Items: 1 to 50 of 131

1.

Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial.

Antcliffe DB, Burnham KL, Al-Beidh F, Santhakumaran S, Brett SJ, Hinds CJ, Ashby D, Knight JC, Gordon AC.

Am J Respir Crit Care Med. 2019 Apr 15;199(8):980-986. doi: 10.1164/rccm.201807-1419OC.

2.

Post-operative immune suppression is mediated via reversible, Interleukin-10 dependent pathways in circulating monocytes following major abdominal surgery.

Torrance HDT, Longbottom ER, Vivian ME, Lalabekyan B, Abbott TEF, Ackland GL, Hinds CJ, Pearse RM, O'Dwyer MJ.

PLoS One. 2018 Sep 13;13(9):e0203795. doi: 10.1371/journal.pone.0203795. eCollection 2018.

3.

A community approach to mortality prediction in sepsis via gene expression analysis.

Sweeney TE, Perumal TM, Henao R, Nichols M, Howrylak JA, Choi AM, Bermejo-Martin JF, Almansa R, Tamayo E, Davenport EE, Burnham KL, Hinds CJ, Knight JC, Woods CW, Kingsmore SF, Ginsburg GS, Wong HR, Parnell GP, Tang B, Moldawer LL, Moore FE, Omberg L, Khatri P, Tsalik EL, Mangravite LM, Langley RJ.

Nat Commun. 2018 Feb 15;9(1):694. doi: 10.1038/s41467-018-03078-2.

4.

Pharmacogenomic biomarkers do not predict response to drotrecogin alfa in patients with severe sepsis.

Annane D, Mira JP, Ware LB, Gordon AC, Hinds CJ, Christiani DC, Sevransky J, Barnes K, Buchman TG, Heagerty PJ, Balshaw R, Lesnikova N, de Nobrega K, Wellman HF, Neira M, Mancini ADJ, Walley KR, Russell JA.

Ann Intensive Care. 2018 Jan 31;8(1):16. doi: 10.1186/s13613-018-0353-2.

5.

Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis.

Lashin HMS, Nadkarni S, Oggero S, Jones HR, Knight JC, Hinds CJ, Perretti M.

Shock. 2018 Apr;49(4):393-401. doi: 10.1097/SHK.0000000000000989.

PMID:
28930915
6.

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.

Scicluna BP, van Vught LA, Zwinderman AH, Wiewel MA, Davenport EE, Burnham KL, Nürnberg P, Schultz MJ, Horn J, Cremer OL, Bonten MJ, Hinds CJ, Wong HR, Knight JC, van der Poll T; MARS consortium.

Lancet Respir Med. 2017 Oct;5(10):816-826. doi: 10.1016/S2213-2600(17)30294-1. Epub 2017 Aug 29.

PMID:
28864056
7.

Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia.

Burnham KL, Davenport EE, Radhakrishnan J, Humburg P, Gordon AC, Hutton P, Svoren-Jabalera E, Garrard C, Hill AVS, Hinds CJ, Knight JC.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):328-339. doi: 10.1164/rccm.201608-1685OC.

8.

Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28Day Mortality.

Scherag A, Schöneweck F, Kesselmeier M, Taudien S, Platzer M, Felder M, Sponholz C, Rautanen A, Hill AVS, Hinds CJ, Hossain H, Suttorp N, Kurzai O, Slevogt H, Giamarellos-Bourboulis EJ, Armaganidis A, Trips E, Scholz M, Brunkhorst FM.

EBioMedicine. 2016 Oct;12:239-246. doi: 10.1016/j.ebiom.2016.08.043. Epub 2016 Sep 15.

9.

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study.

Davenport EE, Burnham KL, Radhakrishnan J, Humburg P, Hutton P, Mills TC, Rautanen A, Gordon AC, Garrard C, Hill AV, Hinds CJ, Knight JC.

Lancet Respir Med. 2016 Apr;4(4):259-71. doi: 10.1016/S2213-2600(16)00046-1. Epub 2016 Feb 23.

10.

Epigenetic regulatory pathways involving microRNAs may modulate the host immune response following major trauma.

Owen HC, Torrance HD, Jones TF, Pearse RM, Hinds CJ, Brohi K, O'Dwyer MJ.

J Trauma Acute Care Surg. 2015 Nov;79(5):766-72. doi: 10.1097/TA.0000000000000850.

PMID:
26496100
11.

Features of Postoperative Immune Suppression Are Reversible With Interferon Gamma and Independent of Interleukin-6 Pathways.

Longbottom ER, Torrance HD, Owen HC, Fragkou PC, Hinds CJ, Pearse RM, O'Dwyer MJ.

Ann Surg. 2016 Aug;264(2):370-7. doi: 10.1097/SLA.0000000000001484.

PMID:
26445474
12.

Have you heard of the 'party drug' GBL (gamma butyrolactone)? A survey of health workers' knowledge of this potentially fatal drug.

Hinds CJ.

Aust N Z J Psychiatry. 2015 Nov;49(11):1069. doi: 10.1177/0004867415605620. Epub 2015 Sep 16. No abstract available.

PMID:
26377750
13.

Response to Schöneweck et al.: Common genomic variation in the FER gene: useful to stratify patients with sepsis due to pneumonia?

Rautanen A, Chapman SJ, Hinds CJ.

Intensive Care Med. 2015 Jul;41(7):1382. doi: 10.1007/s00134-015-3893-z. Epub 2015 Jun 16. No abstract available.

PMID:
26077084
14.

Variants in the Mannose-binding Lectin Gene MBL2 do not Associate With Sepsis Susceptibility or Survival in a Large European Cohort.

Mills TC, Chapman S, Hutton P, Gordon AC, Bion J, Chiche JD, Holloway PA, Stüber F, Garrard CS, Hinds CJ, Hill AV, Rautanen A; ESICM/ECCRN GenOSept Investigators.

Clin Infect Dis. 2015 Sep 1;61(5):695-703. doi: 10.1093/cid/civ378. Epub 2015 May 12.

15.

Changes in gene expression following trauma are related to the age of transfused packed red blood cells.

Torrance HD, Vivian ME, Brohi K, Prowle JR, Pearse RM, Owen HC, Hinds CJ, O'Dwyer MJ.

J Trauma Acute Care Surg. 2015 Mar;78(3):535-42. doi: 10.1097/TA.0000000000000534.

PMID:
25710424
16.

Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study.

Rautanen A, Mills TC, Gordon AC, Hutton P, Steffens M, Nuamah R, Chiche JD, Parks T, Chapman SJ, Davenport EE, Elliott KS, Bion J, Lichtner P, Meitinger T, Wienker TF, Caulfield MJ, Mein C, Bloos F, Bobek I, Cotogni P, Sramek V, Sarapuu S, Kobilay M, Ranieri VM, Rello J, Sirgo G, Weiss YG, Russwurm S, Schneider EM, Reinhart K, Holloway PA, Knight JC, Garrard CS, Russell JA, Walley KR, Stüber F, Hill AV, Hinds CJ; ESICM/ECCRN GenOSept Investigators.

Lancet Respir Med. 2015 Jan;3(1):53-60. doi: 10.1016/S2213-2600(14)70290-5. Epub 2014 Dec 18.

17.

Dynamic preload markers to predict fluid responsiveness during and after major gastrointestinal surgery: an observational substudy of the OPTIMISE trial.

MacDonald N, Ahmad T, Mohr O, Kirk-Bayley J, Moppett I, Hinds CJ, Pearse RM.

Br J Anaesth. 2015 Apr;114(4):598-604. doi: 10.1093/bja/aeu398. Epub 2014 Dec 11.

18.

Perioperative blood transfusion is associated with a gene transcription profile characteristic of immunosuppression: a prospective cohort study.

Fragkou PC, Torrance HD, Pearse RM, Ackland GL, Prowle JR, Owen HC, Hinds CJ, O'Dwyer MJ.

Crit Care. 2014 Oct 1;18(5):541. doi: 10.1186/s13054-014-0541-x.

19.

Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort.

Walden AP, Clarke GM, McKechnie S, Hutton P, Gordon AC, Rello J, Chiche JD, Stueber F, Garrard CS, Hinds CJ; ESICM/ECCRN GenOSept Investigators.

Crit Care. 2014 Apr 1;18(2):R58. doi: 10.1186/cc13812.

20.

Association between gene expression biomarkers of immunosuppression and blood transfusion in severely injured polytrauma patients.

Torrance HD, Brohi K, Pearse RM, Mein CA, Wozniak E, Prowle JR, Hinds CJ, OʼDwyer MJ.

Ann Surg. 2015 Apr;261(4):751-9. doi: 10.1097/SLA.0000000000000653.

PMID:
24670848
21.

Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis.

Dalli J, Norling LV, Montero-Melendez T, Federici Canova D, Lashin H, Pavlov AM, Sukhorukov GB, Hinds CJ, Perretti M.

EMBO Mol Med. 2014 Jan;6(1):27-42. doi: 10.1002/emmm.201303503. Epub 2013 Dec 15.

22.

Patients with faecal peritonitis admitted to European intensive care units: an epidemiological survey of the GenOSept cohort.

Tridente A, Clarke GM, Walden A, McKechnie S, Hutton P, Mills GH, Gordon AC, Holloway PA, Chiche JD, Bion J, Stuber F, Garrard C, Hinds CJ; GenOSept Investigators.

Intensive Care Med. 2014 Feb;40(2):202-10. doi: 10.1007/s00134-013-3158-7. Epub 2013 Dec 4.

PMID:
24306080
23.

Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow.

Bangash MN, Patel NS, Benetti E, Collino M, Hinds CJ, Thiemermann C, Pearse RM.

Crit Care. 2013 Mar 28;17(2):R57. doi: 10.1186/cc12585.

24.

Haemodynamic optimisation improves tissue microvascular flow and oxygenation after major surgery: a randomised controlled trial.

Jhanji S, Vivian-Smith A, Lucena-Amaro S, Watson D, Hinds CJ, Pearse RM.

Crit Care. 2010;14(4):R151. doi: 10.1186/cc9220. Epub 2010 Aug 10.

25.

The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock.

Jhanji S, Stirling S, Patel N, Hinds CJ, Pearse RM.

Crit Care Med. 2009 Jun;37(6):1961-6. doi: 10.1097/CCM.0b013e3181a00a1c.

PMID:
19384212
26.

Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection.

Eisen DP, Dean MM, Boermeester MA, Fidler KJ, Gordon AC, Kronborg G, Kun JF, Lau YL, Payeras A, Valdimarsson H, Brett SJ, Ip WK, Mila J, Peters MJ, Saevarsdottir S, van Till JW, Hinds CJ, McBryde ES.

Clin Infect Dis. 2008 Aug 15;47(4):510-6. doi: 10.1086/590006.

PMID:
18611155
27.

Mortality and utilisation of critical care resources amongst high-risk surgical patients in a large NHS trust.

Jhanji S, Thomas B, Ely A, Watson D, Hinds CJ, Pearse RM.

Anaesthesia. 2008 Jul;63(7):695-700. doi: 10.1111/j.1365-2044.2008.05560.x. Epub 2008 May 16.

28.

Genes and sepsis: how tight is the fit?

Gordon A, Knight JC, Hinds CJ.

Crit Care Med. 2008 May;36(5):1652-4. doi: 10.1097/CCM.0b013e318170f358. No abstract available.

PMID:
18448923
29.

Alterations in inflammatory capacity and TLR expression on monocytes and neutrophils after cardiopulmonary bypass.

Hadley JS, Wang JE, Michaels LC, Dempsey CM, Foster SJ, Thiemermann C, Hinds CJ.

Shock. 2007 May;27(5):466-73.

PMID:
17438450
30.
31.

Lipoproteins in inflammation and sepsis. I. Basic science.

Murch O, Collin M, Hinds CJ, Thiemermann C.

Intensive Care Med. 2007 Jan;33(1):13-24. Epub 2006 Nov 9. Review.

PMID:
17093985
32.

Treatment with GH and IGF-1 in critical illness.

Teng Chung T, Hinds CJ.

Crit Care Clin. 2006 Jan;22(1):29-40, vi. Review.

PMID:
16399018
33.

Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome.

Gordon AC, Waheed U, Hansen TK, Hitman GA, Garrard CS, Turner MW, Klein NJ, Brett SJ, Hinds CJ.

Shock. 2006 Jan;25(1):88-93.

PMID:
16369192
35.

Incidence and outcome of critical illness amongst hospitalised patients with haematological malignancy: a prospective observational study of ward and intensive care unit based care.

Gordon AC, Oakervee HE, Kaya B, Thomas JM, Barnett MJ, Rohatiner AZ, Lister TA, Cavenagh JD, Hinds CJ.

Anaesthesia. 2005 Apr;60(4):340-7.

36.

TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study.

Gordon AC, Lagan AL, Aganna E, Cheung L, Peters CJ, McDermott MF, Millo JL, Welsh KI, Holloway P, Hitman GA, Piper RD, Garrard CS, Hinds CJ.

Genes Immun. 2004 Dec;5(8):631-40.

PMID:
15526005
37.

Challenges in end-of-life care in the ICU: statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003: executive summary.

Thompson BT, Cox PN, Antonelli M, Carlet JM, Cassell J, Hill NS, Hinds CJ, Pimentel JM, Reinhart K, Thijs LG; American Thoracic Society; European Respiratory Society; European Society of Intensive Care Medicine; Society of Critical Care Medicine; Sociètède Rèanimation de Langue Française.

Crit Care Med. 2004 Aug;32(8):1781-4. Review.

PMID:
15286559
38.

High-density lipoproteins in sepsis and septic shock: metabolism, actions, and therapeutic applications.

Wu A, Hinds CJ, Thiemermann C.

Shock. 2004 Mar;21(3):210-21. Review.

PMID:
14770033
39.

Reconstituted high-density lipoprotein attenuates organ injury and adhesion molecule expression in a rodent model of endotoxic shock.

McDonald MC, Dhadly P, Cockerill GW, Cuzzocrea S, Mota-Filipe H, Hinds CJ, Miller NE, Thiemermann C.

Shock. 2003 Dec;20(6):551-7.

PMID:
14625480
40.

Liver albumin synthesis in sepsis in the rat: influence of parenteral nutrition, glutamine and growth hormone.

O'Leary MJ, Koll M, Ferguson CN, Coakley JH, Hinds CJ, Preedy VR, Garlick PJ.

Clin Sci (Lond). 2003 Dec;105(6):691-8.

PMID:
12875649
41.

Persistent neuromuscular and neurophysiologic abnormalities in long-term survivors of prolonged critical illness.

Fletcher SN, Kennedy DD, Ghosh IR, Misra VP, Kiff K, Coakley JH, Hinds CJ.

Crit Care Med. 2003 Apr;31(4):1012-6.

PMID:
12682465
42.

Anabolic strategies in critical illness.

Hadley JS, Hinds CJ.

Curr Opin Pharmacol. 2002 Dec;2(6):700-7. Review.

PMID:
12482734
43.
44.

Effect of growth hormone on muscle and liver protein synthesis in septic rats receiving glutamine-enriched parenteral nutrition.

O'Leary MJ, Ferguson CN, Rennie M, Hinds CJ, Coakley JH, Preedy VR.

Crit Care Med. 2002 May;30(5):1099-105.

PMID:
12006808
45.

An exonic splicing enhancer in human IGF-I pre-mRNA mediates recognition of alternative exon 5 by the serine-arginine protein splicing factor-2/alternative splicing factor.

Smith PJ, Spurrell EL, Coakley J, Hinds CJ, Ross RJ, Krainer AR, Chew SL.

Endocrinology. 2002 Jan;143(1):146-54.

PMID:
11751603
46.

Treatment of sepsis with activated protein C.

Hinds CJ.

BMJ. 2001 Oct 20;323(7318):881-2. No abstract available.

47.

Sequential changes in in vivo muscle and liver protein synthesis and plasma and tissue glutamine levels in sepsis in the rat.

O'Leary MJ, Ferguson CN, Rennie MJ, Hinds CJ, Coakley JH, Preedy VR.

Clin Sci (Lond). 2001 Sep;101(3):295-304.

PMID:
11524047
48.

Differential expression of suppressors of cytokine signalling genes in response to nutrition and growth hormone in the septic rat.

Johnson TS, O'Leary M, Justice SK, Maamra M, Zarkesh-Esfahani SH, Furlanetto R, Preedy VR, Hinds CJ, El Nahas AM, Ross RJ.

J Endocrinol. 2001 May;169(2):409-15.

PMID:
11312157
50.

In rats with sepsis, the acute fall in IGF-I is associated with an increase in circulating growth hormone-binding protein levels.

O'Leary MJ, Quinton N, Ferguson CN, Preedy VR, Ross RJ, Hinds CJ.

Intensive Care Med. 2000 Oct;26(10):1547-52.

PMID:
11126270

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